The impact of serum testosterone level to reflect age-related multi-organ functions by Tomoya Shirakawa, Julius Fink, Zen-u Hotta, Yosuke Shimada, Yan Lu, Junhua Du, Kazuhito Matsushita, Satoshi Hori, Hisamitsu Ide, Shigeo Horie

“…A multiple regression analysis was conducted to determine whether biomarkers including hemoglobin (Hb), hematocrit (Hct), luteinizing hormone (LH), follicle stimulating hormone (FSH), alkaline phosphatase (ALP), albumin (ALB), creatinine (Cre), aspartate aminotransferase (AST), alanine aminotransferase (ALT), glucose (Glu), C-reactive protein (CRP), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) values were associated with serum total testosterone concentration. …”
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Self-Care Practices and the Associated Socio-Demographic Variables of Persons with Type 2 Diabetes Mellitus (T2dm) in Southeast, Nigeria. by Okafor, Christiana Nkiru, Okonkwo, Uchenna Prosper, Ani, Kenneth Umezulike, Onuora, Ethel Ogoemeka, Nwokike, Mathew, Byabagambi, Jane Turyasingura, Tamu, JohnBosco Munezero, Mfitumukiza, Valence, Nwankwo, Mercy Chinenye, Tumusiime, Alex

“…Only 7.9% practiced 3-monthly laboratory blood glucose testing while 16.5% went for eye checks every 6 months. …”
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Self-Care Practices and the Associated Socio-Demographic Variables of Persons With Type 2 Diabetes Mellitus (T2dm) in Southeast, Nigeria. by Okafor, Christiana Nkiru, Okonkwo, Uchenna Prosper, Ani, Kenneth Umezulike, Onuora, Ethel Ogoemeka, Nwokike, Mathew, Turyasingura, Jane Byabagambi, Munezero, Tamu JohnBosco, Mfitumukiza1, Valence, Nwankwo, Mercy Chinenye, Tumusiime, Alex

“…Only 7.9% practiced 3-monthly laboratory blood glucose testing while 16.5% went for eye checks every 6 months. …”
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Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease by Thomas F Baumert, Charlotte Bach, Patrick Pessaux, Catherine Schuster, Frank Jühling, Sarah C Durand, Yujin Hoshida, Fabien Zoulim, Atish Mukherji, Naoto Fujiwara, Marine A Oudot, Armando Andres Roca Suarez, Michel L Tremblay, Barbara Testoni, Joachim Lupberger, Romain Parent, Laurent Mailly, Nassim Dali-Youcef, Emanuele Felli, Maria Saez-Palma, Julien Moehlin, Alessia Virzì, Nicolas Brignon, Eugenie Schaeffer, Romain Martin, Laura Meiss-Heydmann, Zakaria Boulahtouf, Lea Girard, Emma Osswald, Carole Jamey, Daniel Brumaru, Bhuvaneswari Koneru

“…Patients with obesity and low hepatic PTPRD expression exhibit increased levels of metabolic risk factors.Conclusion Our data revealed an important regulatory role of the hepatic PTPRD-STAT3 axis in maintaining glucose/lipid homeostasis, which is recapitulated in clinical manifestations of metabolic liver disease.…”
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Metabolic profile of blood serum in experimental arterial hypertension by A. A. Seryapina, A. A. Malyavko, Yu. K. Polityko, L. V. Yanshole, Yu. P. Tsentalovich, A. L. Markel

“…Such a ratio of the metabolite concentrations is associated with changes in the regulation of glucose metabolism (metabolic markers – leucine, isoleucine, valine, myoinositol), of nitric oxide synthesis (ornithine) and catecholamine pathway (tyrosine), and with inflammatory processes (metabolic markers – betaine, tryptophan), all of these changes being typical for hypertensive status. …”
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Visceral Adipose Tissue Inflammation and Vascular Complications in a Rat Model with Severe Dyslipidemia: Sex Differences and PAI-1 Tissue Involvement by Irena Markova, Martina Hüttl, Natalie Gayova, Denisa Miklankova, Kristyna Cerna, Martina Kavanova, Petra Skaroupkova, Sona Cacanyiova, Hana Malinska

