Integrating MAPK pathway inhibition into standard-of-care therapy for pediatric low-grade glioma by Erin E. Crotty, Aimee A. Sato, Aimee A. Sato, Mohamed S. Abdelbaki

“…This review highlights current approaches for the clinical implementation of MEK and RAF kinase inhibitors for pLGG, focusing on the practical aspects of drug administration, toxicity management, response monitoring, and distribution to patients experiencing geographic or financial barriers to care. Additionally, we review important considerations for the off-label use of these agents while contemporaneous clinical trials assessing front-line efficacy are ongoing. …”
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Circular Economy Alternative Repurposing Textile Solid Discarded Materials from the Leather Goods Sector in Ubrique (Cádiz), Southern Spain by Miguel Suffo, José Luis García-Morales, José María Abelleira-Pereira, Pierpaolo D’Agostino

“…The leather industry is experiencing a significant rise in production, resulting in an increase in discarded materials–often classified as urban waste—that end up in landfills or are incinerated. Given the geographical proximity of the leather goods sector in Ubrique to the cork stopper manufacturing industry in El Puerto de Santa María/Jerez and to the viticulture sector in Jerez/Sanlúcar/Chiclana, it is essential to explore synergies that can address environmental challenges by contemplating a circular economy approach. …”
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Hypertensive load predicts recovery of renal function for patients undergoing revascularisation for renal artery stenosis by Ben Edgar, Rob Pearson, Andrew Jackson, Callum Stove, Ram Kasthuri, Keith Hussey, Christian Delles, Colin Geddes, Patrick Mark, Giles Roditi, Linsay McCallum, David B. Kingsmore

“…A retrospective analysis was performed of all patients who had renal revascularisation for renal impairment in a defined geographical area (West of Scotland, population 2.4 million) between 2008 and 2024. …”
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Protecting the Airway and the Physician: Lessons from 214 Cases of Endotracheal Intubation Litigation by Jean Daniel Eloy, Anna A. Pashkova, Molly Amin, Christy Anthony, Daisy Munoz, Yuriy Gubenko, Shivani Patel, Anna Korban, Andrea Perales, Peter F. Svider, Jean Anderson Eloy

“…Ultimately, 214 jury verdict and settlement reports were examined for various factors, including outcome, award, geographic location, defendant specialty, setting in which an injury occurred, patient demographics, and other causes of malpractice. …”
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The water footprint of lithium extraction technologies: Insights from environmental impact reports in Argentina's salt flats by Walter Fernando Díaz Paz, Lucas Seghezzo, Ariela Griselda Salas Barboza, Melisa Escosteguy, Paula Valentina Arias-Alvarado, Eduardo Kruse, Marc Hufty, Martín Alejandro Iribarnegaray

“…Our findings underscore that the water consumption of lithium mining can have important impacts that vary significantly with geographic context. EIRs provide a useful basis for estimating WF and BC, though certain limitations and challenges persist, particularly regarding incomplete or insufficiently detailed data.…”
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Ecological imbalance on the area of Shapahar Upazila, Naogaon district over three decades (1993÷2023) and prediction trend next ten years: a GIS approach by Nazmul Hossain, Ahammodullah Hasan, Jannatul Adnan, Tasmia Jahin Mim, Arman Hossain, Ariful Molla, Noor Hossain, Habib Ibne Jahan, Abdulla Al Mamun

“…This study analyzes land cover changes over three decades (1993-2023) in Shapahar Upazila using Geographic Information Systems (GIS) and remote sensing techniques. …”
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Dimensi Spasial Determinan Kemiskinan Kabupaten/Kota di Provinsi Aceh by Muhammad Fathahillah Dewantara Almismary, Dyah Retno Panuju, Galuh Syahbana Indraprahasta

