“One Ring to Bind Them All”—Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition by David Monchaud, Anton Granzhan, Nicolas Saettel, Aurore Guédin, Jean-Louis Mergny, Marie-Paule Teulade-Fichou

Get full text

Gama Radyasyonun İndüklediği Nefrotoksiteye Karşılık Pycnogenolün Koruyucu Etkisi by Oğuz Galip Yıldız, Güler Toprak, Arzu Hanım Yay, Fazile Cantürk Tan

Get full text

Prediction of protein biophysical traits from limited data: a case study on nanobody thermostability through NanoMelt by Aubin Ramon, Mingyang Ni, Olga Predeina, Rebecca Gaffey, Patrick Kunz, Shimobi Onuoha, Pietro Sormanni

Get full text

PPARα Is Required for PPARδ Action in Regulation of Body Weight and Hepatic Steatosis in Mice by Wojciech G. Garbacz, Jeffrey T. J. Huang, Larry G. Higgins, Walter Wahli, Colin N. A. Palmer

Get full text

Deciphering regulatory architectures of bacterial promoters from synthetic expression patterns. by Rosalind Wenshan Pan, Tom Röschinger, Kian Faizi, Hernan G Garcia, Rob Phillips

“…For the vast majority of genes in sequenced genomes, there is limited understanding of how they are regulated. …”
Get full text

Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation by Chao-Yang Lai, Yu-Wen Su, Kuo-I Lin, Li-Chung Hsu, Tsung-Hsien Chuang

Get full text

Investigating the Prognostic and Oncogenic Roles of Membrane-Associated Ring-CH-Type Finger 9 in Colorectal Cancer by Jiayan Zhang, Qinghan Jiao, Zhigang Chen

“…We leveraged data from the Cancer Genome Atlas (TCGA) cohort to evaluate MARCHF9 expression profiles in CRC. …”
Get full text

Soil-Borne Microbial Functional Structure across Different Land Uses by Eiko E. Kuramae, Jizhong Z. Zhou, George A. Kowalchuk, Johannes A. van Veen

Get full text

Bioinformatics Analysis of miRNAs Targeting TRAF5 in DLBCL Involving in NF-κB Signaling Pathway and Affecting the Apoptosis and Signal Transduction by Chunyao Li, Lanshan Huang, Yongqin Wen, Muhua Yi, Min Gao

“…The Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) were applied to analyse DEGs. Then multiple databases were searched for related miRNAs within DLBCL, TNF receptor-associated factor 5 (TRAF5) and NF-kappa B (NF-κB) signaling pathways. …”
Get full text

Divergent Cotton leaf curl Multan betasatellite and three different alphasatellite species associated with cotton leaf curl disease outbreak in Northwest India. by Kajal Kumar Biswas, Nenavath Balram, Marimuthu Elangovan, Supratik Palchoudhury, Utpal Kumar Bhattacharyya, Halima Khatoon, Shilpi Aggarwal, Shruti Godara, Pradeep Kumar, Satish Kumar Sain, Rupesh Arora, Sibnarayan Datta

“…Total plant DNAs were isolated, subjected to rolling circle amplification (RCA), cloning and sequencing. Full-length genome of 12 betasatellites and 13 alphasatellites, those were obtained in the present study, were analyzed. …”
Get full text

Genetic Variation in Taste Receptor Genes (SCNN1B, TRPV1) and Its Correlation with the Perception of Saltiness in Normotensive and Hypertensive Adults by Pradtana Tapanee, Diane K. Tidwell, M. Wes Schilling, Daniel G. Peterson, Terezie Tolar-Peterson

Get full text

Innovative technologies and social inequalities in health: A scoping review of the literature. by Daniel Weiss, Håvard T Rydland, Emil Øversveen, Magnus Rom Jensen, Solvor Solhaug, Steinar Krokstad

“…Additionally, focus on health care services technologies must be accompanied by investigating emerging technologies influencing healthy lifestyle, genomics, and personalized devices in health. Findings also suggest that choosing one measure of social position over another has important implications for the interpretation of research results. …”
Get full text

Enhancing computational accuracy with parallel parameter optimization in variational quantum eigensolver by Daisuke Tsukayama, Jun-ichi Shirakashi, Tetsuo Shibuya, Hiroshi Imai

Get full text

Dissection of Ire1 functions reveals stress response mechanisms uniquely evolved in Candida glabrata. by Taiga Miyazaki, Hironobu Nakayama, Yohsuke Nagayoshi, Hiroshi Kakeya, Shigeru Kohno

“…C. glabrata Ire1 did not cleave mRNAs encoding Hac1 and other bZIP transcription factors identified in the C. glabrata genome. Microarray analysis revealed that the transcriptional response to ER stress is not mediated by Ire1, but instead is dependent largely on calcineurin signaling and partially on the Slt2 MAPK pathway. …”
Get full text

Prenatal maternal stress in rats alters the epigenetic and transcriptomic landscape of the maternal-fetal interface across four generations by Stephanie E. King, Nicola A. Schatz, Olena Babenko, Yaroslav Ilnytskyy, Igor Kovalchuk, Gerlinde A. S. Metz

Get full text

Exploring the Mechanisms of Zhenbao Pills in the Treatment of Stroke through Network Pharmacology Combined with Mendelian Randomization by Yanhong Liu, Yunqi Hua, Xiaoe Jia

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses revealed that these targets are involved mainly in oxidative stress processes, lipid metabolism, and the PI3K–Akt signaling pathway. …”
Get full text

Coagulase gene and agr complex polymorphism-based genotyping of <i>Staphylococcus aureus</i> isolated from non-human primates by V. A. Kalashnikova

“…Apart from human Staphylococcus aureus, in whose genome agrI prevails, agrIV prevailed in the isolates outlined in this paper (59.3%); agrII and agrIII were detected in 5.5 and 2.1% of the isolates, respectively.…”
Get full text

The Potential Dual Role of H2.0-like Homeobox in the Tumorgenesis and Development of Colorectal Cancer and Its Prognostic Value by Shuo Chen, Lin Zhang, Kai Wang, Jizhen Huo, Siqi Zhang, Xipeng Zhang

“…In this study, the data were collected from The Cancer Genome Atlas and Gene Expression Omnibus databases. …”
Get full text

Smart Contract Penyimpanan Data Genetika Manusia Berbiaya Murah pada Blockchain Ethereum by Tri Stiyo Famuji, Herman Herman, Sunardi Sunardi

“…Genetika manusia merujuk pada informasi yang dikumpulkan tentang genom atau warisan genetik individu manusia. Data ini mencakup sekuens DNA, variasi genetik, mutasi, dan informasi lain yang terkait dengan sifat dan karakteristik genetik individu manusia. …”
Get full text

Genetic risk factors associated with gestational diabetes in a multi-ethnic population. by Paula Benny, Hyeong Jun Ahn, Janet Burlingame, Men-Jean Lee, Corrie Miller, John Chen, Johann Urschitz

“…<h4>Aims</h4>Genome-wide association studies have shown an increased risk of type-2-diabetes (T2DM) in patients who carry single nucleotide polymorphisms in several genes. …”
Get full text