Oxidative Stress, Glutaredoxins, and Their Therapeutic Potential in Posterior Capsular Opacification by Chenshuang Li, Weijia Yan, Hong Yan

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Genome-wide identification and expression analysis of glutaredoxin in Puccinellia tenuiflora under salinity stress by Yanshuang Liu, Xia Han, Juanjuan Yu, Yueyue Li, Meihong Sun, Qiuying Pang, Ying Li, Shaojun Dai

Subjects: “…Glutaredoxins (GRX) gene family…”
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Molecular basis for the enzymatic inactivity of class III glutaredoxin ROXY9 on standard glutathionylated substrates by Pascal Mrozek, Stephan Grunewald, Katrin Treffon, Gereon Poschmann, Fabian Rabe von Pappenheim, Kai Tittmann, Christiane Gatz

“…Abstract Class I glutaredoxins (GRXs) are nearly ubiquitous proteins that catalyse the glutathione (GSH)-dependent reduction of mainly glutathionylated substrates. …”
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Aromatic Residue Variations in the Central β‑Sheet Influence Stability and Activity of E. coli Glutaredoxin 3 by Mohammed Shazaly A. Elhassan, Trang Van Tran, ChangWoo Lee

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The SP/NK1R System-Mediated ROS Generation in GBM Cells through Inhibiting Glutaredoxin Protein by Negeen Mehrabani, Mohammad Reza Vaezi Kakhki, Hossein Javid, Safieh Ebrahimi, Seyed Isaac Hashemy

“…Concurrently, the activity of glutaredoxin was also analyzed by a commercial kit (ZellBio GmbH). …”
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HSP₇₀ Modulators for the Correction of Cognitive, Mnemonic, and Behavioral Disorders After Prenatal Hypoxia by Olena Aliyeva, Igor F. Belenichev, Ivan Bilai, Iryna Duiun, Lyudmyla Makyeyeva, Valentyn Oksenych, Oleksandr Kamyshnyi

“…The newborns received intraperitoneal injections of Angiolin (50 mg/kg), Thiotriazoline (50 mg/kg), Mexidol (100 mg/kg), Cerebrocurin (150 µL/kg), L-arginine (200 mg/kg), Glutaredoxin (200 µg/kg), HSF-1 (50 mg/kg), or Mildronate (50 mg/kg) for 30 days. …”
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Oxidative Stress Defense Module in Lung Cancers: Molecular Pathways and Therapeutic Approaches by Eunsun Lee, Jeong Hee Hong

“…Thus, we highlighted several enzymatic antioxidant components, such as superoxide dismutase, catalase, heme oxygenase-1, peroxiredoxin, glutaredoxin, thioredoxin, thioredoxin reductase, glutathione peroxidase, and antioxidant components, including glutathione, nuclear factor erythroid 2–related factor 2, 8-oxo-7,8-dihydro-2′-deoxyguanosine, and mitochondrial citrate carrier SLC25A1, based on PubMed and Scopus-indexed literature. …”
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Grxcr1 regulates hair bundle morphogenesis and is required for normal mechanoelectrical transduction in mouse cochlear hair cells. by Beatriz Lorente-Cánovas, Stephanie Eckrich, Morag A Lewis, Stuart L Johnson, Walter Marcotti, Karen P Steel

“…The origin of this mutation is the insertion of a transgene which disrupts expression of the Grxcr1 (glutaredoxin cysteine rich 1) gene. We report here that Grxcr1 exons and transcript sequences are not affected by the transgene insertion in tde homozygous (tde/tde) mice. …”
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Redox homeostasis and inflammation in fibroblasts of patients with Friedreich Ataxia: a possible cross talk by Andrea Quatrana, Sara Petrillo, Caterina Torda, Eleonora De Santis, Enrico Bertini, Fiorella Piemonte

“…We found a significant activation of the TLR4/NF-kB/IL-1β axis in patients, associated to a consistent increase of the redox enzymes thioredoxin 1 (TRX1) and glutaredoxin 1 (GLRX1), which are essential to activate NF-kB under oxidative stress conditions. …”
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A multi-centre study on the role of the thioredoxin system in breast cancer cell proliferation by E. V. Shakhristova, E. A. Stepovaya, O. L. Nosareva, L. S. Litvinova, D. A. Skuratovskaya, E. V. Rudikov, A. A. Sadykova, V. V. Novitsky

“…Redox proteins (thioredoxin, glutaredoxin) are key macromolecules capable of modulating intracellular processes. …”
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Ochratoxin A Degradation and Stress Response Mechanism of <i>Brevundimonas naejangsanensis</i> ML17 Determined by Transcriptomic Analysis by Zitong Zhao, Zehui Niu, Zhihong Liang

“…Notably, genes related to antioxidant activity, such as peroxiredoxin, superoxide dismutase, and glutaredoxin 3, were significantly upregulated, indicating that ML17 can resist the toxic effects of OTA through adjusting its metabolic processes, and the enzyme-coding <i>gene0095</i>, having OTA degradation activity, was found to be upregulated. …”
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Allergen degradation of bee pollen by lactic acid bacteria fermentation and its alleviatory effects on allergic reactions in BALB/c mice by Shuting Yin, Qiangqiang Li, Yuxiao Tao, Enning Zhou, Kun Wang, Wanwen Chen, Xiangxin Li, Liming Wu

