Multiomics integration unravels genotype‐microbiome interactions shaping the conjunctival transcriptome by Qiaoxing Liang, Guo‐Wang Lin, Xiaohu Ding, Bin Zou, Xiaomin Liu, Jing Li, Yuxin Zhang, Xiaofeng Wen, Lingyi Liang, Jin‐Xin Bei, Mingguang He, Huijue Jia, Lai Wei

“…We developed a modeling approach, MicroGenix, that screens for GMIs from host genome, transcriptome, and microbiome data and identifies GMIs associated with the disease through gene‐based association tests. …”
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The causal relationship between steroid hormones and risk of stroke: evidence from a two-sample Mendelian randomization study by Yang Zhang, Miaowen Jiang, Di Wu, Ming Li, Xunming Ji

“…Therefore, Mendelian randomization (MR) technique was employed in this study to examine this association. Through genome-wide association meta-analysis, the genetic variants of steroid hormones, including testosterone/17β-estradiol (T/E2) ratio, aldosterone, androstenedione, progesterone, and hydroxyprogesterone, were acquired as instrumental variables. …”
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Renin-Angiotensin System Gene Variants and Type 2 Diabetes Mellitus: Influence of Angiotensinogen by Siew Mei Joyce-Tan, Shamsul Mohd Zain, Munavvar Zubaid Abdul Sattar, Nor Azizan Abdullah

“…Genome-wide association studies (GWAS) have been successfully used to call for variants associated with diseases including type 2 diabetes mellitus (T2DM). …”
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Selective utilization of medicinal polysaccharides by human gut Bacteroides and Parabacteroides species by Zepeng Qu, Hongbin Liu, Ji Yang, Linggang Zheng, Jumin Huang, Ziming Wang, Chun Xie, Wenlong Zuo, Xiong Xia, Lin Sun, Yifa Zhou, Ying Xie, Jingguang Lu, Yizhun Zhu, Lili Yu, Lihua Liu, Hua Zhou, Lei Dai, Elaine Lai-Han Leung

“…This distinct utilization profile was associated with genomic variation in carbohydrate-active enzymes, rather than monosaccharides composition variation among medicinal polysaccharides. …”
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The Proviral Reservoirs of Human Immunodeficiency Virus (HIV) Infection by Andrey I. Murzin, Kirill A. Elfimov, Natalia M. Gashnikova

“…Human Immunodeficiency Virus (HIV) proviral reservoirs are cells that harbor integrated HIV proviral DNA within their nuclear genomes. These cells form a heterogeneous group, represented by peripheral blood mononuclear cells (PBMCs), tissue-resident lymphoid and monocytic cells, and glial cells of the central nervous system. …”
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Multi-omic spatial effects on high-resolution AI-derived retinal thickness by V. E. Jackson, Y. Wu, R. Bonelli, J. P. Owen, L. W. Scott, S. Farashi, Y. Kihara, M. L. Gantner, C. Egan, K. M. Williams, B. R. E. Ansell, A. Tufail, A. Y. Lee, M. Bahlo

“…The macula is disproportionately affected by high disease burden retinal disorders such as age-related macular degeneration and diabetic retinopathy, which both involve metabolic dysregulation. Analysis of common genomic variants, metabolomic, blood and immune biomarkers, disease PheCodes and genetic scores across a fine-scale macular thickness grid, reveals multiple novel genetic loci including four on the X chromosome; retinal thinning associated with many systemic disorders including multiple sclerosis; and multiple associations to correlated metabolites that cluster spatially in the retina. …”
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Marker-Assisted Selection for Recognizing Wheat Mutant Genotypes Carrying HMW Glutenin Alleles Related to Baking Quality by Mohammad Javad Zamani, Mohammad Reza Bihamta, Behnam Naserian Khiabani, Zahra Tahernezhad, Mohammad Taher Hallajian, Marzieh Varasteh Shamsi

“…Some of the primers were extracted from previous studies and the others were designed based on D genome subunits of wheat. SDS-PAGE method accomplished having confidence in these marker’s results. …”
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A review of simulation and modeling approaches in microbiology by A. I. Klimenko, Z. S. Mustafin, A. D. Chekantsev, R. K. Zudin, Yu. G. Matushkin, S. A. Lashin

“…The multiaspect nature of integration approaches used to model microbial communities is based on the need to take into account heterogeneous data obtained from various sources by applying high-throughput genome investigation methods.…”
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Studying the effect of the OsGATA rice transcription factor on salt stress tolerance in wheat by A. A. Verbitskaia, A. S. Egorova, E. A. Tsarkova, A. K. Gaponenko

