Leydig Cell Tumor in a Patient with 46,XX Disorder of Sex Development (DSD), Ovotesticular: A Case Report and a Review of the Literature by Steffen Gretser, Maria-Noemi Welte, Frederik Roos, Jens Köllermann

“…This shows that although 46,XX DSD, ovotesticular is known to have a low potential for germ cell neoplasia, nongerm cell tumors can develop and should be into account for the management of those patients.…”
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Sperm-borne small non-coding RNAs: potential functions and mechanisms as epigenetic carriers by Muhammad Naveed, Zhaokang Shen, Jianqiang Bao

“…Once considered mere byproducts during germ cell maturation, these sncRNAs have now been recognized as crucial carriers of epigenetic information, playing a significant role in transmitting acquired traits from paternal to offspring, particularly under environmental influences. …”
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Chemokine (C-X-C) Ligand 12 Facilitates Trafficking of Donor Spermatogonial Stem Cells by Zhiyv Niu, Shaun M. Goodyear, Mary R. Avarbock, Ralph L. Brinster

“…The chemokine (C-X-C) receptor type 4 (CXCR4) is an early marker of primordial germ cells (PGCs) essential for their migration and colonization of the gonads. …”
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Late Recurrence in Ovarian Dysgerminoma Presenting as a Primary Retroperitoneal Tumor: A Case Report and Review of the Literature by Yuichiro Sato, Tohru Hayashi, Hidetaka Yamamoto, Ichiro Niina, Naoya Kuroki, Takeshi Iwamura, Junji Onishi

“…Ovarian dysgerminoma is a rare type of germ cell tumor. The majority of patient relapses occur within 2 years of diagnosis. …”
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Reproductive Cycle of Marphysa sanguinea (Montagu, 1815) (Polychaeta: Eunicidae) in the Lagoon of Tunis by Monia El Barhoumi, Patrick Scaps, Fathia Zghal

“…Germ cells in premeiotic and previtellogenic phases are observed in one cluster. …”
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Suture Granuloma Showing False-Positive Findings on FDG-PET by Kohei Takahara, Hiroaki Kakinoki, Saya Ikoma, Kazuma Udo, Shohei Tobu, Yuji Satoh, Yuji Tokuda, Mitsuru Noguchi, Shigehisa Aoki, Jiro Uozumi

“…We report a case of a 33-year-old male with a mixed germ-cell testicular tumor. Postoperative follow-up FDG-PET revealed concentration of FDG in the left inguinal area which is not tumor metastasis or local recurrence but suture reactivity granuloma. …”
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Oncological outcomes in non-seminomatous testicular tumors and residual mass after cisplatin-based chemotherapy by María A. Ocampo-Gómez, María C. Moreno-Matson, David Ruiz-Londoño, Marino Cabrera, Rodolfo Varela

“…A residual mass (RM) in non-seminomatous germ cell tumors (NSGCT) after chemotherapy (CT) is defined as a mass >1 cm in greatest diameter. …”
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Pure Testicular Seminoma Relapsing Late with Somatic Type Malignancy by Klaus-Peter Dieckmann, Petra Anheuser, Ralf Gehrckens, Waldemar Wilczak, Guido Sauter, Doris Höflmayer

“…Somatic type malignancy (STM) occurs in 2% of all germ cell tumours (GCTs). The prognosis is unfavourable and the origin is poorly understood. …”
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Evaluation of the Effects of STZ-Induced Diabetes on In Vitro Fertilization and Early Embryogenesis Processes by Hüseyin Aktuğ, Vildan Bozok Çetintaş, Ayşegül Uysal, Fatih Oltulu, Altuğ Yavaşoğlu, Saadet Özen Akarca, Buket Kosova

“…Germ cells were obtained from healthy and diabetic rats, analyzed for number, motility, and morphology, and used for IVF. …”
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Heterozygous mutation in BRCA2 induces accelerated age-dependent decline in sperm quality with male subfertility in rats by Yashiro Motooka, Hideaki Tanaka, Yuki Maeda, Misako Katabuchi, Tomoji Mashimo, Shinya Toyokuni

“…Our analyses revealed that the heterozygous rats with the PV in the BRCA2 exon 11 showed increased DNA double-strand breaks and apoptosis in spermatogonia and spermatocytes, accelerated testicular germ cell loss, and deterioration in sperm quality according with aging, ultimately resulting in early male reproductive dysfunction. …”
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Unusual Presentation of Testicular Cancer with Tumor Thrombus Extending to the Inferior Vena Cava by Marie Dusaud, Younes Bayoud, François-Régis Desfemmes, Benoît Molimard, Xavier Durand

