Adverse outcome pathway-based assessment of pulmonary toxicity from the in vivo mixture of biocides dinotefuran and cetylpyridinium chloride by Yoon Cho, Mi-Kyung Song, Dong Im Kim, Min-Seok Kim, Kyuhong Lee

“…Despite the increasing use of biocides globally and their widespread application in various formulations, the understanding of the toxicity of biocide mixtures remains limited. …”
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Climate change and the sustainable use of medicinal plants: a call for “new” research strategies by Olha Mykhailenko, Olha Mykhailenko, Banaz Jalil, Lyndy J. McGaw, Javier Echeverría, Marce Takubessi, Marce Takubessi, Michael Heinrich, Michael Heinrich

“…These species present various challenges related to the sustainability of their use, impacting their current and future status locally and globally. Their economic importance, combined with rising demands and specific risks of overexploitation, are also key factors considered here. …”
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Association of Corticosteroid Inhaler Type with Saliva Microbiome in Moderate-to-Severe Pediatric Asthma by Amir Hossein Alizadeh Bahmani, Mahmoud I. Abdel-Aziz, Simone Hashimoto, Corinna Bang, Susanne Brandstetter, Paula Corcuera-Elosegui, Andre Franke, Mario Gorenjak, Susanne Harner, Parastoo Kheiroddin, Leyre López-Fernández, Anne H. Neerincx, Maria Pino-Yanes, Uroš Potočnik, Olaia Sardón-Prado, Antoaneta A. Toncheva, Christine Wolff, Michael Kabesch, Aletta D. Kraneveld, Susanne J. H. Vijverberg, Anke H. Maitland-van der Zee, on behalf of the SysPharmPediA consortium

“…The microbiome was compared using global diversity (α and β) between two groups of participants based on inhaler devices (MDI (n = 77) and DPI (n = 65)), and differential abundance was compared using the Analysis of Compositions of Microbiomes with the Bias Correction (ANCOM-BC) method. …”
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Development and Validation of a Nomogram to Predict Type 2 Diabetes Mellitus in Overweight and Obese Adults: A Prospective Cohort Study from 82938 Adults in China by Qingqing Liu, Jie Yuan, Maerjiaen Bakeyi, Jie Li, Zilong Zhang, Xiaohong Yang, Fangming Gao

“…The twin epidemic of overweight/obesity and type 2 diabetes mellitus (T2DM) is a major public health problem globally, especially in China. Overweight/obese adults commonly coexist with T2DM, which is closely related to adverse health outcomes. …”
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Impact of Oseltamivir and Diabetes Development by Bor-Show Tzang, Chih-Chen Tzang, Pei-Hua Chuang, I-Ying Kuo, Yu-Chun Pan, Pei-Hsun Wu, Tsai-Ching Hsu

“…<b>Background/Objectives</b>: Influenza is a major global health challenge, causing thousands of deaths annually. …”
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Knowledge, Attitudes, Motivations, Expectations, and Systemic Factors Regarding Antimicrobial Use Amongst Community Members Seeking Care at the Primary Healthcare Level: A Scoping... by Nishana Ramdas, Johanna C. Meyer, Natalie Schellack, Brian Godman, Eunice Turawa, Stephen M. Campbell

“…Background/Objectives: Antimicrobial resistance (AMR) is a major global health challenge, particularly in low- and middle-income countries (LMICs). …”
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Clinical validation and optimization of machine learning models for early prediction of sepsis by Xi Liu, Meiyi Li, Xu Liu, Yuting Luo, Dong Yang, Hui Ouyang, Jiaoling He, Jinyu Xia, Fei Xiao, Fei Xiao, Fei Xiao

“…IntroductionSepsis is a global health threat that has a high incidence and mortality rate. …”
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A novel virulent core genome multilocus sequence type CT 11424 of Listeria monocytogenes isolate causing stillbirth in Bangladesh by Muntasir Alam, Md Saiful Islam, M. Ishrat Jahan, Arpita Shyama Deb, Afruna Rahman, Zahidul Islam, Atique Iqbal Chowdhury, Kazi Munisul Islam, Mohammad Zahid Hossain, Dilruba Ahmed, Shams El Arifeen, Emily S. Gurley, Mustafizur Rahman

“…Genetic divergence and phylogenetic analyses were conducted to determine the relationship with other reported isolates globally. Results The isolate Lm-BD-CHAMPS-01 was identified as a novel cgMLST CT11424. …”
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FadA antigen of Fusobacterium nucleatum: implications for ceRNA network in colorectal cancer and adenomatous polyps progression by Sama Rezasoltani, Elahe Shams, Moein Piroozkhah, Yaser Aidi, Mehdi Azizmohammad Looha, Parmida Bagheri, Roudabeh Behzadi Andouhjerdi, Amir Sadeghi, Leili Rejali, Ehsan Nazemalhosseini-Mojarad

“…Abstract Introduction Colorectal cancer (CRC) is the second most common cause of cancer-related deaths globally. The gut microbiota, along with adenomatous polyps (AP), has emerged as a plausible contributor to CRC progression. …”
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Deep learning model based prediction of vehicle CO2 emissions with eXplainable AI integration for sustainable environment by Gazi Mohammad Imdadul Alam, Sharia Arfin Tanim, Sumit Kanti Sarker, Yutaka Watanobe, Rashedul Islam, M. F. Mridha, Kamruddin Nur

