Factors associated with cancer treatment delay: a protocol for a systematic review and meta-analysis by Timothy P Hanna, Elizabeth T Jacobs, Kristin E Morrill, Rogelio Robles-Morales, Melissa Lopez-Pentecost, Raigam J Martínez Portilla, Ahlam A Saleh, Meghan B Skiba, Taylor S Riall, Jessica D Austin, Rachel Hirschey, Lena Spotleson

“…This review and meta-analysis will evaluate factors associated with treatment delays among patients with five common cancers.Methods and analysis Scientific databases including Ovid MEDLINE, Elsevier Embase, EBSCOhost CINAHL Plus Full Text, Elsevier Scopus and ProQuest Dissertations and Theses Global will be searched to identify relevant articles published between January 2000 and October 2021. …”
Get full text

Temporal changes in prevalence and severity of pulmonary hypertension, and relationship to outcomes in coarctation of aorta by Ahmed Younis, Yogesh N.V. Reddy, William R. Miranda, Ahmed T. Abdelhalim, Barry A. Borlaug, Heidi M. Connolly, Alexander C. Egbe

“…The correlates of Δ RVSP were older age, left atrial (LA) dysfunction, left ventricular (LV) hypertrophy, high LV global afterload, and atrial fibrillation. Of 392 patients, 50 (13 %) died, and Δ RVSP was associated with mortality (adjusted hazard ratio 1.19 [1.08–1.31] per 5 mmHg increase, p = 0.006) after adjustment for baseline RVSP, demographic indices, comorbidities, and echocardiographic indices. …”
Get full text

Facilitators and barriers to protective eyewear acceptance among Indian farmers: A qualitative study by Gopinath Madheswaran, K Eshwari, Judith Shefali Jathanna, Syed Ibrahim, Krithica Srinivasan, Lakshmi Shinde, Ramesh S Ve, Rashima Asokan, S Saravanan, SB Saranya

“…Abstract Background Agriculture, one of the most hazardous occupations globally, accounts for a significant proportion of work-related injuries, particularly in developing countries like India. …”
Get full text

Hypertension and retinal microvascular dysfunction (HyperVasc): protocol of a randomised controlled exercise trial in patients with hypertension by Justin Carrard, Lukas Streese, Timo Hinrichs, Henner Hanssen, Arno Schmidt-Trucksäss, Konstantin Gugleta, Joséphine Gander, Christoph Hauser

“…Introduction Hypertension is a global healthcare burden that affects the structure and function of the macrocirculation and microcirculation and induces disease-specific end-organ damage. …”
Get full text

A machine learning model using the snapshot ensemble approach for soil respiration prediction in an experimental Oak Forest by S.N. Ferdous, J.P. Ahire, R. Bergman, L. Xin, E. Blanc-Betes, Z. Zhang, J. Wang

“…However, because it is highly sensitive to the environment and has large temporal and spatial variability, its contribution to the global carbon cycle remains highly uncertain. Recent advances in ecosystem process models have uniquely constrained soil respiration rates, largely based on results from tracing ecosystem CO2 losses using radioisotope and stable isotope methods. …”
Get full text

Helicobacter pylori infection and staple-line leak in patients with class III obesity undergoing laparoscopic sleeve gastrectomy: a retrospective study by Hani Tamim, Albaraa H Kazim, Fahad Y Bamehriz, Aldanah M Althwanay, Abdullah Aldohayan, Al-Bandari Zamil Abdullah, Bandar AlShehri, Rakan Masoud AlTuwayr, Habeeb I A Razack, Fahad Alsohaibani, Saleh A Alqahtani

“…Objective Globally, over 50% of the population is affected by Helicobacter pylori, yet research on its prevalence and impact in patients with obesity undergoing laparoscopic sleeve gastrectomy (LSG) is inconclusive. …”
Get full text

QTL mapping and candidate gene analysis of element accumulation in rice grains via genome-wide association study and population genetic analysis by Min Li, Mengxue Gao, Jinmei Huang, Shaojuan Jin, Yamei Lv, Lin Wang, Tao Huang, Fengcai Wu, Zhijian Xu, Yinghua Pan, Zhixia Liu, Chaopu Zhang, Yuntao Liang, Lijun Meng, Jianlong Xu

