Neuroprotective Effects of Eugenol Acetate Against Ischemic Stroke by Chen L, Zhang R, Xiao J, Liang Y, Lan Z, Fan Y, Yu X, Xia S, Yang H, Bao X, Meng H, Xu Y, Yu L, Zhu X

“…Liqiu Chen,1,2,* Ran Zhang,1,2,* Jing Xiao,1,2,* Ying Liang,1,2 Zhen Lan,3 Yingao Fan,2 Xi Yu,2 Shengnan Xia,2– 5 Haiyan Yang,2– 5 Xinyu Bao,2– 5 Hailan Meng,1– 6 Yun Xu,1– 6 Linjie Yu,1– 6 Xiaolei Zhu1– 6 1Department of Neurology, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, People’s Republic of China; 2Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, People’s Republic of China; 3Department of Neurology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, 210008, People’s Republic of China; 4State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, 210008, People’s Republic of China; 5Jiangsu Provincial Key Discipline of Neurology, Nanjing, 210008, People’s Republic of China; 6Nanjing Neurology Medical Center, Nanjing, 210008, People’s Republic of China*These authors contributed equally to this workCorrespondence: Linjie Yu; Xiaolei Zhu, Department of Neurology, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, People’s Republic of China, Email yulinjie126@126.com; zhuquelee@126.comObjective: To explore the neuroprotective effect of Eugenol Acetate (EA) on post-stroke neuroinflammation and investigate the underlying mechanisms.Methods: For in vitro experiments, primary microglia were pre-incubated with EA for 2 hours, followed by lipopolysaccharide (LPS) stimulation for 24 hours or Oxygen-Glucose Deprivation (OGD) treatment for 4 hours. Real-time quantitative PCR, enzyme-linked immunosorbent assay (ELISA) and Western blot were performed to examine the expression levels of inflammatory cytokines in primary microglia. …”
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Microglia TRPC1 SUMOylation drives neuroinflammation after stroke by modulating NLRP3 activity via increasing TRPC1 interaction with ARRB2 by Huinan Zhang, Xinzhe Du, Tian Gao, Xing Wang, Huifeng Zhang, Manyang Yu, Jing Huang

“…Our findings suggest a notable increase in microglial TRPC1 SUMOylation within both the middle cerebral artery occlusion reperfusion (MCAO/R) model and the in vitro oxygen-glucose deprivation/regeneration model. Mice with a loss of TRPC1 SUMOylation in microglia exhibited improved stroke outcomes including reduced behavior deficits, infarct volume, blood brain barrier damage as well as neuronal apoptosis. …”
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Oridonin ameliorates renal fibrosis in diabetic nephropathy by inhibiting the Wnt/β-catenin signaling pathway by Jushuang Li, Lan Shu, Qianqian Jiang, Baohong Feng, Zhimin Bi, Geli Zhu, Yanxia Zhang, Xiangyou Li, Jun Wu

“…Here, we investigated the mechanism through which Ori affects the Wnt/β-catenin signaling pathway in diabetic rats and human proximal tubular epithelial cells (HK-2) exposed to high glucose (HG) levels. Our results revealed that Ori treatment markedly decreased urinary protein excretion levels, improved renal function and alleviated renal fibrosis in diabetic rats. …”
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Genotype-Phenotype Correlation of G6PD Mutations among Central Thai Children with G6PD Deficiency by Boonchai Boonyawat, Tim Phetthong, Nithipun Suksumek, Chanchai Traivaree

“…Background. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common X-linked inherited erythroenzymopathy in Thailand. …”
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Cryptococcal Meningitis: A Retrospective Cohort of a Brazilian Reference Hospital in the Post-HAART Era of Universal Access by Aline Z. de Azambuja, Gustavo Wissmann Neto, Guilherme Watte, Luciana Antoniolli, Luciano Z. Goldani

“…Multivariate analysis of Cox regression identified headache at presentation, mechanical ventilation, CSF glucose <20 mg/dL, and CSF cryptococcal antigen ≥1 : 1000 for independent risk factors for death. …”
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Pharmacogenetics of Risperidone and Cardiovascular Risk in Children and Adolescents by Amilton Dos Santos-Júnior, Taciane Barbosa Henriques, Maricilda Palandi de Mello, Osmar Henrique Della Torre, Lúcia Arisaka Paes, Adriana Perez Ferreira-Neto, Letícia Esposito Sewaybricker, Thiago Salum Fontana, Eloisa Helena Rubello Valler Celeri, Gil Guerra-Júnior, Paulo Dalgalarrondo

