Randomised controlled trial of topical kanuka honey for the treatment of rosacea by James Fingleton, Mark Weatherall, Richard Beasley, Irene Braithwaite, Janwillem Kocks, Mark Holliday, Andrew Corin, Colin Helm, Davitt Sheahan, Barney Montgomery, Judith Riley, Anna Hunt, Christopher Tofield

“…Objective To investigate the efficacy of topical 90% medical-grade kanuka honey and 10% glycerine (Honevo) as a treatment for rosacea.Design Randomised controlled trial with blinded assessment of primary outcome variable.Setting Outpatient primary healthcare population from 5 New Zealand sites.Participants 138 adults aged ≥16, with a diagnosis of rosacea, and a baseline blinded Investigator Global Assessment of Rosacea Severity Score (IGA-RSS) of ≥2. 69 participants were randomised to each treatment arm. 1 participant was excluded from the Honevo group, and 7 and 15 participants withdrew from the Honevo and control groups, respectively.Interventions Participants were randomly allocated 1:1 to Honevo or control cream (Cetomacrogol), applied twice daily for 8 weeks.Main outcome measures The primary outcome measure was the proportion of participants who had a ≥2 improvement in the 7-point IGA-RSS at week 8 compared to baseline. …”
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Integrating the GRACE Score with the Ceramide Risk Score Enhances the Predictive Accuracy of Major Adverse Cardiac Events in Patients with Acute Coronary Syndrome Undergoing Percut... by Xiaofei Wang, Chengzhe Liu, Fu Yu, Zizhuo Zhang, Jiale Wang, Xiaoyu Shi, Tianyou Xu, Qiang Deng, Liping Zhou, Wanyue Sang, Hong Jiang, Lilei Yu

“…We explore if integrating the global registry of acute coronary events (GRACE) score with the ceramide risk score (ceramide test 1, CERT1) improves MACE prediction in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). …”
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Prevalence and determinants of intimate partner violence in pregnancy: a multicentre, binational study by Akaninyene E. Ubom, Chidinma P. Ohachenu, Suraiya S. Auwal, Safiyya F. Usman, Akwasi B. Opoku, Caesar A. Ansing, Jamiu S. Shehu, Peter C. Oriji, Komommo O. Okpebri, Ademola S. Olutoye, Rasheedat O. Balogun, Joshua E. Ifebude, Oluwole D. Obadina, Solomon Nyeche, Abdurrahman A. Bunawa, Ukeje J. Ifeanyi, Fatima A. Mahmud, Hauwa S. Gumbi, Akeem O. Ojugbele, Olubusayo O. Areo, Olakunle E. Ogunjide, Mariam M. Shiru, Ada C. Okpighe, Chia Iornengen, David M. Aqua, Suleiman Z. Abubakar, Fadekemi O. Gabriel-Raji, Oyiana I. Gregory, Lukman O. Lawal, Mathias Abude, David Walawah, Aderopo I. Adelola, Akpofure H. Ese, Jane C. Orijani, Ephraim A. Suobite, Olire C. Afon, Obinna P. Ekwebalam, Baderinwa O. Akanji, Emmanuel E. John, Ibraheem O. Awowole, Omotade A. Ijarotimi, Ngozi Thompson, John I. Ikimalo, Olusola B. Fasubaa

“…Abstract Background Globally, intimate partners are the most common perpetrators of violence against women. …”
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Whole-genome analysis of a ST45-SCCmec IVa (2B)-t116 methicillin-resistant Staphylococcus aureus strain isolated from the sputum of a 5-year-old child with pneumonia by Lin Huang, Rui Guo, Jingxian Lin, Xiaowei Li, Zhicong Li, Limei Zhang, Wenting Li, Rui Xue, Cheng Zhang, Xiaosan Feng, Xiaobin Li, Xiaobin Li

“…IntroductionMethicillin-resistant Staphylococcus aureus (MRSA) sequence type (ST) 45 is a major global MRSA lineage with huge strain diversity and a high clinical impact. …”
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Evaluating cutinase from Fusarium oxysporum as a biocatalyst for the degradation of nine synthetic polymer by Maycon Vinicius Damasceno de Oliveira, Gabriel Calandrini, Clauber Henrique Souza da Costa, Carlos Gabriel da Silva de Souza, Cláudio Nahum Alves, José Rogério A. Silva, Anderson H. Lima, Jerônimo Lameira

“…Abstract Plastic poses a significant environmental impact due to its chemical resilience, leading to prolonged and degradation times and resulting in widespread adverse effects on global flora and fauna. Cutinases are essential enzymes in the biodegradation process of synthetic polymers like polyethylene terephthalate (PET), which recognized organisms can break down. …”
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Pseudovibriamides from Pseudovibrio marine sponge bacteria promote flagellar motility via transcriptional modulation by Yitao Dai, Vitor Lourenzon, Laura P. Ióca, Dua Al-Smadi, Lydia Arnold, Ian McIntire, Roberto G. S. Berlinck, Alessandra S. Eustáquio

