Student Manual Kabale University by Kabale University

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Paracrine activity of Smurf1-silenced mesenchymal stem cells enhances bone regeneration and reduces bone loss in postmenopausal osteoporosis by Alberto González-González, Itziar Álvarez-Iglesias, Daniel García-Sánchez, Monica Dotta, Ricardo Reyes, Ana Alfonso-Fernández, Alfonso Bolado-Carrancio, Patricia Díaz-Rodríguez, María Isabel Pérez-Núñez, José Carlos Rodríguez-Rey, Jesús Delgado-Calle, Flor M. Pérez-Campo

“…Abstract Background Osteoporosis (OP), characterized by reduced bone mass and mineral density, is a global metabolic disorder that severely impacts the quality of life in affected individuals. …”
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Differentiating Latent Tuberculosis from Active Tuberculosis Through Activation Phenotypes and Chemokine Markers HLA-DR, CD38, MCP-1, and RANTES: A Systematic Review and Meta-Analy... by Chaimae Kadi, Narjisse Ahmadi, Anass Houdou, Imad El Badisy, Oumnia Bouaddi, Zakaria Mennane, Nouhaila Najimi, Maryam Benlamari, Saber Boutayeb, Mohamed Khalis, Noureddine EL Mtili, Fouad Seghrouchni

“…Background: Latent TB infection (LTBI) affects one fourth of the global population. Currently, there is an absence of an optimal strategy for distinguishing between active tuberculosis (aTB) and LTBI. …”
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Pathogenic potential of ornithogenic <i>Escherichia coli</i> strains detected in the Earth's polar regions by Batyrbek I. Aslanov, Daniil V. Azarov, Maria A. Makarova, Elizaveta G. Marysheva, Lyudmila A. Kraeva, Aleksey S. Mokhov, Ekaterina A. Lebedeva, Nikita E. Goncharov, Natalya V. Lebedeva, Dmitry A. Starikov, Victoria V. Kolodzhieva, Dmitry E. Polev, Artemy E. Goncharov

“…The analysis of the geographical distribution of the sequence types of polar E. coli strains determined by the cgMLST method showed their global representation in geographically distant regions of the planet. …”
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CPEB4 modulates liver cancer progression by translationally regulating hepcidin expression and sensitivity to ferroptosis by M. Eugenia Delgado, Salvador Naranjo-Suarez, Marta Ramírez-Pedraza, Beatriz I. Cárdenas, Carmen Gallardo-Martínez, Alexandra Balvey, Eulalia Belloc, Judit Martín, Mark Boyle, Raúl Méndez, Mercedes Fernandez

“…Background &amp; Aims: Liver cancer is a significant global health issue, with its incidence rising in parallel with the obesity epidemic. …”
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New multilocus sequence typing scheme for Enterococcus faecium reveals sequential outbreaks of vancomycin-resistant E. faecium ST1162 and ST610 in a Japanese tertiary medical cente... by Masaki Karino, Masashi Yanagihara, Tetsuya Harada, Megumi Sugo, Mizuki Karino, Hirofumi Ohtaki, Hiroyuki Hanada, Toru Takano, Masaya Yamato, Shigefumi Okamoto

“…With high discriminatory power comparable with PFGE and global availability, the Bezdíček scheme is a practical and valuable tool for controlling nosocomial VREfm infections in clinical laboratories.IMPORTANCEIn areas where vancomycin-resistant Enterococcus faecium is common, hospital-acquired infections pose a considerable threat to patients’ lives owing to treatment difficulties. …”
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Integrated removal of chromium, lead, and cadmium using nano-zero-valent iron-supported biochar: Mechanistic insights and eco-toxicity assessment by Yuzhen Wei, Jialu Yu, Fasih Ullah Haider, Qinhu Zhang, Run Chu, Cai Liqun

“…The contamination of water and soil by heavy metals (HMs) is a global issue that should be given much more concern. …”
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The impact of different gastrointestinal reconstruction techniques on gut microbiota after gastric cancer surgery by Yu Yang, Yu Yang, Hang-Yu Zhou, Guo-Min Zhou, Guo-Min Zhou, Jin Chen, Rui Ming, Dong Zhang, Huai-Wu Jiang, Huai-Wu Jiang

“…This is particularly significant in China, where a large proportion of global new cases of gastric cancer and related deaths occur. …”
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Impact of antiparasitic therapy on cardiovascular outcomes in chronic Chagas disease. A systematic review and meta-analysisResearch in context by Anis Rassi, Jr, Alyssa Grimshaw, Ashwin Sarwal, Ranjit Sah, Sangam Shah, Nelson I. Agudelo Higuita, Fabio Mahamed Rassi, Michaele Francesco Corbisiero, Hannah M. Kyllo, Jordan Stellern, Samantha Kaplan, Luis A. Marcos, Edgar A. Ramírez-García, Martin Casapia, Peter Hotez, Maria Elena Bottazzi, Shital Patel, Carlos Franco-Paredes, José Antonio Marin-Neto, Andrés F. Henao-Martínez

