Naxos Disease and Related Cardio-Cutaneous Syndromes by Alexandros Protonotarios, MD, Angeliki Asimaki, Ph.D, Cristina Basso, MD, Zafeirenia Xylouri, MD, Emanuele Monda, MD, Ioannis Protonotarios, MD, Giulia Crisci, MD, Dominic JR. Abrahms, MMBS, MD, MBA, Aris Anastasakis, MD, Loizos Antoniades, MD, Athanasios Bakalakos, MD, Andreina Carbone, MD, Aman S. Coonar, MD, Juan Ramon Gimeno, MD, George Lazaros, MD, Stamatis Lerakis, MD, Luisa Mestroni, MD, George Papadopoulos, MD, Leandro Pecchia, MD, Francesca Romana Prandi, MD, Petros Syrris, MD, Julia Cadrin-Turigny, MD, Anargyros Vasilakis, MSc, Jeffrey E. Saffitz, MD, PhD, Stamatios Gaetano Thiene, MD, Perry M. Elliott, MD, Juan Pablo Kaski, MD, William J. McKenna, MD, Eduardo Bossone, MD, Giuseppe Limongelli, MD, Adalena Tsatsopoulou, MD

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CD38 deficiency leads to a defective short-lived transcriptomic response to chronic graft-versus-host disease induction, involving purinergic signaling-related genes and distinct t... by Mercedes Zubiaur, Laura C. Terrón-Camero, Fernando Gordillo-González, Eduardo Andrés-León, Alicia Barroso-del Jesús, Luz María Canet-Antequera, María M. Pérez Sánchez-Cañete, África Martínez-Blanco, Marilú Domínguez-Pantoja, María Botia-Sánchez, Sonia Pérez-Cabrera, Nerea Bello-Iglesias, Antonio Alcina, Ana-Clara Abadía-Molina, Fuencisla Matesanz, Esther Zumaquero, Ramón Merino, Jaime Sancho

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Annexin A8 deficiency delays atherosclerosis progression by Carmen Gutiérrez‐Muñoz, Rafael Blázquez‐Serra, Irene San Sebastian‐Jaraba, Sandra Sanz‐Andrea, Maria J. Fernández‐Gómez, Gonzalo Nuñez‐Moreno, Pablo Mínguez, Joan Carles Escolá‐Gil, Paula Nogales, Veronique Ollivier, Jose L. Martín‐Ventura, Benoit Ho‐Tin Noe, Ursula Rescher, Nerea Méndez‐Barbero, Luis M. Blanco‐Colio

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Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms by Mie Suzuki Okutani, Shinya Okamura, Tang Gis, Hitomi Sasaki, Suni Lee, Akiho Kashiwabara, Simon Goto, Mai Matsumoto, Mayuko Yamawaki, Toshiaki Miyazaki, Tatsuya Nakagawa, Masahito Ikawa, Wataru Kamitani, Shiro Takekawa, Koichi Yamanishi, Hirotaka Ebina

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Multiple programmed cell death patterns predict the prognosis and drug sensitivity in gastric cancer by Qiying Song, Shihe Liu, Di Wu, Aizhen Cai

“…The diverse patterns of programmed cell death (PCD) are significantly associated with the pathogenesis and progression of GC, and it has the potential to serve as prognostic and drug sensitivity indicators for GC.MethodThe sequencing data and clinical characteristics of GC patients were downloaded from The Cancer Genome Atlas and GEO databases. LASSO cox regression method was used to screen feature genes and develop the PCD score (PCDS). …”
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An approximate likelihood method reveals ancient gene flow between human, chimpanzee and gorilla by Galtier, Nicolas

“…Distinguishing between the two processes is a key objective of current evolutionary genomics. This is most often pursued via the so-called ABBA-BABA type of method, which relies on a prediction of symmetry of gene tree discordance made by the incomplete lineage sorting hypothesis. …”
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Detection of Residual Levels and Associated Health Risk of Seven Pesticides in Fresh Eggplant and Tomato Samples from Narayanganj District, Bangladesh by Md. Nur Alam, M. Alamgir Zaman Chowdhury, M. Sabir Hossain, Mohammad Mijanur Rahman, M. Abdur Rahman, Siew Hua Gan, Md. Ibrahim Khalil

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Evaluation of Positron Emission Tomographic Tracers for Imaging of Papillomavirus-Induced Tumors in Rabbits by Sonja Probst, Stefan Wiehr, Frederic Mantlik, Holger Schmidt, Armin Kolb, Peter Münch, Maria Delcuratolo, Frank Stubenrauch, Bernd J. Pichler, Thomas Iftner

“…New Zealand White rabbits were infected with cottontail rabbit papillomavirus genomes and were imaged for up to 10 months with a simultaneous PET/MR system during the course of infection. …”
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Author Correction: MADS-box encoding gene Tunicate1 positively controls maize yield by increasing leaf number above the ear by Yan Li, Jian Wang, Shuyang Zhong, Qiang Huo, Qun Wang, Yunlu Shi, Hangqin Liu, Jiacheng Liu, Yang Song, Xiaojian Fang, Zhongwei Lin

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The Role of the Key Differentially Mutated Gene FGFR3 in the Immune Microenvironment of Bladder Cancer by Jun Jiang, Yan Zhan, Jun Li

