Breeding for disease resilience: opportunities to manage polymicrobial challenge and improve commercial performance in the pig industry by Xuechun Bai, Graham S. Plastow

“…Altogether genomic approaches provide exciting opportunities for the pig industry to overcome the challenges provided by hard-to-manage diseases as well as new environmental challenges associated with climate change.…”
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Gene networks and metabolomic screening analysis revealed specific pathways of amino acid and acylcarnitine profile alterations in blood plasma of patients with Parkinson’s disease... by A. A. Makarova, P. M. Melnikova, A. D. Rogachev, P. S. Demenkov, T. V. Ivanisenko, E. V. Predtechenskaya, S. Y. Karmanov, V. V. Koval, A. G. Pokrovsky, I. N. Lavrik, N. A. Kolchanov, V. A. Ivanisenko

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Reconstruction and computer analysis of the structural and functional organization of the gene network regulating cholesterol biosynthesis in humans and the evolutionary characteri... by A. D. Mikhailova, S. A. Lashin, V. A. Ivanisenko, P. S. Demenkov, E. V. Ignatieva

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Mycobacteria Exploit Host GPR84 to Dampen Pro-Inflammatory Responses and Promote Infection in Macrophages by Reziya Wumaier, Ke Zhang, Jing Zhou, Zilu Wen, Zihan Chen, Geyang Luo, Hao Wang, Juliang Qin, Bing Du, Hua Ren, Yanzheng Song, Qian Gao, Bo Yan

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A Two-Stage Method for Improving the Prediction Accuracy of Complex Traits by Incorporating Genotype by Environment Interactions in Brassica napus by Sican Xiong, Meng Wang, Jun Zou, Jinling Meng, Yanyan Liu

“…Improving the prediction accuracy of a complex trait of interest is key to performing genomic selection (GS) for crop breeding. For the complex trait measured in multiple environments, this paper proposes a two-stage method to solve a linear model that jointly models the genetic effects and the genotype × environment interaction (G × E) effects. …”
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“Sichuanvirus”, a novel bacteriophage viral genus, able to lyse carbapenem-resistant Klebsiella pneumoniae by Juan Li, Qingqing Fang, Huan Luo, Yan Feng, Yu Feng, Zhiyong Zong

“…We also obtained three bacterial mutants resistant to the phage and performed genome sequencing for them. We therefore discovered that the interruption of a capsular polysaccharide biosynthesis-related gene wcaJ by insertion sequences mediated the resistance to this phage. …”
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Biological features and cultivation of sesame (a review) by N. V. Kishlyan, M. Sh. Asfandiyarova, Y. V. Yakusheva, A. G. Dubovskaya

“…Recently, thanks to the deciphering of the sesame nuclear genome and the development of various genomic resources, including molecular markers for qualitative and quantitative characters, molecular breeding has become possible for such agronomic traits as high oil content and its composition, drought resistance, resistance to waterlogging, disease resistance, and high yield. …”
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The clinical value and most informative threshold of polygenic risk score in the Quebec City Case-Control Asthma Cohort by Martin Pariès, Stéphanie Bougeard, Aida Eslami, Zhonglin Li, Michel Laviolette, Louis-Philippe Boulet, Evelyne Vigneau, Yohan Bossé

“…Abstract Genome-wide association studies (GWAS) have identified genetic variants robustly associated with asthma. …”
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Homologs of the rolC gene of naturally transgenic toadflaxes Linaria vulgaris and Linaria creticola are expressed in vitro by T. V. Matveeva, O. D. Bogomaz, L. A. Golovanova, Yu. S. Li, D. Dimitrov

“…Such plants are called naturally transgenic plants, and T-DNA in their genomes is called cellular (cT-DNA). It is proposed that in the evolution of these genera, the introduced sequences played an important role. …”
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Ribosome pausing in amylase producing Bacillus subtilis during long fermentation by Yaozu Han, Biwen Wang, Alberto Agnolin, Gaurav Dugar, Frans van der Kloet, Christopher Sauer, Paul Igor Costea, Max Fabian Felle, Mathis Appelbaum, Leendert W. Hamoen

“…After achieving single codon resolution for ribosome pausing, we determined the genome wide ribosome pausing sites for B. subtilis at 16 h and 64 h growth under batch fermentation. …”
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In silico characterisation of the avocado WAK/WAKL gene family with a focus on genes involved in defence against Phytophthora cinnamomi by Aaron Harvey, Aaron Harvey, Noëlani van den Berg, Noëlani van den Berg, Velushka Swart, Velushka Swart

