Do antibody CDR loops change conformation upon binding? by Chu’nan Liu, Lilian M. Denzler, Oliver E.C. Hood, Andrew C.R. Martin

“…We analyzed the conformational change of the Cα backbone of each CDR upon binding and found that, in most cases, the CDRs (other than CDR-H3) show minimal movement, while 70.6% and 87% of CDR-H3s showed global Cα RMSD ≤ 1.0Å and ≤ 2.0Å, respectively. We also compared bound CDR conformations with the conformational space of unbound CDRs and found most of the bound conformations are included in the unbound conformational space. …”
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Changes in Different Classes of Precipitation and the Impacts on Sediment Yield in the Hekouzhen-Longmen Region of the Yellow River Basin, China by Suzhen Dang, Xiaoyan Liu, Xiaoyu Li, Manfei Yao, Dan Zhang

“…The sediment yield of the Yellow River Basin has obviously decreased since the 1980s, and the impacts of precipitation on sediment yield changes have become increasingly important with the global climate change. The spatial and temporal variations in annual precipitation and different classes of precipitation in the Hekouzhen-Longmen region (HLR) in the middle reaches of the Yellow River Basin were investigated using data collected from 301 rainfall stations from 1966 to 2016. …”
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Influencing Factors and Prevalence of Anxiety in Medical Students: A Cross-Sectional Study by Huong Thi Nguyen, Yen Thi Hoai Phan, Anh-Vu Nguyen-Hoang, Tri-Bao Nguyen, Gia-Phuoc Tran-Thien

“…Introduction: While current research highlights student anxiety globally, limited data exists on the specific situation of Vietnamese medical students. …”
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Results of a modified Delphi consensus on the optimal testing pathway for oesophago-gastric cancer care in the UK by Philippe Taniere, Manuel Rodriguez-Justo, Naureen Starling, Wasat Mansoor, Thomas Bird, Martin Eatock

“…Six domains of focus were agreed on and used to develop. 36 agreed statements were developed into a Likert survey, which was distributed by a third party (M3 Global Research). Completed surveys were analysed to produce an arithmetic agreement score for each statement. …”
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Effect of Kinases in Extracellular Vesicles from HIV-1-Infected Cells on Bystander Cells by Gifty A. Mensah, Anastasia Williams, Pooja Khatkar, Yuriy Kim, James Erickson, Alexandra Duverger, Heather Branscome, Kajal Patil, Hafsa Chaudhry, Yuntao Wu, Olaf Kutsch, Fatah Kashanchi

“…Although great strides have been made in treatment options for HIV-1, and our understanding of the HIV-1 life cycle has vastly improved since the start of this global health crisis, a functional cure remains elusive. …”
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ReLTER: An R interface for environmental observation in long term ecological research by Alessandro Oggioni, Micha Silver, Paolo Tagliolato, Arnon Karnieli

“…This paper describes the functionality of the ReLTER package and its potential within the global ecological community.…”
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A real–time distributed optimization control for power sharing and voltage restoration in inverter–based microgrids by Asad Khan, Muhammad Mansoor Khan, Jiang Chuanwen, Danish Khan

“…The proposed method simplifies the global optimization problem into multiple sub–optimal problems by virtually segregating each GFM source into two decoupled sources. …”
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Spatial Characterization of Woody Species Diversity in Tropical Savannas Using GEDI and Optical Data by Franciel Eduardo Rex, Carlos Alberto Silva, Eben North Broadbent, Ana Paula Dalla Corte, Rodrigo Leite, Andrew Hudak, Caio Hamamura, Hooman Latifi, Jingfeng Xiao, Jeff W. Atkins, Cibele Amaral, Ernandes Macedo da Cunha Neto, Adrian Cardil, Angelica M. Almeyda Zambrano, Veraldo Liesenberg, Jingjing Liang, Danilo Roberti Alves De Almeida, Carine Klauberg

“…In this study, we evaluate the potential of Global Ecosystem Dynamics Investigation (GEDI) data, combined with conventional satellite optical imagery and climate reanalysis data, to predict in situ alpha diversity (Species richness, Simpson index, and Shannon index) among tree species. …”
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Molecular Mechanisms Underlying Substance Transport, Signal Transduction, and Anti-Stress Regulation, as Well as Anti-Alkaline Regulation via <i>Bursicon</i> in the Cerebral Gangli... by Meiyao Wang, Jun Zhou, Jiachun Ge, Gangchun Xu, Yongkai Tang

“…(1) Background: Global climate change is intensifying, and the vigorous development and utilization of saline–alkali land is of great significance. …”
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Fusion-Decomposition Pan-Sharpening Network With Interactive Learning of Representation Graph by Yunxuan Tang, Xue Wang, Peng Liu, Tong Li

