Lucidin from <i>Rubia cordifolia</i> Outperforms FDA-Approved Lapatinib as a Potential Multitargeted Candidate for Breast Cancer Signalling Proteins by Akram Ahmed Aloqbi, Hadil Alahdal, Amany I. Alqosaibi, Mashael M. Alnamshan, Ibtesam S. Al-Dhuayan, Ahood A. Al-Eidan, Hind A. S. Alzahrani, Nouf K. ALaqeel, Fatmah Hazza Alsharif, Abeer Al Tuwaijri

“…<b>Background:</b> Breast cancer remains a significant global health concern, with approximately 2.3 million diagnosed cases and 670,000 deaths annually. …”
Get full text

Towards a Noninvasive Intracranial Tumor Irradiation Using 3D Optical Imaging and Multimodal Data Registration by R. Posada, Ch. Daul, D. Wolf, P. Aletti

“…The geometrical relationship between the coordinate systems of the 3D sensor and the irradiation machine is given by a calibration of the sensor position in the therapy room. The global transformation, computed with the two previous transformations, is sufficient to predict the tumor position in the irradiation machine coordinate system with only the corresponding position in the CT-coordinate system. …”
Get full text

Performance evaluation of hyper-parameter tuning automation in YOLOV8 and YOLO-NAS for corn leaf disease detection by Huzair Saputra, Kahlil Muchtar, Nidya Chitraningrum, Agus Andria, Alifya Febriana

“…The findings highlighted the potential of advanced AI-driven detection systems in revolutionizing crop management and supporting global food security.…”
Get full text

Molecular investigation on active compounds in papaya leaves (Carica papaya Linn) as anti-malaria using network pharmacology, molecular docking, clustering-based analysis and molec... by Arwansyah Arwansyah, Sitti Rahmawati, Siti Nuryanti, Yenni Yusuf, Hartono, Abdur Rahman Arif

“…Malaria remains a significant global health issue. In Indonesia, >400,000 cases of malaria were reported, with the highest prevalence in Papua Province. …”
Get full text

Understanding the Relationship Between Cerebrovascular Disease and the Gut Microbiome by William Roth, Elaine Lo, Orlando De Leon, Sajid Suriya, Farima Fakhri, James R. Brorson, Sean Polster, Tareq Kass‐Hout, Shyam Prabhakaran, James E. Siegler

“…In this review, we summarize the latest evidence illustrating the impact of the microbiome on cerebrovascular disease and highlight the potential applications of this information on individualized and global scales.…”
Get full text

The Presence of Two Distinct Lineages of the Foot-And-Mouth Disease Virus Type A in Russia in 2013–2014 Has Significant Implications for the Epidemiology of the Virus in the Region... by Victor V. Nikiforov, Sergey A. Noskov, Alexander V. Sprygin, Mohammad Abed Alhussen, Anastasia S. Krylova, Taisia V. Erofeeva, Svetlana N. Fomina, Svetlana R. Kremenchugskaya, Fedor I. Korennoy, Maxim V. Patrushev, Ilya A. Chvala, Tamara K. Mayorova, Stepan V. Toshchakov

“…The accessibility of genetic data will facilitate a more comprehensive delineation of FMDV phylogeny on a global scale. In this study, we investigated the FMDV strains circulating in Russia during the 2013–2014 period in geographically distant regions utilizing whole genome sequencing followed by maximum-likelihood phylogenetic reconstruction of whole genome and VP1 gene sequences. …”
Get full text

Genetic and biochemical characterization of a radical SAM enzyme required for post-translational glutamine methylation of methyl-coenzyme M reductase by Roy J. Rodriguez Carrero, Cody T. Lloyd, Janhavi Borkar, Shounak Nath, Liviu M. Mirica, Satish Nair, Squire J. Booker, William Metcalf

“…Structural characterization of MgmA revealed a fold similar to other B12-dependent rSAMs, with a wide active site cleft capable of binding an McrA peptide in an extended, linear conformation.IMPORTANCEMethane plays a key role in the global carbon cycle and is an important driver of climate change. …”
Get full text

Do antibody CDR loops change conformation upon binding? by Chu’nan Liu, Lilian M. Denzler, Oliver E.C. Hood, Andrew C.R. Martin

“…We analyzed the conformational change of the Cα backbone of each CDR upon binding and found that, in most cases, the CDRs (other than CDR-H3) show minimal movement, while 70.6% and 87% of CDR-H3s showed global Cα RMSD ≤ 1.0Å and ≤ 2.0Å, respectively. We also compared bound CDR conformations with the conformational space of unbound CDRs and found most of the bound conformations are included in the unbound conformational space. …”
Get full text

Changes in Different Classes of Precipitation and the Impacts on Sediment Yield in the Hekouzhen-Longmen Region of the Yellow River Basin, China by Suzhen Dang, Xiaoyan Liu, Xiaoyu Li, Manfei Yao, Dan Zhang

“…The sediment yield of the Yellow River Basin has obviously decreased since the 1980s, and the impacts of precipitation on sediment yield changes have become increasingly important with the global climate change. The spatial and temporal variations in annual precipitation and different classes of precipitation in the Hekouzhen-Longmen region (HLR) in the middle reaches of the Yellow River Basin were investigated using data collected from 301 rainfall stations from 1966 to 2016. …”
Get full text

