Targeting protein synthesis pathways in MYC-amplified medulloblastoma by Devendra Kumar, Ranjana Kanchan, Nagendra K. Chaturvedi

“…Evidence strongly proposes that MYC/mTOR-driven tumorigenic signaling can predominantly control the translational machinery to elicit cooperative effects on increased cell proliferation, cell cycle progression, and genome dysregulation as a mechanism of cancer initiation. …”
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Lived experiences of social support in Paralympic swimmers: A protocol for a qualitative study by Paul Martin, Alison Rushton, Nicola R Heneghan, Andrew Soundy, Beth Aitchison

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Ulcerative Colitis Preceding Asymptomatic Wilson’s Disease: A Case Report and Literature Review by Jun Kunizaki, Yuko Yoto, Yoshinobu Nagaoka, Akira Ishii, Tomoe Kazama, Kohei Wagatsuma, Noriyuki Akutsu, Aki Ishikawa, Toju Tanaka, Shintaro Sugita, Takeshi Tsugawa, Hiroshi Nakase

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Development of a Novel Prognostic Model for Lung Adenocarcinoma Utilizing Pyroptosis-Associated LncRNAs by Hong-Yan Bai, Tian-Tian Li, Li-Na Sun, Jing-Hong Zhang, Xiu-He Kang, Yi-Qing Qu

“…This study used genotype-tissue expression (GTEx) and the cancer genome atlas (TCGA) databases to obtain 477 lung adenocarcinoma (LUAD) and 347 healthy individuals’ samples as research subjects and divided LUAD patients into low-risk and high-risk groups based on prognostic risk scores. …”
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The use of wheatgrass (<i>Thinopyrum intermedium</i>) in breeding by I. V. Pototskaya, V. P. Shamanin, A. N. Aydarov, A. I. Morgounov

“…The first consensus map of wheatgrass containing 10,029 markers was obtained, which is important for searching for genes and their introgressions to the wheat genome. The results of research on the nutritional and technological properties of wheatgrass grain for the development of food products as well as the differences in the quality of wheatgrass grain and wheat grain are presented.…”
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Characterization of gene expression profiles in Alzheimer's disease and osteoarthritis: A bioinformatics study. by Nian Liu, Qian Deng, Zining Peng, Danning Mao, Yuanbo Huang, Fanyu Meng, Xiaoyu Zhang, Jiayan Shen, Zhaofu Li, Weitian Yan, Jiangyun Peng

“…In addition, the core genes were analyzed using gene set enrichment analysis and single-gene genome variation analysis.<h4>Results</h4>Analysis of DEGs on gene chips from OA and AD patients revealed significant changes in gene expression patterns. …”
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Antioxidant Properties of Popular Turmeric (Curcuma longa) Varieties from Bangladesh by E. M. Tanvir, Md. Sakib Hossen, Md. Fuad Hossain, Rizwana Afroz, Siew Hua Gan, Md. Ibrahim Khalil, Nurul Karim

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Bidirectional causal associations between frailty measures and sleep disturbances: a two-sample Mendelian randomization study by Che L, Zang H, Bi Y, Wen B, Xu L

“…We aimed to investigate the bidirectional causal relationships between frailty measures and sleep disturbances employing a two-sample Mendelian randomization (MR) analysis.Methods: Two-sample MR analyses were performed based on large-scale genome-wide association studies (GWAS) of the European population for frailty index (FI) (N = 175,226), Fried Frailty Score (FFS) (N = 386,565), insomnia (N = 283,595), sleep duration (N = 445,966) and sleep apnea (N = 523,366). …”
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Hemorrhagic Shock Induces a Rapid Transcriptomic Shift of the Immune Balance in Leukocytes after Experimental Multiple Injury by Lisa Debler, Annette Palmer, Sonja Braumüller, Bettina Klohs, Tom Eirik Mollnes, Karlheinz Holzmann, Markus Huber-Lang, Rebecca Halbgebauer

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Shared genetic factors and the interactions with fresh fruit intake contributes to four types squamous cell carcinomas. by Mengqing Mo, Can Hou, Huangbo Yuan, Renjia Zhao, Mingyang Chen, Yanfeng Jiang, Kelin Xu, Tiejun Zhang, Xingdong Chen, Chen Suo

