Design of a new class of broad-spectrum therapeutics targeted to drug-resistant bacteria by Amrutha Surendran, Agnes Turnbull, Allen Flockhart, Fern Findlay-Greene, Martyna Nowosielska, Donald Morrison, David J. Mincher, Samantha Donnellan

“…The anthraquinone-TPP conjugates (4) and (5) were active in vitro against Mycobacterium smegmatis (graphical abstract) and were equipotent as determined by their MIC values; in contrast to MRSA, the less hydrophobic (4) had 2-fold greater bactericidal potency than (5) as measured by their MBC values. …”
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NAT10 promotes ovarian cancer cell migration, invasion, and stemness via N4-acetylcytidine modification of CAPRIN1 by Yang Song, Min Cheng

“…These findings suggest that NAT10 may be a promising therapy target for OC. Graphical abstract…”
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Linearity of natural versus laboratory-imparted remanence demagnetization diagram and reliability of relative paleointensity estimation by Toshitsugu Yamazaki, Jiaxi Li

“…In sediments with changing proportion of magnetofossils, normalization with IRM may work better than ARM. Graphical Abstract…”
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Factors Hindering the Proper Management of Academic Libraries in Kabale Municipality: A Case Study of the Uganda Martyrs University Kabale Campus Library. by Oliva, Arineitwe

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Dysregulation of transposable elements and PIWI-interacting RNAs in myelodysplastic neoplasms by Zdenek Krejcik, David Kundrat, Jiri Klema, Andrea Hrustincova, Iva Trsova, Monika Belickova, Jaroslav Cermak, Anna Jonasova, Jiri Dostal, Michaela Dostalova Merkerova

“…Conclusions Our findings demonstrate the parallel dysregulation of TEs and piRNAs in HR-MDS patients, highlighting their potential role in MDS progression and indicating that the PIWIL2 level is a promising molecular marker for prognosis. Graphical Abstract…”
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Improving 10-year cardiovascular risk prediction in patients with type 2 diabetes with metabolomics by Ruijie Xie, Teresa Seum, Sha Sha, Kira Trares, Bernd Holleczek, Hermann Brenner, Ben Schöttker

“…Given the latest cost reduction and standardization efforts, NMR metabolomics has the potential for translation into the clinical routine. Graphical abstract…”
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Inhibition of METTL14 overcomes CDK4/6 inhibitor resistance driven by METTL14-m6A-E2F1-axis in ERα-positive breast cancer by Chenlin Liu, Dong Fan, Jiahui Sun, Guodong Li, Ruoxin Du, Xiaoshuang Zuo, Kuo Zhang, Wangqian Zhang, Shuning Wang, Xiaojv Li, Mingrui Du, Donghui Wang, Qiang Hao, Yingqi Zhang, Meng Li, Cun Zhang, Yuan Gao

“…Together, our findings reveal the mechanism of CDK4/6i resistance and provide a strategy for overcoming CDK4/6i resistance via METTL14 inhibition. Graphical Abstract…”
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Salvage transoral laser microsurgery for early local recurrence of glottic squamous cell cancer by Zhimou Cai, Huijun Yue, Lin Chen, Yang Xv, Yun Li, Bingjie Tang, Yu Lin, Wenbin Lei

“…Conclusion Salvage TLM can be used as an effective treatment option for suitable patients after a full, comprehensive, and careful assessment of the characteristics of early locally recurrent glottic carcinoma. Graphical Abstract…”
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Development of a patient reported outcome instrument for chronic sialadenitis by Fatemeh Ramazani, Amr Hamour, Caroline C. Jeffery, Vincent Biron, Yaser Alrajhi, Daniel O’Connell, David W. J. Côté

“…Level of evidence Level V. Graphical Abstract…”
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Feedback loop centered on MAF1 reduces blood–brain barrier damage in sepsis-associated encephalopathy by Xuebiao Wei, Wenqiang Jiang, Zhonghua Wang, Yichen Li, Yuanwen Jing, Yongli Han, Linqiang Huang, Shenglong Chen

“…Clinical trial number: not applicable. Graphical Abstract…”
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The burden of irritable bowel syndrome and functional dyspepsia in Poland: a cross-sectional study from West Pomeranian Voivodship by Patrycja Krynicka, Mariusz Kaczmarczyk, Karolina Skonieczna-Żydecka, Danuta Cembrowska-Lech, Konrad Podsiadło, Krzysztof Dąbkowski, Katarzyna Gaweł, Natalia Botke, Iwona Zawada, Małgorzata Ławniczak, Andrzej Białek, Wojciech Marlicz

“…Our findings highlight the need for regional studies to understand local DGBI prevalence, aiding targeted healthcare strategies. Graphical Abstract…”
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aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed... by Yi Tang, Qingling Shen, Peng Lin, Zhixin Chen, Denghui Fan, Minling Zhuo, Yajiao Gan, Yixi Su, Qingfu Qian, Liwu Lin, Ensheng Xue, Zhikui Chen

