Metabolomics-Driven Biomarker Discovery for Breast Cancer Prognosis and Diagnosis by Rasanpreet Kaur, Saurabh Gupta, Sunanda Kulshrestha, Vishal Khandelwal, Swadha Pandey, Anil Kumar, Gaurav Sharma, Umesh Kumar, Deepak Parashar, Kaushik Das

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Evaluation Frequency of Human Papillomavirus and Its Related Genotypes in Women of the General Population Living in 11 Provinces of Iran by Somayeh Hassani, Proshat Sadat Nadji, Anita Mohseni, Marjan Rahnamaye Farzami, Siamak Mirab Samiee, Makan Sadr, Seyed Alireza Nadji

“…The study was performed on 2562 vaginal specimens that were referred to the laboratory of the present study. HPV genome was detected by the nested MY-GP method and papillomavirus genotyping was performed using the PCR multiplex method to identify 19 papillomavirus genotypes. …”
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Regulation of interferon alpha production by the MAGUK-family protein CASK under H5N1 infection by Jing-Ying Huang, Jing-Ying Huang, Pei-Shan Sung, Shie-Liang Hsieh, Shie-Liang Hsieh, Shie-Liang Hsieh, Shie-Liang Hsieh

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Spatio‐Temporal Changes in Effective Population Size in an Expanding Metapopulation of Eurasian Otters by Nia Evelyn Thomas, Elizabeth A. Chadwick, Michael W. Bruford, Frank Hailer

“…We obtained clear bottleneck signals in East England, and signals of recent population expansion in Wales and South West England in some analyses, consistent with national otter surveys and recent findings from whole‐genome sequencing. Analyses that did not account for spatial genetic structuring yielded strong spurious signals of United Kingdom‐wide population expansion, and Ne estimates from these analyses were suppressed by a factor of 3–4. …”
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Nutrigenomics: A promising frontier in chronic disease prevention by Seyed Morteza Hosseiniara, Solmaz Sadat Hosseini Zijoud

“…These include the integration of diverse and complex datasets from various sources -such as genomics, metabolomics, and proteomics- the development of robust bioinformatics tools for data analysis and interpretation, and careful consideration of ethical implications, including privacy concerns and the potential for genetic discrimination.Moving forward, the integration of multi-omics approaches -encompassing a comprehensive analysis of an individual's genetic, epigenetic, metabolic, and proteomic profiles- will be crucial for advancing the field of nutrigenomics. …”
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Upregulated GSDMB in Clear Cell Renal Cell Carcinoma Is Associated with Immune Infiltrates and Poor Prognosis by Yuanshan Cui, Zhongbao Zhou, Yumeng Chai, Yong Zhang

“…The transcriptional expression profiles of GSDMB in ccRCC tissues in addition to normal tissues were retrieved from The Cancer Genome Atlas (TCGA) and additionally verified in a different independent cohort, which was obtained from the Gene Expression Omnibus (GEO) database. …”
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Identification of ubiquitination-related key biomarkers and immune infiltration in Crohn’s disease by bioinformatics analysis and machine learning by Wei Chen, Zeyan Xu, Haitao Sun, Wen Feng, Zhenhua Huang

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed. Key genes were selected by combining hub genes from the protein-protein interaction (PPI) network with feature genes identified by Lasso and Random Forest (RF) algorithms. …”
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Causal Effects of Sleep Traits on Angina Pectoris: Mediation by Cardiovascular Risk Factors by Zeng C, Ke Y, Li H, Zhang C, Chen J, Chen M

“…Our study aims to declare the causality of sleep traits on AP by Mendelian randomization (MR) analyses.Methods: Genome-wide association study (GWAS) data of sleep traits (sleep duration, insomnia, nap during day, chronotype, getting up in morning, narcolepsy, snoring) were obtained from the UK Biobank. …”
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Associations between Tissue Visfatin/Nicotinamide, Phosphoribosyltransferase (Nampt), Retinol Binding Protein-4, and Vaspin Concentrations and Insulin Resistance in Morbidly Obese... by Zeynep Goktas, Shannon Owens, Mallory Boylan, David Syn, Chwan-Li Shen, Debra B. Reed, Susan San Francisco, Shu Wang

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La genèse et la manifestation des structures d’un point de vue cognitiviste et (post-)structuraliste by Sébastien Miravete

