Side-stepping the guardian of the genome: current cancer therapeutics targeting mutant p53 by Iulianna C. Taritsa, Eric T. Fossel

“…Cancer therapies have attempted to target the transcription factor p53, a gene also described as the “guardian of the genome,” for decades. However, the approach has faced numerous barriers to clinical efficacy due to several factors: mutations in p53 occur in almost half of all human cancers, mutations are cancer-specific, and the associated genomic changes grant mutant p53 with oncogenic potential unique from that of wild-type p53. …”
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High quality genome assembly of the brown hare (Lepus europaeus) with chromosome-level scaffolding by Michell, Craig, Collins, Joanna, Laine, Pia K., Fekete, Zsófia, Tapanainen, Riikka, Wood, Jonathan M. D., Goffart, Steffi, Pohjoismäki, Jaakko L. O.

“…This brown hare genome represents the first Finnish contribution to the European Reference Genome Atlas pilot effort to generate reference genomes for European biodiversity. …”
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A dedicated caller for DUX4 rearrangements from whole-genome sequencing data by Pascal Grobecker, Stefano Berri, John F. Peden, Kai-Jie Chow, Claire Fielding, Ivana Armogida, Helen Northen, David J. McBride, Peter J. Campbell, Jennifer Becq, Sarra L. Ryan, David R. Bentley, Christine J. Harrison, Anthony V. Moorman, Mark T. Ross, Martina Mijuskovic

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Insights into the Genome Sequence of Chromobacterium amazonense Isolated from a Tropical Freshwater Lake by Alexandre Bueno Santos, Patrícia Silva Costa, Anderson Oliveira do Carmo, Gabriel da Rocha Fernandes, Larissa Lopes Silva Scholte, Jeronimo Ruiz, Evanguedes Kalapothakis, Edmar Chartone-Souza, Andréa Maria Amaral Nascimento

“…International Journal of Genomics…”
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Complete genome of mangrove-derived anti-MRSA streptomycete, Streptomyces pluripotens MUSC 135T by Hooi-Leng Ser, Kok-Gan Chan, Wen-Si Tan, Wai-Fong Yin, Bey-Hing Goh, Nurul-Syakima Ab Mutalib, Learn-Han Lee

“…Here we report the first complete genome of S. pluripotens MUSC 135T genome which comprise of 7.35 Mbp with G+C content of 69.9 %. …”
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The complete plastid genome of Citrus hystrix DC. 1813 (Rutaceae) and its phylogenetic analysis by Wan Shuan Lee, Warut Donrung, Bui Manh Hung, Nurien Hidayu Muhamad Rusly, Shiou Yih Lee, Tawatchai Tanee

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Addressing genome scale design tradeoffs in Pseudomonas putida for bioconversion of an aromatic carbon source by Deepanwita Banerjee, Javier Menasalvas, Yan Chen, Jennifer W. Gin, Edward E. K. Baidoo, Christopher J. Petzold, Thomas Eng, Aindrila Mukhopadhyay

“…Abstract Genome-scale metabolic models (GSMM) are commonly used to identify gene deletion sets that result in growth coupling and pairing product formation with substrate utilization and can improve strain performance beyond levels typically accessible using traditional strain engineering approaches. …”
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Optical genome mapping to decipher the chromosomal aberrations in families seeking for preconception genetic counseling by Kaili Yin, Mengmeng Li, Hanzhe Zhang, Jiazhen Chang, Qingwei Qi, Xiya Zhou, Jiangshan Guo, Yaru Wang, Xuequn Mao, Na Hao, Yulin Jiang

Subjects: “…Optical genome mapping…”
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Blood Genome-Wide Transcriptional Profiles of HER2 Negative Breast Cancers Patients by Ovidiu Balacescu, Loredana Balacescu, Oana Virtic, Simona Visan, Claudia Gherman, Flaviu Drigla, Laura Pop, Gabriela Bolba-Morar, Carmen Lisencu, Bogdan Fetica, Oana Tudoran, Ioana Berindan-Neagoe

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Complete mitochondrial genome and phylogenetic analysis of the Atrato slider, Trachemys medemi (Testudines, Emydidae) by Sebastián Cuadrado-Ríos, Mario Vargas-Ramírez, Christian Kehlmaier, Uwe Fritz

