Propionate metabolism in Desulfurella acetivorans by Eugenio Pettinato, Thomas M. Steiner, Eric A. Cassens, Thomas Geisberger, Christian Seitz, Simone König, Wolfgang Eisenreich, Ivan A. Berg

“…These results highlight the uncertainty of genomic predictions in the analysis of microbial metabolic pathways and the need for their experimental confirmation.…”
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Cancer multi-omics-based differential expression analysis and prognostic potential of identified hub targets of myco-metabolites for breast carcinoma and lung carcinoma by Singh Shreya, Debadatta Mohapatra, Gaurav Gopal Naik, Pooja Kathait, Soki Malang, Pradeep Patel, Shambhavi, Gulzar Alam, Alakh N. Sahu

“…In the present work, web servers UALCAN, GEPIA2, and KM plotter were used to explore the genomic and proteomic expression of these hub targets, along with their prognosis potential in BC and LC. …”
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Research Note: Novel reassortant avian influenza A(H9N2) Viruses in Wild Birds in Shanghai, China, 2020–2023 by Jie Hu, Yuting Xu, Min Ma, Chenyao Zhao, Yue Yuan, Guimei He

“…To better understand the genetic characteristics of these H9N2 viruses in Shanghai, the whole genome sequences were analyzed. Phylogenetical analysis showed that the nine H9N2 viruses have undergone complicated reassortment with waterfowl viruses along the East Asian-Australasian flyways. …”
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Cell migration in dense microenvironments by de Freitas Nader, Guilherme Pedreira, García-Arcos, Juan Manuel

“…The nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating extracellular mechanical inputs into intracellular signaling. …”
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How does the mode of evolutionary divergence affect reproductive isolation? by De Sanctis, Bianca, Schneemann, Hilde, Welch, John J.

“…When divergent populations interbreed, the outcome will be affected by the genomic and phenotypic differences that they have accumulated. …”
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Prion protein promotes copper toxicity in Wilson disease by Raffaella Petruzzelli, Federico Catalano, Roberta Crispino, Elena V. Polishchuk, Mariantonietta Elia, Antonio Masone, Giada Lavigna, Anna Grasso, Maria Battipaglia, Lucia Vittoria Sepe, Banu Akdogan, Quirin Reinold, Eugenio Del Prete, Diego Carrella, Annalaura Torella, Vincenzo Nigro, Enrico Caruso, Nicole Innocenti, Emiliano Biasini, Ludmila V. Puchkova, Alessia Indrieri, Ekaterina Y. Ilyechova, Pasquale Piccolo, Hans Zischka, Roberto Chiesa, Roman S. Polishchuk

“…Unfortunately, the molecular targets for normalizing Cu homeostasis in Wilson disease remain poorly understood. Here, using genome-wide screening, we identified the cellular prion protein (PrP) as an important mediator of Cu toxicity in WD. …”
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Gemcitabine combined with baicalein exerts antiviral activity against PEDV by inhibiting the entry and replication phases by Yingge Zheng, Yanfei Zhang, Fangying Xiong, Dehua Luo, Yuxiang Wang, Yijia Zhang, Dengguo Wei

“…Porcine epidemic diarrhea virus (PEDV) is a member of the Coronaviridae family, whose genome consists of a single strand of positive-sense RNA and has evolved into multiple epidemic lineages with no available drugs in clinical practice. …”
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Pengkontruksian Bidirected Overlap Graph untuk Perakitan Sekuens DNA by Wisnu Ananta Kusuma, Albert Adrianus

“…Tahapan ini diperlukan untuk merakit atau menyambungkan kembali fragmen-fragmen DNA (reads) yang dihasilkan oleh Next Generation Sequencing menjadi genom yang utuh. Masalah perakitan DNA ini dapat direpresentasikan sebagai masalah Shortest Common Superstring (SCS). …”
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Integrative prognostic modeling of ovarian cancer: incorporating genetic, clinical, and immunological markers by Aidi Lin, Feifei Xue, Chenxiang Pan, Lijiao Li

“…Utilizing data from The Cancer Genome Atlas (TCGA), we identified significant prognostic genes through differential expression and survival analysis, integrating these with clinical features and immune landscape assessments including immune cell infiltration and checkpoint expression. …”
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Detection of gene mutation in a case of Nagashima-type palmoplantar keratoderma by CAO Yuanyuan, YUAN Zhaojun, JIN Chuanyang, WANG Tianzi, LIAO Xiaojie, LIU Hong

“…[Methods] Clinical data of the patient were collected. Genomic DNA was extracted from the patient′s peripheral blood sample. …”
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Effects of mode of reproduction on genetic polymorphism and divergence in wild yams (Dioscoreaceae: Dioscorea) by Xin Wang, Qing-Hong Feng, Zhi-Hua Zeng, Zhi-Qiang Zhang, Jie Cai, Gao Chen, De-Zhu Li, Hong Wang, Wei Zhou