“…Finally, we observed many differentially expressed genes (up to 29% of the total gene number) indicating that pseudovibriamides have a global effect on transcription that goes beyond motility.IMPORTANCEMarine sponges are found throughout the oceans from tropical coral reefs to polar sea floors, playing crucial roles in marine ecosystems. …”
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Optimization of the Antibacterial Activity of a Three-Component Essential Oil Mixture from Moroccan <i>Thymus satureioides</i>, <i>Lavandula angustifolia</i>, and <i>Origanum major... by Amine Elbouzidi, Mohamed Taibi, Naoufal El Hachlafi, Mounir Haddou, Mohamed Jeddi, Abdellah Baraich, Saad Bougrine, Ramzi A. Mothana, Mohammed F. Hawwal, Waleed A. Alobaid, Abdeslam Asehraou, Bouchra El Guerrouj, Hanae Naceiri Mrabti, Francois Mesnard, Mohamed Addi

“…Background/Objectives: The rise of antibiotic-resistant pathogens has become a global health crisis, necessitating the development of alternative antimicrobial strategies. …”
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Socially interactive industrial robots: a PAD model of flow for emotional co-regulation by Fabrizio Nunnari, Dimitra Tsovaltzi , Matteo Lavit Nicora , Matteo Lavit Nicora , Sebastian Beyrodt , Pooja Prajod , Lara Chehayeb , Ingrid Brdar , Antonella Delle Fave , Luca Negri , Elisabeth André, Patrick Gebhard , Matteo Malosio 

“…The proposed post-processing method helps quantify the parameters needed to control the frequency of intervention of the agent; still leaving the experimenter with a run-time adjustable global control of its sensitivity. A controlled empirical study (Study 1, N = 20), tested the model’s main theoretical assumptions about Flow, Dominance, Self-Efficacy, and boredom, to legitimate its implementation in this context. …”
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Prevención del cáncer de piel en preescolares: experiencia parental en fotoprotección by Jessica Paulina Guerrero Rodríguez, Angélica Salomé Herrera Molina, Viviana del Rocío Mera Herrera, Paola Maricela Machado Herrera, Yuleydi Alcaide Guardado, Jacobo Cambil Martín

“…<strong>Fundamento:</strong> como promedio se han generan tres millones de casos de cáncer de piel a nivel global en los últimos años. Esta situación ocurre entre otras razones por la constante exposición a la radiación solar y la no aplicación de fotoprotección. …”
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A Review on Blockchain Applications in Operational Technology for Food and Agriculture Critical Infrastructure by Chengliang Zheng, Xiangzhen Peng, Ziyue Wang, Tianyu Ma, Jiajia Lu, Leiyang Chen, Liang Dong, Long Wang, Xiaohui Cui, Zhidong Shen

“…The food and agriculture sector is a cornerstone of critical infrastructure (CI), underpinning global food security, public health, and economic stability. …”
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Dietary supplementation of composite feed additive reduces enteric methane production and enhances feed efficiency, milk production and immunity in Murrah buffalo (Bubalus bubalis) by Avijit Dey, Shyam S. Paul, Satbir S. Dahiya, Ashok K. Balhara, Jerome Andonissamy, Balbir S. Punia, Yendrembam M. Chanu

“…India ranks first in the world’s total milk production, where about 50% of milk is contributed by 108.9 million total buffaloes, 57% of the global buffalo population. At the same time, buffaloes are one of the country’s most significant contributors to greenhouse gases. …”
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The Role of Omega-3 Polyunsaturated Fatty Acids in Patients with Metabolic Syndrome and Endothelial Dysfunction by Andrej Dzupina, Dominik Pella, Pavol Zenuch, Zuzana Zenuchova, Jaipaul Singh, Monika Jankajova, Jan Fedacko

“…MS also affects a substantial portion of the global population. Understanding the risk factors, the development and treatment associated with MS are of paramount importance for early identification, treatment and prevention. …”
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First microscopic and molecular identification of Cryptosporidium spp. in fat sand rats (Psammomys obesus) in Egypt and their potential zoonotic implications by Sara Abdel-Aal Mohamed, Fatma A. S. Anwar, Ahmed Gareh, Marwa M. I. Ghallab, Remigio Martínez, Asmaa Aboelabbas Gouda, Fatemah Enad Alajmi, Hind Alzaylaee, Ignacio García-Bocanegra, Ignacio García-Bocanegra, Ehab Kotb Elmahallawy, Ehab Kotb Elmahallawy