“…Penelitian ini bertujuan untuk menganalisis pola sebaran kemiskinan dan faktor-faktor yang memengaruhinya di Provinsi Aceh menggunakan model Exploratory Spatial Data Analysis (ESDA) dengan alat analisis Indeks Moran, LISA (Local Indicator of Spatial Autocorrelation), dan GWR (Geographically Weighted Regression). Hasil penelitian menunjukkan bahwa pola sebaran kemiskinan pada 23 kabupaten/kota di Provinsi Aceh merupakan acak (random), dengan tiga kabupaten/kota:  Kabupaten Aceh Tengah, Kabupaten Bireuen, dan Kabupaten Aceh Selatan memiliki autokorelasi spasial signifikan pada tingkat 0,01–0,05. …”
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Metal Biomonitoring Through Arboreal Species in Riparian Ecosystems: <i>Pithecellobium dulce</i> as a Bioindicator Species by Sayuri Hernández-Maravilla, María Luisa Castrejón-Godínez, Efraín Tovar-Sánchez, Hugo Albeiro Saldarriaga-Noreña, Alexis Rodríguez, Marcos Eduardo Rosas-Ramírez, Patricia Mussali-Galante

“…Overall, Cu and Pb concentrations in leaves enabled us to detect pollution gradients for these metals in water and sediment from the sampling sites. Due to its wide geographic distribution, establishment in polluted sites, and metal absorption capacity, <i>P. dulce</i> can be considered a bioindicator species for environmental health studies in riparian ecosystems contaminated with metals.…”
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A dataset on bathymetry and hydrology of an emerging periglacial lagoon in Svalbard, ArcticMendeley Data by Andrius Šiaulys, Aleksej Šaškov, Greta Kilmonaitė, Dzmitry Lukashanets, Tobia Politi, Aurelija Samuilovienė, Anastasija Zaiko, Sergej Olenin

“…Various hydrological parameters were measured during surveys (temperature, salinity, oxygen saturation, dissolved oxygen concentration, pH, photosynthetically active radiation, turbidity, conductivity, density, pressure and sound velocity), which indicate strong vertical stratification with pronounced halocline and thermocline in some parts of the lagoon.The data collected will be utilized to analyze the physical and geographical conditions of the lagoon, as well as the distinguishing characteristics of its various sections, which vary in age by several decades. …”
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Characterization of Active Compounds of Different Garlic (Allium sativum L.) Cultivars by Szychowski Konrad A., Rybczyńska-Tkaczyk Kamila, Gaweł-Bęben Katarzyna, Świeca Michał, Karaś Monika, Jakubczyk Anna, Matysiak Magdalena, Binduga Urszula E., Gmiński Jan

“…Health benefits of garlic depend on its content of biologically-active compounds, which differs between cultivars and geographical regions. The aim of this study was to evaluate and compare the biological activity of aqueous extracts from nine garlic varieties from different countries (Poland, Spain, China, Portugal, Burma, Thailand and Uzbekistan). …”
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Impact Angle Control of Local Intense dB/dt Variations During Shock‐Induced Substorms by Denny M. Oliveira, James M. Weygand, Eftyhia Zesta, Chigomezyo M. Ngwira, Michael D. Hartinger, Zhonghua Xu, Barbara L. Giles, Daniel J. Gershman, Marcos V. D. Silveira, Vítor M. Souza

“…SECS analyses also reveal that geographic areas with dB/dt surpassing the thresholds 1.5 and 5 nT/s, usually linked to high‐risk GICs, are larger and occur earlier due to the symmetric compression caused by the nearly head‐on impact. …”
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Preparedness of European pediatric oncologists to integrate AI in the clinical routine by Alberto E. Tozzi, Diana Ferro, Ileana Croci, Francesco Fabozzi, Angela Mastronuzzi

“…Regarding the clinical scenarios, 34.9 % of respondents would ask for a procedure for confirming their diagnosis in case of discrepancy between AI decision support and human diagnosis; 55.8 % would be concerned about the generalizability an AI decision support system in case of lack of data from certain geographic areas during algorithm training; 47.6 % would feel uncomfortable in the informed consent process for an AI intervention; 10.2 % would no longer trust AI in case of a cyberattack affecting AI support for diagnosis. …”
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Spatial-Temporal Patterns of Litterfall Mercury Concentration and Flux in Typical Vegetation in China by Shuyu Han, Xiang Niu, Bing Wang, Zhangwei Wang, Xiaoshan Zhang, Qiang Wang, Jiajie Du, Pingping Liu, Donghuan Liu, Fengshi Pan, Tingyu Xu

