Telomere DNA in the insect order Dermaptera and the first evidence for the non-canonical telomeric motif TTCGG in Arthropoda by Vladimir A. Lukhtanov

“…In this study, analysis of the chromosome-level genome assembly shows that the telomeric DNA of the earwig Labia minor (Linnaeus, 1758) (Polyneoptera, Dermaptera, Spongiphoridae) consists of repeats of the 5 bp motif TTCGG/CCGAA. …”
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Fatal Hepatocellular Carcinoma in a Patient with Occult Hepatitis B Virus Infection following the Administration of R-CHOP for Diffuse Large B-Cell Lymphoma by Vincenzo Pitini, Massimo Rizzo, Carmela Arrigo, Patrizia Mondello, Giuseppe Altavilla

“…Like overt HBV infection, OBI can be associated with the integration of HBV sequences into the host genome and has a substantial clinical relevance for patients who are severely immunosuppressed for long durations. …”
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Emergence of a novel reassortant highly pathogenic avian influenza clade 2.3.4.4b A(H5N2) Virus, 2024 by Rabeh El-Shesheny, Mokhtar Gomaa, Mohamed El Sayes, Mina Nabil Kamel, Ahmed El Taweel, Omnia Kutkat, Mohamed GabAllah, Amany Elkhrsawy, Hager Emam, Yassmin Moatasim, Ahmed Kandeil, Pamela P. McKenzie, Richard J. Webby, Mohamed Ahmed Ali, Ghazi Kayali

“…Reassortant highly pathogenic avian influenza A(H5N2) clade 2.3.4.4.b viruses were detected from ducks and environmental samples in Egypt, June 2024. Genomic and phylogenetic analyses revealed a novel genotype produced by the reassortment of an A(H5N1) clade 2.3.3.4b virus with an A(H9N2) G1-like virus. …”
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p53 Mutations and DNA Ploidy in Colorectal Adenocarcinomas by Paola Campomenosi, Paola Assereto, Massimo Bogliolo, Gilberto Fronza, Angelo Abbondandolo, Antonella Capasso, Patrizia F. Bellomo, Roberto Monaco, Anna Rapallo, Andrea Sciutto, Roberto Orecchia, Elio Geido, Walter Giaretti

“…The p53 tumour suppressor gene has an important role in the the maintenance of genome stability and its mutational inactivation may be at the origin of aneuploidy in cancer cells. …”
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An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines by Bo Dong, Dante S. Zarlenga, Xiaofeng Ren

“…Pseudorabies virus (PRV) is a double-stranded, DNA-based swine virus with a genome approximating 150 kb in size. PRV has many nonessential genes which can be replaced with genes encoding heterologous antigens but without deleterious effects on virus propagation. …”
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A Review of Adult Obesity Prevalence, Trends, Risk Factors, and Epidemiologic Methods in Kuwait by Stalo Karageorgi, Osama Alsmadi, Kazem Behbehani

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Trigeminal Neuralgia, Glossopharyngeal Neuralgia, and Myofascial Pain Dysfunction Syndrome: An Update by Mohammad Khan, Shamima Easmin Nishi, Siti Nazihahasma Hassan, Md. Asiful Islam, Siew Hua Gan

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Diagnostics of lung cancer by fragmentated blood circulating cell-free DNA based on machine learning methods by Ivan O. Meshkov, Alexander P. Koturgin, Pavel V. Ershov, Liubov A. Safonova, Julia A. Remizova, Valentina V. Maksyutina, Ekaterina D. Maralova, Vasilisa A. Astafieva, Alexey A. Ivashechkin, Boris D. Ignatiev, Antonida V. Makhotenko, Ekaterina A. Snigir, Valentin V. Makarov, Vladimir S. Yudin, Anton A. Keskinov, Sergey M. Yudin, Anna S. Makarova, Veronika I. Skvortsova

“…Twelve variables, describing the abundance and length distribution of cfDNA fragments within each genomic interval, and 40 variables based on the values of position-weight matrices, describing combinations of 5-bp-long terminal motifs of cfDNA fragments, were used to characterize genomic fragmentation. …”
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Spatial deconvolution from bulk DNA methylation profiles determines intratumoral epigenetic heterogeneity by Binbin Liu, Yumo Xie, Yu Zhang, Guannan Tang, Jinxin Lin, Ze Yuan, Xiaoxia Liu, Xiaolin Wang, Meijin Huang, Yanxin Luo, Huichuan Yu