“…Abstract Background Toxic heavy metal elements in soils are major global environmental issues and easily migrate to crop grains to cause severe problems in human health, whereas moderately essential elements such as selenium are beneficial for human health. …”
Get full text

Enhancing cardiac diagnostics: a deep learning ensemble approach for precise ECG image classification by Ahmed Alsayat, Alshimaa Abdelraof Mahmoud, Saad Alanazi, Ayman Mohamed Mostafa, Nasser Alshammari, Majed Abdullah Alrowaily, Hosameldeen Shabana, Mohamed Ezz

“…Abstract Cardiovascular diseases are a global health challenge that necessitates improvements in diagnostic accuracy and efficiency. …”
Get full text

MGATAF: multi-channel graph attention network with adaptive fusion for cancer-drug response prediction by Dhekra Saeed, Huanlai Xing, Barakat AlBadani, Li Feng, Raeed Al-Sabri, Monir Abdullah, Amir Rehman

“…Results We introduce multimodal multi-channel graph attention network with adaptive fusion (MGATAF), a framework designed to enhance drug response predictions by capturing both local and global interactions among graph nodes. MGATAF improves drug representation by integrating SMILES and fingerprints, resulting in more precise predictions of drug effects. …”
Get full text

Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet by Xiaojuan Li, Luming Qiao, Wei Wang, Ying Shi, Lei Yuan, Zhiwei Zhai

“…Obesity is affecting global health with multiple complications, including cardiac dysfunction. …”
Get full text

Effects of time restricted feeding combined with Lacto Ovo vegetarian diet on metabolic associated fatty liver disease management: a randomized clinical trial by Mahshad Shafiee, Amir Sadeghi, Fateme Ghafouri-Taleghani, Maryam Nilghaz, Maryam Ghods, Behnaz Narimani, Azita Hekmatdoost, Atoosa saidpour

“…Abstract Metabolic Associated Fatty Liver Disease (MAFLD) is becoming a major global health concern due to its links with obesity, insulin resistance, and cardiovascular risk. …”
Get full text

Climate smart crop-livestock integrated farming as a sustainable agricultural strategy for humid tropical islands by T. P. Swarnam, A. Velmurugan, T. Subramani, N. Ravisankar, N. Subash, A. S. Pawar, P. Perumal, I. Jaisankar, S. Dam Roy

“…Climate change and its impacts on agriculture are relatively well documented at the global and regional levels, while adaptation measures to sustain food production are mostly location specific. …”
Get full text

Volume contracted state, mortality and functional outcomes in patients with acute ischaemic stroke due to large vessel occlusion by Risheng Xu, Max Wintermark, Gregory W Albers, Jeremy J Heit, Adam A Dmytriw, Adrien Guenego, Yasmin Aziz, Kambiz Nael, Benjamin Pulli, Victor Urrutia, Dhairya A Lakhani, Tobias D Faizy, Argye Hillis, Vivek Yedavalli, Dylan Wolman, Licia P Luna, Elisabeth B Marsh, Hamza Adel Salim, Janet Mei, Vaibhav Vagal, Aakanksha Sriwastwa, Raf Llinas, Hanzhang Lu, Mona N Bahouth

“…Background Acute ischaemic stroke (AIS) is a leading cause of mortality and disability globally, with volume contracted state (VCS), as indicated by an elevated blood urea nitrogen to creatinine (BUN/Cr) ratio, potentially influencing outcomes. …”
Get full text

Graph analysis based on SCN reveals novel neuroanatomical targets related to tinnitus distress by Yawen Lu, Yifeng Yang, Meijing Yan, Lianxi Sun, Caixia Fu, Jianwei Zhang, Jianwei Zhang, Yuehong Liu, Kefeng Li, Zhao Han, Guangwu Lin, Shihong Li

“…Compared with HCs, tinnitus patients had significantly higher characteristic path length, lambda, transitivity, and assortativity (p < 0.05), and significantly lower global efficiency (p < 0.05). Tinnitus patients had higher clustering coefficient and reduced gamma and modularity, but neither was remarkable. …”
Get full text

