Polygenic burden of short tandem repeat expansions promotes risk for Alzheimer’s disease by Michael H. Guo, Wan-Ping Lee, Badri Vardarajan, Gerard D. Schellenberg, Jennifer E. Phillips-Cremins

“…Here, we genotype 312,731 polymorphic STR tracts genome-wide using PCR-free whole genome sequencing data from 2981 individuals (1489 AD case and 1492 control individuals). …”
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Nano-technological advancements in multimodal diagnosis and treatment by Dinesh Bhatia, Tania Acharjee, Shruti Shukla, Monika Bhatia

“…Similarly, in CVD, NPs target arterial plaques to improve treatment accuracy while reducing systemic adverse effects. Furthermore, the genomic “blueprint” is evolving parallel to nanotechnology, with India's “Genome India” initiative mapping 10,000 genomes, lighting the path for genetic chips suited for specific disorders and moment tests. …”
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Pea (Pisum sativum L.): the uneasy fate of the first genetical object by O. E. Kosterin

“…Meanwhile, we await the completion of pea nuclear genome sequencing in 2016. For working out new molecular markers in pea, the synteny of its genome to the sequenced genome of Medicago truncatula is extensively used. …”
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Diversity of <i>mariner</i>-like elements in Orthoptera by K. Ustyantsev, M. Biryukov, I. Sukhikh, N. V. Shatskaya, V. Fet, A. Blinov, I. Konopatskaia

“…In the present study, we explore the diversity of MLEs elements in 16 species of Orthoptera belonging to three infraorders, Acridoidea (Caelifera), Grylloidea (Ensifera), and Tettigoniidea (Ensifera) by combining data mined from computational analysis of sequenced degenerative PCR MLE amplicons and available Orthoptera genomic scaffolds. In total, 75 MLE lineages (Ortmar) were identified in all the studied genomes. …”
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First-principles investigation of adhesion strength and interfacial bonding in Mg/X (X = Ti, Zr, Hf, V, Nd, Cr, Mo, Mn, and Fe) interface by Longke Bao, Zhifu Yao, Yuhui Zhang, Cuiping Wang, Kaihong Zheng, Rongpei Shi, Xingjun Liu, Fusheng Pan

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Approaches to Analyze Protein Interactions by Stanley Fields, Becky Drees, Tony R. Hazbun, Chandra Tucker, Amy Hin Yan Tong, Marie Evangelista, Charles Boone, Giuliano Nardelli, Luisa Castagnoli, Adriana Zucconi, Gianni Cesareni, Gary Bader, Chris Hogue

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Efficacy of melatonin treatment in a cystic fibrosis mouse model of airway infection by Kristen R. Schaefer, Sara Rogers, Zachary Faber, Thomas J. Kelley

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A singular limit for an age structured mutation problem by Jacek Banasiak, Aleksandra Falkiewicz

“…The spread of a particular trait in a cell population often is modelled by an appropriate system of ordinary differential equations describing how the sizes of subpopulations of the cells with the same genome change in time. On the other hand, it is recognized that cells have their own vital dynamics and mutations, leading to changes in their genome, mostly occurring during the cell division at the end of its life cycle. …”
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Mechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage by Robert L. Eoff, Jeong-Yun Choi, F. Peter Guengerich

“…The inherent instability of DNA is a major obstacle to genomic maintenance and contributes in varying degrees to cellular dysfunction and disease in multi-cellular organisms. …”
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MOLECULAR DIVERSITY OF COMMON WHEAT INTROGRESSION LINES (T. AESTIVUM / T. TIMOPHEEVII) by I. N. Leonova, O. A. Orlovskaya, M. S. Röder, M. A. Nesterov, E. B. Budashkina

“…Evaluation of SSR polymorphisms and indices H in the three genomes of introgression lines indicated that the chromosomes of genome B had higher rates than A or D (B &gt; A &gt; D) which was probably a result of alien introgression into these chromosomes. …”
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Crown Gall Induced by a Natural Isolate of <i>Brucella</i> (<i>Ochrobactrum</i>) <i>pseudogrignonense</i> Containing a Tumor-Inducing Plasmid by Marjolein J. G. Hooykaas, Paul J. J. Hooykaas

