The association between stress-induced hyperglycemia ratio and cardiovascular events as well as all-cause mortality in patients with chronic kidney disease and diabetic nephropathy by Boning Cao, Zhendong Guo, Dan-Ting Li, Le-Ying Zhao, Zhen Wang, Ya-Bin Gao, Yao-Xian Wang

“…Abstract The stress hyperglycemia ratio (SHR) is an emerging biomarker used to assess blood glucose levels under acute stress conditions and has been linked to the incidence of adverse clinical outcomes. …”
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Strategies to Promote ResiliencY (SPRY): a randomised embedded multifactorial adaptative platform (REMAP) clinical trial protocol to study interventions to improve recovery after s... by Derek C Angus, Jennifer Holder-Murray, Katherine Moll Reitz, Christopher W Seymour, Jennifer Vates, Melanie Quintana, Kert Viele, Michelle Detry, Michael Morowitz, Alison Morris, Barbara Methe, Jason Kennedy, Brian Zuckerbraun, Timothy D Girard, Oscar C Marroquin, Stephen Esper, Anne B Newman, Scott Berry, Matthew Neal

“…We describe a randomised, embedded, multifactorial, adaptative platform (REMAP) trial to investigate multiple perioperative interventions, the first of which is metformin and selected for its anti-inflammatory and anti-ageing properties beyond its traditional blood glucose control features.Methods and analysis Within a multihospital, single healthcare system, the Core Protocol for Strategies to Promote ResiliencY (SPRY) will be embedded within both the electronic health record (EHR) and the healthcare culture generating a continuously self-learning healthcare system. …”
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Antimicrobial Activities of Polysaccharide-Rich Extracts from the Irish Seaweed <i>Alaria esculenta</i>, Generated Using Green and Conventional Extraction Technologies, Against Foo... by Ailbhe McGurrin, Rahel Suchintita Das, Arturo B. Soro, Julie Maguire, Noelia Flórez Fernández, Herminia Dominguez, Maria Dolores Torres, Brijesh K. Tiwari, Marco Garcia-Vaquero

“…The chemical composition of the extracts demonstrated that they were high in total soluble sugars, with the highest total sugars being seen from the extract prepared with UAE, having 32.68 mg glucose equivalents/100 mg dried extract. Extracts had antimicrobial activity against <i>E. coli</i> and featured minimum inhibitory concentration (MIC) values of 6.25 mg/mL (in the case of the extract prepared with UAE) and 12.5 mg/mL (in the case of the extracts prepared with MAE, UMAE, and conventional maceration). …”
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Effects of Astrocaryum aculeatum Meyer (Tucumã) on Diet-Induced Dyslipidemic Rats by Geórgia Craveiro Holanda Malveira Maia, Mozer da Silva Campos, Janice Barros-Monteiro, Juan Eduardo Lucas Castillo, Murilo Soares Faleiros, Rejane Souza de Aquino Sales, Denise Moraes Lopes Galeno, Edson Lira, Francisca das Chagas do Amaral Souza, Carmen Ortiz, Luisa Morales, Rosany Piccolotto Carvalho

“…Plasma was analyzed for cholesterol, triglycerides, HDL-C, LDL-C, VLDL, total protein, glucose, insulin, and leptin concentrations. Our results show that the ECG group tended to consume more food, while the groups that were fed with tucumã pulp (STG and ETG) presented a greater tendency to gain body mass. …”
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Efficacy of Fetal Wharton’s Jelly Mesenchymal Stem Cells-Derived Small Extracellular Vesicles in Metabolic Syndrome by Illayaraja Krishnan, Magdalene Tan Mei Ling, Min Hwei Ng, Jia Xian Law, Mohd Rafizul Mohd Yusof, Thavachelvi Thangarajah, Zalina Mahmood, Nurul Izzati Uda Zahli, Shathiya Rajamanickam, Baskar Subramani, Yogeswaran Lokanathan

“…Background/Objective: Metabolic syndrome (MetS) is characterized by abdominal obesity, increased blood pressure (BP), fasting blood glucose (FBG) and triglyceride levels, and reduced high-density lipoprotein (HDL) levels. …”
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Skipping Breakfast Is Associated with an Atherogenic Lipid Profile in Overweight and Obese Prepubertal Children by A. Blasetti, S. Franchini, V. Castorani, L. Comegna, E. Fornari, F. Daniele, G. Prezioso, C. Piona, V. Federico, D. Zona, I. Bresadola, F. Chiarelli, C. Maffeis