Association between risk of ischemic stroke and liver enzymes levels: a systematic review and meta-analysis by Omnia Samy El-Sayed, Asmaa Zakria Alnajjar, Abdelfattah Arafa, Hazem E. Mohammed, Abdelrahman M. Elettreby, Safiya Ibraheem, Dalia Esam Tawfik, Menna Allah Ashraf Abdullah, Mohamed Ahmed Tolba

“…Abstract Background Ischemic stroke is a major public health concern, contributing significantly to global morbidity and mortality. Recent studies have suggested that alterations in liver enzymes may be linked to the risk of developing a stroke. …”
Get full text

ZSH‐2208: A novel retinoid with potent anti‐tumour effects on ESCC stem cells via RARγ–TNFAIP3 axis by Ruoxue Chen, Xuan Huang, Jiayun Hou, Junjie Ni, Wenrui Zhao, Quanlin Li, Heng Jiao, Xin Cao

“…Abstract Backgroud Oesophageal cancer ranks among the most prevalent malignant tumours globally, primarily consisting of oesophageal squamous cell carcinoma (ESCC). …”
Get full text

Exome-wide genetic risk score (ExGRS) to predict high myopia across multi-ancestry populations by Jian Yuan, Ruowen Qiu, Yuhan Wang, Zhen Ji Chen, Haojun Sun, Wei Dai, Yinghao Yao, Ran Zhuo, Kai Li, Shilai Xing, Myopia Associated Genetics and Intervention Consortium, Xiaoguang Yu, Liya Qiao, Jia Qu, Jianzhong Su

“…Abstract Background High myopia (HM), characterized by a severe myopic refractive error, stands as a leading cause of visual impairment and blindness globally. HM is a multifactorial ocular disease that presents high genetic heterogeneity. …”
Get full text

Cryptic transmission of a SARS-CoV-2 variant detected by wastewater surveillance in Panama by Melissa Gaitán, Yamitzel Zaldivar, Michelle Hernandez, Jessica Góndola, Oris Chavarría, Brechla Moreno, Danilo Franco, Rodrigo DeAntonio, Santiago Mirazo, Florencia Cancela, Maria Eugenia Barnett, Alexander A. Martinez, Juan Miguel Pascale, Sandra López-Vergès

“…Wastewater surveillance allowed the identification of the Omicron sublineage JN.1.16.1 in the capital city and its surroundings, which was not detected by the clinical surveillance in the country, despite its global circulation. This highlights the critical need to sustain both genomic surveillance programs beyond the pandemic in countries like Panama that serve as pivotal exchange hubs.…”
Get full text

Release Profile and Antibacterial Activity of <i>Thymus sibthorpii</i> Essential Oil-Incorporated, Optimally Stabilized Type I Collagen Hydrogels by Caglar Ersanli, Ioannis Skoufos, Konstantina Fotou, Athina Tzora, Yves Bayon, Despoina Mari, Eleftheria Sarafi, Konstantina Nikolaou, Dimitrios I. Zeugolis

“…Antimicrobial resistance is one of the drastically increasing major global health threats due to the misuse and overuse of antibiotics as traditional antimicrobial agents, which render urgent the need for alternative and safer antimicrobial agents, such as essential oils (EOs). …”
Get full text

Conflicts in the tourist city from the perspective of local social movements by Yolanda Romero-Padilla, Alfonso Cerezo-Medina, Enrique Navarro-Jurado, José María Romero-Martínez, Antonio Guevara-Plaza

“…Los resultados evidencian que en las ciudades con turismo clásico de litoral ya existía la vivienda de alquiler desde sus orígenes como destino y ahora se ha visibilizado porque las plataformas digitales lo han puesto en el mercado global; en ciudades con turismo urbano-cultural las viviendas son una nueva forma de alojamiento que genera nuevos conflictos; por último, los resultados contrastan las características del modelo crecentista en la ciudad turística frente a las reivindicaciones de los movimientos sociales que cuya base es la compatibilidad del turismo con la preservación y mejora de la calidad de la vida cotidiana. …”
Get full text