“…The mitochondrial genome of three Trachemys medemi was sequenced and annotated for the first time. …”
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Genomic analysis of global Plasmodium vivax populations reveals insights into the evolution of drug resistance by Gabrielle C. Ngwana-Joseph, Jody E. Phelan, Emilia Manko, Jamille G. Dombrowski, Simone da Silva Santos, Martha Suarez-Mutis, Gabriel Vélez-Tobón, Alberto Tobón Castaño, Ricardo Luiz Dantas Machado, Claudio R. F. Marinho, Debbie Nolder, François Nosten, Colin J. Sutherland, Susana Campino, Taane G. Clark

“…However, the molecular drivers of CQR remain unclear. Using a genome-wide approach, we perform a genomic analysis of 1534 P. vivax isolates across 29 endemic countries, detailing population structure, patterns of relatedness, selection, and resistance profiling, providing insights into potential drivers of CQR. …”
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Comprehensive genome annotation of Trilocha varians, a new model species of Lepidopteran insects by Jung Lee, Toshiaki Fujimoto, Katsushi Yamaguchi, Shuji Shigenobu, Ken Sahara, Toru Shimada

“…ATAC-seq was also conducted to determine chromatin accessibility across the genome. Finally, piRNA-targeted small RNA-seq revealed T. varians genome harbours 517 piRNA clusters (piCs). …”
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Genome-Wide Expression Profiles of Hemp (Cannabis sativa L.) in Response to Drought Stress by Chunsheng Gao, Chaohua Cheng, Lining Zhao, Yongting Yu, Qing Tang, Pengfei Xin, Touming Liu, Zhun Yan, Yuan Guo, Gonggu Zang

“…International Journal of Genomics…”
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Genomic and mutational analysis of Pseudomonas syringae pv. tagetis EB037 pathogenicity on sunflower by Jude E. Maul, John Lydon, Dilip Lakshman, Colin Willard, Hyesuk Kong, Daniel P. Roberts

“…In all, the Pstag EB037 genome contained homologues for at least 44 T3SS effectors with 30 having known functions. …”
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Unveiling the omics tapestry of B-acute lymphoblastic leukemia: bridging genomics, metabolomics, and immunomics by Yin Le, Shicong Zhu, Hongling Peng, Zhihua Wang

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Dataset for Genome Sequencing and De Novo Assembly of the Candidate Phyla Radiation in Supragingival Plaque by Song Jiang, Jie Nie, Yuxing Chen, Shiying Zhang, Xiaoyan Wang, Feng Chen

“…Here, we used metagenomic assembly and binning to reconstruct more and higher quality metagenome-assembled genomes (MAGs) of CPR from oral dental plaque. These MAGs represent novel CPR species, which differed from all known CPR organisms. …”
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Biological and economic characteristics of the allotetraploid with genomic formula DDAuAu from the cereal family by K. U. Kurkiev, I. G. Adonina, M. Kh. Gadjimagomedova, L. V. Shchukina, T. A. Pshenichnikova

“…A tetraploid synthetic  with genomic formula DDAuAu was obtained by N.A. Navruzbekov through crossing Aegilops tauschii Coss. and Triticum urartu Thum. ex Gandil. …”
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Attention-Based Hybrid Deep Learning Models for Classifying COVID-19 Genome Sequences by A. M. Mutawa

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Label-Free Surface-Enhanced Raman Scattering for Genomic DNA Cytosine Methylation Reading by Kazi Morshed Alom, Anastasiia Tukova, Nana Lyu, Alison Rodger, Yuling Wang

“…DNA methylation has been widely studied with the goal of correlating the genome profiles of various diseases with epigenetic mechanisms. …”
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Considering best practice standards for routine whole-genome sequencing for TB care and control by J.T. Denholm, G. de Vries, R. Anthony, E. Robinson, M. Backx, I.F. Laurenson, A.L. Seagar, H. Modestil, L. Trieu, J.S. Meissner, D.H.L. Ng, J.Y. Tay, H.H. Lin, R. Lee, V. Sintchenko, B.J. Marais, E.J. Donnan

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