Potentialities and critical issues of liquid biopsy in clinical practice: An umbrella review by Nicola Veronese, Claudio Luchini, Stefano Ciriminna, Katia Spinelli, Santo Fruscione, Paola Mattiolo, Miriam Belluzzo, Veronica Messina, Lee Smith, Mario Barbagallo, Walter Mazzucco

“…Methods: We searched three repositories from database inception up to October 1, 2023 and we included meta-analyses of observational studies reporting data on the use of LB, compared to gold standard, and its accuracy (area under the curve, AUC). …”
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Induced mesenchymal stem cells generated from periodontal ligament fibroblast for regenerative therapy by Hemanathan Vembuli, Sheeja Rajasingh, Patrick Nabholz, Jefferson Guenther, Brian R. Morrow, Margaret M. Taylor, Marziyeh Aghazadeh, Vinoth Sigamani, Johnson Rajasingh, Johnson Rajasingh, Johnson Rajasingh

“…Despite autologous bone grafts remain the gold standard for treatment, challenges such as limited bone availability, immune reactions, and the risk of infectious disease transmission have driven the search for alternative cell-based therapies for bone regeneration. …”
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The Simulation of a Surface Plasmon Resonance Metallic Grating for Maximizing THz Sensitivity in Refractive Index Sensor Application by Asmar Sathukarn, Chia Jia yi, Sakoolkan Boonruang, Mati Horprathum, Khwanchai Tantiwanichapan, Kiattiwut Prasertsuk, Chayut Thanapirom, Woraprach Kusolthossakul, Kittipong Kasamsook

“…To demonstrate our methodology, we design a gold-coated grating with a polydimethylsiloxane (PDMS) as a substrate, in order to perform quantitative analysis of gasoline-toluene mixture composition, which has a refraction index variation of 0.1 at THz frequency. …”
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Utility of the Rose Bengal Test as a Point-of-Care Test for Human Brucellosis in Endemic African Settings: A Systematic Review by Abel B. Ekiri, Christopher Kilonzo, Brian H. Bird, Elizabeth VanWormer, David J. Wolking, Woutrina A. Smith, Honorati Masanja, Rudovick R. Kazwala, Jonna A.K. Mazet

“…The diagnostic sensitivity (DSe) and specificity (DSp) of RBT compared to culture as the gold standard were 87.5% and 100%, respectively, in studies that used suitable “true positive” and “true negative” patient comparison groups and were considered to be of high scientific quality. …”
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Latent class cluster analysis of knowledge on acute myocardial infarction in community residents: a cross-sectional study in Tianjin, China by Jing Wang, Xu Zhang, Yan Zhang, Jing Ma, Nan Zhang, Yuan Wang, Jing Gao, Jian-yong Xiao, Yin Liu, Ji-xiang Wang, Xiao-wei Li, Ming-dong Gao, Jing-xian Wang, Shi-bo Xu

“…This study aimed to identify clusters of knowledge on symptoms and RFs of AMI, compare characteristics and the awareness of the need for prompt treatment.Design Multistage stratified sampling was used in this cross-sectional study. Latent GOLD Statistical Package was used to identify and classify the respondent subtypes of the knowledge on AMI symptoms or modifiable RFs. …”
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Comparative efficacy of conventional pap smear and liquid based cytology for screening of cervical cancer in women of reproductive age group in a tertiary care centre in rural Madh... by Shambhavi, Suresh Kumar Sutrakar, Lokesh Tripathi, Parul Singh Rajpoot, Priyanka Agrawal, Uday Raj Singh, Jagannath Jatav, Deepti Tiwari, Pushpkunjika Sharma

“…CPS, LBC (Ezyprep™), and colposcopy-guided biopsies were utilized, with histopathology as the gold standard. Statistical analysis involved sensitivity, specificity, and receiver operating characteristic curves. …”
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Gas-phase fractionation DDA promotes in-depth DIA phosphoproteome analysis by Zhiwei Tu, Yabin Li, Shuhui Ji, Shanshan Wang, Rui Zhou, Gertjan Kramer, Yu Cui, Fei Xie

