Damoctocog Alfa Pegol, a PEGylated B-domain Deleted Recombinant Extended Half-life Factor VIII for the Treatment of Hemophilia A: A Product Review by Mark T. Reding, Shadan Lalezari, Gili Kenet, Giovanni Di Minno, Jonathan Ducore, Alexander Solms, Anita Shah, Pål André Holme, Lone H. Poulsen, Karina Meijer, Mindy Simpson, Maria Elisa Mancuso

“…Low bleeding rates were achieved across the studies, with twice weekly, every 5-day and every 7-day prophylaxis offering patients ≥ 12 years and their clinicians the chance to tailor treatment to individual needs and lifestyles, while maintaining long-term protection from bleeds and their consequences. Graphical Abstract…”
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A national study of choanal atresia in tertiary care centers in Canada – part I: clinical presentation by Josee Paradis, Agnieszka Dzioba, Hamdy El-Hakim, Paul Hong, Frederick K. Kozak, Lily H. P. Nguyen, Demitri Perera, Evan Jon Propst, Jennifer M. Siu, Monika Wojtera, Murad Husein, National Choanal Atresia Study Working Group

“…Further investigation into hereditary linkages to CA development is warranted. Graphical abstract…”
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Longitudinal functional outcomes and late effects of radiation following treatment of nasopharyngeal carcinoma: secondary analysis of a prospective cohort study by Gia Gill, Ciaran Lane, Candace Myers, Evan D. Kerr, Pascal Lambert, Andrew Cooke, Paul D. Kerr

“…Higher radiation volumes are associated with poorer outcomes that worsen over time. Graphical Abstract…”
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Using Attention for Improving Defect Detection in Existing RC Bridges by Sergio Ruggieri, Angelo Cardellicchio, Andrea Nettis, Vito Reno, Giuseppina Uva

“…The model was finally embedded in an end-to-end tool offering a graphical user interface (GUI) to allow an effective interaction between the domain expert and the machine. …”
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Polymerase delta-interacting protein 2 mediates brain vascular permeability by regulating ROS-mediated ZO-1 phosphorylation and localization at the interendothelial border by Keke Wang, Hongyan Qu, Ruinan Hu, Bernard Lassègue, Douglas C. Eaton, Chang Song, Jianjun Mu, Kathy K. Griendling, Marina S. Hernandes

“…Conclusions These data reveal a novel mitochondrial ROS-driven mechanism by which Poldip2 induces ZO-1 tyrosine phosphorylation and promotes EC permeability following cerebral ischemia. Graphical Abstract…”
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Identification of compounds against atherosclerosis induced by ox-LDL based on cell extraction/UPLC–MS/MS from mulberry twigs and their mechanistic analysis by Zhihui Jin, Wei Xiang, Xiaowen Shi, Fenglin Jiang, Yanan Jia, Yuansong Zhang, Lingshu Zeng, Xianzhi Huang, Li Xu

“…These compounds hold potential in treating atherosclerosis and related oxidative stress diseases. Graphical Abstract…”
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The relationships between mental health and social media addiction, and between academic burnout and social media addiction among Chinese college students: A network analysis by Tingwei Feng, Buyao Wang, Mingdi Mi, Lei Ren, Lin Wu, Hui Wang, Xufeng Liu, Xiuchao Wang

“…Network analysis was performed using R to model the relationships between study variables, employing Gaussian Graphical Models and the least absolute shrinkage and selection operator technique for robust network estimation. …”
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Easy, fast and reproducible Stochastic Cellular Automata with chouca by Génin, Alexandre, Dupont, Guillaume, Valencia, Daniel, Zucconi, Mauro, Ávila-Thieme, M. Isidora, Navarrete, Sergio A., Wieters, Evie A.

“…Exact and mean-field simulations can be run, and both numerical and graphical results can be easily exported. Besides providing better reproducibility and accessibility, a fast engine for SCA unlocks novel, computationally intensive statistical approaches, such as simulation-based inference of ecological interactions from field data, which represents by itself an important avenue for research. …”
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Impact of diabetes remission or progression on the incidence of cardiovascular disease in Japan: historical cohort study using a nationwide claims database by Chihiro Shimayama, Kazuya Fujihara, Laymon Khin, Hiroki Takizawa, Chika Horikawa, Takaaki Sato, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Hirohito Sone

“…Conclusions In a real-world setting without intensive intervention, diabetes remission decreased the risk of CVD by approximately 30% regardless of changes in BMI, suggesting that diabetes remission can prevent CVD without weight loss in routine care and emphasizing the importance of achieving remission. Graphical Abstract…”
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Development and validation of the modified index of fragility in head and neck cancer surgery by Koorosh Semsar-Kazerooni, Keith Richardson, Véronique-Isabelle Forest, Alex Mlynarek, Michael P. Hier, Nader Sadeghi, Marco. A. Mascarella

