Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus by Maria Sultan, Maria Razzaq, Joohyun Lee, Shreyasi Das, Shrute Kannappan, Vinod Kumar Subramani, Wanki Yoo, Truc Kim, Hye-Ra Lee, Akhilesh K. Chaurasia, Kyeong Kyu Kim

“…Abstract Background The rapid emergence of multiple drug-resistant (MDR) bacterial pathogens and the lack of a novel antibiotic pipeline pose a serious threat to global healthcare. The limited number of established targets further restricts the identification of novel antibiotics to treat life-threatening MDR infections caused by Staphylococcus aureus strains. …”
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Oncometabolite D-2HG drives tumor metastasis and protumoral macrophage polarization by targeting FTO/m6A/ANGPTL4/integrin axis in triple-negative breast cancer by Siyue Zhang, Ning Zhang, Tong Wan, Yinqiao He, Jie Hao, Yiwei Liu, Yidong Liu, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Chao Gao, Qifeng Yang

“…Mechanistically, D-2HG enhanced global m6A RNA modifications in TNBC cells, notably upregulating m6A modification on ANGPTL4 mRNA, which was mediated by the inhibition of Fat-mass and obesity-associated protein (FTO), resulting in increased recognition of m6A-modified ANGPTL4 by YTH N6-methyladenosine RNA binding protein F1 (YTHDF1), thereby promoting the enhanced translation of ANGPTL4. …”
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Residence-based disparities of composite index of anthropometric failures in East African under five children; multivariate decomposition analysis by Aznamariam Ayres, Yawkal Tsega, Abel Endawkie, Shimels Derso Kebede, Eyob Tilahun Abeje, Ermias Bekele Enyew, Chala Daba, Lakew Asmare, Amare Muche, Fekade Demeke Bayou, Mastewal Arefaynie, Asnakew Molla Mekonen, Abiyu Abadi Tareke, Awoke Keleb, Kaleab Mesfin Abera, Natnael Kebede, Endalkachew Mesfin Gebeyehu

“…Abstract Background Undernutrition remains a global challenge and public health concern, despite the presence of policies, programs and interventions. …”
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Assessing learning, behaviour, and stress level in goats while testing a virtual fencing training protocol by L. Wilms, D. Hamidi, C.H.U. Lüntzel, M. Hamidi, M. Komainda, R. Palme, J. Isselstein, S. Waiblinger, M. Egerbacher

“…Virtual fencing (VF) is a modern fencing technology using Global Positioning System-enabled collars which emit acoustic signals and, if the animal does not respond, electric pulses. …”
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Characterization of the bioaccumulation and toxicity of copper pyrithione, an antifouling compound, on juveniles of rainbow trout by Bourdon, Charlotte, Cachot, Jérôme, Gonzalez, Patrice, Couture, Patrice

“…Since the global ban on tributyltin in antifouling paints in 2008 by the International Maritime Organization, new products have been developed and brought to the market. …”
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Low ITN utilization among households in SWEPR Ethiopia: challenge for malaria elimination, a mixed design approach by Wondwossen Niguse, Bezuayehu Alemayehu, Tadesse Gebremedhin, Mathewos Alemu, Girma Mamo, Ephrem Negeri, Ibrahim Temam, Haile Zewdie, Tamirat Bogale, Erkyihun pawulos, Endale Sahlie

“…Abstract Introduction To prevent malaria starting from 2005 more than 2 billion insecticide-treated nets (ITNs) have been distributed globally. Even though Ethiopia has been doing nationwide ITN distribution starting from 2016 with 64% ITN coverage, there is a significant gap in its utilization in different settings. …”
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Effect of zinc added to a daily small-quantity lipid-based nutrient supplement on diarrhoea, malaria, fever and respiratory infections in young children in rural Burkina Faso: a cl... by Elizabeth Yakes Jimenez, Sonja Y Hess, Souheila Abbeddou, Kenneth H Brown, Jean-Bosco Ouedraogo, Jérôme W Somé, Zinéwendé P Ouédraogo, Rosemonde M Guissou, Stephen A Vosti

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Deep learning-based CT-free attenuation correction for cardiac SPECT: a new approach by Pei Yang, Zeao Zhang, Jianan Wei, Lisha Jiang, Liqian Yu, Huawei Cai, Lin Li, Quan Guo, Zhen Zhao

“…Changes in perfusion categories were observed in 4.19% and 5.9% of studies assessed for global perfusion scores in the training set and testing set. …”
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Predicting ixodid tick distribution in Tamil Nadu domestic mammals using ensemble species distribution models by Ayyanar Elango, Hari Kishan Raju, Ananganallur Nagarajan Shriram, Ashwani Kumar, Manju Rahi