“…Library-based DIA database searching against project-specific data-dependent acquisition (DDA) spectral libraries is the gold standard. These libraries are constructed using material-consuming pre-fractionation two dimensional DDA analysis. …”
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A genomic strategy for precision medicine in rare diseases: integrating customized algorithms into clinical practice by Cristina Méndez-Vidal, Nereida Bravo-Gil, Javier Pérez-Florido, Irene Marcos-Luque, Raquel M. Fernández, José Luis Fernández-Rueda, María González-del Pozo, Marta Martín-Sánchez, Elena Fernández-Suárez, Marcela Mena, Rosario Carmona, Joaquín Dopazo, Salud Borrego, Guillermo Antiñolo

“…Abstract Background Despite the use of Next-Generation Sequencing (NGS) as the gold standard for the diagnosis of rare diseases, its clinical implementation has been challenging, limiting the cost-effectiveness of NGS and the understanding, control and safety essential for decision-making in clinical applications. …”
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Efficacy and safety of transanal endoscopic microsurgery for early rectal cancer: a meta-analysis by Chunqiang Wang, Tianye Huang, Xuebing Wang

“…BackgroundThe gold standard for the treatment of rectal cancer is radical surgery with total mesorectal excision (TME). …”
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Validity, Agreement and Reliability of the ForceFrame Dynamometer in Patients with Anterior Cruciate Ligament Injury by Kamilla Arp, Thomas Frydendal, Troels Kjeldsen, Ulrik Dalgas, Signe Timm, Bjarke Viberg, Kim Ingwersen, Claus Varnum

“…Day one included validity assessments with FF, a gold-standard ID and a handheld dynamometer (HHD). …”
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The use of bacterial culture for Leptospirosis di- agnosis in female water buffaloes by Rosaura Pérez-Gil, Oriana Gavidia, Juan Torres

“…The bacteriological culture of Leptospira spp. is the gold standard test because it can demonstrate the agent’s presence. …”
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Evaluating the feasibility, sensitivity, and specificity of next-generation molecular methods for pleural infection diagnosis by Peter T. Bell, Timothy Baird, John Goddard, Olusola S. Olagoke, Andrew Burke, Shradha Subedi, Tiana R. Davey, James Anderson, Derek S. Sarovich, Erin P. Price

“…However, we encountered challenges that complicated pleural infection interpretation, including: (i) uncertainties regarding microbial pathogenicity and the impact of prior antibiotic therapy on diagnostic performance; (ii) lack of a clinical diagnostic gold-standard for molecular performance comparisons; (iii) potential microbial contamination during specimen collection or processing; and (iv) difficulties distinguishing background microbial noise from true microbial signal in low-biomass specimens. …”
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Primary repair vs arthroscopic reconstruction for proximal anterior cruciate ligament tears: a comparative study by Sergey A. Gerasimov, Ekaterina A. Morozova, Daria A. Naida, Denis O. Kolmakov, Andrey A. Zykin, Ekaterina V. Khramtsova

“…Anterior cruciate ligament (ACL) reconstruction is the gold standard surgical option for ACL tears. Another treatment method is primary ACL repair. …”
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The value of metagenomic next-generation sequencing in the diagnosis of fever of unknown origin by Lan Min Lai, Qing-gen Chen, Yang Liu, Rui Zhao, Mei Ling Cao, Lei Yuan

“…The sensitivity and specificity of culture and mNGS were analyzed based on the final clinical diagnosis as the gold standard to assess the diagnostic value of mNGS in FUO cases. …”
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Discovery and in vitro characterization of a human anti-CD36 scFv by Cecilia Mata-Cruz, Cecilia Mata-Cruz, Sandra L. Guerrero-Rodríguez, Keyla Gómez-Castellano, Gregorio Carballo-Uicab, Juan Carlos Almagro, Juan Carlos Almagro, S. Mayra Pérez-Tapia, S. Mayra Pérez-Tapia, S. Mayra Pérez-Tapia, Marco A. Velasco-Velázquez