“…Among these, Cryptosporidium spp. are recognized globally as leading causes of waterborne and foodborne diarrheal illnesses in humans. …”
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Early-life tobacco smoke elevating later-life osteoporosis risk: Mediated by telomere length and interplayed with genetic predisposition by Dongsheng Di, Haolong Zhou, Zhangbo Cui, Jianli Zhang, Qian Liu, Tingting Yuan, Tingting Zhou, Xiao Luo, Danyang Ling, Qi Wang

“…Introduction: The growing prevalence of osteoporosis (OP) in an aging global population presents a significant public health concern. …”
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Molecular Data Confirm the Occurrence of the Allochthonous <i>Gambusia holbrooki</i> (Pisces: Poeciliidae) in Sicily and the Maltese Archipelago by Luca Vecchioni, Mirko Liuzzo, Arnold Sciberras, Jeffrey Sciberras, Justin Formosa, Alan Deidun, Gabriele Giacalone, Vincenzo Arizza, Marco Arculeo, Federico Marrone, Francesco Paolo Faraone

“…<i>affinis</i> were asynchronously introduced from the United States into Europe and subsequently translocated globally as biocontrol agents of the malaria vector (i.e., the larvae of the <i>Anopheles</i> mosquitoes), with dramatic consequences for the inland water native fauna. …”
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Genetic Polymorphisms in RNF138, ABCA1 and ESRRG-GPATCH2 Genes and their Role in Insulin Resistance Risk among Normal BMI Individuals in Indian Population: A Case-control Study by Sabitha Thummala, Sarah Fathima, Nithya Kruthi, Junaid Ahmed Khan Ghori, Katherine Saikia, Vivek Belde, Balamurali Andiyakkal Rajendran, Rahul Ranganathan

“…Genotyping for rs4799327 (RNF138), rs2275543 (ABCA1), and rs1497828 (ESRRG-GPATCH2) was performed using the Illumina Infinium Global Screening Array (GSA). Statistical analyses, including Odds Ratios (ORs), 95% Confidence Intervals (CIs), and inheritance model analysis, were conducted to assess the association between genotypes and IR. …”
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A digital intervention to reduce home-office workers’ sedentary behaviour: protocol for the evaluation of the Click2Move programme, a cluster randomised controlled trial by Judit Bort-Roig, Iris Parés-Salomón, Bette Loef, Cristina Vaqué-Crusellas, Alan Coffey, Arnau Gustems-Morral, Anna M. Señé-Mir, Izabela Luznik, Maja Pajek, Kieran P. Dowd, Anna Puig-Ribera, Karin I. Proper

“…Secondary outcomes will include device-based (activPAL3TM) and self-reported (Global Physical Activity Questionnaire and Workforce Sitting Questionnaire) physical activity and sedentary behaviour; self-reported musculoskeletal disorders (Standardised Nordic Questionnaire) and pain (Numeric Rating Scale); self-reported presenteeism and absenteeism (Health and Work Performance Questionnaire), job satisfaction (Need for Recovery scale) and fatigue (single-item 5-point Likert scale). …”
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A workplace-based HIV self-testing intervention as a determinant for self-testing knowledge, beliefs, and use among unskilled workers in Wakiso Uganda by Gerald Mukisa Nsereko, Khamisi Musanje, Eron Robinah Ayesiga, Loyce Kiiza Kobusingye, Rhoda Namubiru, Moses Sempala, Christine Kiwala, Martin Mabunda Baluku

“…Abstract Background The HIV burden still persists to date, as a public global health challenge despite numerous prevention interventions that have been proposed toward achieving 95% of all people living with HIV aware of their HIV status by 2030. …”
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Heatwave warnings mitigate long-term cardiovascular diseases risk from heat-related illness: a real-world prospective cohort studyResearch in context by Qi Huang, Limei Ke, Linfeng Liu, Yuyang Liu, Yanjun Li, Guoqing Feng, Bo Yin, Wenxin Xiang, Jiarun Li, Keyi Lyu, Miao Wang, Qiannan Tian, Liqun Wu, Xiaofeng He, Wannian Liang, Huatang Zeng, Jiming Zhu, Kuiying Gu, Qian Di

“…Summary: Background: Global warming is intensifying, exacerbating associated health issues. …”
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Estimated Aerosol Health and Radiative Effects of the Residential Coal Ban in the Beijing-Tianjin-Hebei Region of China by Kelsey R. Bilsback, Jill Baumgartner, Michael Cheeseman, Bonne Ford, John K. Kodros, Xiaoying Li, Emily Ramnarine, Shu Tao, Yuanxun Zhang, Ellison Carter, Jeffrey R Pierce

“…Abstract Particle-phase air pollution is a leading risk factor for premature death globally and impacts climate by scattering or absorbing radiation and changing cloud properties. …”
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