Structure-based identification of HNF4α agonists: Rosmarinic acid as a promising candidate for NAFLD treatment by Xi Chen, Xinqi Zhu, Gang Wu, Xiaobo Wang, Yu Zhang, Nan Jiang

“…The prevention and treatment of metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD), have emerged as critical global health challenges. Current lipid-lowering pharmacotherapies are associated with side effects, including hepatotoxicity, rhabdomyolysis, and decreased erythrocyte counts, underscoring the urgent need for safer therapeutic alternatives. …”
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Patterns of pharmacological treatment in patients with atrial fibrillation: an analysis from the prospective GLORIA-AF Registry Phase III by Bernadette Corica, Giulio Francesco Romiti, Giuseppe Boriani, Brian Olshansky, Tze-Fan Chao, Menno V. Huisman, Marco Proietti, Gregory Y. H. Lip, on behalf of the GLORIA-AF Investigators

“…Methods Based on data from the prospective global GLORIA-AF Registry Phase III (recruiting patients with AF and CHA2DS2-VASc score ≥ 1), we performed a latent class analysis to identify treatment patterns based on 14 drug classes including cardiovascular (CV) and non-CV drugs. …”
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Effect of intermittent theta burst stimulation combined with acoustic startle priming motor training on upper limb motor function and neural plasticity in stroke individuals: study... by Jing Zhang, Yu Chen, Mingzhu Wang, Nan Xia, Jinghong Li, Weiqiang Liang, Yangyang Yin, Linhan Zhai, Qiuxia Wang

“…Introduction Stroke is a major cause of acquired disability globally, yet the neural mechanisms driving motor recovery post-stroke remain elusive. …”
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The role of CTGF and MFG-E8 in the prognosis assessment of SCAP: a study combining machine learning and nomogram analysis by Tingting Lin, Tingting Lin, Huimin Wan, Jie Ming, Yifei Liang, Linxin Ran, Jingjing Lu

“…BackgroundSevere Community-Acquired Pneumonia (SCAP) is a serious global health issue with high incidence and mortality rates. …”
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Clinical Study of Limosilactobacillus reuteri for the Treatment of Children with Chronic Tic Disorders/Tourette Syndrome: A Mid-Term Efficacy Evaluation by Yan Liang, Lin Wan, Guanglei Wang, Huimin Yan, Jing Zhang, Xinting Liu, Ziyan Zhang, Gang Zhu, Guang Yang

“…Methods Patients were randomly assigned to receive either Limosilactobacillus reuteri or clonidine transdermal patch treatment for 8 weeks while maintaining their existing treatment. The Yale Global Tic Severity Scale (YGTSS); Swanson, Nolan, and Pelham-IV Scale (SNAP-IV); and Child Behavior Check List (CBCL) scores were assessed before and after treatment. …”
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Discovery of anti-Ebola virus multi-target inhibitors from traditional Chinese medicine database using molecular screening, biophysical investigation, and binding free energy calcu... by Abbas Khan, Abrar Mohammad Sayaf, Anwar Mohammad, Fahad M. Alshabrmi, Tarek Benameur, Dong-Qing Wei, Kar Kheng Yeoh, Abdelali Agouni

“…The lack of effective treatment or vaccine for this pathogen poses a serious threat to a global pandemic. Therefore, it is imperative to explore new drugs and therapies to combat this life-threatening infection. …”
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Effectiveness of a specialist palliative home care nurse–patient consultation followed by an interprofessional telephone case conference compared with usual care among patients wit... by Judith Dams, Hans-Helmut König, Tim Friede, Nils Schneider, Stephanie Stiel, Martin Scherer, Silke Böttcher, Gabriella Marx, Ingmar Schäfer, Nadine Janis Pohontsch, Hendrik van den Bussche, Friedemann Nauck, Michael Freitag, Eva Hummers, Tina Mallon, Franziska Schade, Manuel Zimansky, Thomas Asendorf, Christiane A Mueller

