The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis by Samuel García, Carmen Conde

“…Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme with a crucial role in the maintenance of genomic stability. In addition to the role of PARP-1 in DNA repair, multiple studies have also demonstrated its involvement in several inflammatory diseases, such as septic shock, asthma, atherosclerosis, and stroke, as well as in cancer. …”
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Pantoea eucrina: Catheter‐Related Bloodstream Infection in a Woman With Short Bowel Syndrome by Ida Saksenborg Kølle, Lars Vinter‐Jensen, Morten Eneberg Nielsen, Hans Linde Nielsen

“…Despite presenting with only minor clinical symptoms, blood cultures from both central and peripheral sites confirmed the presence of P. eucrina, identified by matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS) and whole‐genome sequencing. The infection was successfully cleared following a 13‐day course of gentamicin lock therapy and intravenous piperacillin–tazobactam, after which the catheter was removed.…”
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Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA Damage by David Reisman, Paula Takahashi, Amanda Polson, Kristy Boggs

“…The p53 tumor suppressor induces the transcription of genes that negatively regulate progression of the cell cycle in response to DNA damage or other cellular stressors and thus participates in maintaining genome stability. Numerous studies have demonstrated that p53 transcription is activated before or during early S-phase in cells progressing from G0/G1 into S-phase through the combined action of two DNA-binding factors RBP-Jκ and C/EBPβ-2. …”
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HERITAGE OF ACADEMICIAN N.V. TSITSIN: STATE-OF-THE-ART AND POTENTIAL OF THE COLLECTION OF INTERMEDIATE WHEAT × COUCH-GRASS HYBRIDS by V. P. Upelniek, V. I. Belov, I. P. Ivanova, S. P. Dolgova, A. S. Demidov

“…Data on the biodiversity of botanical varieties of the Triticum agropyrotriticum Cicin species, gliadin polymorphism, and genome in situ hybridization are provided.…”
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The role of oestrogen and oestrogen-calcium axis in endometrial carcinoma by Jingyi Zhou, Jianliu Wang, Xuerun Liu

“…In recent years, a series of studies by our team revealed that the non-genomic transcriptional effects of oestrogen can influence the progression of endometrial carcinoma by regulating calcium ions, suggesting that inhibiting calcium ion channel proteins could serve as an adjuvant therapy for endometrial cancer. …”
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iPSCs: A Minireview from Bench to Bed, including Organoids and the CRISPR System by Andrés Javier Orqueda, Carla Alejandra Giménez, Federico Pereyra-Bonnet

“…When Dolly the sheep was born, the first probe into an adult mammalian genome traveling back in time and generating a whole new animal appeared. …”
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VALUE FOUNDATIONS OF SCIENTIFIC KNOWLEDGE (Conference Review) by Galina L. Belkina, Sergey N. Korsakov

“…The consequences of interference in genome, physiology, human mentality can be irreversible and fatal. …”
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Protocol for in vivo chromatin immunoprecipitation on purified chromatin isolated from mouse liver nuclei by Lei Li, May G. Akl, Scott B. Widenmaier

“…Summary: Chromatin immunoprecipitation (ChIP) is used to investigate genome binding by transcription factors, but it can be problematic. …”
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Study of pathogenesis and immune response at experimental infection of broiler chicks with avian metapneumovirus subtype В by M. A. Volkova, P. S. Yaroslavtseva, V. Yu. Sosi Pato Rova, T. L. Eroshina, I. A. Chvala

“…Using real-time RT-PCR avian metapneumovirus genome was detected in the upper part of the respiratory tract, infraorbital sinuses and Harderian gland within 2-12 days post infection. …”
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New data on the distribution of six morphologically cryptic species of Niphargus stygius species complex (Amphipoda: Niphargidae) by Janko Šet, Špela Borko

“… Subterranean amphipods, morphologically resembling Niphargus stygius species complex, were molecularly analysed. We isolated genomic DNA and amplified the subunit I of mitochondrial cytochrome oxidase gene (COI) for 94 specimens from 37 localities. …”
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Beyond DNA: An Integrated and Functional Approach for Classifying Germline Variants in Breast Cancer Genes by T. Pesaran, R. Karam, R. Huether, S. Li, S. Farber-Katz, A. Chamberlin, H. Chong, H. LaDuca, A. Elliott

