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Genetic studies of normal tension glaucoma
Published 2024-12-01“…Variations in a number of TBK1 gene copies are also associated with NTG development in some populations. Among multiple genome-wide association studies (GWAS) of the glaucoma, genetic architecture of NTG has been studied only in isolated cases. …”
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5763
Analysis of polymorphism at the <i>FaRca1</i> locus to identify strawberry genotypes resistant to <i>Colletotrichum acutatum</i>
Published 2025-01-01“…Promising genetic sources for marker-assisted breeding are strawberry cultivars combining several resistance factors in the genome: ‘Borovitskaya’ and ‘Aprica’ (FaRca1 and Rca2 anthracnose resistance loci), ‘Korona’ and ‘Ostara’ (FaRca1 anthracnose resistance locus, and 08 To-f powdery mildew resistance locus), and ‘Bylinnaya’ (FaRca1 anthracnose resistance locus, 08 To-f powdery mildew resistance locus, and Rpf1 red stele root rot resistance locus).…”
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5764
Effect of Mitochondrial Tu Translation Elongation Factor on Water-holding Capacity of Qinchuan Cattle Meat during Postmortem Aging
Published 2025-01-01“…Through proteomics, 23 differential proteins related to TUFM were identified, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that the differential proteins could mediate cellular autophagy by participating in energy metabolism through a variety of pathways. …”
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5765
Expression and clinical significance of disulfidptosis-related LncRNA in gastric cancer
Published 2024-09-01“…Methods The multi-omics features of disulfidptosis genes in gastric cancer were first analyzed based on The Cancer Genome Atlas(TCGA) database. DRLncs were further screened, and disulfidptosis related gene recurrence score (DRG-RS) model was constructed to predict the overall survival(OS) and correlation with the clinical characteristics of gastric cancer patients. …”
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5766
Toll-like receptor 4 pathway evolutionary trajectory and functional emergence
Published 2025-01-01“…Our previous work on pan-genome-wide survey, indicates Callorhincus milli to be the ancestral organism with both TRAM and TRIF proteins.MethodsTo gain a deeper insight into the protein function and to compare them with Homo sapiens adaptor proteins, we modeled the docking of the TRAM–TRIF complex of representative organisms across various taxa. …”
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5767
Liver Microbiome in Healthy Rats: The Hidden Inhabitants of Hepatocytes
Published 2023-01-01“…The main function composition of the genomes of annotated bacteria was correlated with metabolism (79.92±0.24%). …”
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5768
Identification and characterization of CONSTANS-like (COL) gene family in upland cotton (Gossypium hirsutum L.).
Published 2017-01-01“…In this study, we identified 42 COL homologs (GhCOLs) in the G. hirsutum genome, and many of them were previously unreported. …”
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Monitoring of single-nucleus chromatin landscape of ischemic stroke in mouse cerebral cortex across time
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5771
Acute Genetic Damage Induced by Ethanol and Corticosterone Seems to Modulate Hippocampal Astrocyte Signaling
Published 2024-01-01“…However, there is no information associating primary damage to the astrocyte genome, the DNA damage response (DDR), and the EV and NT repertoire. …”
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The SpxA1-TenA toxin-antitoxin system regulates epigenetic variations of Streptococcus pneumoniae by targeting protein synthesis.
Published 2024-12-01“…As manifested by phase switch between opaque and transparent colonies, different genome methylation patterns or epigenomes confer pathogenesis-associated traits, but it is unknown how the pathogen controls the hsdS inversion orientations. …”
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Molecular genetic characteristics of broccoli (Brassica oleracea L. var. italica Plenck) from the VIR collection
Published 2020-10-01“…For the analysis, 35 markers of microsatellite sequences specific to the Brassica L. genome were selected. PCR products were separated by electrophoresis on a 3% agarose gel.Results and conclusions. …”
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5776
Exploring the influences of education, intelligence and income on mental disorders
Published 2024-02-01“…However, the direct effects of each factor on major mental disorders are unclear.Aims We aimed to evaluate the overall and independent causal effects of the three psychosocial factors on common mental disorders.Methods Using genome-wide association study summary datasets, we performed Mendelian randomisation (MR) and multivariable MR (MVMR) analyses to assess potential associations between the 3 factors (EA, N=766 345; household income, N=392 422; intelligence, N=146 808) and 13 common mental disorders, with sample sizes ranging from 9907 to 807 553. …”
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5777
The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization
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5778
Marek's disease virus-1 unique gene LORF1 is involved in viral replication and MDV-1/Md5-induced atrophy of the bursa of Fabricius.
Published 2025-02-01“…To this end, an infectious bacterial artificial chromosome (BAC) harboring the complete genome of the MDV-1 very virulent strain Md5 was generated, and the rescued rMd5 maintained biological properties similar to the parental virus both in vitro and in vivo. …”
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Development of a 3-MicroRNA Signature and Nomogram for Predicting the Survival of Patients with Uveal Melanoma Based on TCGA and GEO Databases
Published 2022-01-01“…Methods. miRNA and mRNA sequencing data for 80 UM patients were obtained from The Cancer Genome Atlas (TCGA) database. The patients were further randomly assigned to a training set (n = 40, used to identify key miRNAs) and a testing set (n = 40, used to internally verify the signature). …”
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Activation of endogenous tolerance to bleaching stress by high salinity in cloned endosymbiotic dinoflagellates from corals
Published 2025-01-01“…The findings also suggest the genomes of coral symbiotic dinoflagellates have undergone evolutionary processes to develop mechanisms, regulated by gene expression, to mitigate damages caused by high temperature and high light stress. …”
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