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Targeting transforming growth factor-β1 by methylseleninic acid/seleno-L-methionine in clear cell renal cell carcinoma: Mechanisms and therapeutic potential
Published 2024-01-01“…Clear cell renal cell carcinoma (ccRCC) poses a significant global health challenge as its incidence continues to rise, resulting in a substantial annual mortality rate. …”
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Public insight into knee osteoarthritis: a cross-sectional study from the West Bank, Palestine
Published 2025-02-01“…Abstract Background Osteoarthritis (OA) is a significant global health concern and is characterized by the degeneration of joint structures, leading to pain, stiffness, and functional limitations It is estimated that 654.1 million individuals are affected by osteoarthritis worldwide, with females, especially those older than 60 years of age, being the population most impacted. …”
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The SGLT-2 Inhibitors and their Role in the Treatment of Heart Failure - A Review of Literature
Published 2025-02-01“… • The purpose of research: Heart failure (HF) is an important global health concern. Despite advancements in treatment, HF remains the leading cause of hospitalization among the elderly. …”
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Socio-Demographic and Lifestyle Factors Influencing Adherence to AntiHypertensive Treatment in a Rural Area of Ludhiana, India
Published 2025-02-01“…Conclusions Hypertension is becoming a global health issue and is yet a preventable disease if timely and adequately treated. …”
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Immune-endocrine crossroads: the impact of nuclear receptors in Tuberculosis and Chagas disease
Published 2025-02-01“…These diseases remain significant global health concerns, particularly in developing countries, highlighting the importance of understanding the molecular mechanisms underlying host-pathogen interactions mediated by NRs.…”
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Respiratory pathogen spectrum and epidemiological trends in Hainan Province: a retrospective analysis from 2017 to 2023
Published 2025-02-01“…Abstract Background Respiratory tract infections (RTIs) pose a significant global health burden, caused by various pathogens. The COVID-19 pandemic and non-pharmaceutical interventions (NPIs) have created unprecedented challenges for public health systems, inadvertently altering the dynamics of other respiratory pathogens. …”
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Hepatocellular carcinoma: signaling pathways and therapeutic advances
Published 2025-02-01“…Abstract Liver cancer represents a major global health concern, with projections indicating that the number of new cases could surpass 1 million annually by 2025. …”
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The forgotten link: how the oral microbiome shapes childhood growth and development
Published 2025-02-01“…Childhood stunting, defined as impaired linear growth and development, remains a significant global health challenge with long-term consequences on cognitive and physical well-being. …”
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COPD with Eosinophilic Inflammation is Susceptible to Particulate Air Pollution Exposure
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Effects of time restricted feeding combined with Lacto Ovo vegetarian diet on metabolic associated fatty liver disease management: a randomized clinical trial
Published 2025-02-01“…Abstract Metabolic Associated Fatty Liver Disease (MAFLD) is becoming a major global health concern due to its links with obesity, insulin resistance, and cardiovascular risk. …”
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RETRACTED ARTICLE: A prospective diagnostic model for breast cancer utilizing machine learning to examine the molecular immune infiltrate in HSPB6
Published 2024-10-01“…The molecular processes that propel breast cancer progression are not fully elucidated, highlighting the intricate nature of the underlying biology and its crucial impact on global health. The objective of this research was to perform bioinformatics analyses on breast cancer-related datasets to gain a comprehensive understanding of the molecular mechanisms at play and to identify key genes associated with the disease. …”
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Elimination of olfactory sensory neurons by zinc sulfate inoculation prevents SARS-CoV-2 infection of the brain in K18-hACE2 transgenic mice
Published 2024-11-01“…Abstract Coronavirus disease-2019 (COVID-19), attributed to the severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2), has posed global health challenges since it first emerged in 2019, and its impact continues to persist. …”
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Pharmacological regression of atherosclerotic plaque in patients with type 2 diabetes
Published 2025-03-01“…Atherosclerosis of the coronary arteries continues to be one of the major global health burdens and acute coronary syndrome is responsible annually for at least 30 % of all deaths globally. …”
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Self-assessed depressive symptoms in adolescents comparing two Swedish cohorts born 15 years apart
Published 2025-04-01“…Background: Depression in adolescence is a significant global health concern, notably in Sweden where recent trends suggest an increase in depressive symptoms among adolescents. …”
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