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5962
Exploring the Causal Relationship and Molecular Mechanisms Between Fasting Insulin and Androgenetic Alopecia: A Mendelian Randomization Study with Bioinformatics Analysis
Published 2025-02-01“…In this study, a Mendelian randomization (MR) analysis was utilized to discover the causal associations between FI and AGA.Methods: Genome-wide association study (GWAS) data for FI and AGA were retrieved, and bidirectional MR analysis was conducted. …”
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5963
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5964
Depletion of key gut bacteria predicts disrupted bile acid metabolism in inflammatory bowel disease
Published 2025-02-01“…BA-transformation activity mediated by the bile acid inducible (bai) operon has been functionally characterized in the genus Clostridium, and homologous bai gene sequences have been found in metagenome-assembled genomes (MAGs) belonging to other taxa in the human gut, but it is unclear which species of bai-carrying bacteria perform physiologically significant amounts of bile acid transformation in healthy and sick individuals. …”
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5965
A Bidirectional Mendelian Randomization Study Investigating the Causal Relationship Between Ankylosing Spondylitis and Chronic Obstructive Pulmonary Disease
Published 2025-02-01“…The analysis utilized publicly available statistics on AS and COPD from the Genome-wide Association Study (GWAS). The primary MR method employed was Inverse-Variance Weighting (IVW), supplemented by additional MR methods such as weighted median, MR-Egger, simple mode, and weighted mode. …”
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5966
The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses.
Published 2012-01-01“…<h4>Methodology/principal findings</h4>S. mansoni genome searches revealed 13 members (SmTAL1-13) within the species. …”
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5967
Genetic variability and population structure analysis of Protostrongylus oryctolagi (Nematoda: Protostrongylidae) in Lepus europaeus from Central and Northern Italy.
Published 2025-01-01“…Finally, the presence of unconventional shortened amplicons revealed the presence of NUMTs (nuclear copy of mitochondrial genes) in the P. oryctolagi nuclear genome, suggesting caution when using DNA barcode as unique marker for the identification of species belonging to this genus. …”
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5968
Comprehensive guide for epigenetics and transcriptomics data quality control
Published 2025-03-01Get full text
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5969
Construction and characterization of an infectious cDNA clone of turtle grass virus X from a naturally infected Thalassia testudinum plant
Published 2025-01-01“…This study presents the construction and characterization of an infectious cDNA clone of the potexvirus turtle grass virus X (TGVX). The complete genome of this positive-sense single-stranded RNA virus was amplified from field samples of Thalassia testudinum and assembled into a pLX-based mini binary vector using a multi-fragment directional cloning strategy, resulting in the infectious clone pLX-TGVX. …”
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5970
Mechanistic insights into pachymic acid’s action on triple-negative breast Cancer through TOP2A targeting
Published 2025-01-01“…Enrichment analysis included Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). We conducted a pan-cancer analysis, tumor immune microenvironment analysis, and molecular docking. …”
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5972
Separating the Effects of Early-Life and Adult Body Size on Chronic Kidney Disease Risk: A Mendelian Randomization Study
Published 2025-01-01“…Genetic associations with early-life and adult body size were obtained from a genome-wide association study of 453,169 participants in the U.K. …”
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5973
Characterization of <i>PHT</i> Genes in ‘duli’ (<i>Pyrus betulifolia Bunge</i>) and Expression Analysis of <i>PbPHTs</i> in Response to Plant Growth Regulators, P, and Salt Stress...
Published 2025-01-01“…A total of 158 <i>PbPHTs</i> were identified from the genome of ‘duli’ (<i>Pyrus betulifolia Bunge</i>) in this study, including 70 <i>PbPHT1s</i>, 2 <i>PbPHT2s</i>, 70 <i>PbPHT3s</i>, 12 <i>PbPHT4s</i>, and 4 <i>PbPHT5s</i>. …”
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5975
Expression divergence of BAG gene family in maize under heat stress
Published 2025-01-01“…Twenty-one (21) BAG genes were identified in the latest maize genome. The evolutionary relationship of Zea mays BAGs (ZmBAGs) with Arabidopsis thaliana, Solanum lycopersicum, Theobroma cacao, Sorghum bicolor, Ananas comosus, Physcomitrium patens, Oryza sativa and Populus trichocarpa were represented by the phylogenetic analysis. …”
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5976
Phenotypic stability of spring bread wheat regenerant lines
Published 2023-04-01“…Selection of somaclonal variation under callus culture (СС) conditions is one of the methods of undirected genome change induction which has become actively used in the development of cultivars with high adaptive potential. …”
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5977
Methylome profiling of cell-free DNA during the early life course in (un)complicated pregnancies using MeD-seq: Protocol for a cohort study embedded in the prospective Rotterdam pe...
Published 2025-01-01“…We will for the first time longitudinally investigate cfDNA methylation during pregnancy by using Methylated DNA Sequencing (MeD-seq), which is compatible with low cfDNA levels and has an extensive genome-wide coverage. We aim to investigate DNA methylation in placental tissues and cfDNA during different trimesters in uncomplicated pregnancies, and in pregnancies with placental-related complications, including preeclampsia and fetal growth restriction. …”
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5978
A perspective on intermittent fasting and cardiovascular risk in the era of obesity pharmacotherapy
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5979
High-Performance Edge-Contact Monolayer Molybdenum Disulfide Transistors
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5980
Comprehensive analysis of heat shock protein 110, 90, 70, 60 families and tumor immune microenvironment characterization in clear cell renal cell carcinoma
Published 2025-01-01“…The data obtained from the Cancer Genome Atlas (TCGA) were applied to determine the differential expression of HSPs in normal tissues and ccRCC. …”
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