The rise of weekly insulins: addressing the challenges of type 2 diabetes care in Brazil by André Gustavo Daher Vianna, Daniely Freitas Alves, Taís Silveira Assmann, Rosângela Roginski Réa

“…Insulin therapy plays a crucial role in managing T2D, helping to maintain glucose and energy homeostasis. Moreover, early initiation of insulin is crucial for hyperglycemic control and prevention of chronic complications. …”
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Selective Glucocorticoid Receptor (GR-II) Antagonist Reduces Body Weight Gain in Mice by Tomoko Asagami, Joseph K. Belanoff, Junya Azuma, Christine M. Blasey, Robin D. Clark, Philip S. Tsao

“…At the end of the four week treatment period, mice receiving CORT 108297 40 mg/kg BID or CORT 108297 80 mg/kg QD also had significantly lower steady plasma glucose than mice receiving vehicle. However, steady state plasma glucose after treatment was not highly correlated with reduced weight gain, suggesting that the effect of the glucocorticoid receptor antagonist on insulin sensitivity may be independent of its mitigating effect on weight gain.…”
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Construction of a multienzyme cascade reaction system and its application in D-tagatose biosynthesis by Xiaoxiao Zhang, Jie Chu, Yuanqiang Lv, Xuan Li, Aijiao Yin, Yanhua Huang

“…This multienzyme approach improved the conversion of the intermediate product D-glucose to D-tagatose by 3.84% compared with the dual-enzyme system. …”
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Association between Intrapancreatic Fat Deposition and Lower High-Density Lipoprotein Cholesterol in Individuals with Newly Diagnosed T2DM by Jianliang Wang, Qingyun Cai, Xiaojuan Wu, Jiaxuan Wang, Xiaona Chang, Xiaoyu Ding, Jia Liu, Guang Wang

“…The present study aimed to investigate IPFD and its associations with various aspects of glucose and lipid metabolism in individuals with newly diagnosed T2DM. …”
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Sildenafil alters biogenic amines and increases oxidative damage in brain regions of insulin-hypoglycemic rats by Guzmán David Calderón, Brizuela Norma Osnaya, Herrera Maribel Ortíz, Peraza Armando Valenzuela, Mejía Gerardo Barragán, Olguín Hugo Juárez, Jiménez Francisca Trujillo

“…Administration of insulin and sildenafil promotes biometabolic responses in glucose control, namely, it induces hypoglycemia and hypotension. …”
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Social isolation increases impulsive choice with minor changes on metabolic function in middle‐aged rats by Jassmyn J. Venegas, Jacob M. Weisz, Chan Young Choi, Ren E. Herringshaw, Omar A. Nabelsi, Nu‐Chu Liang

“…Two months later, IC behavior was assessed using a delay‐discounting task and anxiety‐like behavior through a novelty‐suppressed feeding (NSF) task. Lastly, glucose tolerance and insulin sensitivity following exposure to a high‐fat diet were assessed using an oral glucose tolerance test (OGTT) and an insulin tolerance test (ITT). …”
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Identification of Individuals at Risk of Developing Type 2 Diabetes by Belkis Vicente Sánchez, Ernesto Vicente Peña, Aylín Altuna Delgado, Miriam Costa Cruz

“…The Finnish Diabetes Risk Score was used and a glucose tolerance test was applied to those at high and very high risk. …”
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Consistency between Self-Reported and Recorded Values for Clinical Measures by Joseph Thomas III, Mindy Paulet, Jigar R. Rajpura

“…Self-reported values were collected for the clinical measures: systolic blood pressure, diastolic blood pressure, glucose level, height, weight, and cholesterol from health risk assessments completed by enrollees in a privately insured cohort. …”
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Frequency of Insulin Resistance in People with Thyroid Dysfunction by Shaza Abdalla Elwali, Sulaf I Abdelaziz

“…Thyroid hormones have a remarkable effect on glucose metabolism and can cause insulin resistance (IR). …”
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Malathion-Induced Hematoxicity and Its Recovery Pattern in Barbonymus gonionotus by Cynthia E. Mrong, Md. R. Islam, Kamrunnaher Kole, Nusrat N. Neepa, Md. J. Alam, Md. R. Haque, Umme O. Rahman, Golam M. Mostakim

“…During the recovery period, all blood parameters (micronucleus, glucose, Hb, PCV, RBC, WBC, MCV, MCH, and MCHC) partially recovered, which means that the recovery period was not long enough for the organisms to recover from the previous exposure. …”
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The protective effect of dietary flavonoid fraction from Acanthophora spicifera on streptozotocin induced oxidative stress in diabetic rats by Lavakumar Vuppalapati, Ravichandiran Velayudam, K.F.H. Nazeer Ahamed, Sowmya Cherukuri, Bhaskar Reddy Kesavan