“…By integrating a large-scale genotype data of 1,928 Pan-SCCs cases and 7,712 age- and sex-matched controls in the UK Biobank cohort, as well as multiple transcriptome and protein databases, we conducted a multi-omics analysis. Genome-wide association analysis (GWAS) was used to identify genetic susceptibility loci of SCCs. …”
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Circular RNA microarray expression profile and potential function of circDOCK1 in colorectal cancer by Guojing Zhang, Xiaoyan Wu, Hongmin Fu, Daqing Sun

“…After Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and circRNA–miRNA network analyses, circDOCK1 was chosen for further investigation. …”
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The problem of norovirus infection in animals (literature review) by V. А. Mischenko, A. V. Mischenko, T. B. Nikeshina, O. N. Petrova, Yu. V. Brovko, A. I. Kushlubaeva

“…The noroviruses were detected in fecal samples from humans, cattle, pigs, sheep, dogs, cats, mice, as well as in pork and milk samples. The norovirus genome is prone to mutations, resulting in antigenic shifts and recombination, as well as the emergence and rapid spread of new epidemic and epizootic variants. …”
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MAIP1-Related Tumor Immune Infiltration: As a Potential Prognostic Biomarker for Esophageal Cancer by Xiaoyu He, Fu Gan, Yongjian Lin, Guoqing Liu, Yunhua Lin, Dongxu Chen

“…We obtained RNA-seq datasets and corresponding clinical data for EC patients from the Cancer Genome Atlas (TCGA) database via the UCSC Xena browser to extract MAIP1 expression and plot survival curves to determine their prognosis. …”
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Using the appropriate modulus of elasticity of periodontal ligament matters in stress analysis of human first premolar tooth and periodontium structures by Phetcharat Dhammayannarangsi, Sorapon Na Lampang, Kevin A. Tompkins, Vincent Everts, Thanaphum Osathanon, Chalida Nakalekha Limjeerajarus, Nuttapol Limjeerajarus

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Molecular Detection and Phylogenetic Analysis of the alkB Gene in Klebsiella oxytoca Strains Isolated from the Gut of Tenebrio molitor by Tsitsi Lynn Mupamhadzi, Oleen Machona, Farisai Chidzwondo, Rumbidzai Mangoyi

“…The alkB gene sequence identical to fourteen alkB gene sequences derived from Actinobacteria whole genome was detected in Klebsiella oxytoca for the first time to the best of our knowledge. …”
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Exploring potential therapeutic targets for small cell lung cancer based on transcriptomics combined with Mendelian randomization analysis by Zhicheng Liao, Pengcheng Jia, Yifan Li, Zhihui Zheng, Jizhou Zhang

“…Based on expression quantitative trait loci data and the genome-wide association study data of SCLC, MR analysis was used to screen the genes closely related to SCLC disease, which intersect with DEGs to obtain co-expressed genes (CEGs), and the biological functions and pathways of CEGs were further explored by enrichment analysis. …”
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A method for siRNA-mediated knockdown of target genes in RA-induced neurogenesis using P19 cells by Hossein Khodadadi, Hiroaki Taniguchi

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Eight patients with inflammatory myofibroblastic tumor treated with rigid bronchoscopy by Byeong-Ho Jeong, Rong Lih Ho, Ho Yun Lee, Joungho Han, Hojoong Kim

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Repurposing antiviral drugs targeting the PARP-1 and HER2 pathways with multifaceted impacts through integrated network analysis and molecular mechanics by Uma Maheshwari Mugundan, Praveen Sekar, Rajanandh Muhasaparur Ganesan

“…Through the application of network pharmacology, gene ontology, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses, this study identified Human Epidermal Growth Factor Receptor 2 (HER2) and Poly [ADP ribose] polymerase 1(PARP-1) as key targets involved in the molecular pathways associated with breast cancer. …”
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Ginkgo biloba L.: An Updated Review on the Pharmacological Activities, Pharmacokinetics and Drug Interactions by Zahra Moeinipour, Maryam Akaberi, Zahra Sobhani

“…Also, the use of technologies such as genomics, metabolomics, and transcriptomics can provide a more comprehensive understanding of how G. biloba interacts with drugs at the molecular level. …”
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