Effects of replacing fishmeal with soybean meal on growth performance, liver antioxidant capacity and intestinal health in juvenile Asian red-tailed catfish (Hemibagrus wyckioides) by Weijia Cai, Xinping Li, Minglang Cai, Zhe Tang, Bo Zhu, Mengxi Yang, Yi Hu, Jihong Dai

“…In the SBM45 and SBM60 groups, the lamina propria of the intestinal villi became wider, and the number of goblet cells increased. The tight junction proteins zo-1, claudin-4 and occludin were significantly downregulated in the SBM45 and SBM60 groups. …”
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Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota by Tao Wang, Panpan Wang, Li Yin, Xiuchao Wang, Yuanyuan Shan, Yanglei Yi, Yuan Zhou, Bianfang Liu, Xin Wang, Xin Lü

“…Moreover, this probiotic could ameliorate the damage of intestinal barrier by recovering tight junction protein expression (like Occludin, Claudin-1, and ZO-1) and preventing goblet cell loss. Furthermore, the oxidative stress was alleviated by increasing the level of antioxidant mediators (like GSH and SOD) and reducing the level of oxidative mediators (like MDA and MPO). …”
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Development of an in vitro triculture model of intestine inflammation to assess the immunomodulatory properties of cassava and roselle, two African green leafy vegetables by Nelly Fioroni, Maria Del Carmen Ponce de León Rodríguez, Nicolas Leconte, Claire Mouquet-Rivier, Caroline Guzman, Frédéric Boudard, Claudie Dhuique-Mayer, Myriam Collin, Anaïs Deglos, Emmanuelle Reboul, Ángela Bravo-Núñez, Caroline Laurent-Babot

“…Therefore, to study the anti-inflammatory effects of cassava and roselle leaves, commonly consumed as sauces, we developed an in vitro triculture model of intestine inflammation using intestinal Caco-2 (colorectal adenocarcinoma) and HT29-MTX (goblet cell-like) together with the macrophage-like THP-1 cells. …”
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Anti-IL-5 treatment, but not neutrophil interference, attenuates inflammation in a mixed granulocytic asthma mouse model, elicited by air pollution by Joyceline De Volder, Annelies Bontinck, Valerie Haelterman, Louis Boon, Guy F. Joos, Guy G. Brusselle, Tania Maes

“…Outcome parameters included eosinophils subsets (homeostatic EOS and inflammatory EOS), proinflammatory cytokines, goblet cell hyperplasia and airway hyperresponsiveness. …”
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Therapeutic Potential of Combined 5% Lifitegrast and Tocopherol Eye Drops in Managing Inflammation and Oxidative Stress in Murine Dry Eye by Jayoung Moon, Enying Jiang, Jingting Liu, Hui Jin, Hee Su Yoon, Hoon-In Choi, Ji Suk Choi, Hong Qi, Hyeon-Jeong Yoon, Kyung Chul Yoon

“…Clinical parameters (tear volume, tear break-up time (TBUT), corneal fluorescein staining score (CFSS), tear film lipid layer grade (TFLLG)) were assessed on days 7 and 14. Goblet cell density in the conjunctiva, CD4+ IFN-γ+ T cells, interleukin levels, reactive oxygen species (ROS) levels, and corneal apoptotic cells were analyzed on day 14. …”
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Development and assessment of an intestinal tri-cellular model to investigate the pro/anti-inflammatory potential of digested foods by Marina Ramal-Sanchez, Chiara Bravo-Trippetta, Veronica D’Antonio, Elena Corvaglia, Angela A. M. Kämpfer, Roel P. F. Schins, Mauro Serafini, Donato Angelino

“…This study aims to develop and test an in vitro tri-culture model, simulating the complexity of the intestinal tract and its multiple cell interactions.MethodsTo achieve this, the intestinal epithelial barrier was established by co-culturing human Caco-2 enterocyte-like and HT29-MTX-E12 mucus producing goblet-like colon cells, then adding human monocyte THP-1 cells to the basolateral compartment. …”
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Phenotypic Analysis of BrdU Label-Retaining Cells during the Maturation of Conducting Airway Epithelium in a Porcine Lung by Yuanyuan Jia, Xuehong You, Ningxia Ma, Hui Li, Guopan Liu, Ying Wang, Jing Xue, Juan Shi, Jun Wei, Yong Li, Jiali Yang, Xiaoming Liu

“…The results showed a pseudostratified mucociliary epithelium comprised of basal, ciliated, goblet, and columnar cells in the conducting airway of a porcine lung. …”
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Effect of Fish Meal Substitution with Black Soldier Fly (Hermetia illucens) on Growth Performance, Feed Stability, Blood Biochemistry, and Liver and Gut Morphology of Siamese Fight... by Zulhisyam Abdul Kari, Guillermo Téllez-Isaías, Noor Khalidah Abdul Hamid, Nor Dini Rusli, Khairiyah Mat, Suniza Anis Mohamad Sukri, Muhammad Anamul Kabir, Ahmad Razali Ishak, Nazri Che Dom, Abdel-Wahab A. Abdel-Warith, Elsayed M. Younis, Martina Irwan Khoo, Faizuan Abdullah, Md Shahjahan, Md Fazle Rohani, Simon J. Davies, Lee Seong Wei