“…Evolutionary transitions from sexual to asexual reproduction should have significant influences on genetic divergence and polymorphism at the genome level. Plant lineages with diverse reproductive systems provide opportunities to investigate this question using comparative approaches and studies of molecular evolution. …”
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The association of codon 392 polymorphism in ESR2 gene with breast cancer in Iran by Sakineh Abbasi, Samira Kalbasi

“…Epidemiological studies revealed that the pattern of age onset of breast cancer in the Middle East region differ from those in Caucasians. Therefore, genomic data for ESR2 (ER-?) is of the value in the clinical setting for that ethnic group and the aim of the current investigation is investigated whether polymorphisms in the ER-? …”
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STUDY OF Bacillus licheniformis BACTERIA AS A BIO-CONTROL AGENT IN REDUCING AFLATOXIN B1 TOXICITY IN DRIED GRAPE SAMPLES by H. Z. Hussein, E. K. Abdul-Karim, M. I. Alghannoum

“…The isolate with the highest toxin production was identified through nucleotide sequences deposited in the World Genomic Organization's Gene Bank under accession number OR192858. …”
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Genetics and biological characteristics of duck reoviruses isolated from ducks and geese in China by Xiaohong Sun, Jing Guo, Jinyan Shen, Mengdi Guan, Lili Liu, Yujiao Xie, Hongke Xu, Mengjing Wang, Anran Ren, Wenxi Li, Feng Cong, Xuyong Li

“…In this study, we identified and isolated six duck reoviruses from clinical samples of sick or deceased farmed ducks and geese and sequenced their full genomes. Phylogenetic analysis revealed the evolutionary landscape of duck reoviruses and the complex reassortment of these circulating viruses with avian orthoreovirus and Muscovy duck reovirus. …”
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Inactivation of the CMAH gene and deficiency of Neu5Gc play a role in human brain evolution by Yuxin Liu, Jinhong Li, Qicai Liu

“…Abstract During human evolution, some genes were lost or silenced from the genome of hominins. These missing genes might be the key to the evolution of humans’ unique cognitive skills. …”
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ASGCL: Adaptive Sparse Mapping-based graph contrastive learning network for cancer drug response prediction. by Yunyun Dong, Yuanrong Zhang, Yuhua Qian, Yiming Zhao, Ziting Yang, Xiufang Feng

“…Personalized cancer drug treatment is emerging as a frontier issue in modern medical research. Considering the genomic differences among cancer patients, determining the most effective drug treatment plan is a complex and crucial task. …”
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Drosophila melanogaster as an alternative animal model in fat metabolism studies by Dilan de Silva, Mangala Gunatilake

“…It serves as one of the best alternative model organisms as it comprises most genes related to metabolism which are conserved in the human genome. The simplicity in genetics as well as their rapid life cycle makes it a righteous model organism that can be efficiently utilized in research. …”
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A biallelically active embryonic enhancer dictates GNAS imprinting through allele-specific conformations by Yorihiro Iwasaki, Monica Reyes, Harald Jüppner, Murat Bastepe

“…Abstract Genomic imprinting controls parental allele-specific gene expression via epigenetic mechanisms. …”
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Massively parallel variant-to-function mapping determines functional regulatory variants of non-small cell lung cancer by Congcong Chen, Yang Li, Yayun Gu, Qiqi Zhai, Songwei Guo, Jun Xiang, Yuan Xie, Mingxing An, Chenmeijie Li, Na Qin, Yanan Shi, Liu Yang, Jun Zhou, Xianfeng Xu, Ziye Xu, Kai Wang, Meng Zhu, Yue Jiang, Yuanlin He, Jing Xu, Rong Yin, Liang Chen, Lin Xu, Juncheng Dai, Guangfu Jin, Zhibin Hu, Cheng Wang, Hongxia Ma, Hongbing Shen

“…Abstract Genome-wide association studies have identified thousands of genetic variants associated with non-small cell lung cancer (NSCLC), however, it is still challenging to determine the causal variants and to improve disease risk prediction. …”
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XGBoost-enhanced ensemble model using discriminative hybrid features for the prediction of sumoylation sites by Salman Khan, Sumaiya Noor, Tahir Javed, Afshan Naseem, Fahad Aslam, Salman A. AlQahtani, Nijad Ahmad

“…Abstract Posttranslational modifications (PTMs) are essential for regulating protein localization and stability, significantly affecting gene expression, biological functions, and genome replication. Among these, sumoylation a PTM that attaches a chemical group to protein sequences—plays a critical role in protein function. …”
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