A Novel Power Prediction Model Based on the Clustering Modification Method for a Heavy-Duty Gas Turbine by Jing Kong, Wei Yu, Jinwei Chen, Huisheng Zhang

“…Data-driven models utilizing machine learning algorithms provide an effective approach for predicting power in heavy-duty gas turbines, extracting valuable insights from large-scale operational datasets. However, global unified models often struggle to meet the accuracy requirements of all data when dealing with complex and variable operating conditions, leading to limited prediction accuracy for local conditions. …”
Get full text

Unveiling the potential anticancer activity of Spirulina maxima extract-nanoemulsion through in vitro and in vivo studies by Mohammed Yasser Hussein, Merna Nasr, Veronia Emad, Julie Maged, Portia George, Amina Emad, Abeer Mahmoud Badr, Mehrez E. El-Naggar, Sayeda M. Abdo, Jihan Hussein

“…Abstract Being the second leading cause of death globally, cancer has been a long-standing and rapidly evolving focus of biomedical research and practice in the world. …”
Get full text

Influencing Factors and Prevalence of Anxiety in Medical Students: A Cross-Sectional Study by Huong Thi Nguyen, Yen Thi Hoai Phan, Anh-Vu Nguyen-Hoang, Tri-Bao Nguyen, Gia-Phuoc Tran-Thien

“…Introduction: While current research highlights student anxiety globally, limited data exists on the specific situation of Vietnamese medical students. …”
Get full text

Results of a modified Delphi consensus on the optimal testing pathway for oesophago-gastric cancer care in the UK by Philippe Taniere, Manuel Rodriguez-Justo, Naureen Starling, Wasat Mansoor, Thomas Bird, Martin Eatock

“…Six domains of focus were agreed on and used to develop. 36 agreed statements were developed into a Likert survey, which was distributed by a third party (M3 Global Research). Completed surveys were analysed to produce an arithmetic agreement score for each statement. …”
Get full text

Prevalence of psychological distress: a scientific approach towards the mental health and wellbeing of population during the SARS-COV-2 outbreak [version 2; peer review: 2 approved... by Shazia Sadaf, Sara Noreen, Ahmed Alsubaie, Inayat Shah, Saman Tauqir, Saqib Ali

“…Background The global challenge of the novel coronavirus has led to an unprecedented downturn, adversely affecting the health and mental wellbeing of communities worldwide. …”
Get full text

Effect of Kinases in Extracellular Vesicles from HIV-1-Infected Cells on Bystander Cells by Gifty A. Mensah, Anastasia Williams, Pooja Khatkar, Yuriy Kim, James Erickson, Alexandra Duverger, Heather Branscome, Kajal Patil, Hafsa Chaudhry, Yuntao Wu, Olaf Kutsch, Fatah Kashanchi

“…Although great strides have been made in treatment options for HIV-1, and our understanding of the HIV-1 life cycle has vastly improved since the start of this global health crisis, a functional cure remains elusive. …”
Get full text

ReLTER: An R interface for environmental observation in long term ecological research by Alessandro Oggioni, Micha Silver, Paolo Tagliolato, Arnon Karnieli

“…This paper describes the functionality of the ReLTER package and its potential within the global ecological community.…”
Get full text

A real–time distributed optimization control for power sharing and voltage restoration in inverter–based microgrids by Asad Khan, Muhammad Mansoor Khan, Jiang Chuanwen, Danish Khan

“…The proposed method simplifies the global optimization problem into multiple sub–optimal problems by virtually segregating each GFM source into two decoupled sources. …”
Get full text

The economic burden of atopic dermatitis in Romania: a broad perspective by Alin Codruț Nicolescu, Stefan Strilciuc, Stefan Strilciuc, Rozalina Lăpădatu, Diana-Alecsandra Grad, Cristian Vlădescu, Cristian Vlădescu, Rodica Olteanu

“…Despite extensive studies globally, there is a gap in understanding the impact of this condition in Romania. …”
Get full text

Multiscale Residual Weighted Classification Network for Human Activity Recognition in Microwave Radar by Yukun Gao, Lin Cao, Zongmin Zhao, Dongfeng Wang, Chong Fu, Yanan Guo

“…During the pre-training process, large-scale residual networks, medium-scale residual networks, and small-scale residual networks are used to extract global information, texture information, and semantic information, respectively. …”
Get full text

Spatial Characterization of Woody Species Diversity in Tropical Savannas Using GEDI and Optical Data by Franciel Eduardo Rex, Carlos Alberto Silva, Eben North Broadbent, Ana Paula Dalla Corte, Rodrigo Leite, Andrew Hudak, Caio Hamamura, Hooman Latifi, Jingfeng Xiao, Jeff W. Atkins, Cibele Amaral, Ernandes Macedo da Cunha Neto, Adrian Cardil, Angelica M. Almeyda Zambrano, Veraldo Liesenberg, Jingjing Liang, Danilo Roberti Alves De Almeida, Carine Klauberg

“…In this study, we evaluate the potential of Global Ecosystem Dynamics Investigation (GEDI) data, combined with conventional satellite optical imagery and climate reanalysis data, to predict in situ alpha diversity (Species richness, Simpson index, and Shannon index) among tree species. …”
Get full text