Exploring the antiviral potential of shikimic acid against Chikungunya virus through network pharmacology, molecular docking, and in vitro experiments by Jialiang Xin, Xingxing Song, Haohong Zheng, Wenjing Li, Yuyang Qin, Wei Wang, Wei Wang, He Zhang, Guangneng Peng

“…Chikungunya virus (CHIKV) is an arbovirus that can lead to chronic arthritis and significantly diminish the quality of life of patients. Given the expanding global prevalence of CHIKV and the absence of specific antiviral therapies, there is an urgent need to explore effective treatment options. …”
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Sustainable CO₂ Capture: N,S-Codoped Porous Carbons Derived from Petroleum Coke with High Selectivity and Stability by Jiawei Shao, Yingyi Wang, Mingyang Che, Ya Liu, Yongfu Jiang, Qiang Xiao, Muslum Demir, Linlin Wang, Xin Hu

“…CO₂ capture from the flue gas is a promising approach to mitigate global warming. However, regulating the carbon-based adsorbent in terms of textural and surface modification is still a challenge. …”
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Impact of the COVID-19 Pandemic on Acute Ischemic Stroke Presentation, Treatment, and Outcomes by Timothy G. White, Gabriela Martinez, Jason Wang, Michele Gribko, Artem Boltyenkov, Rohan Arora, Jeffrey M. Katz, Henry H. Woo, Pina C. Sanelli

“…The World Health Organization declared COVID-19 a global pandemic last year. While a clear impact of COVID-19 on the declining stroke volume has been reported, its overall impact on stroke presentation and clinical outcomes has not been established. …”
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Microfragmented Adipose Tissue Injection (MFAT) May Be a Solution to the Rationing of Total Knee Replacement: A Prospective, Gender-Bias Mitigated, Reproducible Analysis at Two Yea... by Nima Heidari, Tiffanie-Marie Borg, Stefano Olgiati, Mark Slevin, Alessandro Danovi, Brady Fish, Adrian Wilson, Ali Noorani

“…Knee osteoarthritis (KOA) is a significant cause of disability in a globally ageing population. Knee replacement surgery has been shown to improve function and quality of life. …”
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The Role of Neuroglial Crosstalk and Synaptic Plasticity-Mediated Central Sensitization in Acupuncture Analgesia by Zhongxi Lyu, Yongming Guo, Yinan Gong, Wen Fan, Baomin Dou, Ningcen Li, Shenjun Wang, Yuan Xu, Yangyang Liu, Bo Chen, Yi Guo, Zhifang Xu, Xiaowei Lin

“…Although pain is regarded as a global public health priority, analgesic therapy remains a significant challenge. …”
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Comprehensive Assessment of the Effect of Urban Built-Up Land Expansion and Climate Change on Net Primary Productivity by Pengyan Zhang, Yanyan Li, Wenlong Jing, Dan Yang, Yu Zhang, Ying Liu, Wenliang Geng, Tianqi Rong, Jingwen Shao, Jiaxin Yang, Mingzhou Qin

“…The net primary productivity (NPP) is an important indicator of global change, rapid urbanization and climate change will have a significant impact on NPP, and urban expansion and climate change in different regions have different impacts on NPP, especially in densely populated areas. …”
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Structural and free energy landscape analysis for the discovery of antiviral compounds targeting the cap-binding domain of influenza polymerase PB2 by Amr S. Abouzied, Saad Alqarni, Kareem M. Younes, Sanad M. Alanazi, Dana M. Alrsheed, Rawabi K. Alhathal, Bader Huwaimel, Akram M. Elkashlan

“…Abstract Influenza poses a significant threat to global health, with the ability to cause severe epidemics and pandemics. …”
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Diabetes and Cataracts Development—Characteristics, Subtypes and Predictive Modeling Using Machine Learning in Romanian Patients: A Cross-Sectional Study by Adriana Ivanescu, Simona Popescu, Adina Braha, Bogdan Timar, Teodora Sorescu, Sandra Lazar, Romulus Timar, Laura Gaita

“…<i>Background and Objectives:</i> Diabetes has become a global epidemic, contributing to significant health challenges due to its complications. …”
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Molecular characterization of putative antibiotic resistance determinant and virulence factors genes of Acinetobacter baumannii strains isolated from intensive care unit patients i... by Faris A. Alanazi, Khalid S. Almaary, Turki M. Dawoud, Mohamed A. El-Tayeb, Yahya B. Elbadawi, Ayman S. Mubarak, Ali M. Somily

“…Background: Multidrug resistance in Acinetobacter baumannii (A. baumannii) is a major global health threat. The resistance in A. baumannii is attributed to numerous factors, including antimicrobial resistance and virulence-determinant genes. …”
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Factors associated with cancer treatment delay: a protocol for a systematic review and meta-analysis by Timothy P Hanna, Elizabeth T Jacobs, Kristin E Morrill, Rogelio Robles-Morales, Melissa Lopez-Pentecost, Raigam J Martínez Portilla, Ahlam A Saleh, Meghan B Skiba, Taylor S Riall, Jessica D Austin, Rachel Hirschey, Lena Spotleson

“…This review and meta-analysis will evaluate factors associated with treatment delays among patients with five common cancers.Methods and analysis Scientific databases including Ovid MEDLINE, Elsevier Embase, EBSCOhost CINAHL Plus Full Text, Elsevier Scopus and ProQuest Dissertations and Theses Global will be searched to identify relevant articles published between January 2000 and October 2021. …”
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Temporal changes in prevalence and severity of pulmonary hypertension, and relationship to outcomes in coarctation of aorta by Ahmed Younis, Yogesh N.V. Reddy, William R. Miranda, Ahmed T. Abdelhalim, Barry A. Borlaug, Heidi M. Connolly, Alexander C. Egbe