“…The analysis identified 14 Persea americana (Pa)WAKs and 62 PaWAKLs across the West-Indian (pure accession reference), Dusa®, Leola™ and R0.12 avocado rootstock genomes. These genes showed distribution across the West-Indian genome’s chromosomes, with MCScanX analyses predicting tandem duplications. …”
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Fractional hitting sets for efficient multiset sketching by Timothé Rouzé, Igor Martayan, Camille Marchet, Antoine Limasset

“…Abstract The exponential increase in publicly available sequencing data and genomic resources necessitates the development of highly efficient methods for data processing and analysis. …”
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Fine-mapping of PmHHM, a broad-spectrum allele from a wheat landrace conferring both seedling and adult resistance to powdery mildew by Bisheng Fu, Bisheng Fu, Bisheng Fu, Zhixin Lin, Lijuan Yan, Qiaofeng Zhang, Caiyun Liu, Caiyun Liu, Jin Cai, Jin Cai, Wei Guo, Wei Guo, Ying Liu, Wenling Zhai, Shuangjun Gong, Feng Xu, Jizhong Wu, Jizhong Wu, Jizhong Wu

“…To map its PM resitance gene, bulked segregant analysis, molecular mapping and comparative genomic analysis were also used in the present study.ResultsHHM shows remarkable adult resistance in the field and is nearly immune to all 25 Bgt isolates used in seedling tests, making it an excellent source of PM resistance. …”
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Correcting scale distortion in RNA sequencing data by Christopher Thron, Farhad Jafari

“…Abstract RNA sequencing (RNA-seq) is the conventional genome-scale approach used to capture the expression levels of all detectable genes in a biological sample. …”
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Landscape of Alternative Splicing Events Related to Prognosis and Immune Infiltration in Glioma: A Data Analysis and Basic Verification by Hong-xin Su, Gang Yang, Fei Su, Chen-xiao Hu, Tao Zhang, Jun-tao Ran, Quan-lin Guan

“…Alternative splicing (AS), as a pervasive transcriptional regulatory mechanism, amplifies the coding capacity of the genome and promotes the progression of malignancies. …”
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Set of 15 SNP-SNP Markers for Detection of Unbalanced Degraded DNA Mixtures and Noninvasive Prenatal Paternity Testing by Ranran Zhang, Yu Tan, Li Wang, Hui Jian, Jing Zhu, Yuanyuan Xiao, Mengyu Tan, Jiaming Xue, Fan Yang, Fan Yang, Weibo Liang

“…Besides, all fetal alleles in maternal plasma were confirmed by genotyping fetal genomic DNA from amniocentesis and paternal genomic DNA from peripheral blood. …”
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Intratumor heterogeneity: models of malignancy emergence and evolution by R. A. Ivanov, S. A. Lashin

“…Traditional experimental methods involve genomic profiling techniques such as next­generation sequencing and fluorescence in situ hybridization. …”
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African swine fever in the Primorsky Krai: disease situation and molecular and biological properties of the isolate recovered from a wild boar long bone by А. R. Shotin, A. S. Igolkin, Ali Mazloum, I. V. Shevchenko, N. S. Bardina, E. O. Morozova, А. А. Shevtsov

“…The incubation period and duration of the disease course in experimentally infected pigs were 4–6 and 3–5 days post infection, respectively. The ASFV genome was detected in blood samples collected from infected pigs on 5–8 days post infection by real-time polymerase chain reaction. …”
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A transgenic cell line with inducible transcription for studying (CGG)n repeat expansion mechanisms by I. V. Grishchenko, A. A. Tulupov, Y. M. Rymareva, E. D. Petrovskiy, A. A. Savelov, A. M. Korostyshevskaya, Y. V. Maksimova, A. R. Shorina, E. M. Shitik, D. V. Yudkin

“…In addition, a criterion was developed for the quantif ication of exogenous (CGG)n repeat instability in the transgenic cell lines’ genome.…”
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The relationship of lamins with epigenetic factors during aging by R. N. Mustafin, E. K. Khusnutdinova

“…The key factor of genome instability during aging is transposon dysregulation. …”
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