Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin by Gao Y, Qin G, Liang S, Yin J, Wang B, Jiang H, Liu M, Luo F, Li X

“…Yijie Gao,1 Gaofeng Qin,2 Shichao Liang,3 Jiajie Yin,4 Baofu Wang,1 Hong Jiang,1 Mengru Liu,1 Fangyuan Luo,3 Xianlun Li1 1National Integrated Traditional and Western Medicine Center for Cardiovascular Disease, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 2Department of Traditional Chinese Medicine, Binzhou Medical University Hospital, Shandong, People’s Republic of China; 3China-Japan Friendship Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 4Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People’s Republic of ChinaCorrespondence: Xianlun Li, Email leexianlun@163.comBackground: Acute myocardial infarction (AMI) is a significant contributor to global morbidity and mortality. Allicin exhibits promising therapeutic potential in AMI as a primary bioactive component derived from garlic; however, its underlying mechanisms remain incompletely elucidated.Methods: Our study induced AMI in mice by ligating the left coronary artery, and administered allicin orally for 28 days. …”
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Assessing the physical activity training needs and preferences of community health workers in South Africa by Mark Stoutenberg, Blanca S. Noriega Esquives, Ruth G. St Fleur, Susanna S. Koen, Estelle D. Watson, Francia G. Portacio, Georgia Torres

“…Most CHPs felt that they had sufficient PA knowledge (93.1%) and reported knowing global PA guidelines (90.5%). However, only 10.5% correctly identified the guidelines for aerobic activity or muscle-strengthening, and none correctly identified both. …”
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Quantification of Soil–Water Erosion Using the RUSLE Method in the Mékrou Watershed (Middle Niger River) by Rachid Abdourahamane Attoubounou, Hamidou Diawara, Ralf Ludwig, Julien Adounkpe

“…Soil properties, including texture and organic matter content, were derived from FAO global soil databases to assess soil erodibility. …”
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La influencia del big data en el proceso de optimización SEO para e-commerce en la era del COVID-19 by Elena Fernández-Díaz, Carlos Rivilla Gil

“…Se propone, por lo tanto, volver a analizar ambos casos de estudio en otros periodos, también teniendo en cuenta la estacionalidad asociada a ambos productos, y de esta forma poder determinar una comparativa más global de los resultados. Sus principales implicaciones se basan en la optimización de una estrategia de posicionamiento en buscadores a partir de una serie de recomendaciones aplicados a dos casos reales de e-commerce Business to Consumer en España. …”
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Public insight into knee osteoarthritis: a cross-sectional study from the West Bank, Palestine by Haya Jebreen Mohammed Warasna, Bashar Yaser Hasan Awad, Mohamad A. Banat, Mohammad Yaser Hasan Awad, Ahmed Farid Gadelmawla, Jameel Suliman, Tarek A. Owais, Ahmad J. Warasna

“…Abstract Background Osteoarthritis (OA) is a significant global health concern and is characterized by the degeneration of joint structures, leading to pain, stiffness, and functional limitations It is estimated that 654.1 million individuals are affected by osteoarthritis worldwide, with females, especially those older than 60 years of age, being the population most impacted. …”
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Optimizing composite ecological networks through Synergistic risk Management, ecological Conservation, and recreational Integration: A case study of Beijing’s shallow mountain regi... by Lei Cao, Kaiping Wang, Xinyao Zhao, Yunlu Zhang

“…It provides a theoretical foundation and technical support for the coordinated optimization of ecological conservation and economic development in shallow mountainous regions globally.…”
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Have gender and ethnic disparities in ophthalmology disappeared? Insights from a workforce-based study in Israel (2006–2021) by Asaf Israeli, Eytan Z. Blumenthal, Achia Nemet, Shiri Zayit-Soudry, Hadas Pizem, Eedy Mezer

“…A paucity of data exists globally on this subject in ophthalmology. The purpose of this study was to analyze nationwide trends in gender-, ethnic- and country of graduation disparities among ophthalmologists in Israel. …”
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Characterization of the Vibrio anguillarum VaRyhB regulon and role in pathogenesis by Yingjie Li, Xinran Yu, Peng Li, Xin Li, Lushan Wang

“…Iron uptake is a prerequisite for virulence and is strictly controlled by a global iron uptake regulator, Fur, which acts as a repressor under iron-replete conditions. …”
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Association of workforce participation with depression among US older adults: results from NHANES 2005–2018 by Zhenyu Sun, Yi Wang, Xi Chen, Dongfu Qian

“…Abstract Background The challenges of global aging would boost more workforce participation of older adults, and depression rate was increasing among older adults. …”
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Retention strategies for medical doctors in low- and middle-income countries (LMICs): are they effective? A scoping review by Norehan Jinah, Izzuan Khirman Adnan, Pangie Bakit, Ili Abdullah Sharin, Kun Yun Lee

“…It is imperative to emphasise the lack of a one-size-fits-all solution for this global issue. Thus, a multifaceted, comprehensive approach is essential in producing sustainable health workforce development that ensures optimal health outcomes, especially for populations in underserved areas. …”
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Human cytomegalovirus (HCMV) trends in Sri Lanka: insights from a hospital-based seroprevalence analysis by Narapity Pathirannehalage Sunil-Chandra, Madawala Vithanage Madusha Lakmali Jayasundara, Maththe Gama Ralalage Shobha Sanjeewani Gunathilaka, Suduwa Dewage Himal Suminda