“…The 13% BSFL diet group had an intact epithelial barrier in the goblet cell arrangement and a well-organized villus structure and tunica muscularis, compared to the other treatment groups. …”
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JinQi Jiangtang Tablet Regulates Gut Microbiota and Improve Insulin Sensitivity in Type 2 Diabetes Mice by Ying Cao, Guowang Yao, Yuanyuan Sheng, Li Yang, Zixuan Wang, Zhen Yang, Pengwei Zhuang, Yanjun Zhang

“…Gut mucosal barrier function experiment showed that the level of D-LA was obviously decreased in JQJT tablet-treated groups compared with the model group and the number of goblet cells was significantly increased by JQJT tablet treatment. …”
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Migrasomes derived from human umbilical cord mesenchymal stem cells: a new therapeutic agent for ovalbumin-induced asthma in mice by Weifeng Gu, Tingting Zheng, Wen Li, Xinkai Luo, Xiaowei Xu, Ying Wang, Chaoming Mao, Yongbin Ma, Liyang Dong

“…Results Here, we showed that inhibition of migrasomes’ production dramatically impaired the anti-inflammatory effects of hUCMSCs in OVA animals, as evidenced by a notable increase in both the infiltration of inflammatory cells and the number of epithelial goblet cells. We successfully isolated hUCMSC-migrasomes, which were morphologically intact and positive for the specific migrasomes markers. …”
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Anatomy, histology, and morphology of fish gills in relation to feeding habits: a comparative review of marine and freshwater species by Mohamed A. M. Alsafy, Hanan H. Abd-Elhafeez, Ahmed M. Rashwan, Atef Erasha, Safwat Ali, Samir A. A. El-Gendy

“…Histological findings revealed various types of cells, such as superficial pavement cells, large chloride cells, mucous goblet cells, and basal epithelial cells. The lymph space is situated within the gill arch epithelia and is encompassed by cells that resemble tenocytes. …”
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Corneal Mucin‐Targeting Liposome Nanoplatforms Enable Effective Treatment of Dry Eye Diseases by Integrated Regulation of Ferroptosis and Inflammation by Yin Zhang, Tinglian Zhou, Kai Wang, Chenqi Luo, Dan Chen, Zeen Lv, Haijie Han, Ke Yao

“…The CF@SNPs treatment comprehensively alleviates DED symptoms, including improving corneal defects, augmenting goblet cell count, and restoring tear secretion. Specifically, CF@SNPs attenuate dry eye pathology by suppressing p53‐SLC7A11‐GSH‐dependent ferroptosis and TNF‐α‐associated inflammatory cascades, accompanied by favorable biocompatibility in vivo. …”
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The effects of citral on the intestinal health and growth performance of American bullfrogs (Aquarana catesbeiana) by Xiaoting Zheng, Qiuyu Chen, Xueying Liang, Jingyi Xie, Alfredo Loor, Hongbiao Dong, Jinlong Yang, Jiasong Zhang

“…Citral supplementation significantly improved intestinal morphology, with goblet cell numbers, mucosal thickness, and villus-to-crypt ratios peaking at 2–4 mL/kg (P < 0.05). …”
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Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor Microenvironment by Tatsuya Usui, Masashi Sakurai, Shuhei Enjoji, Hideyoshi Kawasaki, Koji Umata, Takashi Ohama, Nobuyuki Fujiwara, Ryotaro Yabe, Shunya Tsuji, Hideyuki Yamawaki, Shoichi Hazama, Hiroko Takenouchi, Masao Nakajima, Ryouichi Tsunedomi, Nobuaki Suzuki, Hiroaki Nagano, Koichi Sato

“…Expression of an epithelial cell marker, E-cadherin, a goblet cell marker, MUC2, and a fibroblast marker, vimentin, but not a myofibroblast marker, α-smooth muscle actin (SMA), was observed in normal organoids. …”
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Alleviating effect of intranasal zinc on symptoms of allergic rhinitis by Huadong Xu, PhD, Keming Tong, BS, Naruhito Iwasaki, MD, PhD, Nobutaka Ohgami, PhD, Akira Tazaki, PhD, Takumi Kagawa, MMSc, Yanjun Gao, MMSc, Delgama A.S.M. Nishadhi, MMSc, Akihito Harusato, MD, PhD, Masafumi Sakashita, MD, PhD, Kazuhiro Ogi, MD, PhD, Shigeharu Fujieda, MD, PhD, Shogo Sumiya, MD, Shinichi Iwasaki, MD, PhD, Masashi Kato, MD, PhD

“…The relative number of mucin-secreting goblet cells, a sign of provocative allergic rhinitis, in the mice was decreased by intranasal treatment with Zn. …”
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Comparison of air-liquid interface transwell and airway organoid models for human respiratory virus infection studies by Camilla T. Ekanger, Camilla T. Ekanger, Camilla T. Ekanger, Nilima Dinesh Kumar, Rosanne W. Koutstaal, Fan Zhou, Martin Beukema, Joanna Waldock, Simon P. Jochems, Noa Mulder, Cécile A. C. M. van Els, Cécile A. C. M. van Els, Othmar G. Engelhardt, Nathalie Mantel, Kevin P. Buno, Karl Albert Brokstad, Karl Albert Brokstad, Agnete S. T. Engelsen, Agnete S. T. Engelsen, Rebecca J. Cox, Rebecca J. Cox, Barbro N. Melgert, Barbro N. Melgert, Anke L. W. Huckriede, Puck B. van Kasteren

“…Using a shared stock of influenza A virus, we then assessed viral growth kinetics, epithelial cytokine responses, and serum-mediated inhibition of infection.ResultsThe presence of club, goblet, and ciliated cells was confirmed in all models. …”
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