MicroRNA Profiling: From Dark Matter to White Matter, or Identifying New Players in Neurobiology by Anna M. Krichevsky

“…Missed by researchers for decades due to their tiny size, usually mapping to non-protein-coding regions of genomes, miRNAs and miRNA-mediated regulatory networks have been the “dark matter” of molecular biology. …”
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Blood-based DNA methylation markers for lung cancer prediction by Marc Chadeau-Hyam, Paolo Vineis, Caroline Relton, Mattias Johansson, Gianluca Severi, Roger L Milne, Melissa C Southey, Pierre-Antoine Dugué, Florence Guida, Mikael Johansson, Torkjel Sandanger, Justina Ucheojor Onwuka, Ryan Langdon, Therese Haugdahl Nøst, Hilary A. Robbins, Matthew Suderman

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Human soft tissue sarcomas harbor an intratumoral viral microbiome which is linked with natural killer cell infiltrate and prognosis by William J Murphy, Robert J Canter, Nikhil Joshi, Sean J Judge, Morgan A Darrow, Steve W Thorpe, Alicia A Gingrich, Lauren M Perry, Sylvia M Cruz, Kara T Kleber, Louis B Jones, Ugur N Basmaci, Matthew L Settles, Blythe P Durbin-Johnson, Arta Monir Monjazeb, Janai Carr-Ascher, Jonathan A Eisen

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Single-cell multiomics reveal divergent effects of DNMT3A- and TET2-mutant clonal hematopoiesis in inflammatory response by Wazim Mohammed Ismail, Jenna A. Fernandez, Moritz Binder, Terra L. Lasho, Minsuk Kim, Susan M. Geyer, Amelia Mazzone, Christy M. Finke, Abhishek A. Mangaonkar, Jeong-Heon Lee, Liguo Wang, Kwan Hyun Kim, Vernadette A. Simon, Fariborz Rakhshan Rohakthar, Amik Munankarmy, Seul Kee Byeon, Susan M. Schwager, Jonathan J. Harrington, Melissa R. Snyder, Keith D. Robertson, Akhilesh Pandey, Eric D. Wieben, Nicholas Chia, Alexandre Gaspar-Maia, Mrinal M. Patnaik

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Craniodentofacial Manifestations in a Rare Syndrome: Orofaciodigital Type IV (Mohr-Majewski Syndrome) by Meltem Ozdemir-Karatas, Didem Ozdemir-Ozenen, P. Suzanne Hart, Thomas C. Hart

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Linking obesity-associated genotype to child language development: the role of early-life neurology-related proteomics and brain myelinationResearch in context by Jian Huang, Jinyi Che, Michelle Z.L. Kee, Ai Peng Tan, Evelyn C. Law, Patricia Pelufo Silveira, Irina Pokhvisneva, Sachin Patel, Keith M. Godfrey, Lourdes Mary Daniel, Kok Hian Tan, Yap Seng Chong, Shiao-Yng Chan, Johan G. Eriksson, Dennis Wang, Jonathan Yinhao Huang

“…Interpretation: This study demonstrates the potential of examining early-life proteomics in conjunction with deep genotyping and phenotyping and provides biological insights into the shared genomic links between obesity and language development. …”
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Functional analysis of a novel homozygous missense IVD gene variant: a case report with dual genetic diagnoses by Yuying Zhu, Ke Wu, Hanying Wen

“…BackgroundGenomic or exome sequencing is beneficial for identifying more than one pathogenic variation causing blended atypical and/or severe phenotypes. …”
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Cryptic species and hybridisation in corals: challenges and opportunities for conservation and restoration by Riginos, Cynthia, Popovic, Iva, Meziere, Zoe, Garcia, Vhon, Byrne, Ilha, Howitt, Samantha M., Ishida, Hisatake, Bairos-Novak, Kevin, Humanes, Adriana, Scharfenstein, Hugo, Richards, Thomas, Briggs, Ethan, Clark, Vanessa, Lei, Chuan, Khan, Mariam, Prata, Katharine E.

“…Here, we investigate the prevalence of cryptic coral groups and assess evidence for their permeability to gene flow (hybridisation) via a structured literature review of genomic studies. Using reproducible criteria to detect distinct genetic groups that are sympatric, we find that 68% of nominal species represented in population genomic studies show evidence for comprising partially reproductively isolated groups and that these distinct groups are often linked by gene flow. …”
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Characterization of novel human endogenous retrovirus structures on chromosomes 6 and 7 by Nicholas Pasternack, Nicholas Pasternack, Ole Paulsen, Avindra Nath

“…Human endogenous retroviruses (HERV) represent nearly 8% of the human genome. Of these, HERV-K subtype HML-2 is a transposable element that plays a critical role in embryonic development and in the pathogenesis of several diseases. …”
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The Single-Nucleotide Polymorphism (SNP) Validity to Detect Omicron Variants by Lia Gardenia Partakusuma, Luhung Budiailmiawan, null Budiman, Ida Parwati, null Aryati, Basti Andriyoko, Louisa Markus, Corine Niswara, Cut Nur Cinthia Alamanda