“…We searched Ovid Embase, Ovid MEDLINE, Ovid Global Health, Scopus, Web of Science Core Collection, Cochrane Library, PubMed, Google Scholar, and Virtual Health Library databases from inception to May 18, 2024. …”
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COVID-19 on patients with immune-mediated rheumatic disease: a comparative study of disease activity, fatigue, and psychological distress over six months by Claudia Marques, Marcelo M. Pinheiro, Jennifer Lopes, Sandra Lúcia Euzébio Ribeiro, Mary Vânia Marinho de Castro, Lilian David de Azevedo Valadares, Aline Ranzolin, Nicole Pamplona Bueno de Andrade, Rafaela Cavalheiro do Espírito Santo, Nafice Costa Araújo, Cintya Martins Vieira, Valéria Valim, Flavia Patricia Sena Teixeira Santos, Laurindo Ferreira da Rocha, Adriana Maria Kakehasi, Ana Paula Monteiro Gomides Reis, Edgard Torres dos Reis-Neto, Gecilmara Salviato Pileggi, Gilda Aparecida Ferreira, Licia Maria Henrique da Mota, Odirlei Monticielo, Ricardo Machado Xavier

“…Post-COVID-19 worsening in RA patients correlated with medical global assessment (MGA) and CDAI scores, with a moderate to large effect size. …”
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Engineered T cells secreting αB7-H3-αCD3 bispecific engagers for enhanced anti-tumor activity against B7-H3 positive multiple myeloma: a novel therapeutic approach by Punchita Rujirachaivej, Teerapong Siriboonpiputtana, Kornkan Choomee, Kamonlapat Supimon, Thanich Sangsuwannukul, Pucharee Songprakhon, Krissada Natungnuy, Piriya Luangwattananun, Pornpimon Yuti, Mutita Junking, Pa-thai Yenchitsomanus

“…Abstract Background Multiple myeloma (MM) is an incurable plasma cell malignancy with increasing global incidence. Chimeric antigen receptor (CAR) T-cell therapy targeting BCMA has shown efficacy in relapsed or refractory MM, but it faces resistance due to antigen loss and the tumor microenvironment. …”
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Prediction model for type 2 diabetes mellitus and its association with mortality using machine learning in three independent cohorts from South Korea, Japan, and the UK: a model de... by Hayeon Lee, Seung Ha Hwang, Seoyoung Park, Yunjeong Choi, Sooji Lee, Jaeyu Park, Yejun Son, Hyeon Jin Kim, Soeun Kim, Jiyeon Oh, Lee Smith, Damiano Pizzol, Sang Youl Rhee, Hyunji Sang, Jinseok Lee, Dong Keon Yon

“…Summary: Background: Type 2 diabetes mellitus (T2DM) is a significant global public health concern that has steadily increased over the past few decades. …”
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Virological Aspects of COVID-19 in Patients with Hematological Malignancies: Duration of Viral Shedding and Genetic Analysis by Asma Themlaoui, Massimo Ancora, Kais Ghedira, Yosra Mhalla, Manel Hamdoun, Maroua Bahri, Lamia Aissaoui, Raihane Ben Lakhal, Adriano Di Pasquale, Cesare Camma, Olfa Bahri

“…Three types of variants were detected; the most frequent was the Omicron. Globally, the mean intra-host variability in the SARS-CoV-2 genome was 1.31 × 10⁻³ mutations per site per year; it was 1.44 × 10⁻³ in the persistent group and 1.3 × 10⁻³ in the non-persistent group. …”
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SO₂ emissions derived from TROPOMI observations over India using a flux-divergence method with variable lifetimes by Y. Chen, Y. Chen, R. J. van der A, J. Ding, H. Eskes, J. E. Williams, N. Theys, A. Tsikerdekis, P. F. Levelt, P. F. Levelt, P. F. Levelt