“…The correlates of Δ RVSP were older age, left atrial (LA) dysfunction, left ventricular (LV) hypertrophy, high LV global afterload, and atrial fibrillation. Of 392 patients, 50 (13 %) died, and Δ RVSP was associated with mortality (adjusted hazard ratio 1.19 [1.08–1.31] per 5 mmHg increase, p = 0.006) after adjustment for baseline RVSP, demographic indices, comorbidities, and echocardiographic indices. …”
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Facilitators and barriers to protective eyewear acceptance among Indian farmers: A qualitative study by Gopinath Madheswaran, K Eshwari, Judith Shefali Jathanna, Syed Ibrahim, Krithica Srinivasan, Lakshmi Shinde, Ramesh S Ve, Rashima Asokan, S Saravanan, SB Saranya

“…Abstract Background Agriculture, one of the most hazardous occupations globally, accounts for a significant proportion of work-related injuries, particularly in developing countries like India. …”
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Hypertension and retinal microvascular dysfunction (HyperVasc): protocol of a randomised controlled exercise trial in patients with hypertension by Justin Carrard, Lukas Streese, Timo Hinrichs, Henner Hanssen, Arno Schmidt-Trucksäss, Konstantin Gugleta, Joséphine Gander, Christoph Hauser

“…Introduction Hypertension is a global healthcare burden that affects the structure and function of the macrocirculation and microcirculation and induces disease-specific end-organ damage. …”
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A machine learning model using the snapshot ensemble approach for soil respiration prediction in an experimental Oak Forest by S.N. Ferdous, J.P. Ahire, R. Bergman, L. Xin, E. Blanc-Betes, Z. Zhang, J. Wang

“…However, because it is highly sensitive to the environment and has large temporal and spatial variability, its contribution to the global carbon cycle remains highly uncertain. Recent advances in ecosystem process models have uniquely constrained soil respiration rates, largely based on results from tracing ecosystem CO2 losses using radioisotope and stable isotope methods. …”
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QTL mapping and candidate gene analysis of element accumulation in rice grains via genome-wide association study and population genetic analysis by Min Li, Mengxue Gao, Jinmei Huang, Shaojuan Jin, Yamei Lv, Lin Wang, Tao Huang, Fengcai Wu, Zhijian Xu, Yinghua Pan, Zhixia Liu, Chaopu Zhang, Yuntao Liang, Lijun Meng, Jianlong Xu

“…Abstract Background Toxic heavy metal elements in soils are major global environmental issues and easily migrate to crop grains to cause severe problems in human health, whereas moderately essential elements such as selenium are beneficial for human health. …”
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Enhancing cardiac diagnostics: a deep learning ensemble approach for precise ECG image classification by Ahmed Alsayat, Alshimaa Abdelraof Mahmoud, Saad Alanazi, Ayman Mohamed Mostafa, Nasser Alshammari, Majed Abdullah Alrowaily, Hosameldeen Shabana, Mohamed Ezz

“…Abstract Cardiovascular diseases are a global health challenge that necessitates improvements in diagnostic accuracy and efficiency. …”
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MGATAF: multi-channel graph attention network with adaptive fusion for cancer-drug response prediction by Dhekra Saeed, Huanlai Xing, Barakat AlBadani, Li Feng, Raeed Al-Sabri, Monir Abdullah, Amir Rehman

“…Results We introduce multimodal multi-channel graph attention network with adaptive fusion (MGATAF), a framework designed to enhance drug response predictions by capturing both local and global interactions among graph nodes. MGATAF improves drug representation by integrating SMILES and fingerprints, resulting in more precise predictions of drug effects. …”
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Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet by Xiaojuan Li, Luming Qiao, Wei Wang, Ying Shi, Lei Yuan, Zhiwei Zhai

“…Obesity is affecting global health with multiple complications, including cardiac dysfunction. …”
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Effects of time restricted feeding combined with Lacto Ovo vegetarian diet on metabolic associated fatty liver disease management: a randomized clinical trial by Mahshad Shafiee, Amir Sadeghi, Fateme Ghafouri-Taleghani, Maryam Nilghaz, Maryam Ghods, Behnaz Narimani, Azita Hekmatdoost, Atoosa saidpour

“…Abstract Metabolic Associated Fatty Liver Disease (MAFLD) is becoming a major global health concern due to its links with obesity, insulin resistance, and cardiovascular risk. …”
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Volume contracted state, mortality and functional outcomes in patients with acute ischaemic stroke due to large vessel occlusion by Risheng Xu, Max Wintermark, Gregory W Albers, Jeremy J Heit, Adam A Dmytriw, Adrien Guenego, Yasmin Aziz, Kambiz Nael, Benjamin Pulli, Victor Urrutia, Dhairya A Lakhani, Tobias D Faizy, Argye Hillis, Vivek Yedavalli, Dylan Wolman, Licia P Luna, Elisabeth B Marsh, Hamza Adel Salim, Janet Mei, Vaibhav Vagal, Aakanksha Sriwastwa, Raf Llinas, Hanzhang Lu, Mona N Bahouth

“…Background Acute ischaemic stroke (AIS) is a leading cause of mortality and disability globally, with volume contracted state (VCS), as indicated by an elevated blood urea nitrogen to creatinine (BUN/Cr) ratio, potentially influencing outcomes. …”
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