Inflammatory Nasal Swelling due to Leishmania tropica by Hajiba Fellah, Maryam Hakkour, Bouchra Delouane, Asmae Hmamouch, Abdelhakim Bouyahya, Faiza Sebti, Abderrahim Sadak

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Single-Cell Sequencing Technology in Oncology: Applications for Clinical Therapies and Research by Baixin Ye, Qingping Gao, Zhi Zeng, Creed M. Stary, Zhihong Jian, Xiaoxing Xiong, Lijuan Gu

“…Single-cell sequencing (SCS) technology has been recently employed for analyzing the genetic polymorphisms of individual cells at the genome-wide level. SCS requires (1) precise isolation of the single cell of interest; (2) isolation and amplification of genetic material; and (3) descriptive analysis of genomic, transcriptomic, and epigenomic data. …”
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Modes and mechanisms for the inheritance of mitochondria and plastids in pathogenic protists. by Sophie L Collier, Sarah N Farrell, Christopher D Goodman, Geoffrey I McFadden

“…However, mutations within the organellar genomes of mitochondria and plastids can lead to drug resistance. …”
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Functions and applications of RNA interference and small regulatory RNAs by Feng Xuezhu, Guang Shouhong

“…Small regulatory RNAs play a variety of crucial roles in eukaryotes, influencing gene regulation, developmental timing, antiviral defense, and genome integrity via a process termed RNA interference (RNAi). …”
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Devilish Details in Apes and Atoms

“…Nature leads with a preview of an upcoming workshop on sequencing the ape genome. Science leads off this week with a story about a new measurement that comes tantalizingly close to overturning the longstanding Standard Model of particle physics.…”
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Corrigendum to “Chromosome 3p Inverted Duplication with Terminal Deletion: Second Postnatal Case Report with Additional Clinical Features” by Jacquelyn D. Riley, Catherine M. Stefaniuk, Francine Erenberg, Angelika L. Erwin, Lauren Palange, Caroline Astbury

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Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth by Flavie Coquel, Sing-Zong Ho, Keng-Chang Tsai, Chun-Yen Yang, Antoine Aze, Julie Devin, Ting-Hsiang Chang, Marie Kong-Hap, Audrey Bioteau, Jerome Moreaux, Domenico Maiorano, Philippe Pourquier, Wen-Chin Yang, Yea-Lih Lin, Philippe Pasero

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Identification of GBN5 as a molecular biomarker of pan-cancer species by integrated multi-omics analysis by Qian Guo, Xinxin Zhong, Zihan Dang, Baiquan Zhang, Zixin Yang

“…Materials and methods We employed a multi-omics approach, including transcriptomic, genomic, proteomic, single-cell cytomic, spatial transcriptomic, and genomic data, to explore the prognostic value and potential oncogenic mechanisms of GBN5 across pan-cancers from multiple perspectives. …”
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Identification of G-quadruplex-forming Sequences in Nucleocapsid Gene of SARS-CoV-2 Variants of Concern: An In Silico Analysis by Saeedeh Ghazaey Zidanloo

“…Recent studies emphasized that G-quadruplex structures are intrinsic obstacles to genome replication and targeting them in viral genomes could be a novel antiviral strategy to develop antiviral agents. …”
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Comparison of the evolutionary patterns of DNA repeats in ancient and young invertebrate species flocks of Lake Baikal by Wang Yuxiang, T. E. Peretolchina, E. V. Romanova, D. Y. Sherbakov

“…DNA repeat composition of low coverage (0.1–0.5) genomic libraries of four amphipods species endemic to Lake Baikal (East Siberia) and four endemic gastropod species of the fam. …”
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Prospects for mineral biofortification of wheat: classical breeding and agronomy by I. N. Leonova, E. V. Ageeva, V. K. Shumny

“…Despite the promise of transgenesis and genome editing, these labor-intensive methods require significant investments, so these technologies, when applied to wheat, are still at the development stage and cannot be applied routinely. …”
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Molecular Detection and Determination of Phylogenetic Position of Watermelon Chlorotic Stunt Virus Khouzestan Isolate Based on Coat Protein Gene by Samira Pakbaz, Zahra Jelavi, Ehsan Hasanvand, Hossein Mirzaei Najafgholi

