Suggested Topics within your search.
Suggested Topics within your search.
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221
Computational biology and artificial intelligence in mRNA vaccine design for cancer immunotherapy
Published 2025-01-01“…This paper reviews technologies that streamline mRNA vaccine development, from genomic sequencing to lipid nanoparticle (LNP) formulation. …”
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222
Regulation of Pear Fruit Quality: A Review Based on Chinese Pear Varieties
Published 2024-12-01“…Key aspects include metabolic regulation of fruit traits such as sweetness, color, texture, and physiological disorders; factors influencing stone cell formation; sugar content regulation; roles of plant hormones including ethylene, gibberellins, and abscisic acid; translational regulation and post-translational modifications such as ubiquitination, methylation, and acetylation; as well as the application of genomic sequencing technologies. Furthermore, the review offers practical suggestions for improving pear fruit quality and provides insights for researchers in related fields. …”
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223
De Novo Genome Assembly for an Endangered Lemur Using Portable Nanopore Sequencing in Rural Madagascar
Published 2025-01-01“…While the advent of next‐generation sequencing technologies and the resulting reduction in associated costs have led to the proliferation of genomic data and high‐quality reference genomes, global discrepancies in genomic sequencing capabilities often result in biological samples from biodiverse host countries being exported to facilities in the Global North, creating inequalities in access and training within genomic research. …”
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224
Wilson and Walker's Principles and Techniques of Biochemistry and Molecular Biology /
Published 2018Table of Contents: “…Biochemical and molecular biological methods in life sciences studies -- Basic principles -- Cell culture techniques -- Recombinant DNA techniques and molecular cloning -- Preparative protein biochemistry -- Electrophoretic techniques -- Immunochemical techniques -- Flow cytometry -- Radioisotope techniques -- Principles of clinical biochemistry -- Microscopy -- Centrifugation and ultracentrifugation -- Spectroscopic techniques -- Basic techniques probing molecular structure and interactions -- Mass spectrometric techniques -- Fundamentals of bioinformatics -- Fundamentals of chemoinformatics -- The python programming language -- Data analysis -- Fundamentals of genome sequencing and annotation -- Fundamentals of proteomics -- Fundamentals of metabolomics -- Enzymes and receptors -- Drug discovery and development.…”
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225
Wilson and Walker's Principles and Techniques of Biochemistry and Molecular Biology /
Published 2018Table of Contents: “…Biochemical and molecular biological methods in life sciences studies -- Basic principles -- Cell culture techniques -- Recombinant DNA techniques and molecular cloning -- Preparative protein biochemistry -- Electrophoretic techniques -- Immunochemical techniques -- Flow cytometry -- Radioisotope techniques -- Principles of clinical biochemistry -- Microscopy -- Centrifugation and ultracentrifugation -- Spectroscopic techniques -- Basic techniques probing molecular structure and interactions -- Mass spectrometric techniques -- Fundamentals of bioinformatics -- Fundamentals of chemoinformatics -- The python programming language -- Data analysis -- Fundamentals of genome sequencing and annotation -- Fundamentals of proteomics -- Fundamentals of metabolomics -- Enzymes and receptors -- Drug discovery and development.…”
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226
Importance of appropriate genome information for the design of mating type primers in black and yellow morel populations
Published 2022-08-01“…Sexual reproduction in fungi is controlled by mating-type (MAT) genes and morels are thought to be mainly heterothallic with two idiomorphs, MAT1-1 and MAT1-2. Genomic sequencing of black (Elata clade) and yellow (Esculenta clade) morel species has led to the development of PCR primers designed to amplify genes from the two idiomorphs for rapid genotyping of isolates from these two clades. …”
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227
Surveillance of SARS-CoV-2 variants in Henan, China from 2023 to 2024
Published 2025-02-01“…Genome sequence analysis was performed with CLC Genomics Workbench, and genotyping and sequence alignment were carried out using the Nextclade platform. …”
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228
Isolation and Characterization of Colistin-Resistant <i>Enterobacteriaceae</i> from Foods in Two Italian Regions in the South of Italy
Published 2025-01-01“…The majority of the isolates belonged to <i>Enterobacter</i> spp. (60%), followed by <i>Moellerella wisconsensis</i>, <i>Atlantibacter hermannii</i>, <i>Klebsiella pneumoniae</i>, and <i>Escherichia coli</i>, among others. Genomic sequencing and antimicrobial susceptibility testing revealed high levels of resistance to β-lactams, with most isolates exhibiting multidrug resistance (MDR). …”