“…Blood samples were collected to evaluate glucose and lipid metabolisms and hormone profile (growth hormone (GH), IGF-1, insulin, and cortisol). …”
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Extraction of American ginseng polysaccharide by ultrasound-assisted deep eutectic solvents-based three-phase partitioning: Process optimization, structural characterization, and a... by Zhongnan Wu, Chong Li, Junhao Li, Tanggan Wang, Meifeng Li, Leyi Zhao, Huimei Ye, Jiaheng Chen, Jiajia Zan, Lijun Song, Qian Zhang, Shaojie Zhang

“…AGP-DES-4 has a broad molecular weight distribution (2.48–174.64 kDa) and mainly consists of mannose, glucose, galactose, and arabinose. In vivo Drosophila models show that AGP-DES-4 improves UC fly survival and enhances intestinal barrier function by regulating the proliferation and differentiation of intestinal epithelial cells (IECs) and intestinal stem cells (ISCs). …”
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Targeting aldose reductase using natural African compounds as promising agents for managing diabetic complications by Miriam E. L. Gakpey, Shadrack A. Aidoo, Toheeb A. Jumah, George Hanson, Siyabonga Msipa, Florence N. Mbaoji, Omonijo Bukola, Palesa C. Tjale, Mamadou Sangare, Hedia Tebourbi, Olaitan I. Awe

“…Inhibiting Aldose Reductase (AR), an enzyme that converts glucose to sorbitol, has been studied to prevent long-term diabetic consequences. …”
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Anemia, Hyperglycemia, and Reduced Left Ventricular Ejection Fraction Improve the GRACE Score&rsquo;s Predictability for In-hospital Mortality in Acute Coronary Syndrome; Single-Ce... by Turu' Allo IJ, Pramudyo M, Akbar MR

“…Anemia was defined as hemoglobin < 13 g/dL in men and < 12 g/dL in women, while hyperglycemia was indicated with random blood glucose (RBG) ≥ 200 mg/dL at admission. Patients with LVEF < 50% were classified as having reduced LVEF. …”
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Establishment and evaluation of a UPLC-MS/MS method for simultaneous determination of bongkrekic acid and dehydroacetic acid in rice noodles by Lingguo Zhao, Ronggui Lv, Ronggui Lv, Jiang Song, Xi Chen, Lei Lei, Weixian Zeng, Miaowen She, Miaowen She, Dabing Li, Xiaxia Yu, Zhanguo Liu, Xiao Wang, Yong Liu

“…The results showed that the established method could also be used to qualitatively screen BA and its isomer isobongkrekic acid (IBA) in GVC enrichment broth, potato glucose agar and rice sample, which facilitates a rapid and accurate judgement of whether the isolated bacterium strain produces BA. …”
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A Randomized, Placebo-Controlled, Single-Center, Crossover Study to Evaluate the Effects of Pre-Meal Whey Protein Microgel on Post-Prandial Glucometabolic and Amino Acid Response i... by Ian J Neeland, Luiz H de Gregório, Roberto Zagury, Bo Ahrén, Joel Neutel, Christian Darimont, John Corthesy, Yohan Grzywinski, Emilie Perrin, Maximilian von Eynatten, Odd Erik Johansen

“…<b>Purpose</b>: Whey protein (WP) consumption prior to a meal curbs appetite and reduces postprandial glucose (PPG) through stimulating endogenous GLP-1 secretion and insulin. …”
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Curcumin administration alleviates seminal vesicle damage in type 1 diabetic rats by promoting AQP8 expression through AR activation by Dawei Ni, Kun Liu, Ning Wu, Bin You, Baibing Yang, Wei Wu, Yutian Dai

“…The results revealed that the expression of AR and APQ8 in high glucose-treated seminal vesicle cells was decreased and that curcumin treatment upregulated the expression of AR and AQP8. …”
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Senescent cell depletion alleviates obesity-related metabolic and cardiac disorders by Tábatha de Oliveira Silva, Guilherme Lunardon, Caroline A. Lino, Amanda de Almeida Silva, Shiju Zhang, Maria Cláudia Costa Irigoyen, Yao Wei Lu, John D. Mably, Maria Luiza M. Barreto-Chaves, Da-Zhi Wang, Gabriela P. Diniz

“…Methods and Results: We found that the increase in body weight and adiposity, glucose intolerance, insulin resistance, dyslipidemia, hyperleptinemia, and hepatic disorders which were induced by an obesogenic diet were alleviated by senolytic cocktail treatment in mice. …”
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Genetic variability and performance of Asian swamp eel Monopterus albus (Zuiew, 1793) from West Java cultured in saline water medium by Dinar Tri Soelistyowati, Ahmad Fahrul Syarif, Ridwan Affandi, Dendi Hidayatullah

