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3641
Human microbiomes in cancer development and therapy
Published 2023-04-01“…Abstract Colonies formed by bacteria, archaea, fungi, and viral groups and their genomes, metabolites, and expressed proteins constitute complex human microbiomes. …”
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3642
Improved 11α-hydroxycanrenone production by modification of cytochrome P450 monooxygenase gene in Aspergillus ochraceus
Published 2021-03-01“…To improve the efficiency of 11α-hydroxycanrenone production, the CYP monooxygenase-coding gene of MF018 was predicted and cloned based on whole-genome sequencing results. A recombinant A. ochraceus strain MF010 with the high expression of CYP monooxygenase was then obtained through homologous recombination. …”
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3643
Induced Pluripotent Stem Cells in Cardiovascular Medicine
Published 2011-01-01“…Human iPS cells are currently generated by transgene introduction principally through viral vectors, which integrate into host genomes, although the associated risk of tumorigenesis is driving research into nonintegration methods. …”
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3644
Detection of Chromosome X;18 Breakpoints and Translocation of the Xq22.3;18q23 Regions Resulting in Variable Fertility Phenotypes
Published 2012-01-01“…Maternal inheritance and various genomic events contributed to the resultant genotypes. …”
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3645
The association of codon 392 polymorphism in ESR2 gene with breast cancer in Iran
Published 2019-12-01“…Epidemiological studies revealed that the pattern of age onset of breast cancer in the Middle East region differ from those in Caucasians. Therefore, genomic data for ESR2 (ER-?) is of the value in the clinical setting for that ethnic group and the aim of the current investigation is investigated whether polymorphisms in the ER-? …”
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3646
MftG is crucial for ethanol metabolism of mycobacteria by linking mycofactocin oxidation to respiration
Published 2025-01-01“…Here, we show that MftG enzymes are almost exclusively found in genomes containing mycofactocin biosynthetic genes and are present in 75% of organisms harboring these genes. …”
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3647
Gastric Cancer in Young Adults: A Different Clinical Entity from Carcinogenesis to Prognosis
Published 2020-01-01“…According to molecular classifications, the cancer of most GCYA patients belongs to the genomically stable or microsatellite stable/epithelial-mesenchymal transition subtype, with the common genetic aberrations being mutations in CDH1. …”
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3648
8q22.2q22.3 Microdeletion Syndrome Associated with Hearing Loss and Intractable Epilepsy
Published 2019-01-01“…A minimal/maximal deletion of 5.238 Mb and 5.374Mb, respectively, at 8q22.2q22.3 was diagnosed using a genome-wide array. The clinical phenotype is similar to the others seven patients previously reported; however, the severity of epilepsy and the concomitant hearing loss is remarkable, characteristics previously observed independently in only two patients. …”
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3649
Global evolution of research on autohydrolysis (hydrothermal) pretreatment as a green technology for biorefineries: A bibliometric analysis
Published 2025-02-01“…Concurrently, the domain of hydrothermal pretreatment has progressively become more cross-disciplinary, intertwining with the sectors of microbial populations and genomes.…”
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3650
STUDY OF Bacillus licheniformis BACTERIA AS A BIO-CONTROL AGENT IN REDUCING AFLATOXIN B1 TOXICITY IN DRIED GRAPE SAMPLES
Published 2025-01-01“…The isolate with the highest toxin production was identified through nucleotide sequences deposited in the World Genomic Organization's Gene Bank under accession number OR192858. …”
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3651
ncRNA-Mediated High Expression of LPCAT1 Correlates with Poor Prognosis and Tumor Immune Infiltration of Liver Hepatocellular Carcinoma
Published 2022-01-01“…In this study, expression analysis and survival analysis for LPCAT1 in pan cancers were first performed by using The Cancer Genome Atlas (TCGA) data, which suggested that LPCAT1 might be a potential LIHC oncogene. …”
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3652
Amino Acid-Mediated Metabolism: A New Power to Influence Properties of Stem Cells
Published 2019-01-01“…This review summarizes the metabolic characteristics and regulation pathways of AA in different stem cells, not only from the nutritional perspective but also from the genomic perspective that have been reported in the recent five years. …”
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3653
Identification of DLEC1 D215N Somatic Mutation in Formalin Fixed Paraffin Embedded Melanoma and Melanocytic Nevi Specimens
Published 2013-01-01“…DLEC1 D215N somatic mutation (COSM36702) was identified in a melanoma cell line through whole genome sequencing. However, little is known about the implication and prevalence of this mutation in primary melanomas or in melanocytic nevi. …”
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3654
Advances in PIWI-piRNA function in female reproduction in mammals
Published 2024-11-01“…PIWI-interacting RNAs (piRNAs), which associate with PIWI clade Argonaute proteins to form piRNA-induced <sc>silencing</sc> complexes (piRISCs) in germline cells, are responsible for maintaining genomic integrity and reproductive function through transcriptional or post-transcriptional suppression of transposable elements and regulation of protein-coding genes. …”
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3655
Exploring PANoptosis in head and neck cancer: A novel approach to cancer therapy
Published 2025-01-01“…This study utilises transcriptomic and clinical data related to HNSC from the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. …”
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3656
Identification of Genes Regulating Gene Targeting by a High-Throughput Screening Approach
Published 2011-01-01“…Homologous gene targeting (HGT) is a precise but inefficient process for genome engineering. Several methods for increasing its efficiency have been developed, including the use of rare cutting endonucleases. …”
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3657
DNA Extraction from Bronchial Aspirates for Molecular Cytology: Which Method to Take?
Published 2003-01-01“…It was the aim of the present study to evaluate the ability of 50% ethanol/2% carbowax (Saccomanno fixative) to preserve bronchial secretions with high quality genomic DNA as well as to compare different DNA extraction methods. …”
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3658
Biofilm-associated proteins: from the gut biofilms to neurodegeneration
Published 2025-12-01“…It discusses the biofilm-associated proteins (BAPs) of the gut microbiota, maps the amyloidogenic domains of these proteins, and analyzes the presence of bap genes within accessory genomes linked with transposable elements. Furthermore, the evidence supporting the existence of amyloids in the gut are presented. …”
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3659
Vaccination with an Attenuated Ferritin Mutant Protects Mice against Virulent Mycobacterium tuberculosis
Published 2015-01-01“…However, significant distinctions in the disease pathology and host genome-wide lung transcriptome suggest improved containment of Mtb infection in animals vaccinated with the bfrB mutant, compared to BCG. …”
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3660
Genetics and biological characteristics of duck reoviruses isolated from ducks and geese in China
Published 2025-02-01“…In this study, we identified and isolated six duck reoviruses from clinical samples of sick or deceased farmed ducks and geese and sequenced their full genomes. Phylogenetic analysis revealed the evolutionary landscape of duck reoviruses and the complex reassortment of these circulating viruses with avian orthoreovirus and Muscovy duck reovirus. …”
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