“…Patients diagnosed with CHF (New York Heart Association (NYHA) classification 3–4), COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage classification 3–4, group D) or dementia GDS stage 4 or above). …”
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Role of laparoscopic surgery in blunt abdominal trauma; retrospective analysis in a tertiary trauma center by Rifan Alyami, Ahad E. Alotaibi, Leen Almohayya, Ajyad Al Jawad, Raghad Almukhayzim, Abeer Alhoumedan, Rakan S. Aldusari

“…Abstract Purpose Trauma is a significant health concern globally and is one of the leading causes of illness and death. …”
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Gut microbiota interacting with vitamin D but not anandamide might contribute to the pathogenesis of preeclampsia: a preliminary study by Xiao-Qiang Han, Xiao-Qiang Han, Hui-Hui Jiang, Meng-Ling Chen, Meng-Ling Chen, De-Yang Han, De-Yang Han, Su-Fen Zhou, Su-Fen Zhou, Jin-Wen Wang, Shu-Shen Ji, Ling-Yun Wang, Jing-Wei Lou, Ming-Qun Li, Ming-Qun Li

“…IntroductionPreeclampsia (PE) is a pregnancy-specific multisystem disorder and a leading cause of maternal and perinatal mortality globally. Despite numerous studies highlighting the potential roles of gut microbiota, anandamide (AEA), and Vitamin D (VitD) in PE, none have established them as reliable biomarkers for predicting disease onset. …”
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Immune checkpoint inhibitor‐related type 1 diabetes incidence, risk, and survival association by Fumika Kamitani, Yuichi Nishioka, Miyuki Koizumi, Hiroki Nakajima, Yukako Kurematsu, Sadanori Okada, Shinichiro Kubo, Tomoya Myojin, Tatsuya Noda, Tomoaki Imamura, Yutaka Takahashi

“…ABSTRACT Aim/Introduction Although immune checkpoint inhibitor‐related type 1 diabetes mellitus (ICI‐T1DM) is a rare condition, it is of significant concern globally. We aimed to elucidate the precise incidence, risk factors, and impact of ICI‐T1DM on survival outcomes. …”
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Correlations among lymphocyte count, white matter hyperintensity and brain atrophy in patients with ischemic stroke by Chenchen Liu, Dai Shi, Xiaoqiong Ni, Shoujiang You, Shoujiang You, Xiaofen Wu, Sheng Zhuang, Sheng Zhuang, Wu Cai, Liang Xu, Liang Xu

“…Brain atrophy was defined as global cortical atrophy score ≥ 1. Multivariable logistic regression models were used to assess the association between lymphocyte count and WMH and brain atrophy.ResultsAmong 727 AIS, 517 (71.1%), 442 (60.8%), 459 (63.1%), 583 (80.2%) had WMH, PVH, DWMH and brain atrophy, respectively. …”
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Exploring Innovative Approaches for the Analysis of Micro- and Nanoplastics: Breakthroughs in (Bio)Sensing Techniques by Denise Margarita Rivera-Rivera, Gabriela Elizabeth Quintanilla-Villanueva, Donato Luna-Moreno, Araceli Sánchez-Álvarez, José Manuel Rodríguez-Delgado, Erika Iveth Cedillo-González, Garima Kaushik, Juan Francisco Villarreal-Chiu, Melissa Marlene Rodríguez-Delgado

“…These particles, typically less than 5 mm, are found globally, from deep seabeds to human tissues, and are known to adsorb and release harmful pollutants, exacerbating ecological and health risks. …”
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Using remote sensing and machine learning to generate 100-cm soil moisture at 30-m resolution for the black soil region of China: Implication for agricultural water management by Liwen Chen, Boting Hu, Jingxuan Sun, Y. Jun Xu, Guangxin Zhang, Hongbo Ma, Jingquan Ren

“…To assess the applicability of our research methodology, we selected the typical black soil zone in Northeast of China, which is one of the four major black soil regions globally and characterized by intensive agricultural activities. …”
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Characterizing avocado production systems for Ugandan exports: the need for consolidation and support for sustainable development by Peter Sseruwagi, Peter Sseruwagi, Edouard Lehmann, Paul Sigombe, Gabriel Ddamulira, Jan Willem Van Casteren, Pieterjan De Bauw