“…Average nucleotide identity (ANIb, ANIm) and genome-to-genome distance (GGDC) values above the thresholds of 96% and 70%, respectively, showed that NBC51/LBA8980 belonged to the species <i>Brucella</i> (<i>Ochrobactrum) pseudogrignonense.…”
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Alternative Splicing in Self-Renewal of Embryonic Stem Cells by Clara Y. Cheong, Thomas Lufkin

“…Progressing beyond the limitations of a fixed genomic sequence, alternative splicing offers an additional layer of complexity to produce protein variants that may differ in function and localization that can direct embryonic stem cells to specific differentiation pathways. …”
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Blood-based epigenome-wide association study and prediction of alcohol consumption by Elena Bernabeu, Aleksandra D. Chybowska, Jacob K. Kresovich, Matthew Suderman, Daniel L. McCartney, Robert F. Hillary, Janie Corley, Maria Del C. Valdés-Hernández, Susana Muñoz Maniega, Mark E. Bastin, Joanna M. Wardlaw, Zongli Xu, Dale P. Sandler, Archie Campbell, Sarah E. Harris, Andrew M. McIntosh, Jack A. Taylor, Paul Yousefi, Simon R. Cox, Kathryn L. Evans, Matthew R. Robinson, Catalina A. Vallejos, Riccardo E. Marioni

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Splicing accuracy varies across human introns, tissues, age and disease by S. García-Ruiz, D. Zhang, E. K. Gustavsson, G. Rocamora-Perez, M. Grant-Peters, A. Fairbrother-Browne, R. H. Reynolds, J. W. Brenton, A. L. Gil-Martínez, Z. Chen, D. C. Rio, J. A. Botia, S. Guelfi, L. Collado-Torres, M. Ryten

“…We find support for the latter by observing a genome-wide increase in splicing inaccuracies in samples affected with Alzheimer’s disease as compared to neurologically normal individuals. …”
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Rational metabolic engineering of <i>Corynebacterium glutamicum</i> to create a producer of L-valine by M. E. Sheremetieva, K. E. Anufriev, T. M. Khlebodarova, N. A. Kolchanov, A. S. Yanenko

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Efficiency of Polyphenol Extraction from Artificial Honey Using C18 Cartridges and Amberlite® XAD-2 Resin: A Comparative Study by Chua Yung An, Md. Murad Hossain, Fahmida Alam, Md. Asiful Islam, Md. Ibrahim Khalil, Nadia Alam, Siew Hua Gan

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Search for and functional annotation of multi-domain PLA2 family proteins in flatworms by M. E. Bocharnikova, I. I. Turnaev, D. A. Afonnikov

“…The paper provides a search for and a comparative analysis of PLA2 sequences encoded in the genomes of flatworms. 44 species represented by two free-living and 42 parasitic organisms were studied. …”
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Geo-behavioural predictors of diagnosed hypertension in Igbo Ora Area, Oyo State, Nigeria by Olalekan J. Taiwo, Joshua O. Akinyemi, Ayodeji Adebayo, Oluwafemi A. Popoola, Rufus O. Akinyemi, Onoja M. Akpa, Paul Olowoyo, Akinkunmi P. Okekunle, Ezinne O. Uvere, Omotolani Titilayo Ajala, Chukwuemeka Nwimo, Olayinka J. Adebajo, Adewale E. Ayodele, Ayodeji Salami, Oyedunni S. Arulogun, Olanrewaju Olaniyan, Richard W. Walker, Carolyn Jenkins, Bruce Ovbiagele, Mayowa Owolabi

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Bacterial Diversity in Native Heart Valves in Infective Endocarditis by Anna Sinitskaya, Alexander Kostyunin, Maxim Asanov, Maria Khutornaya, Anastasia Klyueva, Alyona Poddubnyak, Alexey Tupikin, Marsel Kabilov, Maxim Sinitsky

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Peculiar Evolutionary History of miR390-Guided TAS3-Like Genes in Land Plants by Maria S. Krasnikova, Denis V. Goryunov, Alexey V. Troitsky, Andrey G. Solovyev, Lydmila V. Ozerova, Sergey Y. Morozov

“…Importantly, cloning and sequencing of Marchantia polymorpha genomic DNA showed miR390 and TAS3-like sequences which were also found among genomic reads of M. polymorpha at NCBI database. …”
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