“…The genome-wide methylation profiles were generated with methylation array. …”
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Are There Mutator Polymerases? by Miguel Garcia-Diaz, Jose F. Ruiz, Raquel Juarez, Gloria Terrados, Luis Blanco

“…DNA polymerases are involved in different cellular events, including genome replication and DNA repair. In the last few years, a large number of novel DNA polymerases have been discovered, and the biochemical analysis of their properties has revealed a long list of intriguing features. …”
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Molecular Basis of Triple Negative Breast Cancer and Implications for Therapy by Parvin F. Peddi, Matthew J. Ellis, Cynthia Ma

“…Recent genomewide gene expression and DNA sequencing studies indicate that this cancer type is composed of a molecularly heterogeneous group of diseases that carry multiple somatic mutations and genomic structural changes. These findings have implications for therapeutic target identification and the design of future clinical trials for this aggressive group of breast cancer.…”
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Obstacles to Early Diagnosis of Gaucher Disease by Nishimura S, Ma C, Sidransky E, Ryan E

“…Samantha Nishimura,* Charis Ma,* Ellen Sidransky, Emory Ryan National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA*These authors contributed equally to this workCorrespondence: Ellen Sidransky, National Human Genome Research Institute, National Institutes of Health, Building 35A -1E623 Convent Drive, MSC 3708, Bethesda, MD, 20892-3708, USA, Tel +1-301-451-0901, Fax +301-402-6438, Email sidranse@nih.govAbstract: Gaucher disease (GD) is a rare lysosomal storage disorder resulting from a deficiency of the lysosomal enzyme glucocerebrosidase caused by biallelic variants in the GBA1 gene. …”
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Investigating the role of exosomal long non-coding RNAs in drug resistance within female reproductive system cancers by Nooshafarin Shirani, Neda Abdi, Matin Chehelgerdi, Matin Chehelgerdi, Hajar Yaghoobi, Mohammad Chehelgerdi, Mohammad Chehelgerdi

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Synthetic augmentation of cancer cell line multi-omic datasets using unsupervised deep learning by Zhaoxiang Cai, Sofia Apolinário, Ana R. Baião, Clare Pacini, Miguel D. Sousa, Susana Vinga, Roger R. Reddel, Phillip J. Robinson, Mathew J. Garnett, Qing Zhong, Emanuel Gonçalves

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A Unique Trinucleotide-Bloc Mutation-Based Two SARS-CoV-2 Genotypes with Potential Pathogenic Impacts by Mustak Ibn Ayub

“…SARS-CoV-2, the novel coronavirus behind the COVID-19 pandemic, is acquiring new mutations in its genome. Although some mutations provide benefits to the virus against human immune response, others may result in their reduced pathogenicity and virulence. …”
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LAMA2 Congenital Muscle Dystrophy: A Novel Pathogenic Mutation in Bulgarian Patient by Ivanka Dimova, Ivo Kremensky

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PIWI proteins and piRNAs: key regulators of stem cell biology by Fernando Claro-Linares, Patricia Rojas-Ríos

“…Similarly, in Drosophila intestinal stem cells, the PIWI protein Piwi regulates metabolic pathways and genome integrity, impacting longevity and gut homeostasis. …”
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A paradoxical population structure of var DBLα types in Africa. by Mun Hua Tan, Kathryn E Tiedje, Qian Feng, Qi Zhan, Mercedes Pascual, Heejung Shim, Yao-Ban Chan, Karen P Day

“…The var multigene family encodes Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), central to host-parasite interactions. Genome structure studies have identified three major groups of var genes by specific upstream sequences (upsA, B, or C). …”
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FDA-approved kinase inhibitors: a promising therapeutic avenue for traumatic brain injury by Dezhu Gao, Yu Shi, Zhiliang Wang, Weiming Liu

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Identification of novel genes responsible for a pollen killer present in local natural populations of Arabidopsis thaliana. by Anthony Ricou, Matthieu Simon, Rémi Duflos, Marianne Azzopardi, Fabrice Roux, Françoise Budar, Christine Camilleri

“…By exploiting available de novo genomic sequences, we propose a scenario for the emergence of this pollen killer in A. thaliana. …”
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