“…Il ne semble pas toujours possible en effet d’expliquer leur apparition à partir du génome humain. Comment les êtres humains parviennent-ils, dès lors, à acquérir des structures et à leur donner une apparence spécifique ? …”
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Conjunctival scarring in trachoma is associated with the HLA-C ligand of KIR and is exacerbated by heterozygosity at KIR2DL2/KIR2DL3. by Chrissy H Roberts, Sandra Molina, Pateh Makalo, Hassan Joof, Emma M Harding-Esch, Sarah E Burr, David C W Mabey, Robin L Bailey, Matthew J Burton, Martin J Holland

“…<h4>Principle findings</h4>We found that the odds of trachomatous scarring increased with the number of genome copies of HLA-C2 (C1/C2 OR = 2.29 BHP-value = 0.006; C2/C2 OR = 3.97 BHP-value = 0.0004) and further increased when both KIR2DL2 and KIR2DL3 (C2/C2 OR = 5.95 BHP-value = 0.006) were present.…”
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Amelioration of liver fibrosis with autologous macrophages induced by IL-34-based condition by Yuichi Igarashi, Haruka Wada, Masato Muto, Ryohei Sone, Yoshinori Hasegawa, Ken-ichiro Seino

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Naturally occurring variation in a cytochrome P450 modifies thiabendazole responses independently of beta-tubulin. by J B Collins, Clayton M Dilks, Steffen R Hahnel, Briana Rodriguez, Bennett W Fox, Elizabeth Redman, Jingfang Yu, Brittany Cooke, Kateryna Sihuta, Mostafa Zamanian, Peter J Roy, Frank C Schroeder, John S Gilleard, Erik C Andersen

“…However, mutations in beta-tubulin alone do not fully explain all BZ resistance. We performed a genome-wide association study using a genetically diverse panel of Caenorhabditis elegans strains to identify loci that contribute to resistance to the BZ drug thiabendazole (TBZ). …”
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Effects of Particulate Matter Exhaust on Functional Parameters of Organ Systems and Reactive Oxygen Species: A Cross-Sectional Study by Manjula Shivanagappa, SS Malini, Thanmayi Mahadeshwara Prasad, D. R. Mahadeshwara Prasad

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Computational analysis of spliced leader trans-splicing in the regenerative flatworm <i>Macrostomum lignano</i> reveals its prevalence in conserved and stem cell related genes by K. V. Ustyantsev, E. V. Berezikov

“…By reanalyzing the existing genome and transcriptome data of M. lignano, we estimate that 30 % of its genes are SL trans-spliced, 15 % are organized in operons, and almost 40 % are both SL trans-spliced and in operons. …”
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YAP1 as a Novel Negative Biomarker of Immune Checkpoint Inhibitors for EGFR-Mutant Non-Small-Cell Lung Cancer by Ling-Chen Li, Xie-Wan Chen, Ling Fang, Chun-Li Jian, Yong-Xin Yu, Xing-Yun Liao, Jian-Guo Sun

“…All the clinical data of NSCLC were downloaded from Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) for GSE11969 and GSE72094. …”
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An increased proportion of transgenic plants in the progeny of rapeseed (<i>Brassica napus</i> L.) transformants by G. N. Raldugina, T. Z. Hoang, H. B. Ngoc, I. V. Karpichev

“…We also found that in individual transformants gfp is randomly inherited throughout the central peduncle; its presence in the genome of seedlings does not depend on the location of the pod. …”
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Repression of CADM1 transcription by HPV type 18 is mediated by three-dimensional rearrangement of promoter-enhancer interactions. by Karen Campos-León, Jack Ferguson, Thomas Günther, C David Wood, Steven W Wingett, Selin Pekel, Christy S Varghese, Leanne S Jones, Joanne D Stockton, Csilla Várnai, Michelle J West, Andrew Beggs, Adam Grundhoff, Boris Noyvert, Sally Roberts, Joanna L Parish

“…Analysis of CTCF binding in the host cell genome by ChIP-Seq revealed that while the total number of CTCF binding sites is not altered by the virus, there are a sub-set of CTCF binding sites that are either enriched or depleted of CTCF. …”
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Plant genetic resources in India: management and utilization by K. Singh, K. Gupta, V. Tyagi, S. Rajkumar

“…Presently, our focus is on characterization of ex situ conserved germplasm and detailed evaluation of prioritized crops for enhanced utilization; assessment of impact of on-farm conservation practices on genetic diversity; genome-wide association mapping for identification of novel genes and alleles for enhanced utilization of PGR; identification and deployment of germplasm/landraces using climate analog data; validation of trait-specific introduced germplasm for enhanced utilization.…”
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Investigating cooked rice textural properties by instrumental measurements by Keyu Tao, Wenwen Yu, Sangeeta Prakash, Robert G. Gilbert

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