“…Conclusion The modified index of fragility is a reliable and easily accessible tool to predict risk of postoperative adverse events and death in patients undergoing head and neck cancer surgery. Graphical Abstract…”
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Upskilling or deskilling? Measurable role of an AI-supported training for radiology residents: a lesson from the pandemic by Mattia Savardi, Alberto Signoroni, Sergio Benini, Filippo Vaccher, Matteo Alberti, Pietro Ciolli, Nunzia Di Meo, Teresa Falcone, Marco Ramanzin, Barbara Romano, Federica Sozzi, Davide Farina

“…This approach is advisable for evaluating AI tools in radiology training. Graphical Abstract…”
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Enhanced penetration and biofilm eradication by sophorolipid micelles encapsulating Honokiol: a comprehensive solution for biofilm-associated lung infections by Shiyu Lin, Xiaojuan Li, Wei Zhang, Gang Shu, Tim Tolker-Nielsen, Haohuan Li, Funeng Xu, Juchun Lin, Guangneng Peng, Li Zhang, Hualin Fu

“…Conclusions HK-SL Ms offers a novel strategy for the clinical treatment of biofilm-associated infections by dispersing and removing S. aureus biofilms and preventing new infections. Graphical Abstract…”
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A new scheme for boosting in situ Fenton-like reaction in plant pathogenic tissues for selective structural degradation of capsid proteins by Jun Ma, Ming Chen, Yujie Wang, Jiaying Li, Jian Tang, Shengjun Wu, Chi He, J. Paul Chen

“…Our findings provide a new, efficient, and environmentally friendly approach for plant virus control. Graphical Abstract…”
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The association between TyG index and cardiovascular mortality is modified by antidiabetic or lipid-lowering agent: a prospective cohort study by Changchang Fang, Nanqin Peng, Jiang Cheng, Xiyu Zhang, Wenli Gu, Zicheng Zhu, Xiaoping Yin, Zhiwei Yan, Jing Zhang, Peng Yu, Xiao Liu

“…These findings suggest that future studies on the TyG index and its relationship with CVD and mortality should account for the modifying effects of these agents. Graphical abstract…”
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Is otologic surgery contributing to the opioid epidemic? by Valerie Dahm, Justin T. Lui, Rudolfs Liepins, Joseph M. Chen, Trung N. Le, Christoph Arnoldner, Vincent Y. W. Lin

“…Studies to evaluate pain after these operations as well as efficacy of analgesics following ear surgery are an important next step. Graphical abstract…”
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Comparison of ELISA and IFAT for Leishmania infantum by European and Middle Eastern diagnostic laboratories by Kurayi G. Mahachi, Marie Ozanne, Patrick Bourdeau, Juliana Sarquis, Eric Kontowicz, Laia Solano-Gallego, Luis Cardoso, Gaetano Oliva, Gad Baneth, Maria Grazia Pennisi, Angela M. Toepp, Guadalupe Miró, Margaret Carrel, Christine A. Petersen

“…Studies and interventional trials that use these tests will remain valid because of high diagnostic agreement between sites. Graphical Abstract…”
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Nicotinamide riboside supplementation ameliorates ovarian dysfunction in a PCOS mouse model by Zhenye Zhu, Min Lei, Ruizhi Guo, Yining Xu, Yanqing Zhao, Chenlu Wei, Qingling Yang, Yingpu Sun

“…These findings suggest that supplementing with NAD+ precursors could be a promising therapeutic strategy for addressing ovarian infertility associated with PCOS. Graphical Abstract Ovarian NAD+ levels decreased in DHEA-induced PCOS mice, accompanied by mitochondrial dysfunction in oocytes and ovarian stromal cells, resulting in reduced oocyte quantity and quality, decreased early embryonic development potential, and increased ovarian fibrosis. …”
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ACTION: Augmentation and computation toolbox for brain network analysis with functional MRI by Yuqi Fang, Junhao Zhang, Linmin Wang, Qianqian Wang, Mingxia Liu

“…The ACTION is a Python-based and cross-platform toolbox with graphical user-friendly interfaces. It enables automatic fMRI augmentation, covering blood-oxygen-level-dependent (BOLD) signal augmentation and brain network augmentation. …”
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Fluralaner systemic treatment of chickens results in mortality in Triatoma gerstaeckeri, vector of the agent of Chagas disease by Cassandra Durden, Yuexun Tian, Koyle Knape, Cory Klemashevich, Keri N. Norman, John B. Carey, Sarah A. Hamer, Gabriel L. Hamer

“…Conclusions Xenointoxication using fluralaner in poultry is a potential new tool for integrated vector control to reduce risk of Chagas disease. Graphical Abstract…”
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Mathematical modelling and optimization of cutting conditions in turning operation on MDN 350 steel with carbide inserts by Syed Adil, A. Krishnaiah, D. Srinivas Rao

“…The machining performance indicators of the first set are optimized using graphical method of contour plots. Artificial neural networks technique, which is well known for its versatility to model linear as well as non-linear data, is used to express the surface roughness as a function of tool geometrical variables. …”
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