“…Using male and female hereditary hypertriglyceridemic (HHTg) rats—a nonobese prediabetic model featuring dyslipidemia, hepatic steatosis, and insulin resistance—we found that HHTg females exhibited more pronounced hypertriglyceridemia than males, while HHTg males had higher non-fasting glucose levels. Additionally, HHTg females had higher platelet counts, larger platelet volumes, and lower antithrombin inhibitory activity. …”
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Reprogramming of Adult Retinal Müller Glial Cells into Human-Induced Pluripotent Stem Cells as an Efficient Source of Retinal Cells by Amélie Slembrouck-Brec, Amélie Rodrigues, Oriane Rabesandratana, Giuliana Gagliardi, Céline Nanteau, Stéphane Fouquet, Gilles Thuret, Sacha Reichman, Gael Orieux, Olivier Goureau

“…With a modified retinal maturation protocol characterized by the presence of serum and high glucose levels, our study revealed that the retinal organoids contained pseudolaminated neural retina with important features reminiscent of mature photoreceptors, both rod and cone subtypes. …”
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Ginsenoside Rk2 alleviates hepatic ischemia/reperfusion injury by enhancing AKT membrane translocation and activation by Hong Shen, Jiajun Fu, Jiayue Liu, Toujun Zou, Kun Wang, Xiao‐Jing Zhang, Jian‐Bo Wan

“…Rk2 significantly reduced inflammation and apoptosis caused by oxygen‐glucose deprivation and reperfusion in hepatocytes and dose dependently protected against hepatic I/R‐induced liver injury in mice. …”
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Trajectories of self-rated health in an older general population and their determinants: the Lifelines Cohort Study by Barbara C van Munster, Nynke Smidt, Sophia E de Rooij, Marlies Feenstra, Janet L MacNeil Vroomen

“…Covariates included demographics (age, gender, education), chronic diseases, health-risk behaviour (physical activity, smoking, drinking) and physiological markers (body mass index, cardiovascular function, lung function, glucose metabolism, haematological condition, endocrine function, renal function, liver function and cognitive function).Results Four stable trajectories were identified, including excellent (n=607, 6%), good (n=2111, 19%), moderate (n=7677, 65%) and poor SRH (n=1205, 10%). …”
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Evaluation of Preptin and other Biomarkers in Coronary Artery Disease Patients with and without Diabetes Mellitus by Saja T. Yassen, Layla O. Farhan

“…However, in addition to insulin, pancreatic hormone (Preptin) is released in response to elevated blood glucose levels. Preprint’s primary metabolic effect is to raise insulin synthesis, which is achieved through both an amplifying mechanism and a triggering route that is dependent on calcium signalling. …”
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Ketosis Onset Type 2 Diabetes Had Better Islet β-Cell Function and More Serious Insulin Resistance by Hongyun Lu, Fang Hu, Yingjuan Zeng, Lingling Zou, Shunkui Luo, Ying Sun, Hong Liu, Liao Sun

“…After correction of hyperglycemia and ketosis with insulin therapy, plasma C-peptide concentrations were measured at 0, 0.5, 1, 2, and 3 hours after 75 g glucose oral administration. Area under the curve (AUC) of C-peptide was calculated. …”
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Negative association between 15 obesity- and lipid-related indices and testosterone in adult males: a population based cross-sectional study by Wei Guo, Shuo Zhao, Qinzheng Chang, Jiajia Sun, Yidong Fan, Jikai Liu

“…Within the model that incorporated all adjustments, the triglyceride glucose-waist to height ratio (TyG-WHtR) has the best performance for predicting TD (Overall: AUC = 0.762, 95%CIs: 0.743, 0.782, cut-off = 5.186). …”
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The association between lipid-related obesity indicators and severe headache or migraine: a nationwide cross sectional study from NHANES 1999 to 2004 by Xu Sun, Jimei Song, Rixun Yan, Jianwei Diao, Yibo Liu, Zhangzhi Zhu, Weichi Lu