“…FRF treatment of diabetic rats significantly (P < 0.05) diminishes the blood glucose altitudes to normal in contrast with diabetic rats. …”
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Glyoxylate, a New Marker Metabolite of Type 2 Diabetes by Victoria J. Nikiforova, Pieter Giesbertz, Jan Wiemer, Bianca Bethan, Ralf Looser, Volker Liebenberg, Patricia Ruiz Noppinger, Hannelore Daniel, Dietrich Rein

“…A retrospective study using samples of long-term blood donors revealed that glyoxylate levels unlike glucose levels became significantly elevated up to 3 years prior to diabetes diagnosis (difference to control P=0.034). …”
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Leaner Women with Impaired Insulin Secretion Accounts for about 40% of Gestational Diabetes Mellitus in Japan by Seishi Furukawa, Yoichi Kobayashi

“…A cross-sectional study was conducted comprising 219 at-risk pregnant women who underwent a 75g glucose tolerance test at a single institute in Tokyo, Japan. …”
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Effects of Low-Intensity Laser Irradiation on Wound Healing in Diabetic Rats by Hui Ma, Ying-xin Li, Hong-li Chen, Mei-ling Kang, Timon Cheng-Yi Liu

“…Results. Blood glucose of all groups remained at similar levels throughout the experiment. …”
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The Effect of Tianmai Xiaoke Pian on Insulin Resistance through PI3-K/AKT Signal Pathway by Nana Wang, Tiegang Li, Ping Han

“…Eight weeks later, fasting blood glucose (FBG) and oral glucose tolerance tests (OGTT) were performed. …”
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Glycemic Index, Starch, and Protein Digestibility in Tempeh Gembus Cookies by Valentina A. Manullang, Ayu Rahadiyanti, Syafira N. Pratiwi, Diana N. Afifah

“…Diabetes mellitus is directly related to diet and lifestyle. Control of blood glucose levels is needed to reduce the risk of complications, and one way is to choose foods with a low glycemic index. …”
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High Serum Advanced Glycation End Products Are Associated with Decreased Insulin Secretion in Patients with Type 2 Diabetes: A Brief Report by Tsuyoshi Okura, Etsuko Ueta, Risa Nakamura, Yohei Fujioka, Keisuke Sumi, Kazuhisa Matsumoto, Kyoko Shoji, Kazuhiko Matsuzawa, Shoichiro Izawa, Yuri Nomi, Hitomi Mihara, Yuzuru Otsuka, Masahiko Kato, Shin-ichi Taniguchi, Kazuhiro Yamamoto

“…We measured the AGE carboxyethyllysine (CEL), carboxymethyllysine (CML), and methyl-glyoxal-hydro-imidazolone (MG-H1). Plasma glucose and insulin were measured in these participants during a meal tolerance test, and the glucose disposal rate was measured during a euglycemic-hyperinsulinemic clamp. …”
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Anti-diabetic potential of apigenin, luteolin, and baicalein via partially activating PI3K/Akt/Glut-4 signaling pathways in insulin-resistant HepG2 cells by Lingchao Miao, Haolin Zhang, Meng Sam Cheong, Ruting Zhong, Paula Garcia-Oliveira, Miguel A. Prieto, Ka-Wing Cheng, Mingfu Wang, Hui Cao, Shaoping Nie, Jesus Simal-Gandara, Wai San Cheang, Jianbo Xiao

“…All flavonoids improves the glucose consumption and glycogen synthesis abilities in IR-HepG2 cells via activating glucose transporter protein 4 (GLUT4) and phosphor-glycogen synthase kinase (GSK-3β). …”
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Exploration of linear and interpretable models for quantification of cell parameters via contactless short-wave infrared hyperspectral sensing by Anjana Hevaganinge, Eva Lowenstein, Anna Filatova, Mihir Modak, Nandi Thales Mogo, Bryana Rowley, Jenny Yarmowsky, Joshua Ehizibolo, Ravidu Hevaganinge, Amy Musser, Abbey Kim, Anthony Neri, Jessica Conway, Yiding Yuan, Maurizio Cattaneo, Sui Seng Tee, Yang Tao

“…Using only 50% of the dataset for training, reasonable test performance of mean absolute error (MAE) and correlations (r2) are achieved for glucose (r2 = 0.88, MAE = 37 mg/dL), lactate (r2 = 0.93, MAE = 15.08 mg/dL), and VCD (r2 = 0.81, MAE = 8.6 × 105 cells/mL). …”
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The safety and efficacy of a protein-free diet with ketoacid analogues in chronic kidney disease-affected diabetic rats by Ahmed El-Sayed Nour El-Deen, Adel shallaby, Abdel Kader Ibrahim, Mohammed Abdel Aziz Mohammed, Ahmad Taha, Mohamed Zaeim Hafez Ahmed, Muhammad Abdelbaeth Elfiky, Ahmed A. Abd El-Rhman, Ahmed F. Abdel Ghany, Almoatazbellah Mahmoud Elsayed, Ahmed Noaman Ali, Ali Abdeslam

“…Conclusion: A protein-free diet containing KAA improves renal function, lowers blood glucose levels, maintains body weight, and does not worsen nutritional status in DN over time.…”
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