“…The tumor was staged pT1N2M1aS1, which was an intermediate prognosis, based on the International Germ Cell Cancer Collaborative Group consensus (IGCCCG). …”
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THE FREQUENCY OF TESTICULAR LESION IN ATERTIARY CARE CENTER by Prih Bashir, Noshaba Rahat, Humera Shahzad, Asma Jalbani, Farhana Zulfiqar, Bhawani Shankar

“…Among neoplastic lesions, seminoma (7; 4.8%) was the most frequent, followed by mixed germ cell tumor (5; 3.4%). Conclusion: Overall, our results show that the prevalence of testicular non-neoplastic lesions is higher than that of testicular neoplasms. …”
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Clinical phenotype and genetic analysis of patients with severe oligoasthenospermia carrying heterozygous SOHLH1 c.346-1G>A mutation by Xiaojun Wen, Zhiming Li, Lizi Cheng, Jianhong Wei, Wenjuan Yu, Xiufeng Lin, Xiufeng Lin, Xiaowu Fang

“…However, the underlying causes of most SOA cases remain unclear due to the complexity of germ cell development and the significant genetic heterogeneity associated with male infertility. …”
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Malignant Phyllodes Tumor and Acute Megakaryoblastic Leukemia Sharing a Common Clonal Origin by Yngvar Fløisand, Klaus Beiske, Geir Erland Tjønnfjord, Dag Heldal, Bodil Bjerkehagen, Mona-Elisabeth Revheim, Sverre Heim, Øyvind Sverre Bruland, Kirsten Sundby Hall, Anne Tierens, Jan Delabie

“…There is a well-known association in male patients between mediastinal germ cell tumors (GCT) and hematologic malignancies, with a propensity towards acute megakaryoblastic leukemia. …”
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Pan-cancer analysis of SOX2: Prognostic implications and potential as a therapeutic target in immune checkpoint modulation by Shoukai Yu, Lingmei Qian, Liling Xu, Jun Ma

“…Significant downregulation of SOX2 expression was observed in colorectal adenocarcinoma, esophageal carcinoma, rectum adenocarcinoma, stomach adenocarcinoma, and testicular germ cell tumors, whereas its expression was upregulated in cervical squamous cell carcinoma, glioblastoma multiforme, lower grade glioma, lung adenocarcinoma, and lung squamous cell carcinoma.Survival analysis showed that low SOX2 expression correlated with better prognosis in bladder cancer, liver hepatocellular carcinoma, kidney renal clear cell carcinoma, and sarcoma, whereas high SOX2 expression was associated with poor prognosis in lung adenocarcinoma, and lung squamous cell carcinoma, glioblastoma multiforme, lower grade glioma. …”
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The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization by Annekatrin Richter, Hanna Mörl, Maria Thielemann, Markus Kleemann, Raphael Geißen, Robert Schwarz, Carolin Albertz, Philipp Koch, Andreas Petzold, Torsten Kroll, Marco Groth, Nils Hartmann, Amaury Herpin, Christoph Englert

“…There it induces the male sex in a germ cell-independent manner in contrast to sex determination in zebrafish and the medaka. …”
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Pituitary adenoma: literature review and association with TAS2R16 (rs978739, rs1357949) gene polymorphisms by E. Pileckaitė, G. Gedvilaitė, L. Kriaučiūnienė

“…The occurrence of PA is influenced not only by somatic or germ cell defects but also by environmental factors. …”
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Adjuvant Radiotherapy for Synchronous Bilateral Testicular Seminoma: A Case Report and a Review of the Pertinent Literature by Daniel A. Jones, Elizabeth C. Ester, David Leavitt, Robert Sweet, Badrinath Konety, Gautam Jha, L. Chinsoo Cho

“…After 18 months of followup, he remains well, without evidence of recurrence. Bilateral germ cell tumors (BGCTs) are reported consistently at a low rate. …”
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Derivation of Pluripotent Cells from Mouse SSCs Seems to Be Age Dependent by Hossein Azizi, Sabine Conrad, Ursula Hinz, Behrouz Asgari, Daniel Nanus, Heike Peterziel, Akbar Hajizadeh Moghaddam, Hossein Baharvand, Thomas Skutella

“…Here, we aimed to answer important and fundamental questions in germ cell biology with special focus on the age of the male donor cells and the possibility to generate embryonic stem cell- (ESC-) like cells. …”
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Sperm Cryopreservation before Testicular Cancer Treatment and Its Subsequent Utilization for the Treatment of Infertility by Jana Žáková, Eva Lousová, Pavel Ventruba, Igor Crha, Hana Pochopová, Jaroslava Vinklárková, Eva Tesařová, Mohamed Nussir

“…Seminoma was diagnosed in 283 men (54.1%) and nonseminomatous germ cell tumors in 240 men (45.9%). 34 patients who returned for infertility treatment underwent 46 treatment cycles with cryopreserved sperm. …”
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