“…In this work, we downloaded the RNA-seq expression profiles and somatic mutation data of 433 bladder cancer cases from The Cancer Genome Atlas (TCGA) and then employed a comprehensive bioinformatics approach to evaluate them. …”
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Potential Functions and Causal Associations of GNLY in Primary Open-Angle Glaucoma: Integration of Blood-Derived Proteome, Transcriptome, and Experimental Verification by Wang D, Pu Y, Gao X, Zeng L, Li H

“…Dangdang Wang,1,2,* Yanyu Pu,1,2,* Xi Gao,1,2 Lihong Zeng,1,2 Hong Li1,2 1Department of Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Chongqing Key Laboratory for the Prevention and Treatment of Major Blinding Eye Diseases, Chongqing Eye Institute, Chongqing Branch of National Clinical Research Center for Ocular Diseases, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hong Li, Department of Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China, Email lihong@hospital.cqmu.edu.cnPurpose: Genome-wide association studies (GWAS) have identified multiple genetic loci associated with primary open-angle glaucoma (POAG). …”
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The unconventional Xer recombination machinery of Streptococci/Lactococci. by Pascal Le Bourgeois, Marie Bugarel, Nathalie Campo, Marie-Line Daveran-Mingot, Jessica Labonté, Daniel Lanfranchi, Thomas Lautier, Carine Pagès, Paul Ritzenthaler

“…XerCD recombinases and FtsK are found on most sequenced eubacterial genomes, suggesting that the Xer recombination system as described in E. coli is highly conserved among prokaryotes. …”
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The Systematic Analysis of Exercise Mechanism in Human Diseases by Lei Pu, Peng Sun

“…To study and analyze the samples in the GSE18966 gene expression profile, we first performed an analysis on the differential expressed genes (DEGs) through GEO2R, and then the DEGs enrichment in Gene Ontology functions and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways through the Database for Annotation, Visualization and Integrated Discovery database was conducted. …”
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Identification of genes involved in energy metabolism in preeclampsia and discovery of early biomarkers by Ruohua Li, Cuixia Zhou, Kejun Ye, Haihui Chen, Mengjia Peng

“…Enrichment analyses using gene ontology, Kyoto Encyclopedia of Genes and Genomes, and gene set enrichment were performed. Protein-protein interaction networks were constructed to identify key genes, and regulatory networks involving transcription factors, miRNAs, and RNA-binding proteins were established. …”
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Dynamic reprogramming of DNA methylation at an epigenetically sensitive allele in mice. by Marnie E Blewitt, Nicola K Vickaryous, Andras Paldi, Haruhiko Koseki, Emma Whitelaw

“…Haplo-insufficiency for Mel18, a polycomb group protein, introduces epigenetic inheritance at a paternally derived A(vy) allele, and the pedigrees reveal that this occurs after zygotic genome activation and, therefore, despite the rapid demethylation of the locus.…”
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Exploration on Molecular Mechanism of Reversal Effect of Compound Danshen Tablets on Hepatic Fibrosis Based on Network Pharmacology by Minling Cao, Jingyue Fan, Xiaoli Yang, Meifeng Shi, Shanshan Lin, Xiaoling Chi

“…The DAVID enrichment database (the database for annotation, visualization, and integrated discovery) was adopted for GO (Gene Ontology) enrichment and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment of vital nodes. Results. …”
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DMRIntTk: Integrating different DMR sets based on density peak clustering. by Wenjin Zhang, Wenlong Jie, Wanxin Cui, Guihua Duan, You Zou, Xiaoqing Peng

“…<h4>Results</h4>Here, we develop DMRIntTk, a toolkit for integrating DMR sets predicted by different methods on a same dataset. In DMRIntTk, the genome is segmented into bins, and the reliability of each DMR set at different methylation thresholds is evaluated. …”
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Polyethylene Glycol (PEG) Application Triggers Plant Dehydration but Does Not Accurately Simulate Drought by Gulnar Kylyshbayeva, Nazira Bishimbayeva, Sativaldy Jatayev, Serik Eliby, Yuri Shavrukov

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hsa-miR-548d-3p: a potential microRNA to target nucleocapsid and/or capsid genes in multiple members of the Flaviviridae family by H. W. Cayatineto, S. T. Hakim

“…To predict the right alignments between miRNA and viral mRNA genomes, we used computational databases such as miRBase, NCBI, and Basic Alignment Search Tool–nucleotides (BLAST-n).ResultsOf the 2,600 mature miRNAs, hsa-miR-548d-3p revealed complementary sequences with the flavivirus capsid gene and bovine viral diarrhea virus (BVDV) capsid gene and was selected as a possible candidate to inhibit flaviviruses.ConclusionAlthough more detailed in vitro and in vivo studies are required to test the possible inhibitory effects of hsa-miR-548d-3p against flaviviruses, this computational study may be the first step to study further, developing a novel therapeutic for lethal viruses within the Flaviviridae family using suggested candidate miRNAs.…”
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Why Rights are Wrong in ASEAN and Beyond: A Critique of the Foundations of Universal Human Rights by D. Brian Scarnecchia

“…Part Two then examines whether the original axiomatic listing of human rights or an iteration of human rights founded upon the human genome or a Kantian underpinning can legitimise human rights and, if not, whether reference to the human soul made in the image of God with its natural law may substantiate the human rights project, perhaps, articulated as congruent with the purpose and design courts now recognise in the natural laws found in every ecosystem of nature. …”
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