“…Herein, we aimed to identify human anti-CD36 single-chain variable fragment (scFv) with therapeutic potential.MethodsThe semisynthetic ALTHEA Gold Plus Libraries™ were panned using recombinant human CD36. …”
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Effectiveness of Gastric Cancer Endoscopic Screening in Intermediate-Risk Countries: Protocol for a Systematic Review and Meta-Analysis by Maria Beatriz Mourato, Nuno Pratas, Andreia Branco Pereira, Filipa Taré, Raphael Chança, Inês Fronteira, Rui Dinis, Miguel Areia

“…Upper endoscopy with biopsy is the gold standard for GC diagnosis. Several studies have investigated the relevance of endoscopic screening and how to implemente it in IR countries. …”
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Evaluation of in-office tooth whitening treatment with violet LED: protocol for a randomised controlled clinical trial by Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Sandra Kalil Bussadori, Maria Fernanda Setúbal Destro Rodrigues, Ana Eliza Castanho Garrini dos Santos, Marcelo Mendes Pinto, Dácio Antonio Pantano Junior, Aldo Brugnera Jr, Fátima Antonia Aparecida Zanin

“…Introduction In-office tooth whitening treatment using violet light emited diode (LED) (405 nm) is a novel bleaching method that causes less sensitivity while offering the same effectiveness as the gold standard (35% hydrogen peroxide, H2O2). This study describes a protocol for the first randomised controlled clinical trial to compare the effects of the two methods.Methods and analysis Eighty patients will be divided into four groups: G1 violet LED; G2 violet LED +35% carbamide peroxide; G3 35% H2O2 and G4 violet LED +gingivoplasty. …”
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Comparison of Accuracy in Expert Clinical Examination versus Magnetic Resonance Imaging and Arthroscopic Exam in Diagnosis of Meniscal Tear by Seyed Ali Hashemi, Mohammad Reza Ranjbar, Mohammad Tahami, Reza Shahriarirad, Amirhossein Erfani

“…This study was conducted to evaluate the accuracy of clinical examination in comparison with MRI examination and with the help of arthroscopic examination as the gold standard in the diagnosis of meniscal tears. …”
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Recommendations of the Russian Gastroenterological Association on Clinical Use of High-Resolution Manometry in Diagnosis of Esophageal Disorders by V. T. Ivashkin, I. V. Mayev, A. S. Trukhmanov, O. A. Storonova, S. A. Abdulkhakov, D. N. Andreev, D. S. Bordin, E. R. Valitova, I. L. Klyaritskaya, V. V. Krivoy, Yu. A. Kucheryavyi, T. L. Lapina, S. V. Morozov, O. A. Sablin, E. V. Semenikhina, Yu. P. Uspenskiy, A. A. Sheptulin

“…This method of esophageal examination has become the “gold standard” in diagnosis of motor disorders.High-resolution manometry enables detailed investigation of integral quantitative and qualitative characteristics of esophagus motor function and specific related disorders, analysis of esophageal contractile propagation and strictly coordinated synchronous peristalsis of upper esophageal sphincter, esophagus and lower esophageal sphincter, which malfunction may provoke development of achalasia, esophagospasm, hiatal hernia, ineffective eso pha geal motility and other motor disorders.Conclusion. …”
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Use of a microvascular anastomotic coupler device for kidney transplantation in rats by Henrik Lauer, Jana Ritter, Patrick Nachtnebel, Kathrin Simmendinger, Emily Lerchbaumer, Vladyslav Kavaka, Dominik Steiner, Jonas Kolbenschlag, Adrien Daigeler, Johannes C. Heinzel

“…Background: Allogenic kidney transplantation has been the gold standard treatment for end-stage renal disease. …”
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