“…Abstract The transportation industry contributes significantly to climate change through carbon dioxide ( $$\hbox {CO}_{2}$$ CO 2 ) emissions, intensifying global warming and leading to more frequent and severe weather phenomena such as flooding, drought, heat waves, glacier melting, and rising sea levels. …”
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Heat Tolerance Differences Between Hu Sheep and Hu Crossbred Sheep in Microbial Community Structure and Metabolism by Jing-Da Yuan, Li-Wei Wang, Shao-Yin Fu, Ri-Ge-Li-Tu E, Xiao-Qi Ren, Hua Sun, Fang Liu, Biao Wang, Jiang-Hong An, Meng-Ran Zhao, Jiang-Feng He, Xiao-Long He

“…These findings provide an important theoretical basis for the breeding and selection of heat-tolerant meat sheep varieties and offer strong support for the region’s livestock industry in addressing the challenges posed by global warming.…”
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M. A. Fedorova, M. W. Tofique, A. Löf, C. Millward, Z. Günther. Testing and calculation of impact fatigue strength of Flap-X and SS 716 flapper valve steel grades / trans from Engl... by M. A. Fedorova

“…Impact fatigue tests were conducted on a custom-built impact fatigue test rig that used air pulses to produce movement of the reed valves manufactured by a major European compressor manufacturer Nidec Global appliance GmbH, at a frequency of 315 Hz and pulse width of 2,2 milliseconds. …”
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The impact of drought on forest spring phenology in northern China by Haowen Hu, Pengcheng Xue, Shaodong Huang, Zong Wang, Nina Xiong, Liang Shi, Boyi Liang, Jia Wang

“…Global warming is altering ecosystem function and productivity, with changes in vegetation phenology playing a crucial role. …”
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Universal conditional networks (UniCoN) for multi-age embryonic cartilage segmentation with Sparsely annotated data by Nishchal Sapkota, Yejia Zhang, Zihao Zhao, Maria Jose Gomez, Yuhan Hsi, Jordan A. Wilson, Kazuhiko Kawasaki, Greg Holmes, Meng Wu, Ethylin Wang Jabs, Joan T. Richtsmeier, Susan M. Motch Perrine, Danny Z. Chen

“…Abstract Osteochondrodysplasia, affecting 2–3% of newborns globally, is a group of bone and cartilage disorders that often result in head malformations, contributing to childhood morbidity and reduced quality of life. …”
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The association of dietary approaches to stop hypertension measured by the food frequency questionnaire with metabolic syndrome and some inflammatory biomarkers in adolescents with... by Maryam Behrooz, Alireza Ostadrahimi, Samaneh Hajjarzadeh, Mirhadi Mousavi, Afshin Ghalegolab Behbahani, Siamak Shiva

“…Abstract Background Globally, obesity trends are a serious public health concern. …”
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Protocol of the Nurses’ Mental Health Study (NMHS): a nationwide hospital multicentre prospective cohort study by Jiaxin Yang, Chongmei Huang, Shuiyuan Xiao, Xuting Li, Meng Ning, Zengyu Chen, Yusheng Tian, Qiang Yu, Yamin Chen, Ya-Min Li

“…Accounting for more than one-fifth of global nurses, Chinese nurses have a demanding healthcare workload, especially in tertiary hospitals, yet there is no national cohort concerning their mental health and associated factors. …”
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The impact of food-based incentive behaviors on oral health among Saudi children: a cross-sectional study by Yasir Dilshad Siddiqui, Saud Hamdan Almaeen, Ahmed Shawkat Hashem, Ahmed Ali Ahmed Almuntashiri, Mohammed Nadeem Baig, Abdullah Hammad Alshammari, Rital Jamal Alwaqid, Haifa Ali Almutairi, Raha Ahmed, Rakhi Issrani, Farooq Ahmad Chaudhary

“…Abstract Background Childhood dental caries is a common and significant oral health issue globally, resulting in pain, infection, and difficulties in eating and speaking. …”
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Database and geospatial mapping study of those eligible for extracorporeal cardiopulmonary resuscitation in the Thames Valley Region, England by Oscar Millerchip, Jasper Eddison, Alex Rosenberg, Jon Bailey, James Raitt

“…The majority of eligible cases fall outside of the catchment of any one hospital when utilising the hospital-based or rendez-vous models of ECPR. Global Moran’s analysis of the entire region found no significant clustering or dispersal, suggesting a near-random distribution despite some evidence of hotspots. …”
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Efficacy in Japanese adults with growth hormone deficiency receiving weekly somapacitan or daily growth hormone: results from phase 3 REAL 1 trial by Fumio Otsuka, Michael Højby Rasmussen, Takaaki Endo, Claus Sværke, Shigeyuki Tahara, Gudmundur Johannsson

“…A total of 36 Japanese GH-naïve individuals with AGHD were allocated to somapacitan or daily GH (excluding the placebo group of the global trial). Endpoints included change in truncal fat percentage to week 34 measured using dual-energy x-ray absorptiometry, as well as other body composition measures. …”
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Rapid identification and phenotyping of nonalcoholic fatty liver disease patients using a machine‐based approach in diverse healthcare systems by Anna O. Basile, Anurag Verma, Leigh Anne Tang, Marina Serper, Andrew Scanga, Ava Farrell, Brittney Destin, Rotonya M. Carr, Anuli Anyanwu‐Ofili, Gunaretnam Rajagopal, Abraham Krikhely, Marc Bessler, Muredach P. Reilly, Marylyn D. Ritchie, Nicholas P. Tatonetti, Julia Wattacheril

“…Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common global cause of chronic liver disease and remains under‐recognized within healthcare systems. …”
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