“…While often asymptomatic in healthy individuals, HCMV causes symptomatic infections in immunocompromised people and congenital infections in fetuses. It is a common global congenital infection and can lead to morbidity and occasional mortality in newborns. …”
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Overexpressing the ClpC AAA+ unfoldase accelerates developmental cycle progression in Chlamydia trachomatis by Aaron A. Jensen, Saba Firdous, Lei Lei, Derek J. Fisher, Scot P. Ouellette

“…These effects were not observed with overexpression of the ATPase mutant of ClpC, providing strong evidence that the activity of ClpC drives secondary differentiation. By analyzing the global transcriptional response to ClpC overexpression using RNA sequencing, we observed a shift to earlier expression of canonical late developmental cycle genes and other EB-associated genes. …”
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Fear of childbirth and psychiatric disorders decrease the likelihood of subsequent births: a retrospective register-based cohort study by Elina Silvan, Terhi Saisto, Tia Mäkelä, Katariina Salmela-Aro, Mika Gissler, Laura Lampio

“…Abstract Background Mirroring other developed countries globally, the birth rate has decreased in Finland in recent years. …”
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Contextual adaptation of digital wellbeing interventions for young people: insights from a project in Saudi Arabia by Dahlia Aljuboori, Laura K. Clary, Saud Abdulaziz Alomairah, Saud Abdulaziz Alomairah, Michelle Colder Carras, Nazmus Saquib, Juliann Saquib, Fahad Albeyahi, Antonius J. Van Rooij, Anouk Tuijnman, Vincent G. Van der Rijst, Michelle R. Kaufman, Michelle R. Kaufman, Johannes Thrul, Johannes Thrul, Johannes Thrul

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The importance of the Autostrain RV technique in the treatment of right ventricular myocardial alterations in patients with breast cancer receiving chemotherapy by Yan Liang, Ping Du, Yabo Song, Xinshi Li, Yingying Han, Hongfang Dongye, Hongqiang Liu, Jinqiu Li

“…The patients included those with breast cancer who underwent surgery and were primarily administered anthracycline-based chemotherapeutic drugs. (1) Compared with the pre-chemotherapy period, the absolute values of the right ventricular global longitudinal strain (RV4CSL) and right ventricular free-wall longitudinal strain (RVFWSL) decreased after the fourth chemotherapy cycle, and no significant differences were observed in tricuspidannular plane systolic excursion (TAPSE), right ventricular Tei index, and right ventricular fractional area change (FAC); (2) Compared with the pre-chemotherapy period, the absolute values of RV4CSL and RVFWSL decreased after the eighth chemotherapy cycle. …”
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Impact of gas composition, pressure, and temperature on interfacial Tension dynamics in CO₂-Enhanced oil recovery by Rahul Gajbhiye

“…This study offers an in-depth understanding of interfacial tension dynamics in CO2-EOR, a process that is increasingly attracting global attention for CO2 utilization. The research stands out for its innovative experimentation and detailed analysis, which focus on evaluating the impact of individual parameters crucial for modeling. …”
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Assessment of the quality of life in metastatic colorectal cancer patients with KRAS gene mutant: a case-control study by Fahmideh Bagrezaei, Bahram Pourghassem Gargari, Reza Eghdam Zamiri, Abdolrasoul Safaiyan, Mohammad Alizadeh

“…Results Patients in the wild-type KRAS group had significantly higher scores on the global health status (GHS) of the QLQ-C30 scale compared to those with a KRAS mutation [(64.26 ± 4.63 vs. 49.63 ± 4, crude; p = 0.019, adjusted; p = 0.024). …”
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Aetiology of vaginal discharge, urethral discharge, and genital ulcer in sub-Saharan Africa: A systematic review and meta-regression. by Julia Michalow, Magdalene K Walters, Olanrewaju Edun, Max Wybrant, Bethan Davies, Tendesayi Kufa, Thabitha Mathega, Sungai T Chabata, Frances M Cowan, Anne Cori, Marie-Claude Boily, Jeffrey W Imai-Eaton

“…<h4>Methods and findings</h4>We searched Embase, MEDLINE, Global Health, Web of Science, and grey literature from inception until December 20, 2023, for observational studies reporting aetiologic diagnoses among symptomatic populations in SSA. …”
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Participant experiences in HIV cure-directed trial with an extended analytical treatment interruption in Philadelphia, United States by Andrea Bilger, Eion Plenn, Frances K. Barg, Katharine A. Rendle, William B. Carter, Andrea Lamour-Harrington, Nora Jones, Beth Peterson, John A. Sauceda, Pablo Tebas, Karam Mounzer, David Metzger, Luis J. Montaner, Karine Dubé

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Long-Term Safety and Effectiveness of Dimethyl Fumarate in Patients with Multiple Sclerosis Treated in Routine Medical Practice: Final Analysis of the ESTEEM Study by Krupa Shah Pandey, Kathryn Giles, Konstantin Balashov, Richard Macdonell, Jörg Windsheimer, Mikel Martinez, Ivan Božin, Stephanie Raynaud, Matthew Scaramozza, Oksana Mokliatchouk, Zhaonan Sun, Nicholas Belviso, Yayoi Sato, Xiaochen Lin, Annette Okai

“…Methods Patients newly prescribed DMF were recruited from 393 sites globally. The primary objective was to assess the incidence and type of serious adverse events (SAEs) and adverse events (AEs) leading to discontinuation of DMF. …”
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