“…These modules construct a representational graph structure for cross-modal feature communication, generating a global representation that guides the cross-modal semantic aggregation of multispectral and panchromatic data. …”
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Self-assessed depressive symptoms in adolescents comparing two Swedish cohorts born 15 years apart by Carl Wikberg, Pia Augustsson, Marcus Praetorius Björk, Tord Ivarsson, Gudny Sveinsdottir, Eiríkur Örn Arnarson, W. Edward Craighead, Ina Marteinsdottir, Josefine Lilja

“…Background: Depression in adolescence is a significant global health concern, notably in Sweden where recent trends suggest an increase in depressive symptoms among adolescents. …”
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Intelligent Recommendation of Multi-Scale Response Strategies for Land Drought Events by Lei He, Yuheng Lei, Yizhuo Yang, Bin Liu, Yuxia Li, Youcai Zhao, Dan Tang

“…Currently, land drought events have become a frequent and serious global disaster. How to address these droughts has become a major issue for researchers. …”
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Risk assessment for non-carcinogenic effect posed by sulfates in water on the health of residents around The Sumpur River, West Sumatra-Indonesia by Sukarjo, Rahmah Dewi Yustika, Cicik Oktasari Handayani, Triyani Dewi, Yustiawati, Delvi Yanti, Ai Dariah

“…The extensive agricultural activity contributes to runoff and plays a significant role in elevated sulfate concentrations in many global water bodies. In tropical regions, sulfate pollution and its associated health hazards have intensified, emerging as an international concern. …”
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Preventive treatment with guarana powder (Paullinia cupana) mitigates acute paracetamol-induced hepatotoxicity by modulating oxidative stress by Clécia Dias Teixeira, Priscila Oliveira Barbosa, Wanderson Geraldo Lima, Gustavo Silveira Breguez, Miliane Martins de Andrade Fagundes, Daniela Caldeira Costa, Cintia Lopes de Brito Magalhães, Joana Ferreira Amaral, Melina Oliveira de Souza

“…Liver damage caused by high doses of paracetamol is a global public health concern. Consequently, therapeutic strategies are being explored to prevent this damage. …”
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Chronic obstructive pulmonary disease related to wood smoke and impact of the combined exposure to tobacco by C.A. Torres-Duque, C. Jaramillo, A. Caballero, N.J. Proaños-Jurado, M.J. Pareja-Zabala, J.B. Soriano, M. González-García

“…BACKGROUND: Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 highlights the need to explore aetiotypes of chronic obstructive pulmonary disease (COPD) beyond the tobacco-smoking COPD. …”
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Synthesis, Antimalarial Activity and Molecular Dynamics Studies of Pipecolisporin: A Novel Cyclic Hexapeptide with Potent Therapeutic Potential by Nety Kurniaty, Taufik Muhammad Fakih, Rani Maharani, Unang Supratman, Ace Tatang Hidayat, Nurhidanatasha Abu Bakar, Xiaoshuang Wei

“…Malaria, caused by <i>Plasmodium</i> species and transmitted by <i>Anopheles</i> mosquitoes, continues to pose a significant global health threat. Pipecolisporin, a cyclic hexapeptide isolated from <i>Nigrospora oryzae</i>, has emerged as a promising antimalarial candidate due to its potent biological activity and stability. …”
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Strengthening National Immunization Technical Advisory Groups: Twelve Years of Progress (2012–2023) by Louise Henaff, Laure Dumolard, Vinod Bura, Gerald Etapelong Sume, Sidy Ndiaye, Jennifer Sanwogou, Heeyoun Cho, Joachim Hombach, Christoph A. Steffen

“…This paper describes the progress made globally on the establishment and strengthening of these key advisory groups and discusses some of their strengths, challenges, and opportunities. …”
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Development and Testing of a Patient Outcome Measure for Interprofessional Tuberculosis Care: A Delphi Study by Bau D. Ardyansyah, Reinie Cordier, Margo Brewer, Dave Parsons

“…Despite the increasing interest in interprofessional-based care globally, there is a notable lack of measures to assess patient impact. …”
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Quantifying 3D coral reef structural complexity from 2D drone imagery using artificial intelligence by Aviv Suan, Simone Franceschini, Joushua Madin, Elizabeth Madin

“…Coral reef ecosystems hold important biological, ecological and economic value, but are in decline due to a combination of global and local stressors resulting in loss of reef structural complexity and biodiversity. …”
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Two-stage efficiency evaluation of industrial water resources and the role of digital inclusive finance: insight from Yangtze River Delta by Linjie Feng, Tingting Liu, Zhenjie Yang, Yi Shi, Hongxi Chen, Ka Leong Chan, Bin Chen

“…The current paper employed Network Super-SBM and the Global Malmquist-Luenberger index to evaluate industrial water use efficiency and wastewater treatment efficiency of YRD’ cities. …”
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