“…Samples from 120 risperidone users (8–20 years old) were collected and SNPs were analyzed, alongside assessment of chronological and bone ages, prescribed and weight-adjusted doses, use of other psychotropic drugs, waist circumference, BMI z-scores, blood pressure, HOMA-IR index, fasting levels of serum glucose, insulin, cholesterol, triglycerides, transaminases, and leptin. …”
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The relationship between walking speed and changes in cardiovascular risk factors during a 12-day walking tour to Santiago de Compostela: a cohort study by Frank L J Visseren, Yolanda van der Graaf, Wilko Spiering, Remy H H Bemelmans, Paulus P Blommaert, Annemarie M J Wassink, Blai Coll

“…Subjects using lipid-lowering medication were excluded.Intervention Participants walked 281±10 km of the classical route to Santiago de Compostela in 12 days in 2009.Primary and secondary outcome measures Walking speed was recorded and blood pressure, weight, waist circumference, lipids and glucose were measured every other day. Changes in risk factors were compared between gender-pooled groups with faster and slower walking speed. …”
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Effectiveness and safety of metformin in 51 675 patients with type 2 diabetes and different levels of renal function: a cohort study from the Swedish National Diabetes Register by Katarina Eeg-Olofsson, Soffia Gudbjörnsdottir, Ann-Marie Svensson, Björn Eliasson, Linus Schioler, Björn Zethelius, Nils Ekström, Jan Cederholm, Junmei Miao Jonasson

“…Objective To evaluate the effectiveness and safety of metformin use in clinical practice in a large sample of pharmacologically treated patients with type 2 diabetes and different levels of renal function.Design Observational study between July 2004 and December 2010, mean follow-up 3.9 years.Setting Hospital outpatient clinics and primary care in Sweden.Participants 51 675 men and women with type 2 diabetes, registered in the Swedish National Diabetes Register, and on continuous glucose-lowering treatment with oral hypoglycaemic agents (OHAs) or insulin.Main outcome measures Risks of cardiovascular disease (CVD), all-cause mortality and acidosis/serious infection, associated with each treatment regimens, were analysed in all patients and in subgroups with different estimated glomerular filtration rate (eGFR) intervals. …”
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Association of oxidative balance score with metabolic syndrome and its components in middle-aged and older individuals in the United States by Qu Zhang, Yemei Wu, Bo Luo

“…Increased OBS was linked to decreases in waist circumference (WC) (OR 0.41; 95% CI: 0.30–0.51; p &lt; 0.0001), triglycerides (TG) (OR 0.71; 95% CI: 0.53–0.92; p = 0.0139), blood pressure (BP) (OR 0.53; 95% CI: 0.40–0.69; p &lt; 0.0001), and fasting glucose (FG) (OR 0.61; 95% CI: 0.45–0.81; p &lt; 0.0001), while HDL-C increased (OR 0.68; 95% CI: 0.51–0.90; p = 0.0065). …”
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The Usage of Lion’s Mane in Sports and Its Metabolic Impact – a literature review by Karolina Stankevič, Kamila Fuczyło, Ewelina Kopczyńska, Piotr Kulej, Wiktor Biesiada, Justyna Weronika Kmieć, Justyna Woźniak, Anna-Mariia Chernysh, Aleksandra Dusińska, Jakub Waszczyński

“…Results The literature indicates that lion’s mane has potential benefits in enhancing cognitive function, reducing oxidative stress, and improving glucose metabolism—all of which are relevant to sports performance and recovery. …”
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TG : HDL-C Ratio Is a Good Marker to Identify Children Affected by Obesity with Increased Cardiometabolic Risk and Insulin Resistance by Ahmad Kamil Nur Zati Iwani, Muhammad Yazid Jalaludin, Ruziana Mona Wan Mohd Zin, Md Zain Fuziah, Janet Yeow Hua Hong, Yahya Abqariyah, Abdul Halim Mokhtar, Wan Nazaimoon Wan Mohamud

“…Children with elevated TG : HDL-C ratio had lower fasting glucose compared to children with MetS (boys = 5.15 ± 0.4 vs. 6.34 ± 2.85 mmol/l, p=0.02; girls = 5.17 ± 0.28 vs. 6.8 ± 4.3 mmol/l, p=0.03). …”
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Vitamin D and exercise improve VEGF-B production and IGF-1 levels in diabetic rats: insights the role of miR-1 suppression by Fatemeh Mazaheri, Rastegar Hoseini, Ahmad Gharzi

“…Significant differences were observed between the groups in terms of visceral fat, insulin, glucose, and HOMA-IR (p = 0.001 for all variables). …”
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Maternal and Fetal Lipid and Adipokine Profiles and Their Association with Obesity by Mario Solis-Paredes, Salvador Espino y Sosa, Guadalupe Estrada-Gutierrez, Sonia Nava-Salazar, Veronica Ortega-Castillo, Mario Rodriguez-Bosch, Eyerahi Bravo-Flores, Aurora Espejel-Nuñez, Maricruz Tolentino-Dolores, Rubí Gaona-Estudillo, Nancy Martinez-Bautista, Otilia Perichart-Perera

“…Healthy pregnant women at term who delivered by C-section were enrolled. Maternal and fetal glucose, lipid profile, adiponectin, leptin, and resistin levels were analyzed by obesity and maternal weight gain. …”
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Dihydroporphyrin iron (III) enhances low temperature tolerance by increasing carbon and nitrogen metabolism in Andrographis paniculata by Shao-Fen Jian, Shao-Fen Jian, Shao-Fen Jian, Yan-Fen Huang, Yan-Fen Huang, Yan-Fen Huang, Dong-Liang Chen, Chu Zhong, Chu Zhong, Chu Zhong

“…DH-Fe reduced the contents of sucrose, soluble sugar and starch and the activities of sucrose synthase (SS) and hexokinase (HXK), but stimulated the activities of sucrose phosphate synthase (SPS), glucose-6-phosphate dehydrogenase (G6PDH), glyceraldehyde 3-phosphate dehydrogenase (GAPDH), phosphoenolpyruvate carboxylase (PEPC), isocitrate dehydrogenase (ICDH), and malic enzyme (ME). …”
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Efficacy and safety of glucagon-like peptide-1 receptor agonists in the elderly versus non-elderly patients with type 2 diabetes mellitus: insights from a systematic review by Yao Wang, Jiangling Wang, Qian Gong, Haoming Wu, Shuhao Yang, Jufeng He, Xulin Hu, Tianfang Huang

“…In conclusion, while certain AEs leading to discontinuation may be more prevalent in older patients, GLP-1RAs are effective for weight loss and lead to decreased glucose concentrations with a low rate of complications in elderly patients.…”
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Effect of abdominal massage and comprehensive nursing on relieving constipation in elderly patients with diabetes (腹部推拿治疗糖尿病便秘效果观察及护理) by YAN Qiuyan (闫秋艳), LIU Fei (柳菲)

“…All patients were given glucose-lowering Therapy and routine care, and Traditional Chinese Medicine abdominal massage was carried in the observation group. …”
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Net energy of grains for dairy goats differed with processing methods and grain types by Xiaodong Su, Lei Zhang, Yiyang Sun, Yanbo Wu, Jianrong Ren, Shengru Wu, Xinjian Lei, Jun Zhang, Dangdang Wang, Hao Ren, Junhu Yao

“…Both the DRW and SFC diets elevated serum glucose levels. Furthermore, heat increment (HI) and gaseous energy (GasE) related to fermentation were significantly higher in the DRW and SFC groups compared to the DRC group. …”
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TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis by Lin Wang, Diqing Ouyang, Lin Li, Yunchuan Cao, Yingwen Wang, Nina Gu, Zhaosi Zhang, Zhao Li, Shuang Tang, Hui Tang, Yuan Zhang, Xiaochuan Sun, Jin Yan

“…Various techniques were used to assess the role of DAM-like cells in TBI and the effects of glycolysis on DAM-like cells, including RT‒qPCR, immunofluorescence assays, behavioural tests, extracellular acidification rate (ECAR) tests, Western blot analysis, cell magnetic sorting and culture, glucose and lactate assays, and flow cytometry. Results DAM-like cells were observed in the acute phase of TBI in mice, and their transformation depended on TREM2 expression. …”
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Emerging roles of mitochondrial sirtuin SIRT5 in succinylation modification and cancer development by Zhangmin Ke, Zhangmin Ke, Kaikai Shen, Li Wang, Hao Xu, Xia Pan, Zhenjue Qian, Yuting Wen, Tangfeng Lv, Xiuwei Zhang, Yong Song

“…These substrates mediate diverse physiological processes such as glucose oxidation, fatty acid oxidation, ammonia detoxification, reactive oxygen species scavenging, anti-apoptosis, and inflammatory responses. …”
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Controlled Resistant Hypertension Following A Successful Renal Artery Stenting: A Rare Case Report in A Developing Country by Fatihatul Firdaus Munita, Badai Bhatara Tiksnadi, Januar Wibawa Martha, Margareta Ginanti Ratna

“…Screening for secondary hypertension, including laboratory tests (complete blood count, potassium, sodium, creatinine, fasting glucose, lipid profile, urinalysis, thyroid-stimulating hormone, and 24-hour urinary-free cortisol), suggested normal results. …”
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