“…Asian swamp eel adapted better at water salinity 6 ppt which indicated by low mesure of osmotic gradient and blood glucose. Asian swamp eel from Karawang showed superior at survival rate (90%) and daily growth rate (1.42/day).   …”
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Comparative efficacy of repurposed drugs lopinavir-ritonavir and darunavir-ritonavir in hospitalised COVID-19 patients: insights from a tertiary centre cohort by Dóra Paróczai, Dóra Paróczai, András Bikov, András Bikov, Andreea Blidaru, Emanuel Bobu, Ana Lascu, Ana Lascu, Cristian Ion Mot, Cristian Ion Mot, Stefan Mihaicuta, Stefan Mihaicuta, Stefan Frent, Stefan Frent

“…Factors associated with mortality included male gender (HR: 3.63, p=0.02), diabetes (HR: 2.49, p=0.03), oxygen saturation below 90% at admission (HR: 5.23, p&lt;0.01), high blood glucose levels (HR: 3.68, p=0.01), age (HR: 1.04, p=0.02), and more than 25% lesion extension on chest CT scan (HR: 2.28, p=0.03).ConclusionsLPV/r, but not DRV/r, showed a survival benefit in patients hospitalised with COVID-19, but these findings deserve further investigation in a randomised clinical trial.…”
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Identification and validation of glycolysis-related diagnostic signatures in diabetic nephropathy: a study based on integrative machine learning and single-cell sequence by Xiaoyin Wu, Xiaoyin Wu, Buyu Guo, Buyu Guo, Xingyu Chang, Xingyu Chang, Yuxuan Yang, Yuxuan Yang, Qianqian Liu, Qianqian Liu, Jiahui Liu, Jiahui Liu, Yichen Yang, Yichen Yang, Kang Zhang, Yumei Ma, Songbo Fu, Songbo Fu, Songbo Fu

“…In vitro, ELF3, LCN2 and CD163 were induced in high glucose-induced HK-2 cell lines.ConclusionAn integrative machine learning frame established a novel diagnostic signature using glycolysis-related genes. …”
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Estimating the need for diabetic retinopathy services in north India: evidence from a population-based survey in the catchment population of an eye care provider in central Uttar P... by Andrew Bastawrous, Vaibhav Jain, Ian McCormick, Shalinder Sabherwal, Ishaana Sood, Atanu Majumdar, Shamanna B R, Mohd Javed, Sandeep Buttan, Simrat Chandi, Basitali Lakhani, Shreya Tyagi, Utsav Deep

“…People with already diagnosed diabetes and anyone with a random blood glucose ≥200 mg/dL were offered dilated fundus examination.Primary and secondary outcomes Primary and secondary outcomes were the prevalence of DR and screening coverage for DR, respectively.Results The prevalence of diabetes was 7.0% (95% CI 5.9% to 8.0%). 50.2% of all people with diabetes were newly detected. …”
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Effects of soy hull polysaccharide on dyslipidemia and pathoglycemia in rats induced by a high-fat-high-sucrose diet by Qian Lin, Lina Yang, Lin Han, Ziyi Wang, Mingshuo Luo, Danshi Zhu, He Liu, Xin Li, Yu Feng

“…After SHP feeding for 4 weeks, the fasting blood glucose (FBG), serum triglyceride (TG), serum high-density lipoprotein cholesterol (HDL-C), short chain fatty acids (SCFAs), and 16S rDNA gene sequence were determined. …”
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Enhanced Antitumor Efficacy and Reduced Toxicity in Colorectal Cancer Using a Novel Multifunctional Rg3- Targeting Nanosystem Encapsulated with Oxaliplatin and Calcium Peroxide by Xie Y, Zhu M, Bao H, Chen K, Wang S, Dai J, Chen H, Li H, Song Q, Wang X, Yu L, Pei J

“…A multifunctional nanosystem (Rg3-Lip-OXA/CaO2) was established using Ginsenoside Rg3 liposomes targeting glucose transporter 1 overexpressed on the surface of CRC cells to co-deliver OXA and calcium peroxide (CaO2).Methods: The CaO2 nanoparticles were synthesized via the CaCl2-H2O2 reaction under alkaline conditions and characterized using X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). …”
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Associations of health literacy with metabolic status and quality of life among comunity patients with type 2 diabetes in Shanghai by YANG Liping, SONG Haihong, SHEN Jue, GAO Jinli, ZHANG Zhiping, QIAN Liuyu, GONG Huan

“…Patients were assessed using a simplified evaluation form for diabetes-related health literacy and a QoL scale, and metabolic indicators such as blood glucose and blood lipids were measured. Pearson correlation coefficients were employed to assess the relationship between health literacy levels and metabolic indicators as well as QoL. …”
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