“…Methods After the values of waist-to-height ratio (WHtR), body-mass index (BMI), body roundness index (BRI), visceral adiposity index (VAI), lipid accumulation product (LAP), triglyceride glucose index (TyG), cardiac metabolism index (CMI), waist triglyceride Index (WTI), conicity index (CI) and weight-adjusted waist index (WWI) were estimated, with minimal sufficient adjustment for confounders determined by directed acyclic graph (DAG), weighted univariable and multivariable logistic regression analyses were carried out to ascertain the relationship between them and migraine. …”
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Decreased Sex Hormone-Binding Globulin Indicated Worse Biometric, Lipid, Liver, and Renal Function Parameters in Women with Polycystic Ovary Syndrome by Xi Luo, Xin-Ming Yang, Wang-Yu Cai, Hui Chang, Hong-Li Ma, Yan Peng, Xiao-Ke Wu

“…Metabolic parameters included biometric parameters, glucose and lipid panels, and liver and renal function parameters. …”
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Physicochemical Properties of Soluble Dietary Fiber from Passion Fruit Peel Based on Various Extraction Methods by Ya Song, Yunxin Shi, Yuting Liu, Yue Ma, Chenwenyi Lin, Ninglang Nie, Xuqin Song, Jian Yang

“…The SDF extracted by enzyme-assisted extraction method (EAE) showed the highest DPPH free radical scavenging capacity (66.67%), reducing sugar content (5.71%), oil-holding capacity (5.86 g/g), and glucose content (55.9662 µg/mg). The SDF extracted by alkali-assisted extraction method (AAE-2) provided the highest water-holding capacity (7.82 g/g), solubility (4.24 mL/g), and rhamnose content (3.0854 µg/mg). …”
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Behavioral, biochemical, immune, and histological responses of Nile tilapia (Oreochromis niloticus Linnaeus, 1758) to lead, mercury, and pendimethalin exposure: individual and comb... by Rasha M. Reda, Eman M. Zaki, Ahmed A. A. Aioub, Mohamed M. M. Metwally, Aya M. Yassin, Fatma Mahsoub

“…The stress biomarkers, cortisol and glucose, showed greater impact on the MIX and PM groups. …”
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Global, regional, and national burden of pancreatic cancer from 1990 to 2021, its attributable risk factors, and projections to 2050: a systematic analysis of the global burden of... by Tianyu Li, Chen Lin, Weibin Wang

“…Age-standardized DALYs rate (ASDR) and ASMR worldwide were attributable to tobacco smoking, high BMI, and high fasting plasma glucose. Furthermore, our projection model estimates that the ASIR and ASMR of pancreatic cancer will significantly decline, while the ASDR is anticipated to maintain a steady downward trend by 2050. …”
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Early Biomarkers for Detecting Subclinical Exposure to Fumonisin B1, Deoxynivalenol, and Zearalenone in Broiler Chickens by Laharika Kappari, Todd J. Applegate, Anthony E. Glenn, Abhijeet Bakre, Revathi Shanmugasundaram

“…On d21, T2 to T6 birds exhibited reduced serum phosphorus, glucose, and potassium, while total protein, FITC-d, AST, and CK levels increased compared to control (<i>p</i> < 0.05). …”
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Predicting cardiovascular disease and all-cause mortality using the lymphocyte-to-monocyte ratio: Insights from explainable machine learning models by Jichao Wu, Die Huang, Jiefang Li, Jingxing Yi, Yu Lei, Jun Yin

“…While commonly used biomarkers such as low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and blood glucose are widely applied, they have certain limitations. …”
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Development and validation of a Non-INvaSive Pregnancy RIsk ScoRE (INSPIRE) for the screening of high-risk pregnant women for gestational diabetes mellitus in Pakistan by Romaina Iqbal, Iqbal Azam, Subhash Chandir, Rahat Qureshi, Ali Jaffar, Neelofur Babar, Sabahat Naz, Samreen Jamal, Aisha Syed Wali

“…We conducted interviews to collect information on sociodemographic factors and family history of diabetes, measured mid-upper arm circumference (MUAC) and reviewed the medical records of women for obstetric history and oral glucose tolerance test (OGTT) results. We performed a multivariable logistic regression analysis to obtain coefficients of selected predictors for GDM in the derivation dataset. …”
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