History, status and genetic characteristics of native cattle breeds from the Republic of Kazakhstan by A. K. Khamzina, A. A. Yurchenko, N. S. Yudin, P. Sh. Ibragimov, Y. S. Ussenbekov, D. M. Larkin

“…The study examined the genetic structure of the Kazakh white-headed and Alatau breeds based on whole-genome SNP genotyping. Unique genetic components characterizing Kazakhstan cattle breeds were described, and comparisons were made with genetic data from other breeds. …”
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A user-friendly software to accurately count and measure cysts from the parasitic nematode Heterodera glycines by Joffrey Mejias, Djampa K. L. Kozlowski, Jackson Goshon, Thomas R. Maier, Thomas J. Baum

“…Researchers and breeders typically employ exploratory methods such as Genome-Wide Association Studies or Quantitative Trait Loci mapping to identify genes linked to resistance. …”
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Multiomics integration unravels genotype‐microbiome interactions shaping the conjunctival transcriptome by Qiaoxing Liang, Guo‐Wang Lin, Xiaohu Ding, Bin Zou, Xiaomin Liu, Jing Li, Yuxin Zhang, Xiaofeng Wen, Lingyi Liang, Jin‐Xin Bei, Mingguang He, Huijue Jia, Lai Wei

“…We developed a modeling approach, MicroGenix, that screens for GMIs from host genome, transcriptome, and microbiome data and identifies GMIs associated with the disease through gene‐based association tests. …”
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The causal relationship between steroid hormones and risk of stroke: evidence from a two-sample Mendelian randomization study by Yang Zhang, Miaowen Jiang, Di Wu, Ming Li, Xunming Ji

“…Therefore, Mendelian randomization (MR) technique was employed in this study to examine this association. Through genome-wide association meta-analysis, the genetic variants of steroid hormones, including testosterone/17β-estradiol (T/E2) ratio, aldosterone, androstenedione, progesterone, and hydroxyprogesterone, were acquired as instrumental variables. …”
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Renin-Angiotensin System Gene Variants and Type 2 Diabetes Mellitus: Influence of Angiotensinogen by Siew Mei Joyce-Tan, Shamsul Mohd Zain, Munavvar Zubaid Abdul Sattar, Nor Azizan Abdullah

“…Genome-wide association studies (GWAS) have been successfully used to call for variants associated with diseases including type 2 diabetes mellitus (T2DM). …”
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Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation by Peijun Tian, Yunfei Hou, Zheng Wang, Jiaona Jiang, Xin Qian, Zhihao Qu, Jianxin Zhao, Gang Wang, Wei Chen

“…CCFM1025 significantly altered the gut microbial composition and genome function. Key microbial metabolites that may regulate sleep function were also identified, such as isovaleric acid and γ-aminobutyric acid in the gut and purine metabolites in the serum. …”
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The Proviral Reservoirs of Human Immunodeficiency Virus (HIV) Infection by Andrey I. Murzin, