Randomised, placebo-controlled, double-blinded, four-way crossover trial to demonstrate the comparative pharmacodynamic equivalence of a non-invasive diagnostic test for adrenal in... by Judith Cohen, Miguel Debono, Kathleen Baster, Richard J Ross, Charlotte J Elder, Kathryn L Date, Sharon L Caunt, Jane Fearnside, Trevor N Johnson, Rosie N Taylor

“…The Short Synacthen Test (SST) is the current diagnostic test of choice for AI, but it is both invasive and resource intensive. Globally, there is an unmet need for a non-invasive, cost-effective test. …”
Get full text

Genome-Wide Association Study of Bone Mineral Density in Korean Men by Ye Seul Bae, Sun-Wha Im, Mi So Kang, Jin Hee Kim, Soon Hang Lee, Be Long Cho, Jin Ho Park, You-Seon Nam, Ho-Young Son, San Deok Yang, Joohon Sung, Kwang Ho Oh, Jae Moon Yun, Jong Il Kim

“…Osteoporosis is a medical condition of global concern, with increasing incidence in both sexes. …”
Get full text

FGF21 ameliorates diabetic nephropathy through CDK1-dependently regulating the cell cycle by Yudie Zhang, Yudie Zhang, Yudie Zhang, Yudie Zhang, Yudie Zhang, Fan Wang, Fan Wang, Fan Wang, Fan Wang, Chongyang Zhang, Chongyang Zhang, Chongyang Zhang, Chongyang Zhang, Fan Yao, Fan Yao, Fan Yao, Fan Yao, Bin Zhang, Bin Zhang, Bin Zhang, Bin Zhang, Yongping Zhang, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun

“…BackgroundDiabetic nephropathy (DN) is a prevalent global renal illness and one of the main causes of end-stage renal disease (ESRD). …”
Get full text

Chicken C4BPM facilitates replication of H5N1 and H9N2 Avian Influenza Viruses by inhibiting the production of type I interferons by Huizi Li, Shishi Wang, Ruihong Guo, Xijiao Chen, Yuanyuan Huang, Weixin Jia, Zhangyong Ning

“…Avian influenza viruses (AIVs) are potential pandemic of global concern, posing a major threat to both the poultry industry and human health. …”
Get full text

Epigenetics of suicidal behavior by R. N. Mustafin, A. V. Kazantseva, R. F. Enikeeva, Yu. D. Davydova, S. B. Malykh, V. V. Viktorov, E. K. Khusnutdinova

“…Suicide is the second leading cause of death among young people and therefore being a serious global problem worldwide. The study of genetic and epigenetic factors in the development of suicidal behavior plays an important role in the development of advanced methods of diagnosis and treatment of this pathology. …”
Get full text

Understanding road accident injury dynamics in Iran: a growth mixture modelling perspective by Ziba Zarrin, Kamran Gholamizadeh, Elaheh Talebi-Ghane, Erfan Ayubi, Omid Hamidi

“…Objectives Road traffic injuries represent a significant public health concern globally. In Iran, road accidents have become a leading cause of death and disability, necessitating urgent attention to injury prevention strategies. …”
Get full text

Effects of Functional Red Pine Seed Direct-Drinking Oil on Constipation and Intestinal Barrier Function in Mice by Jie Li, Haonan Zheng, Jiahui Liu, Jie Ding, Qingqi Guo, Na Zhang

“…Constipation is a prevalent global health issue that greatly affects human well-being. …”
Get full text

Temporally enhanced RSEI and nighttime lights reveal long-term ecological changes and effective protection in China’s inaugural national parks by Chunhui Wen, Tengfei Long, Guojin He, Weili Jiao, Wei Jiang

“…This study provides recommendations for ecological protection and management in different NPs, offering insights for the effective management of protected areas in China and globally.…”
Get full text

A Series of Novel Alleles of <i>Ehd2</i> Modulating Heading and Salt Tolerance in Rice by Peng Xu, Shulei Hao, Xiaoxia Wen, Guifang Ma, Qinqin Yang, Ling Liu, Galal Bakr Anis, Yingxin Zhang, Lianping Sun, Xihong Shen, Qunen Liu, Daibo Chen, Yongbo Hong, Yuyu Chen, Xiaodeng Zhan, Shihua Cheng, Liyong Cao, Weixun Wu

“…Rice (<i>Oryza sativa</i> L.) is a staple crop for nearly half of the global population and one of China’s most extensively cultivated cereals. …”
Get full text

Production of green steel from low-grade ores: An end-to-end techno-economic assessment by Alireza Rahbari, M. Shahabuddin, Shabnam Sabah, Geoffrey Brooks, John Pye

“…Science for society: Hydrogen ironmaking is a compelling option for eliminating ∼7% of global emissions arising from iron and steel production. …”
Get full text

Seasonal Features and a Case Study of Tropopause Folds over the Tibetan Plateau by Jiali Luo, Wenjun Liang, Pingping Xu, Haiyang Xue, Min Zhang, Lin Shang, Hongying Tian

“…Investigation of the features of tropopause folds over the Tibetan Plateau (TP) is important since the TP is a hotspot in global STE. In this study, we investigated seasonal features of the tropopause fold events over the TP using the 40-year ERA-Interim reanalysis data. …”
Get full text

Association between male involvement during antenatal care and use of maternal health services in Mwanza City, Northwestern Tanzania: a cross-sectional study by Clara C Natai, Neema Gervas, Frybert M Sikira, Beatrice J Leyaro, Juma Mfanga, Mashavu H. Yussuf, Sia E Msuya

“…Background Male involvement in antenatal care (ANC) is among interventions to improve maternal health. Globally male involvement in ANC is low and varies in low-income and middle-income countries including Tanzania where most maternal deaths occur. …”
Get full text

Random forest model that incorporates solar-induced chlorophyll fluorescence data can accurately track crop yield variations under drought conditions by Guangpo Geng, Qian Gu, Hongkui Zhou, Bao Zhang, Zuxin He, Ruolin Zheng

“…Timely and reliable crop yield estimation is vital for ensuring both global and regional food security. Previous studies have primarily used process-based crop models or statistical regression-based models for crop yield estimates. …”
Get full text

Prevalence of chronic kidney disease in Saudi Arabia: an epidemiological population-based study by Mohammed A. Alshehri, Husain Y. Alkhlady, Zuhier A. Awan, Mohammed Ridha Algethami, Hadiah B. Al Mahdi, Hussam Daghistani, Khalid Orayj

“…Abstract Background Chronic kidney disease (CKD) is a prevalent global health issue affecting millions of patients worldwide, impacting quality of life, impeding physical and psychological well-being, causing financial stress, and increasing mortality rates. …”
Get full text

ECOGEOGRAFÍA Y RIESGO DE DESASTRE: APORTES ANALÍTICOS DESDE LA GEOGRAFÍA FÍSICA by Sergio Caruso, Abril Schofrin, Lia Bachmann

“…En la actualidad, a raíz de la magnitud de los impactos que los eventos del medio físico (sismos, inundaciones, etc.) tienen sobre las sociedades, ha conducido a que esta temática sea de suma centralidad en la opinión pública, académica, científico-técnica, política y social a nivel global y nacional.  En este contexto, el presente artículo tiene por objetivo presentar un conjunto de herramientas teórico-conceptuales provenientes del campo de la Geografía Física para analizar dichas situaciones, dejando de lado las interpretaciones fisicalistas y haciendo foco en la integración de las múltiples interacciones que se suceden entre los procesos sociales y naturales. …”
Get full text

A novel lightweight model for tea disease classification based on feature reuse and channel focus attention mechanism by Junjie Liang, Renjie Liang, Dongxia Wang

“…On the other hand, the popular vision transformer(ViT) model has a higher recognition accuracy as it has better global feature expression ability than CNN model. …”
Get full text

Comparing the emotional impact of the UK COVID-19 lockdown in very preterm and full-term born children: a longitudinal study by Zeyuan Sun, Zeyuan Sun, Laila Hadaya, Laila Hadaya, Marguerite Leoni, Marguerite Leoni, Paola Dazzan, Emily Simonoff, Serena J. Counsell, A. David Edwards, Chiara Nosarti, Chiara Nosarti, Lucy Vanes

“…IntroductionThe COVID-19 pandemic has caused a global mental health crisis, especially for those individuals who are vulnerable to stress and anxiety due to pre-existing mental health problems. …”
Get full text

Workload-capacity imbalances and their impact on self-management complexity in patients with multimorbidity: a multicenter cross-sectional study by Binyu Zhao, Yujia Fu, Jingjie Wu, Erxu Xue, Chuyang Lai, Dandan Chen, Qiwei Wu, Jianing Yu, Qiaoyu Wu, Zhihong Ye, Jing Shao

“…Introduction Multimorbidity is increasing globally, emphasizing the need for effective self-management strategies. …”
Get full text

Implementation of international experience in reforming the institute of public administration by Zagurskyy O., Hubska O., Slobodian I.

“…The study found that the transformation of public administration is inevitable, since modern national forms of government and management are incompatible with the needs of the new socio-economic practice of a globalizing society. At the same time, without transformation, it is impossible to achieve a qualitatively new level of management, the main characteristics of which can be synthesized. …”
Get full text

Unravelling the transcriptomic symphony of muscle ageing: key pathways and hub genes altered by ageing and caloric restriction in rat muscle revealed by RNA sequencing by Gulam Altab, Brian J. Merry, Charles W. Beckett, Priyanka Raina, Inês Lopes, Katarzyna Goljanek-Whysall, João Pedro de Magalhães

“…Hence, we employed high-throughput RNA sequencing to survey the global changes in protein-coding gene expression occurring in skeletal muscle with age. …”
Get full text