Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer by Yaojun Ren, Min Xue, Xinhui Hui, Xiuyu Liu, Muhammad Asad Farooq, Yiran Chen, Yuzhou Ji, Yixin Duan, Iqra Ajmal, Jie Yao, Wenzheng Jiang

“…Gastric cancer remains a significant global health burden, characterized by regional variations in incidence and poor survival prospects in advanced stages. …”
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Main Comorbidities and Complications in Type 2 Diabetic Patients from Two Different Perspectives by Diana Serret López, Armando Rodríguez Salvá, Addys María Díaz Piñera, Maritza Benítez Martínez, Geominia Maldonado Cantillo

“…<strong>Foundation:</strong> the global prevalence of diabetes mellitus is 10.5 %, type 2 is the most common and represents 90 % of cases. …”
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Addenbrooke’s Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson’s Disease by Dagmar Berankova, Eva Janousova, Martina Mrackova, Ilona Eliasova, Milena Kostalova, Svetlana Skutilova, Irena Rektorova

“…Statistically significant differences between groups were demonstrated in global ACE-R scores and subscores, except in the language domain. …”
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Comprehensive bioinformatics analysis identifies metabolic and immune-related diagnostic biomarkers shared between diabetes and COPD using multi-omics and machine learning by Qianqian Liang, Yide Wang, Zheng Li, Zheng Li, Zheng Li, Zheng Li

“…BackgroundDiabetes and chronic obstructive pulmonary disease (COPD) are prominent global health challenges, each imposing significant burdens on affected individuals, healthcare systems, and society. …”
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Extraction, Chemical Composition and Antidiabetic Potential of Crude Polysaccharides from Centella asiatica (L.) Urban by Meng Li, Muhammad Shahid, Xiaobin Zhang, Douglas Law, Mukram Muhammad Mackeen, Arnida Hani Teh, Ahmad Abdul Kareem Najm, Shazrul Fazry, Babul Airianah Othman

“…The global prevalence of diabetes mellitus (DM) is escalating, posing a significant challenge to human healthcare systems. …”
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Anti-obesity mechanisms elucidation of essential oil components from Artemisiae Argyi Folium (Aiye) by the integration of GC-MS, network pharmacology, and molecular docking by Yongxiang Liu, Jinhai Luo, Maninder Meenu, Baojun Xu

“…Recently, the global epidemic of obesity is increasing significantly. …”
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SP-YOLO: A Real-Time and Efficient Multi-Scale Model for Pest Detection in Sugar Beet Fields by Ke Tang, Yurong Qian, Hualong Dong, Yuning Huang, Yi Lu, Palidan Tuerxun, Qin Li

“…The model integrates a CNN and transformer (CAT) into the backbone network to capture global features. The lightweight depthwise separable convolution block (DSCB) module is designed to extract multi-scale features and enlarge the receptive field. …”
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Characterization and genomic analysis of a Herelleviridae bacteriophage UHP46 infecting mastitis-causing Staphylococcus aureus by Sara Najeeb, Imran Khan, Javed Muhammad, Muhammad Jahangir, Iqbal Ahmad Alvi, Anza Abbas, Aman Ullah, Arif Ullah, Wajiha Sajjad, Hashir Khan, Amjad Khan, Amjad Khan

“…BackgroundMastitis is a widespread disease on a global scale, significantly impacting the dairy industry. …”
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Priorities in the Modern Organization of University Science in the Light of the Principal-Agent Theory by D. G. Sandler, V. A. Koksharov, V. V. Kruzhaev, A. Р. Bagirova

“…There are two ways to reduce the identified gaps: 1) inclusion of the support for the development of aggregators that allow scientists to quickly obtain the most relevant results with growing volumes of data into the list of tasks facing the principal; 2) development of modern analytical information and digital mechanisms for assessing the prospects of topics, which creates conditions for their compliance with the dynamic global research agenda.…”
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A Gaussian Variogram‐Based Model of Total Electron Content in the Regional Ionosphere of China by Ang Liu, Zishen Li, Ningbo Wang, Ang Li, Zhouyu Zhang, Yunlong Zhang

“…Compared to existing models, including BDS‐3 broadcast ionospheric model (BDGIM), GPS broadcast model (Klobuchar), Galileo broadcast model (NeQuickG) and post‐processing Global Ionospheric Map released by IGS (IGSG), the accuracy of IVMP‐SHAKING improves by 6%–52%. …”
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The influence of selected financial factors on the survival of SMES in V4 countries by Zdenko Metzker, Roman Hlawiczka, Irma Tabaku, Ho Thanh Tung

“…Small and medium-sized enterprises (SMEs) play a crucial role in the global economy. This article examines SMEs’ financial management attitudes in the Visegrad Four countries, aiming to understand how these attitudes impact the firms’ long-term sustainability. …”
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Intervention Programmes for First-Episode Psychosis: A Scoping Review by Marta Gouveia, Tânia Morgado, Tiago Costa, Francisco Sampaio, Amorim Rosa, Carlos Sequeira