“…The total emissions from the 92 largest point-source emissions are estimated to be 2.9 Tg yr<span class="inline-formula">⁻¹</span>, lower than the estimation of 5.2 Tg yr<span class="inline-formula">⁻¹</span> from the global SO<span class="inline-formula">₂</span> catalog MSAQSO<span class="inline-formula">₂</span>LV4. …”
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Overview: quasi-Lagrangian observations of Arctic air mass transformations – introduction and initial results of the HALO–(𝒜 𝒞)³ aircraft campaign by M. Wendisch, S. Crewell, A. Ehrlich, A. Herber, B. Kirbus, C. Lüpkes, M. Mech, S. J. Abel, E. F. Akansu, F. Ament, C. Aubry, C. Aubry, S. Becker, S. Borrmann, S. Borrmann, H. Bozem, M. Brückner, H.-C. Clemen, S. Dahlke, G. Dekoutsidis, J. Delanoë, E. De La Torre Castro, E. De La Torre Castro, E. De La Torre Castro, H. Dorff, R. Dupuy, O. Eppers, F. Ewald, G. George, G. George, I. V. Gorodetskaya, S. Grawe, S. Groß, J. Hartmann, S. Henning, L. Hirsch, E. Jäkel, P. Joppe, P. Joppe, O. Jourdan, Z. Jurányi, M. Karalis, M. Kellermann, M. Klingebiel, M. Lonardi, M. Lonardi, J. Lucke, J. Lucke, A. E. Luebke, M. Maahn, N. Maherndl, M. Maturilli, B. Mayer, J. Mayer, S. Mertes, J. Michaelis, J. Michaelis, M. Michalkov, G. Mioche, M. Moser, M. Moser, H. Müller, R. Neggers, D. Ori, D. Paul, F. M. Paulus, C. Pilz, F. Pithan, M. Pöhlker, M. Pöhlker, V. Pörtge, M. Ringel, N. Risse, G. C. Roberts, S. Rosenburg, J. Röttenbacher, J. Rückert, M. Schäfer, J. Schaefer, V. Schemann, I. Schirmacher, J. Schmidt, S. Schmidt, J. Schneider, S. Schnitt, A. Schwarz, H. Siebert, H. Sodemann, H. Sodemann, T. Sperzel, T. Sperzel, G. Spreen, B. Stevens, F. Stratmann, G. Svensson, C. Tatzelt, T. Tuch, T. Vihma, C. Voigt, C. Voigt, L. Volkmer, A. Walbröl, A. Weber, B. Wehner, B. Wetzel, M. Wirth, T. Zinner

“…<p>Global warming is amplified in the Arctic. However, numerical models struggle to represent key processes that determine Arctic weather and climate. …”
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The incidence of incomplete abortion and the prevalence of abortion-related morbidity in South African public hospitals, 2018 by D N Conco, J Levin, B Komane, K Blanchard, T Bessenaar, N G Nkosi, S Fonn

“…The occurrence of abortion-related morbidity indicates limited access to safe abortion. Globally, unsafe abortions remain a persistent, yet preventable, cause of maternal mortality. …”
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The association between metabolomic profiles of lifestyle and the latent phase of incident chronic kidney disease in the UK Population by Tingting Jin, Yunqi Wu, Siyi Zhang, Ya Peng, Yao Lin, Saijun Zhou, Hongyan Liu, Pei Yu

“…Abstract Chronic kidney disease (CKD) is a global health challenge associated with lifestyle factors such as diet, alcohol, BMI, smoking, sleep, and physical activity. …”
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Temperature Sensitivity Response of Soil Enzyme Activity to Simulated Climate Change at Growth Stages of Winter Wheat by Yaokun Jiang, Bingbing Lu, Meng Liang, Yang Wu, Yuanze Li, Ziwen Zhao, Guobin Liu, Sha Xue

“…This study is of great significance in exploring the effects of global warming on food production and the mechanism of soil ecosystem functional stability under future climate change.…”
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Green Tea Extract (<i>Theaceae</i>; <i>Camellia sinensis</i> L.): A Promising Antimicrobial, Anti-Quorum Sensing and Antibiofilm Candidate Against Multidrug-Resistant <i>Campylobac... by Mona S. Emara, Ahmed M. Ammar, Ashraf M.O. Abdelwahab, Attia A. Elgdawy, Adel Abdelkhalek, Elena Pet, Gabi Dumitrescu, Mirela Ahmadi, Norhan K. Abd El-Aziz

“…Background: Thermophilic <i>Campylobacter</i> species are among the main culprits behind bacterial gastroenteritis globally and have grown progressively resistant to clinically important antimicrobials. …”
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High-risk human papillomavirus: prevalence, association with clinical and morphological characteristics of invasive cervical cancer by L. S. Mkrtchian, V. I. Kiseleva, B. V. Boyko, L. I. Krikunova, V. A. Petrov, V. R. Gusarova, S. A. Ivanov, A. D. Kaprin, I. A. Zamulaeva

“…A literature search was conducted in electronic databases including the National Center for Biotechnology Information Search database (PubMed/Medline), ResearchGate, Scopus, Web of Science, Cancer Tomorrow, Global cancer observatory, Cochrane Library, eLIBRARY, DisserCat. …”
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