“…PCR was performed using two primer pairs of Begomovirus related to AV1 and also AV2 genomic region. The sequencing results confirmed WmCSV infection in the samples. …”
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Human microbiome, applied to clinical practice by V. T. Ivashkin, K. V. Ivashkin

“…The Human microbiome project was designed for identification and characterization of set of human microorganisms as well as for studying the changes in the human health due to microbiome changes. The Human Genome Project assumes: development of the human genome variations database (HapMap; Human Variome Project), interpretation of human phenotype differences (Encyclopedia Of DNA Elements), modeling of human phenomenon (RECON), interpretation of epigenetic variants and hereditary changes in phenotypical manifestations. …”
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Degenerated vision, altered lipid metabolism, and expanded chemoreceptor repertoires enable Lindaspio polybranchiata to thrive in deep-sea cold seeps by Yujie Yan, Inge Seim, Yang Guo, Xupeng Chi, Zhaoshan Zhong, Dantong Wang, Mengna Li, Haining Wang, Huan Zhang, Minxiao Wang, Chaolun Li

“…We sequenced and assembled the genome of L. polybranchiata and performed comparative genomic analyses to investigate the genetic basis of adaptation to the deep sea. …”
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The perspectives of metabolomics studies of potato plants by R. K. Puzanskiy, V. V. Yemelyanov, T. A. Gavrilenko, M. F. Shishova

“…A limited number of systemic studies on potatoes combines metabolome investigation with genome, transcriptome and proteome analysis and suggests an important role of the genome in the determination of metabolic rates. …”
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Tumor mutational burden quantification from targeted gene panels: major advancements and challenges by Sara Gandini, Laura Fancello, Pier Giuseppe Pelicci, Luca Mazzarella

“…However, to date WES remains confined to research settings, due to high cost of the large genomic space sequenced. In the clinical setting, instead, targeted enrichment panels (gene panels) of various genomic sizes are emerging as the routine technology for TMB assessment. …”
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Pseudomonas azotoformans and Pseudomonas putida: Novel kiwifruit-native biological control agents against Pseudomonas syringae pv. actinidiae by Cristiana Correia, Antonio Cellini, Irene Donati, Panagiotis Voulgaris, Adebayo Ebenezer Obafemi, Elia Soriato, Elodie Vandelle, Conceição Santos, Francesco Spinelli

“…Moreover, several biosynthetic gene clusters of secondary metabolites, were predicted in the genome of both strains, including non-ribosomal peptides, and the bacteriocin pyocin was predicted in the genome of BG1. …”
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DNA Ligase IV Prevents Replication Fork Stalling and Promotes Cellular Proliferation in Triple Negative Breast Cancer by Rashmi R. Joshi, Sk Imran Ali, Amanda K. Ashley

“…DNA damage is a hallmark of cancer, and mutation and misregulation of proteins that maintain genomic fidelity are associated with the development of multiple cancers. …”
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Generation and analysis of mouse embryonic stem cells with knockout of the <i>Mcph1</i> (microcephalin) gene by A. M. Yunusova, A. V. Smirnov, T. A. Shnaider, I. E. Pristyazhnuk, S. Y. Korableva, N. R. Battulin

“…Chromatin is not randomly distributed within the nucleus, but organized in a three-dimensional structure that plays a critical role in genome functions. Сohesin and condensins are conserved multi-subunit protein complexes that participate in mammalian genome organization by extruding chromatin loops. …”
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The Presence of Two Distinct Lineages of the Foot-And-Mouth Disease Virus Type A in Russia in 2013–2014 Has Significant Implications for the Epidemiology of the Virus in the Region... by Victor V. Nikiforov, Sergey A. Noskov, Alexander V. Sprygin, Mohammad Abed Alhussen, Anastasia S. Krylova, Taisia V. Erofeeva, Svetlana N. Fomina, Svetlana R. Kremenchugskaya, Fedor I. Korennoy, Maxim V. Patrushev, Ilya A. Chvala, Tamara K. Mayorova, Stepan V. Toshchakov

“…In this study, we investigated the FMDV strains circulating in Russia during the 2013–2014 period in geographically distant regions utilizing whole genome sequencing followed by maximum-likelihood phylogenetic reconstruction of whole genome and VP1 gene sequences. …”
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