“…In conclusion, aPD-L1-modified liquid‒vapor phase-transformation nanoparticles loaded with docetaxel (DTX) and PFP were successfully combined with ultrasound for the molecular diagnosis and targeted treatment of PDAC. aPDL1-DTX/PFP@Lipid could reshape the PDAC TME, offering a new approach for ultrasound-mediated diagnosis and treatment with promising clinical applications. Graphical Abstract…”
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Kruppel-family zinc finger proteins as emerging epigenetic biomarkers in head and neck squamous cell carcinoma by Patrick Pearson, Kendra Smith, Nilita Sood, Elizabeth Chia, Alicia Follett, Michael B. Prystowsky, Simon Kirby, Thomas J. Belbin

“…Future studies will address the underlying molecular mechanisms by which ZNF154 expression in HNSCC contributes to the control of cell growth and migration. Graphical abstract…”
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Epidermal stem cell derived exosomes-induced dedifferentiation of myofibroblasts inhibits scarring via the miR-203a-3p/PIK3CA axis by Shixin Zhao, Haoran Kong, Dahu Qi, Yushuang Qiao, Yu Li, Zhiming Cao, Hanwen Wang, Xuefeng He, Hengdeng Liu, Hao Yang, Suyue Gao, Tao Liu, Julin Xie

“…In vivo studies confirmed that EpiSC-EVs attenuate excessive scarring through the miR-203a-3p/PIK3CA axis, suggesting EpiSC-EVs as a promising therapeutic approach for HS. Graphical abstract…”
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Bidirectional approach of Punica granatum natural compounds: reduction in lung cancer and SARS-CoV-2 propagation by Md. Abul Barkat, Afreen Fatima, Bushra Riaz, Mohd. Zaheen Hassan, Tanveer Ahamad, Abdulkareem A. Alanezi, Harshita Barkat, Afaf F. Almuqati, Yahya I. Asiri, Sahabjada Siddiqui

“…The PGP phytoconstituents are suggested to be dual agents for lung cancer and SARS-CoV-2 pathogenesis. Graphical Abstract…”
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Increased TSPO alleviates neuropathic pain by preventing pyroptosis via the AMPK-PGC-1α pathway by Baolong Li, Kaiming Yu, Xiongyao Zhou, Jialu Sun, Le Qi, Weiye Li, Tuo Yang, Weizhen Li, Ningning Wang, Xiaosong Gu, Shusen Cui, Rangjuan Cao

“…In summary, this study enhances our understanding of the molecular interplay between TSPO, mitochondrial health, and neuropathic pain, highlighting TSPO as a potential therapeutic target for pain management. Graphical Abstract…”
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A state-of-the-art review of the recent advances of theranostic liposome hybrid nanoparticles in cancer treatment and diagnosis by Hannaneh Azimizonuzi, Arman Ghayourvahdat, Mareb Hamed Ahmed, Radhwan Abdul Kareem, Athmar Jaber Zrzor, Aseel Salah Mansoor, Zainab H. Athab, Shaylan Kalavi

“…We conclude by outlining the potential benefits and drawbacks of this theranostic approach to the concurrent detection and treatment of different malignancies, as well as its prospects. Graphical Abstract…”
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Duration of exposure to night work and cardiovascular risk factors: results from 52,234 workers of the CONSTANCES study by Eve Bourgkard, Stéphanie Boini, Michel Grzebyk, Mathieu Dziurla, Jean Ferrières, Marcel Goldberg, Céline Ribet, Yolande Esquirol

“…These results support the need for early and appropriate monitoring of cardiovascular risk factors among current and former night workers. Graphical Abstract…”
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CLINTERVENTIONAL protocol: a randomized controlled trial to evaluate clinical consultations and audiovisual tools for interventional radiology by Pedro Blas García Jurado, Juan José Espejo Herrero, María Sagrario Lombardo Galera, María Eugenia Pérez Montilla, Sara Barranco Acosta, José García-Revillo, Pilar Font Ugalde, Marina Álvarez Benito

“…This study will provide insights about the benefits of consultations and videos in interventional radiology. Graphical Abstract…”
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Interfacial charge transfer on hierarchical synergistic shell wall of MXene/MoS2 on CdS nanospheres: heterostructure integrity for visible light responsive photocatalytic H2 evolut... by Kugalur Shanmugam Ranjith, Ali Mohammadi, Ganji Seeta Rama Raju, Yun Suk Huh, Young-Kyu Han

“…This study examined how the MXene heterostructure template improves the catalytic efficiency and opens a new way to design MXene-based durable heterostructure catalysts for solar-energy conversion. Graphical Abstract…”
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