“…Therefore, in this study, leaf mercury concentrations and mercury fluxes were analyzed in typical sample plots of each vegetation type, which were selected from 7 geographic regions in China. The results showed that the amount of litterfall of each component varied among different vegetation types, with leaves accounting for the largest proportion (51.12% to 80.54%). …”
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Field apple scab susceptibility of a diverse Malus germplasm collection identifies potential sources of resistance for apple breeding by David Papp, Liqiang Gao, Ranjita Thapa, Dan Olmstead, Awais Khan

“…Methods To identify new sources of scab resistance, we evaluated 177 Malus accessions, including 27 primary and 13 hybrid Malus species from diverse geographical origins, in an orchard at Geneva, New York. …”
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Epidemiology of chronic and acute pancreatitis in India (EPICAP-India): protocol for a multicentre study by Sanjeev Kumar, Saransh Jain, Vineet Ahuja, Rakesh Kumar, Anand Krishnan, Pankaj Bhardwaj, Shalimar, Nitya Wadhwa, Ashish Agarwal, Deepak Gunjan, Sudipta Dhar Chowdhury, Anoop Saraya, Saurabh Kedia, Govind K Makharia, Pramod Kumar Garg, Ritvik Amarchand, Deepti Dabar, Rajib Sarkar, Gopal Krishna Dhali, Anmol Gupta, Shivendra Singh, Divya Pillai, Vineeta Baloni, Subhra Samujjwal Basu, Bikash Choudhury, Soumi Das, Pradeep Deshmukh, Krishnadas Devadas, Nitika Monga, Sumit Rungta, Brij Sharma, Chintha Sujatha

“…We plan to cover 110 000 people across 10 geographically distributed sites in 10 states of India to estimate the burden and risk factors of CP. …”
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Molecular markers in the genetic analysis of crossability of bread wheat with rye by I. V. Porotnikov, O. Yu. Antonova, O. P. Mitrofanova

“…In this review, the following issues are considered: genetic resources created by wheat and rye hybridization, the geographical distribution of easy-to-cross forms of wheat, genetic control of the wheat and rye compatibility, advances of the use of molecular markers in the mapping of Kr-genes and their transmission control.…”
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Comparative Oil Composition Study of the Endemic Moroccan Olive (Olea europaea subsp. maroccana) and Wild Olive (var. Sylvestris) in Central West Morocco by Sara Elgadi, Ahmed Ouhammou, Hamza Zine, Nadia Maata, Rachid Ait Babahmad, Abderraouf El Antari

“…Sylvestris as well as comparing their proprieties during two consecutive years (2017 and 2018) from the same geographical area. The fatty acid and the sterol compositions were analysed using gas chromatography. …”
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“We need workable micronutrient data!”: a qualitative study assessing the need for integrated micronutrient data to support evidence-based decisions by Indian food system stakehold... by Rupinder Sahota, Jaswant S. Khokhar, Aakash Deep, Aakash Deep, Katherine P. Adams, Arindam Das, E. Louise Ander, E. Louise Ander, Edward J. M. Joy, Edward J. M. Joy

“…A need for district-level data with further geographical and temporal (including seasonal) disaggregation, with improved accessibility was also identified. …”
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Isolation and Characterization of Potential Antibiotic-Producing Actinomycetes from Water and Soil Sediments of Different Regions of Nepal by Bhanu Shrestha, Dharmendra Kumar Nath, Alina Maharjan, Anju Poudel, Roshani Nhuchhen Pradhan, Sagar Aryal

“…The actinomycetes are diversely distributed microorganisms in nature. The geographical diversity of Nepal is suitable for adaptation of various species of actinomycetes. …”
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Utilization of Interphalangeal Joint Arthroplasty and Arthrodesis in the United States From 2010 to 2019 by Erica L. Smearman, MD, PhD, Anthony L. Karzon, MD, Hayden L. Cooke, BS, Zaamin B. Hussain, MD, EdM, Musab Gulzar, BS, Nina Suh, MD, Michael B. Gottschalk, MD, Eric R. Wagner, MD, MS

“…Volume and incidence were estimated annually and according to sex, age, and US geographical region for 2010 and 2019. Results:. Annual volume and incidence of IPJ arthrodesis increased slightly from 2010 to 2019, though with overlapping confidence intervals for incidence. …”
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