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229
Combined biochemical profiling and DNA sequencing in the expanded newborn screening for inherited metabolic diseases: the experience in an Italian reference center
Published 2025-01-01“…Advanced molecular technologies point to genomic sequencing as an alternative and feasible strategy for the screening of genetic diseases, including IMDs. …”
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230
Spatial and temporal epidemiology of SARS-CoV-2 virus lineages in Teesside, UK, in 2020: effects of socio-economic deprivation, weather, and lockdown on lineage dynamics
Published 2024-09-01“…As the outbreak continued, new variants were detected through two national monitoring programmes that conducted genomic sequencing. This study aimed to determine the effects of weather, demographic features, and national and local COVID-19 restrictions on positive PCR tests at a sub-regional scale. …”
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231
Genome-Wide Approach Identifies Natural Large-Fragment Deletion in ASFV Strains Circulating in Italy During 2023
Published 2025-01-01“…In addition, an in vivo experiment in pigs was performed. Complete genomic sequencing of 30 strains revealed large-fragment deletions and translocations. …”
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232
Molecular underpinnings of exceptional response in primary malignant melanoma of the esophagus to anti-PD-1 monotherapy
Published 2023-01-01“…To explore the molecular mechanisms of the difference in therapeutic efficacy between PMME and NEMM, we performed genomic analysis, bulk RNA sequencing, and multiplex immunohistochemistry staining.Results We found that PMME (n=28) responded better to anti-PD-1 treatment than NEMM (n=64), with a significantly higher objective response rate (33.3% (95% CI 14.3% to 52.3%) vs 6.6% (95% CI 0.2% to 12.9%)) and disease control rate (74.1% (95% CI 56.4% to 91.7%) vs 37.7% (95% CI 25.2% to 50.2%)). Genomic sequencing analysis revealed that the genomic aberration landscape of PMME predominated in classical cancer driver genes, with approximately half of PMME cases harboring mutations in BRAF, N/KRAS, and NF1. …”
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233
A scalable tool for analyzing genomic variants of humans using knowledge graphs and graph machine learning
Published 2025-01-01“…Advances in high-throughput genome sequencing have enabled large-scale genome sequencing in clinical practice and research studies. …”
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234
Survey on Encoding Schemes for Genomic Data Representation and Feature Learning—From Signal Processing to Machine Learning
Published 2018-09-01“…Similar conversion occurs in Genomic Signal Processing (GSP), where genome sequences are transformed into numerical sequences for signal extraction and recognition. …”
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235
Achievements and prospects of applying high-throughput sequencing techniques to potato genetics and breeding
Published 2017-03-01“…The availability of artificially created diploid forms played an essential role in potato genome sequencing, which was completed in 2011. The Potato Genome Sequencing Consortium activities included not only constructing genome libraries, sequencing, assembling and annotation of the genome, but also genome sequence-based investigations uncovering features of potato genome evolution, SNP identification, analysis of genes and gene networks regulating resistance to phytopathogens and technological characteristics. …”
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236
Genomic exploration of pediatric neurological disorders: a case series
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237
Bias Disclosures, Complicated Mice and a Digital Diss
Published 2001-01-01“…In Science, the mouse genome sequence's problematic progress leads the news.…”
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238
I’ll Show You Mine, If You Show Me Yours
Published 2001-01-01“…Both Science and Nature lead this week with articles about the simultaneous publication of the human genome sequence by the private company Celera Genomics and the publicly funded Human Genome Project (HGP).…”
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239
NGS sequencing in barley breeding and genetic studies
Published 2020-07-01“…In 2012, the barley genome sequencing was completed, which provided a broad range of new opportunities – from a more efficient search for candidate genes controlling economically important traits to genomic selection. …”
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240
Unique North American isolates of severe metastatic hypervirulent Klebsiella pneumoniae strain infections with hepatic abscesses seen in young patients within Texas.
Published 2025-01-01“…Country-wide surveillance and whole genome sequencing of these strains is essential to prevent a major public health emergency in the USA.…”
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