“…Genetic transformation methods were used to introduce the GATA gene into the genome of the used wheat genotypes. Transgenic lines were selected on selective media under in vitro conditions.The results of the experimental work showed that the expression of the GATA gene under salt stress may be responsible for the increased compartmentalization of Na+ in the vacuole, which provides improved salt tolerance. …”
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Poly ADP-Ribosylation in a Plant Pathogenic Oomycete <i>Phytophthora infestans</i>: A Key Controller of Growth and Host Plant Colonisation by Viktoriya O. Samarskaya, Sofya Koblova, Tatiana Suprunova, Eugene A. Rogozhin, Nadezhda Spechenkova, Sofiya Yakunina, Andrew J. Love, Natalia O. Kalinina, Michael Taliansky

“…Here, we show that the <i>Phytophthora infestans</i> genome contains two PARP-like protein genes (PiPARP1 and PiPARP2), and provide evidence of PARylation activity for one of them (PiPARP2). …”
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Genetic Polymorphisms in the DR2D, ANKK1, COMT, 5HTT Genes and Dental Fluorosis: Is There Any Interplay? by Luíse Gomes de Souza, Paula Cruz Porto Spada, Juliana Feltrin de Souza, Daniela Silva Barroso de Oliveira, Letícia Maira Wambier, Erika Calvano Küchler, João Armando Brancher

“…Material and Methods: 256 adolescents were examined, and dental fluorosis was diagnosed using the modified Dean index. Genomic DNA was collected, and seven single nucleotide polymorphisms (SNPs), two in the DRD2 (rs6275 and rs6276), one in the ANKK1 (rs1800497), two in the COMT (rs6269 and rs4818), and two in the 5HTT (rs3813034 and rs1042173) were selected. …”
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A Network Pharmacology Study on the Cervix Prescription for Treatment of Cervical Cancer by Yingping Zhu, Liangping Wang, Leilai Xu, Pian Ying

“…Gene ontology (GO) and Kyoto Gene and Genome Encyclopedia (KEGG) pathway enrichment analysis of overlapping targets were performed using DAVID 6.8 online tool. …”
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Small Bowel Adenocarcinoma as the Cause of Gastrointestinal Bleeding in Celiac Disease: A Rare Malignancy in a Common Disease by Jaleh Fallah, Maxwell Eyram Afari, Alfredo C. Cordova, Adam J. Olszewski, Taro Minami

“…Small bowel carcinomas occurring in the context of celiac disease appear to be associated with higher rates of microsatellite instability than sporadic tumors, although other specific genomic abnormalities and mechanisms of carcinogenesis in celiac disease remain unknown. …”
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Decoding vascular aging: implications for atherosclerosis progression and clinical intervention by Silumbwe Ceaser Wankumbu, Xiao-Man Ji, Ming Xu

“…In the review, we highlighted five altered vascular mechanisms in cardiovascular models: genomic instability, neurohormonal deregulation, epigenetics, protein regulation, and the gut microbiome. …”
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Integration of circulating tumor DNA in biliary tract cancer: the emerging landscape by Joy A Awosika, Cecilia Monge, Tim F Greten

“…The acquisition of tissue tumor DNA for genomic analysis in BTC is often anatomically challenging, limited by quantity and quality. …”
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Molecular genetic methods for intestinal microbiome investigation by O. L. Kardymon, A. V. Kudryavtseva

“…Modern molecular genetic methods of microbial investigation combined to the established methods of classical microbiology give the chance not only to identify microorganism species and even a strain, but also to decipher their genomes, to estimate antibiotic resistance and to establish its mechanism at genetic level, to estimate specific properties of specific microbial strain that will allow to define potential and efficacy of their clinical application etc. …”
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Genetic Instability Promotes the Acquisition of Chromosomal Imbalances in T1b and T1c Breast Adenocarcinomas by Harald Blegen, B. Michael Ghadimi, Annukka Jauho, Anders Zetterberg, Elina Eriksson, Gert Auer, Thomas Ried

“…Our results suggest that the sequential acquisition of genomic imbalances during tumor progression is accelerated in aneuploid tumors, and may contribute to the increased malignancy potential.…”
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Linking Epigenetics to Human Disease and Rett Syndrome: The Emerging Novel and Challenging Concepts in MeCP2 Research by Robby Mathew Zachariah, Mojgan Rastegar

“…While MeCP2 was originally found to bind methylated DNA and interact with repressor complexes to inhibit and silence its genomic targets, recent studies have challenged this idea. …”
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Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy by Sang‑Hyuk Jung, Haemin Kim, Young Mi Jung, Manu Shivakumar, Brenda Xiao, Jaeyoung Kim, Beomjin Jang, Jae-Seung Yun, Hong-Hee Won, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun, Dokyoon Kim, Seung Mi Lee

“…We evaluate the genetic risk for hypertensive disorders of pregnancy using a genome-wide polygenic risk score derived from a large-scale GWAS. …”
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Genetic Variants Related to Increased CKD Progression—A Systematic Review by Filipe S. Mira, Bárbara Oliveiros, Isabel Marques Carreira, Rui Alves, Ilda Patrícia Ribeiro

“…The selected studies included cohort studies, case-control studies, and genome-wide association studies (GWASs). The studies involved patients of different ethnicities and with comorbid diseases. …”
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