S100A8-CAMKK2-AMPK axis confers the protective effects of mild hypothermia against cerebral ischemia-reperfusion injury in rats by Dandan Zhang, Yuting Dai, Xiaoyan Xu, Fuguo Ma, Mingshan Wang, Weiwei Qin

“…The Pulsinelli’s four-vessel ligation method was utilized to establish a rat model of global cerebral IR injury. To investigate the role of S100A8 in MH treatment of cerebral IR injury, hippocampus-specific S100A8 loss or gain of function was achieved using an adeno-associated virus system. …”
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Retrospective cohort study based on the MIMIC-IV database: analysis of factors influencing all-cause mortality at 30 days, 90 days, 1 year, and 3 years in patients with different t... by Xuehui Fan, Jing Xu, Ruixue Ye, Qiu Zhang, Yulong Wang

“…Stroke poses a significant global health burden, and understanding its prognostic factors is crucial for clinical management.MethodsThis is a retrospective cohort study based on data from the MIMIC-IV database, including stroke patients from 2010 to 2020. …”
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The Effectiveness of Acupuncture on Myofascial Trigger Points Versus Traditional Chinese Medicine Acupoints for Treating Plantar Fasciitis With Low Back Pain: A Study Protocol for... by Huang Z, Liang X, Luo Y, Fang Z, Xu M, Xu Y, Cheng S, Li L

“…Secondary outcomes include changes from baseline in foot and low back pain, foot and low back function, plantar fascia thickness, and participants’ self-reported global improvement. Statistical analysis will be conducted using a two-sided test with a significance level of 0.05 and 95% confidence intervals.Clinical Trial Registration: This trial has been registered at the Chinese Clinical Trial Registry. …”
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Mid-term outcomes of moderate-severe cystocele repairing with autologous fascia lata harvested through a small incision by Bo Yu, Junfang Yang, Qingyang Nie, Kun Zhang, Jinsong Han, Yiting Wang

“…Patients were evaluated by subjective perception of vaginal bulging, physical examination, Pelvic Floor Distress Inventory (PFDI-20) Questionnaire, patient satisfaction, Patient Global Impression of Improvement (PGI-I) scores, regret rate, willingness to recommend, complications, and harvesting site issue. …”
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Excess mortality and associated community risk factors related to hurricane Maria in Puerto Rico by Kristen N Cowan, Diego E Zavala, Erick Suarez, José A Lopez-Rodriguez, Omar Alvarez

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Use of isavuconazole in mucormycosis: a systematic review by Shobha Sanjeewani Gunathilaka, Reshani Kaumada Keragala, Kasun Madhumal Gunathilaka, Sujanthi Wickramage, Sachithra Ravindi Bandara, Indika Sanjeewa Senevirathne, Asela Sampath Jayaweera

“…Only a few antifungals are available in the arsenal against mucormycosis. The global guidelines for diagnosing and managing mucormycosis recommend high doses of liposomal amphotericin B (LAmB) as the first-line treatment. …”
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A 10-year review of isoniazid-resistant TB management in Uzbekistan 2009-2020 by M.L. Rekart, P. Thit, M. Oluya, S. Moe, T. Hasan, N. Parpieva, K. Safaev, A. Khristusev, T. Zinaida, J. Singh, S. Allamuratova, I. Azamat, C.G. Restrepo, N. Sitali, J. Achar, J.L. Alvaraez, A. Sinha

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Individual- and Community-Level Risk Factors Associated with Childhood Diarrhea in Ethiopia: A Multilevel Analysis of 2016 Ethiopia Demographic and Health Survey by Setegn Muche Fenta, Teshager Zerihun Nigussie

“…Diarrhea is the second cause of child deaths globally. According to World Health Organization reports, in each year, it kills more than 525,000 children under 5 years. …”
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Time to recovery of COVID-19 patients and its predictors: a retrospective cohort study in HUCSH, Sidama, Ethiopia by Ali B. Anteneh, Zeytu Gashaw Asfaw

“…Abstract Introduction The 2019 COVID-19 pandemic had a global impact, leading to numerous deaths, long recovery times, and economic challenges worldwide, especially in countries with limited financial resources like Ethiopia. …”
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Regional Exploration and Characterisation of CO2 Storage Prospects in the Utsira-Skade Aquifer, North Viking Graben, North Sea by C. Lloyd, M. Huuse, B. J. Barrett, A. M. W. Newton

“…Subsurface CO2 storage is considered a key element of reducing anthropogenic emissions in virtually all scenarios compatible with limiting global warming to 1.5°C. The Utsira-Skade Aquifer (Utsira, Eir and Skade Formations), northern North Sea, has been identified as a suitable reservoir. …”
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Protocol for a multicentre randomised controlled trial examining the effects of temporarily pausing Bruton tyrosine kinase inhibitor therapy to coincide with SARS-CoV-2 vaccination... by Abhishek Abhishek, Jonathan A Cook, Helen M Parry, Anne Francis, Lelia Duley, Vicki S Barber, Paul Moss, Nicholas Peckham

