The Inhibitory Effects of Alpha 1 Antitrypsin on Endosomal TLR Signaling Pathways by Ahmed S. Elshikha, Georges Abboud, Rigena Avdiaj, Laurence Morel, Sihong Song

“…Specifically, hAAT completely blocked the R848 induction of germinal center T cells (GC T), B cells (GC B), and plasma cells (GC PCs), as well as T follicular T helper cells (T_FH), which are all critical in lupus development. …”
Get full text

Diagnóstico molecular de distrofia muscular de Duchenne/Becker en una familia sin antecedentes patológicos de la enfermedad by Ivonne Martín Hernández, Alejandro Ariosa Olea, Mariesky Zayas Guillot, Tatiana Zaldívar Vaillant, Celia Rosa Soto Pérez-Stable

“…No se pudo excluir mosaicismo germinal en la madre del niño.<br /><strong>Conclusión:</strong> se infirió la ocurrencia de una mutación de novo. …”
Get full text

Cytogenetic factors decreasing the fertility of pollen and cobs during clogging of tetraploid maize with triploid grains (<i>Zea mays</i> L.) by E. B. Khatefov, A. A. Grushin, V. N. Boyko

“…Triploid grains, along with diploid ones, were able to germinate and show poor fertility. As a result of the fusion between male gametes of triploid and female tetraploid plants, an imbalance in the stability of the tetraploid genome occurred, leading to increased degradation of the cultivar’s productivity with each seed reproduction. …”
Get full text

Trivalent recombinant protein vaccine induces cross-neutralization against XBB lineage and JN.1 subvariants: preclinical and phase 1 clinical trials by Jingyun Yang, Weiqi Hong, Huashan Shi, Cai He, Hong Lei, Yanan Zhou, Hao Yang, Aqu Alu, Zimin Chen, Yun Yang, Wenhai Yu, Cong Tang, Junbin Wang, Bai Li, Qing Huang, Jiong Li, Li Yang, Wei Wang, Guobo Shen, Jinliang Yang, Zhiwei Zhao, Xiangrong Song, Zhaoming Su, Yuquan Wei, Qiangming Sun, Shuaiyao Lu, Zhenling Wang, Youchun Wang, Guangwen Lu, Weimin Li, Xiawei Wei

“…It elicits measurable antigen-specific T cell responses, germinal center B cell responses, and T follicular helper responses, effectively protecting against live Omicron XBB.1.16 challenges. …”
Get full text

Truncated NS1 Influenza A Virus Induces a Robust Antigen-Specific Tissue-Resident T-Cell Response and Promotes Inducible Bronchus-Associated Lymphoid Tissue Formation in Mice by Anna-Polina Shurygina, Marina Shuklina, Olga Ozhereleva, Ekaterina Romanovskaya-Romanko, Sofia Kovaleva, Andrej Egorov, Dmitry Lioznov, Marina Stukova

“…Notably, PR8/NS124 immunisation also leads to the development of inducible bronchus-associated lymphoid tissue (iBALT) in the lungs by day 28, characterised by the presence of antigen-specific Tfh cells and GL7+Fas+ germinal centre B cells. Conclusions: Our findings further underscore the potential of NS1-truncated influenza viruses to drive robust mucosal immune responses and enhance vaccine efficacy.…”
Get full text

Evaluation of selected agricultural by-products as potential feeds for rearing edible grasshopper, Ruspolia differens (Serville) (Orthoptera: Tettigoniidae) by Amos Acur, Geoffrey Maxwell Malinga, Philip Nyeko

“…Methods We evaluated the biology (survival, developmental duration, and adult fresh weight) of Ruspolia differens reared on eleven locally available agricultural by-products in Uganda, namely; dry maize cob, waste from a locally brewed finger millet drink, cotton seed cake, soybean hull meal, sunflower cake, pumpkin pulp, peelings of unripe banana, cassava, sweet potato, pineapple and pumpkin. Germinated finger millet was used as a control. Newly hatched (1 day old) nymphs were reared individually on each diet until 14 days post adult emergence. …”
Get full text

Cecal Patches Generate Abundant IgG2b-Bearing B Cells That Are Reactive to Commensal Microbiota by Masato Tsuda, Hiraku Okada, Natsuki Kojima, Fumiya Ishihama, Yuhei Muraki, Toshiki Oguma, Nanako Hattori, Takumi Mizoguchi, Kiyoaki Mori, Satoshi Hachimura, Yoshimasa Takahashi, Kyoko Takahashi, Shuichi Kaminogawa, Akira Hosono