“…Hass avocado production and trade are rapidly expanding globally, with increasing consumer demands on quality, safety and sustainability. …”
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What Affects Agricultural Green Total Factor Productivity in China? A Configurational Perspective Based on Dynamic Fuzzy-Set Qualitative Comparative Analysis by Danni Lu, Xinhuan Zhang, Degang Yang, Shubao Zhang

“…Agricultural production faces the dual challenge of increasing output while ensuring efficient resource utilization and environmental sustainability amid escalating global climate change and relentless increases in human demand. …”
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Exploring Disparities in Gill Physiological Responses to NaHCO₃-Induced Habitat Stress in Triploid and Diploid Crucian Carp (<i>Carassius auratus</i>): A Comprehensive I... by Shicheng Han, Lin Han, Fangying Yuan, Wenzhi Liu, Jing Wang, Xiaofeng Jin, Yanchun Sun

“…<b>Background</b>: Owing to the progressive rise in saline waters globally, resulting in detrimental impacts on freshwater aquaculture, the underlying molecular distinctions governing the response to alkaline stress between diploid and triploid crucian carp remain unknown. …”
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Scaling Arctic landscape and permafrost features improves active layer depth modeling by Wouter Hantson, Daryl Yang, Shawn P Serbin, Joshua B Fisher, Daniel J Hayes

“…Tundra ecosystems in the Arctic store up to 40% of global below-ground organic carbon but are exposed to the fastest climate warming on Earth. …”
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Ultrasensitive interferons quantification reveals different cytokine profile secretion in inflammatory myopathies and can serve as biomarkers of activity in dermatomyositis by Loïs Bolko, Loïs Bolko, Loïs Bolko, Céline Anquetil, Céline Anquetil, Alba Llibre, Solène Maillard, Damien Amelin, Karim Dorgham, Vincent Bondet, Océane Landon-Cardinal, Océane Landon-Cardinal, Océane Landon-Cardinal, Ségolène Toquet, Ségolène Toquet, Kuberaka Mariampillai, Samuel Malatre, Alexandrine Mahoudeau, Baptiste Hervier, Mathieu Rodero, Guy Gorochov, Darragh Duffy, Olivier Benveniste, Olivier Benveniste, Yves Allenbach, Yves Allenbach

“…ObjectiveThe objective of this study was to evaluate the presence of different types of interferon in idiopathic inflammatory myopathies (IIM) and their subgroups using ultrasensitive cytokine detection techniques (SIMOA) and to assess their potential as activity biomarkers.MethodsDisease activity was measured at the time of serum collection and assessed by manual muscle testing eight (MMT8 score 0-150), muscle enzymes to calculate the Physician Global Assessment (PGA) (0-10). Patients were classified as active if PGA&gt;5.Serum IFN-α and IFN-γ levels was measured using the single molecule array (SIMOA) technique. …”
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Effect of prenatal multiple micronutrient supplementation on birth weight in Ethiopia: protocol for a pragmatic cluster-randomised trial by Joanna Schellenberg, Charles Opondo, Tanya Marchant, Lars Åke Persson, Masresha Tessema, Atkure Defar, Alemneh Kabeta Daba, Girum Taye, Senait Alemayehu, Elias Asfaw, Anene Tesfa, Bedasa Tessema, Kalkidan Zenebe

“…Dissemination of findings will also inform global decision making, particularly in settings where a transition from iron-folic acid to multiple micronutrient supplementation is being contemplated at scale.Trial registration number NCT05708183.…”
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Dissemination of clinical Escherichia coli harboring the mcr-1 gene in Pakistan by Sabahat Abdullah, Sabahat Abdullah, Muhammad Ahmad Mushtaq, Kalim Ullah, Brekhna Hassan, Mariya Azam, Mariya Azam, Muhammad Asif Zahoor, Juan Wang, Jianzhen Xu, Mark A. Toleman, Mashkoor Mohsin

“…Plasmid-mediated mobile colistin-resistant (mcr) genes in Escherichia coli (E. coli) are disseminated globally and are considered to be a major public health threat. …”
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