“…The review identified 47 studies from 2002 to 2023, which revealed a great deal of diversity in programme characteristics and implementation contexts. This reflects a global perspective. The results showed that there is a great deal of variety in the characteristics of the programmes, with interventions ranging from single-component strategies, such as cognitive–behavioural therapy (CBT) and cognitive remediation therapy (CRT), to multicomponent programmes that integrate a number of different approaches, including psychosocial, pharmacological, and family-focused strategies. …”
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Preclinical development of a standardized extract of Ilex paraguariensis A.St.-Hil for the treatment of obesity and metabolic syndrome by Sara E.L. Tolouei, Rodrigo Marcon, Fabiana Cardoso Vilela, Cristina Setim Freitas, Melina Heller, Edineia Lemos de Andrade, Sergio José Macedo Júnior, Adara Áurea dos Santos, Ruth Fernandes Rocha, Guilherme Pasetto Fadanni, Naiani Ferreira Marques, Jarbas Mota Siqueira Júnior, João B. Calixto

“…Obesity is a global epidemic often associated with serious medical complications such as diabetes, hypertension and metabolic dysfunction-associated steatohepatitis. …”
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Reproductive strategies in loggerhead sea turtle Caretta caretta: polyandry and polygyny in a Southwest Atlantic rookery by Laís Amorim, Lara Chieza, Jake A. Lasala, Sarah de Souza Alves Teodoro, Wesley D. Colombo, Ana Carolina Barcelos, Paula Rodrigues Lopes Guimarães, João Luiz Guedes da Fonseca, Ana Claudia Jorge Marcondes, Alexsandro Santos, Sarah Vargas

“…While multiple paternity is a common phenomenon among sea turtles, this study is the first to document polyandry in loggerheads in Brazil and the first to provide evidence of polygyny in this species globally. This research establishes a crucial database for future studies in Brazil, with a focus on the BSR of the Southwest Atlantic subpopulation, offering essential insights for developing effective management strategies for this vulnerable population.…”
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Factors Associated with the Utilization of Traditional Health Services among People with Non-Communicable Diseases in Indonesia: Findings from a Nationwide Survey by Iwan Abdi Suandana, Putu Ayu Swandewi Astuti, Pande Putu Januraga

“… Globally, there is an increasing trend of morbidity and mortality from non-communicable diseases (NCDs). …”
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Lnc-EST885 promotes hepatocellular carcinoma metastasis through PI3K / AKT pathway by interaction with TRAF4 by Shaoliang Zhu, Gang Wang, Yuxuan Zhang, Mengjie Zou, Zhi Li, Shenhong Qu, Xiaosu Zou, Wenqian Nong, Weiwei Miao, Qicong Chen, Juanmei Mo, Huibing Chen, Lequn Li, Xiaofeng Dong, Honglin Luo

“…Background: Hepatocellular carcinoma (HCC) represents a major malignancy globally, characterized by high malignancy and intricate molecular mechanisms. …”
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Development of a duplex real-time recombinase aided amplification assay for the simultaneous and rapid detection of PCV3 and PCV4 by Renjie Sun, Hanze Liu, Siqi Sun, Yating Wang, Ying Shan, Xiaoliang Li, Weihuan Fang, Yongle Yang, Ronghui Xie, Lingyan Zhao

“…Abstract Background Porcine circoviruses 3 (PCV3) and 4 (PCV4) are emerging pathogens with global implications for swine industry, disturbing the diagnosis of PCVs associated diseases due to a range of similar clinical symptoms and increasingly coinfections. …”
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Automatic detection and counting of wheat spike based on DMseg-Count by Hecang Zang, Yilong Peng, Meng Zhou, Guoqiang Li, Guoqing Zheng, Hualei Shen

“…Secondly, an element-by-element point multiplication mechanism was designed to fuse global and local contextual supervision information of wheat spike. …”
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Association of Immune Nutrition Indices with the Risk of All-Cause Mortality and Cardiovascular Mortality in Patients with Heart Failure in the NHANES (1999–2018) by Feifei Zhang, Yuetao Xie, Litian Liu, Huiliang Liu, Ohua Feng, Yingxiao Li, Yi Dang

“…Background: Heart failure (HF) remains a global challenge with disappointing long-term outcomes. …”
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The burden of irritable bowel syndrome and functional dyspepsia in Poland: a cross-sectional study from West Pomeranian Voivodship by Patrycja Krynicka, Mariusz Kaczmarczyk, Karolina Skonieczna-Żydecka, Danuta Cembrowska-Lech, Konrad Podsiadło, Krzysztof Dąbkowski, Katarzyna Gaweł, Natalia Botke, Iwona Zawada, Małgorzata Ławniczak, Andrzej Białek, Wojciech Marlicz

“…Abstract Background Functional gastrointestinal disorders (FGIDs), now known as disorders of gut-brain interaction (DGBIs), such as Irritable Bowel Syndrome (IBS) and Functional Dyspepsia (FD), significantly impact global health, reducing quality of life and burdening healthcare systems. …”
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