“…Gut-associated lymphoid tissue (GALT), such as Peyer’s patches (PPs), are key inductive sites that generate IgA+ B cells, mainly through germinal center (GC) responses. The generation of IgA+ B cells is promoted by the presence of gut microbiota and dietary antigens. …”
Get full text

Impact of Weed Infestation on Growth and Yield of Carrot Plants. by Mutabazi, Cosma

“…After one week, carrot seeds germinated, and weeding started after two weeks. Data Collection Methods used included observation and measurement. …”
Get full text

New acorane-sesequiterpenes and anti-retinoblastoma constituents from the marine algicolous fungus Trichoderma harzianum NTU2180 guided by molecular networking strategy by Andrea Gu, Fan-Li Lin, Chung-Kuang Lu, Tz-Wei Yeh, Yih-Fung Chen, Ho-Cheng Wu, Tzong-Huei Lee

“…Results The feature-based molecular networking (FBMN) analysis showed that T. harzianum NTU2180 fermented on germinated brown rice (GBR) produced more terpenoids. …”
Get full text

Development of highly bioactive long-acting recombinant porcine FSH for batch production management of sows by Jiawei Zhang, Lei Shi, Xiaorong Zhong, Yunhe Bai, Jun Dou, Lu Zhang, Xiaochao Shi, Bingchun Wu, Zemin Tan, Lin Yan, Jinku Yu, Jingru Zhang, Guo Han, Jiansheng Xiong, Hua Zhang, Xingyuan Cao, Haoshu Luo

“…The efficacy of rpFSH-pFc was confirmed by cAMP level evaluation and germinal vesicle breakdown (GVBD) analysis in vitro. …”
Get full text

A revised classification of Dryopteridaceae based on plastome phylogenomics and morphological evidence, with the description of a new genus, Pseudarachniodes by Zheng-Yu Zuo, Germinal Rouhan, Shi-Yong Dong, Hong-Mei Liu, Xin-Yu Du, Li-Bing Zhang, Jin-Mei Lu

Get full text

Clinicopathological analysis of adrenal intravascular large B-cell lymphoma by LIN Jiaxin, WEI Ran, SHUI Ruohong, LU Hongfen, LI Xiaoqiu, YU Baohua

“…Ki-67 proliferation index was high, all above 80%. 80% (4/5) of the cases were of non-germinal-center B-cell-like (non-GCB) phenotype, 100% (4/4) of the cases had MYC/BCL2 double expression. …”
Get full text

Expression of the NUP153 and YWHAB genes from their canonical promoters and alternative promoters of the LINE-1 retrotransposon in the placenta of the first trimester of pregnancy by V. V. Demeneva, E. N. Tolmacheva, T. V. Nikitina, E. A. Sazhenova, S. Yu. Yuriev, A. Sh. Makhmutkhodzhaev, A. S. Zuev, S. A. Filatova, A. E. Dmitriev, Ya. A. Darkova, L. P. Nazarenko, I. N. Lebedev, S. A. Vasilyev

“…This study aimed to analyze the expression of the NUP153 and YWHAB genes, highly active in the placenta, from canonical and alternative LINE-1 promoters in the germinal part of the placenta of spontaneous and induced abortions. …”
Get full text

PATL2 mutations affect human oocyte maternal mRNA homeostasis and protein interactions in cell cycle regulation by Yin-Li Zhang, Zhanhong Hu, Huifang Jiang, Jiamin Jin, Yan Zhou, Mengru Lai, Peipei Ren, Siya Liu, Ying-Yi Zhang, Yan Rong, Wei Zheng, Shen Zhang, Xiaomei Tong, Songying Zhang

“…RNA sequencing revealed that PATL2 mutations decreased mRNA storage in human germinal vesicle (GV) oocytes and impeded mRNA decay during maturation and in early embryos. …”
Get full text

The Role of Potassium Phosphite in Enhancing the Activity of Defense Enzymes in Rice Infected by Sheath Blight by Milad Habibi Daronkolaei, Mohammad Ali Tajick Ghanbary, Valiollah Babaeizad, Heshmatollah Rahimian, Ali Dehestani

“…Subsequently, the seeds were germinated and transferred to plastic pots filled with sterile soil. …”
Get full text