Structure‐based computational design of antibody mimetics: challenges and perspectives by Elton J. F. Chaves, Danilo F. Coêlho, Carlos H. B. Cruz, Emerson G. Moreira, Júlio C. M. Simões, Manassés J. Nascimento‐Filho, Roberto D. Lins

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Estimating the proportion of beneficial mutations that are not adaptive in mammals. by Thibault Latrille, Julien Joseph, Diego A Hartasánchez, Nicolas Salamin

“…Our work confirms that deleterious substitutions are accumulating in mammals and are being reverted, generating a balance in which genomes are damaged and restored simultaneously at different loci. …”
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Innovative approaches in colorectal cancer screening: advances in detection methods and the role of artificial intelligence by Changwei Duan, Jianqiu Sheng, Xianzong Ma

“…This review aims to provide a comprehensive perspective on new strategies for CRC screening, emphasizing the potential of noninvasive detection technologies and the prospects of AI and genomics in clinical applications. Despite several challenges, this review advocates for future large-scale prospective studies to validate the effectiveness and cost-effectiveness of these new screening methods while promoting the implementation of screening protocols tailored to individual characteristics.…”
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Human Gut Microbes Associated with Systolic Blood Pressure by Tulsi Kumari Joishy, Aashish Jha, Mai Oudah, Santanu Das, Atanu Adak, Dibyayan Deb, Mojibur Rohman Khan

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Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus by Md. Sakib Hossen, Siew Hua Gan, Md. Ibrahim Khalil

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Applications of Healthcare Robots in Combating the COVID-19 Pandemic by Shruti Raje, Nikunj Reddy, Houssem Jerbi, Princy Randhawa, Georgios Tsaramirsis, Nikhil Vivek Shrivas, Athanasia Pavlopoulou, Miloš Stojmenović, Dimitris Piromalis

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Peroxisome Proliferator Activated Receptors and Lipoprotein Metabolism by Sander Kersten

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Major Histocompatibility Complex Genes as Therapeutic Opportunity for Immune Cold Molecular Cancer Subtypes by Paweł Karpiński, Łukasz Łaczmański, Maria M. Sąsiadek

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The Relationship between Natriuretic Peptide Precursor a Gene T2238C Polymorphism and Hypertension: A Meta-Analysis by Wenquan Niu

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The Drug Excipient Cyclodextrin Interacts With -Luciferin and Interferes With Bioluminescence Imaging by Jeyan S. Kumar MSc, Lisa M. Miller Jenkins PhD, Michael M. Gottesman MD, Matthew D. Hall PhD

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Identification of the Immune Cell Infiltration Landscape in Head and Neck Squamous Cell Carcinoma (HNSC) for the Exploration of Immunotherapy and Prognosis by Chunli Huang, Jifeng Liu

“…An analysis of the Cancer Genome Atlas (TCGA) database revealed gene expression profiles and corresponding clinical information. …”
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A two-level staging system for the embryonic morphogenesis of the Mediterranean fruit fly (medfly) Ceratitis capitata. by Frederic Strobl, Alexander Schmitz, Marc F Schetelig, Ernst H K Stelzer

“…While the fruit fly Drosophila melanogaster has long been the primary insect model organism for understanding molecular genetics and embryonic development, the Mediterranean fruit fly Ceratitis capitata, also known as medfly, presents a promising complementary model for studying developmental biology. With its sequenced genome and a diverse array of molecular techniques, the medfly is well-equipped for study. …”
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Identifying potential drug targets for myocardial infarction through Mendelian randomization. by Xiangyou Yu, Shasha Liu

“…<h4>Methods</h4>We combined protein quantitative trait loci (pQTL) data for plasma and CSF proteins with genome-wide association study (GWAS) summary statistics for MI. …”
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The autophagy component LC3 regulates lymphocyte adhesion via LFA1 transport in response to outside-in signaling by Naoyuki Kondo, Yuko Mimori-Kiyosue, Keizo Tokuhiro, Giuseppe Pezzotti, Tatsuo Kinashi

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Human cytomegalovirus RNA2.7 inhibits ferroptosis by upregulating ferritin and GSH via promoting ZNF395 degradation. by Mingyi Xu, Shan Ruan, Jingxuan Sun, Jianming Li, Dan Chen, Yanping Ma, Ying Qi, Zhongyang Liu, Qiang Ruan, Yujing Huang

“…The results further showed that RNA2.7 inhibited ferroptosis via enhancing Ferritin Heavy Chain 1 (FTH1) and Solute Carrier Family 7 Member 11 (SLC7A11) expression in Erastin treated cells without involving other viral components. Pooled Genome-wide CRISPR screening revealed zinc finger protein 395 (ZNF395) as a new regulator repressing the expression of FTH1 and SLC7A11. …”
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Unlocking autism’s complexity: the Move Initiative’s path to comprehensive motor function analysis by Ashley Priscilla Good, Elizabeth Horn

“…Meanwhile, we are experiencing a digital healthcare revolution, marked by innovations in the collection and analysis of electronic health records, personal genomes, and diverse physiological measurements. Advanced technologies, including current wearable devices, integrate both active and passive (sensor-based) data collection, providing a more comprehensive view of human health. …”
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Heterogeneity of Genetic Landscapes in Salivary Gland Tumors and Their Critical Roles in Current Management by Anam YOUSAF, Sarina SULONG, Baharudin ABDULLAH, Norhafiza Mat LAZIM

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Modeling the Phylogenetic Rates of Continuous Trait Evolution: An Autoregressive–Moving-Average Model Approach by Dwueng-Chwuan Jhwueng

“…We apply our innovation to analyze the primate body mass dataset and plant genome size dataset and test for the autoregressive effect of the rates of continuous evolution along the tree.…”
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Single-Cell Transcriptome Analysis of Human Adipose-Derived Stromal Cells Identifies a Contractile Cell Subpopulation by Elize Wolmarans, Juanita Mellet, Chrisna Durandt, Fourie Joubert, Michael S. Pepper

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Nature of viruses and the radical change in viral taxonomy by V. V. Makarov, L. P. Buchatsky

“…Co-evolution of the viral and cellular genomes includes mutual horizontal gene transfer and joint development of new biological functions, such as the mechanism of phylogenesis and phylodynamics of coactants. …”
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