“…Secondary outcomes are RBD antibody levels at 12 weeks postbooster vaccination, participant global assessments of disease activity, blood films, full blood count and lactate dehydrogenase levels, impact on quality of life, self-reported adherence with request to temporarily pause or continue BTKi, T cell response against spike protein and relative neutralising antibody titre against SARS-CoV-2 viral variants. …”
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Assessment of factors predicting the nutritional status of geriatric people in Tabuk, Saudi Arabia by Samar Lafi Aljohani

“…Background: On a global level, geriatric malnutrition is a substantial problem as it has many adverse health outcomes including increased morbidity and death rates, in addition to poor health-related quality of life. …”
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Burden of Road Traffic Injuries in Tanzania: One-Year Prospective Study of Consecutive Patients in 13 Multilevel Health Facilities by Hendry R. Sawe, Sveta Milusheva, Kevin Croke, Saahil Karpe, Meyhar Mohammed, Juma A. Mfinanga

“…Road traffic injuries (RTIs) pose a severe public health crisis in Sub-Saharan Africa (SSA) and specifically in Tanzania, where the mortality due to RTIs is nearly double the global rate. There is a paucity of RTI data in Tanzania to inform evidence-based interventions to reduce the incidence and improve care outcomes. …”
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Antimicrobial Resistance Patterns of Bacterial Isolates from Blood Culture among HIV/AIDS Patients at Felege Hiwot Referral Hospital, Northwest Ethiopia by Mohabaw Jemal, Teshiwal Deress, Teshome Belachew, Yesuf Adem

“…The emergence and spread of antimicrobial resistance in bacteria is recognized as a global public health problem. Bloodstream infection with antimicrobial-resistant bacteria in HIV/AIDS patients makes the problem more challenging. …”
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COVID-19 vaccine uptake in Skåne county, Sweden, in relation to individual-level and area-level sociodemographic factors: a register-based cross-sectional analysis by Per-Olof Östergren, Louise Bennet, Jonas Björk, Adam Mitchell, Mahnaz Moghaddassi, Malin Inghammar

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Retrospective evaluation of patients admitted to the intensive care unit due to obstetric reasons in terms of maternal near-miss, a five-year case-control study by Özgür Erdem, Süleyman Cemil Oğlak, İzzettin Toktaş, Seher Baydemir, Ahmet Yosunkaya, Ali Erdem

“…Abstract Background Maternal Near-Miss (MNM) has become globally recognized as an indicator of pregnancy, birth and the first 42 days of postpartum care services. …”
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Optimization of Harvesting Fish Return From Norongoza Pond in Mwanjari Ward Southern Division Kabale Municipality. by Nuwaha, Louis

“…Extinction of species in aquatic systems have been studied globally and the study focused on optimization of fish harvest returns. …”
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Impacts of Tax Laws on the Performance of Small and Medium Enterprises: A Case Study of Kabale Municipality Kabale District. by Abaasa, Ruth

“…Additionally, it sought to evaluate how current tax regulations affect SMEs in Kabale Municipality, investigate potential policy recommendations, and assess how tax compliance costs impact SME performance, particularly their ability to compete globally. The study also aimed to determine the challenges SMEs face in complying with tax laws and explore potential policy recommendations and strategies to improve the tax environment for SMEs and promote their growth. …”
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Plasmodium Falciparum Genetic Diversity and Multiplicity of Infection Among Asymptomatic and Symptomatic Malaria-Infected Individuals in Uganda. by Mwesigwa, Alex, Ocan, Moses, Cummings, Bryan, Musinguzi, Benson, Kiyaga, Shahid, Kiwuwa, Steven M., Okoboi, Stephen, Castelnuovo, Barbara, Bikaitwoha, Everd Maniple, Kalyango, Joan N., Karamagi, Charles, Nankabirwa, Joaniter I., Nsobya, Samuel L., Byakika‐Kibwika, Pauline

“…Plasmodium falciparum (P. falciparum) remains a significant public health challenge globally, especially in sub-Saharan Africa (SSA), where it accounts for 99% of all malaria infections. …”
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Systematic Review and Meta-Analysis on Human African Trypanocide Resistance by Keneth Iceland, Kasozi, Ewan Thomas, MacLeod, Susan Christina, Welburn

“…Conclusion: The emergence of drug resistance across the spectrum of trypanocidal agents that are used to treat HAT is a major threat to the global WHO target to eliminate HAT by 2030. T. brucei strains were largely resistant to diamidines and the use of high trypanocide concentrations in clinical studies have proved fatal in humans. …”
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