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Diversity of frontier processes in Amazonian subnational jurisdictions: Frontier metrics reveal major patterns of human–nature interactions by Guido Briceño, Julie Betbeder, Agnès Bégué, Guillaume Cornu, David Katz-Asprilla, Marie-Gabrielle Piketty, Solen Le Clech, Vinicius Silgueiro, Hélène Dessard, Lilian Blanc

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InfectA-Chat, an Arabic Large Language Model for Infectious Diseases: Comparative Analysis by Yesim Selcuk, Eunhui Kim, Insung Ahn

“…However, these platforms primarily present surveillance data in English, which creates language barriers for non–English-speaking individuals and global public health efforts to accurately observe disease trends. …”
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Psychometric properties of the Arabic emotional and behavioral reaction to intrusions questionnaire among sample of Arabic speaking adults by Emmanuelle Awad, Diana Malaeb, Amthal Alhuwailah, Mai Helmy, Muna Barakat, Rabih Hallit, Sami El Khatib, Mohamad Rahal, Syed Arman Rabbani, Reem Alzayer, Nada H. Farrag, Rita El Hajjar, Jinan Mallouh, Souheil Hallit, Feten Fekih-Romdhane, Sahar Obeid, Rita ElHagar

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Exploring and detecting predictors associated with survival and mortality of cervical cancer patients: a 10-year retrospective study by Shaba Muneeha, Raushan Kumar Chaudhary, Vijith Vittal Shetty, Soumya Patil, Uday Venkat Mateti

“…Abstract Background Cervical cancer is the 4th most prevalent cancer among females globally. In India, approximately 123,907 women are diagnosed with cervical cancer every year, leading to 77,348 deaths annually. …”
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Intervening Non-Small-Cell Lung Cancer Progression by Cell Membrane Coated Platycodin D via Regulating Hsa-miR-1246/FUT9/GSK3β Pathway by Zheng S, Xie Z, Zhou Z, Wang S, Xin Y, Lin J, Cheng K, Lu T, Qi R, Guo Y

“…Shuyu Zheng,1,2 Zejuan Xie,1 Ziao Zhou,1 Shanshan Wang,1 Yanlin Xin,1 Jiamin Lin,1 Keyu Cheng,1 Tianming Lu,1 Ruogu Qi,1 Yuanyuan Guo1 1Department of Biochemistry and Molecular Biology, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, People’s Republic of China; 2Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang Province, 310009, People’s Republic of ChinaCorrespondence: Ruogu Qi; Yuanyuan Guo, Department of Biochemistry and Molecular Biology, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, People’s Republic of China, Email rqi@njucm.edu.cn; guoyy@njucm.edu.cnPurpose: Metastatic non-small cell lung cancer (NSCLC) remains a global health threat, with patients facing inevitable disease progression despite standard-of-care therapy. …”
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Needs Assessment and Tailored Training Pilot for Emergency Care Clinicians in the Prehospital Setting in Rwanda by Naz Karim, Jeanne D’Arc Nyinawankusi, Mikaela S. Belsky, Pascal Mugemangango, Zeta Mutabazi, Catalina Gonzalez Marques, Angela Y. Zhang, Janette Baird, Jean Marie Uwitonze, Adam C. Levine

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Difficultés diagnostiques de la tuberculose cérébrale by Chahrazed Benrabah

“…It constitutes a major public health problem, especially in developing countries, including Algeria. Globally and among all tuberculosis cases, WHO reports 14% extra-pulmonary tuberculosis (EPT) without concomitant pulmonary involvement. …”
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Perbandingan Arsitektur Convolutional Neural Network Pada Klasifikasi Pneumonia, COVID-19, Lung Opacity, dan Normal Menggunakan Citra Sinar-X Thoraks by Agung Wahyu Setiawan

“…Abstract Covid-19 has been a global pandemic since the beginning of 2020. Although there has been a decrease in the number of cases of Covid-19, however, there are still some new cases due to virus mutation. …”
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Sedentarismo e inactividad física según sexo, edad y nivel socioeconómico en el País Vasco. Estudio transversal by Marta Ijalba Martínez, Antonio Moreno Llamas, Unai Martín Roncero

“…Resultados: La prevalencia global de sedentarismo se encontró en torno al 32% para ambos sexos, alcanzando el 60% en el grupo de mayores de 85 años y el 45% en los jóvenes de 18 a 29 años. …”
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