“…Variants of SARS-CoV-2 are determined by the whole genome sequencing (WGS) assay, which is time-consuming, with limited availability (only in several laboratories). …”
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Genetic control of N-glycosylation of human blood plasma proteins by S. Zh. Sharapov, A. N. Timoshchuk, Y. S. Aulchenko

“…It also reviews the results of studies of environmental and genetic factors contributing to the variability of N-glycans as well as the mapping results of the genomic loci of N-glycans by GWAS. The results of functional in vitro and in silico studies are described. …”
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The consensus rye microsatellite map with EST-SSRs transferred from wheat by D. O. Vidakovic, D. Perovic, T. V. Semilet, A. Börner, E. K. Khlestkina

“…One of the sources of novel SSR markers in rye are microsatellites transferable from the wheat genome. Broadening the list of available SSRs in rye mapped to chromosomes is still needed, since some rye chromosome maps still have just a few microsatellite loci mapped. …”
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Development of RT-PCR Assays for Simple Detection and Identification of Sabin Virus Contaminants in the Novel Oral Poliovirus Vaccines by Olga Singh, Hasmik Manukyan, Erman Tritama, Shwu-Maan Lee, Jerry P. Weir, Majid Laassri

“…The nOPV vaccines have a high degree of sequence homology with the parental Sabin 2 genome, and some manufacturing facilities produce and store both Sabin OPV and nOPV. …”
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First note of QTL mapping of low vigor traits using the updated F2 ‘Koroneiki’ linkage map of olive by Irene Granata, Aparna S. Balan, Aparna S. Balan, Claudio Di Vaio, Antonino Ioppolo, Tiziano Caruso, Silvia Fretto, Jubina Benny, Antonio Giovino, Daniel James Sargent, Francesco Paolo Marra, Annalisa Marchese

“…By integrating reference genomes with our genetic analysis, we offer a conceptual advancement that could substantially accelerate breeding timelines compared to traditional approaches. …”
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Altered Viral Replication and Cell Responses by Inserting MicroRNA Recognition Element into PB1 in Pandemic Influenza A Virus (H1N1) 2009 by Xiaoyue Shen, Wenkui Sun, Yi Shi, Zheng Xing, Xin Su

“…Engineering mutant viruses by inserting cell-specific miRNA recognition element (MRE) into viral genome may alter viral infectivity and host responses in vital tissues and organs infected with pandemic influenza A virus (H1N1) 2009 (H1N1pdm). …”
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Faecalibacterium prausnitzii regulates carbohydrate metabolic functions of the gut microbiome in C57BL/6 mice by Peiling Geng, Ni Zhao, Yufan Zhou, Reuben S. Harris, Yong Ge

“…The probiotic impact of microbes on host metabolism and health depends on both host genetics and bacterial genomic variation. Faecalibacterium prausnitzii is the predominant human gut commensal emerging as a next-generation probiotic. …”
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ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer by Pingping Su, Xiaodan Mao, Jincheng Ma, Lixiang Huang, Lirui Yu, Shuting Tang, Mingzhi Zhuang, Zhonglei Lu, Kelvin Stefan Osafo, Yuan Ren, Xinrui Wang, Xite Lin, Leyi Huang, Xiaoli Huang, Elena Ioana Braicu, Jalid Sehouli, Pengming Sun

“…In addition, the expression of ERRα-related pyroptosis genes was analyzed using The Cancer Genome Atlas and Gene Expression Omnibus database. …”
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Co-obligate symbioses have repeatedly evolved across aphids, but partner identity and nutritional contributions vary across lineages by Manzano-Marín, Alejandro, Coeur d’acier, Armelle, Clamens, Anne-Laure, Cruaud, Corinne, Barbe, Valérie, Jousselin, Emmanuelle

“…Lastly, patterns of Buchnera genome evolution reveal that small losses affecting a few key genes can be the onset of these dual systems, while large gene losses can occur without any co-obligate symbiont acquisition. …”
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Short-term evolution and dispersal patterns of fluconazole-resistance in Candida auris clade III by Irving Cancino-Muñoz, Juan Vicente Mulet-Bayona, Carme Salvador-García, Nuria Tormo-Palop, Remedios Guna, Concepción Gimeno-Cardona, Fernando González-Candelas

“…By analyzing complete fungal genomes from around the world, we have confirmed the origin of this clade and unraveled its dispersal patterns in the early 2010s. …”
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Correlation among blastocoel fluid DNA level, apoptotic genes expression and preimplantation aneuploidy by Fattaneh Khajehoseini, Zahra Noormohammadi, Poopak Eftekhari-Yazdi, Hamid Gourabi, Reza Pazhoomand, Shirzad Hosseinishenatal, Masood Bazrgar

“…Following BF aspiration and whole genome amplification, BF-DNA level was quantified. …”
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