“…We discuss some of the nuances that should be considered in the assessment of genomic variants. In addition, we highlight lines of evidence such as functional assays and structural analysis that can be useful in the assessment of rare and complex variants.…”
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Single-nucleotide polymorphisms in dizygotic twin ovine fetuses are associated with discordant responses to antenatal steroid therapy by Erin L. Fee, Haruo Usuda, Sean W. D. Carter, Hideyuki Ikeda, Tsukasa Takahashi, Yuki Takahashi, Yusaku Kumagai, Michael W. Clarke, Demelza J. Ireland, John P. Newnham, Masatoshi Saito, Sebastian E. Illanes, Binny Priya Sesurajan, Liang Shen, Mahesh A. Choolani, Gokce Oguz, Adaikalavan Ramasamy, Sara Ritchie, Andrew Ritchie, Alan H. Jobe, Matthew W. Kemp

“…We aimed to test the degree of concordance in preterm lung function, and correlate this with genomic, transcriptomic, and pharmacokinetic variables in preterm dizygotic twin ovine fetuses. …”
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Low & Anaplastic Grade Glioma Umbrella Study of MOlecular Guided TherapieS (LUMOS-2): study protocol for a phase 2, prospective, multicentre, open-label, multiarm, biomarker-direct... by Marshall Pitz, Eng-Siew Koh, Elizabeth H Barnes, Lucille Sebastian, Mandy L Ballinger, David M Thomas, Christopher O'Callaghan, John Simes, Hui K Gan, Sonia Yip, Hao-Wen Sim, Desma Spyridopoulos, Richard De Abreu Lourenco, Cynthia Hawkins, Kristen McParland, Benjamin Kong, Subotheni Thavaneswaran, Patrick J Wheeler

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Multi-Omics Insights into Regulatory Mechanisms Underlying Differential Deposition of Intramuscular and Abdominal Fat in Chickens by Yuxin Xing, Chenglin Ma, Hongbo Guan, Jianing Shen, Ying Shen, Guoxi Li, Guirong Sun, Yadong Tian, Xiangtao Kang, Xiaojun Liu, Hong Li, Weihua Tian

“…This review systematically summarizes the regulatory mechanisms underlying intramuscular and abdominal fat traits at chromatin, genomic, transcriptional, post-transcriptional, translational, and epigenetic-modification scales. …”
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RECONSTRUCTION OF AMINO ACID SEQUENCES OF CYCLIC PEPTIDES FROM THEIR MASS SPECTRA by E. S. Fomin

“…It allows us both to solve the problem of identification of biological macromolecules and to sequence peptide chains in cases where information on the genomes is scarce or absent. Currently, there are many software programs to support research in this area. …”
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MDM4 Isoform Expression in Melanoma Supports an Oncogenic Role for MDM4-A by Abdullah Alatawi, SoonJye Kho, Michael P. Markey

“…Here, we examine the expression of the two primary inhibitors of p53, MDM2 and MDM4, in genomic databases and biopsy specimens. We find that MDM4 is frequently overexpressed. …”
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Conceptualizing Human Microbiota: From Multicelled Organ to Ecological Community by Betsy Foxman, Deborah Goldberg, Courtney Murdock, Chuanwu Xi, Janet R. Gilsdorf

“…This diverse microbiome (the collective genomes of the microbial symbionts that inhabit a human host) is essential for human functioning. …”
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C-Reactive Protein and Coronary Heart Disease: All Said—Is Not It? by Frederik Strang, Heribert Schunkert

“…This review will highlight the complex results of genomic, epidemiological, and experimental studies on CRP and will show why further studies investigating the relationship between CRP and atherosclerosis might be needed.…”
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Design of therapeutic siRNAs for potential application to infection with chikungunya virus by Ahmed Ahsan Adib, Muhammad Manjurul Karim

“…Here, we considered various parts of the CHIKV genome encoding different essential protein-coding genes for designing siRNAs with a view to silencing them, thereby rendering the virus inactive. …”
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Plasmid Gene Therapy for Monogenic Disorders: Challenges and Perspectives by Marco A. Luís, Marcelo A. D. Goes, Fátima Milhano Santos, Joana Mesquita, Paulo Tavares-Ratado, Cândida Teixeira Tomaz

“…However, despite advancements in gene manipulation tools and delivery systems, several challenges remain unresolved, including inefficient delivery, lack of sustained expression, immunogenicity, toxicity, capacity limitations, genomic integration risks, and limited tissue specificity. …”
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