“…Four novel allergens (glutaredoxin, oleosin-B2, catalase and lipase) were identified with significant decreases in LAB-fermented BP (FBP) than natural BP by proteomics. …”
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Nonketotic Hyperglycinemia of Infants in Taiwan by Chiao-Fan Chiu, Ju-Li Lin, Jainn-Jim Lin, Min-Hua Tseng, Fu-Sung Lo, Ming-Chou Chiang

“…Two neonatal NKH infants had mutation in the GLDC gene, and the other one, who had late-onset NKH, had mutation in the glutaredoxin 5 gene. Conclusion: Compared with other countries, the estimated incidence of NKH was relatively rare in the Taiwanese population. …”
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Proteomic analysis reveals the roles of silicon in mitigating glyphosate-induced toxicity in Brassica napus L. by Probir Kumar Mittra, Md Atikur Rahman, Swapan Kumar Roy, Soo-Jeong Kwon, Abhik Mojumdar, Sung Ho Yun, Kun Cho, Seong-Woo Cho, Meiliang Zhou, Tomoyuki Katsube-Tanaka, Sun-Hee Woo

“…Protein-protein interactome analyses confirmed the involvement of six key proteins, including L-ascorbate peroxidase, superoxide dismutase, glutaredoxin-C2, peroxidase, glutathione peroxidase (GPX) 2, and peptide methionine sulfoxide reductase A3 which involved in antioxidant activity, sulfur assimilation, and herbicide tolerance, contributing to the resilience of B. napus against Gly toxicity. …”
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OsROXY2 Regulates Stamen Number Through Interaction with OsbZIP47 in Rice by Zhongni Wang, Doudou Chen, Xuelei Lin, Jing Wang, Muhammad Arif, Jiali Li, Yanlong Gong, Yue Lei, Xian Wu, Chaoxin Wu, Susong Zhu, Luhua Li

“…STAMENLESS (SL) encodes the CC-type glutaredoxin OsROXY2 and is involved in the regulation of stamen PI. …”
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Characterization and enzymatic function of thioredoxin glutathione reductase in Orientobilharzia turkestanicum isolated from Xizang by Wenqiang Tang, Yongcheng Yue, Bin Shi, Xialing Zhao, Yang Hong

“…Enzymatic activity assays demonstrated that rOtTGRsec possesses thioredoxin reductase, glutaredoxin, and glutathione reductase activities, with optimal activity under physiological pH and temperature conditions. …”
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Agro-physiological and transcriptome profiling reveal key genes associated with potato tuberization under different nitrogen regimes in aeroponics. by Rasna Zinta, Jagesh Kumar Tiwari, Tanuja Buckseth, Umesh Goutam, Rajesh Kumar Singh, Ajay Kumar Thakur, Vinod Kumar, Shwetank Singh, Manoj Kumar

“…In summary, several genes were identified as being involved in high tuber yield component traits in potatoes under different nitrogen conditions. These included glutaredoxin, transcription factors (BTB/POZ, AP2/ERF, and MYB), nitrate transporter, aquaporin TIP1;3, glutamine synthetase, aminotransferase, GDSL esterase/lipase, sucrose synthase, UDP-glycosyltransferases, osmotin, xyloglucan endotransglucosylase/hydrolase, and laccases. …”
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Exogenously added recombinant CLIC proteins provide antioxidant protection to cells in culture by KR Hossain, A Alghalayini, DR Turkewitz, C D’Amario, Catherine A Gorrie, M Wallach, SM Valenzuela

“…Our findings also showed exogenous addition of rCLIC1 or rCLIC4 to skin cells resulted in similar or greater protection against H2O2-induced oxidative damage when compared to other well-known endogenous antioxidants like glutaredoxin (Grx), Glutathione S-transferase-Omega (GST-Ω) and the antioxidant drug, N-acetylcysteine (NAC).…”
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Comparison of the proteomic profile of pork byproducts during their storage by A. G. Akhremko, V. V. Nasonova, M. E. Spirina, N. N. Godswill

“…On the 5th day of storage the highest intensity of manifestation of glyceraldehyde-3-phosphate dehydrogenase (35.8 kDa) in the liver was observed; superoxide dismutase [Cu-Zn] (15.8 kDa) was noted in the kidneys, colony-stimulating factor (16.2 kDa) was observed in the spleen and glutaredoxin –1 (11.8 kDa) in the tongue. In its turn, on the fifth day these chemical processes manifested themselves more intensely, as the fatty acids and glucose broke down. …”
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Transcriptome and metabolome analyses reveal new insights into the regulatory mechanism of early embryoless seed development in rice by Shengjie Liu, Jingjing Peng, Wenhu Zhang, Jun Liu

“…Abstract Background Embryo development holds a pivotal position in the ontogenesis and morphogenesis of rice plants, exerting a direct influence on plant growth and ultimately determining rice yield. Glutaredoxin, an abundant oxidoreductase, plays a crucial role across many facets of plant growth. …”
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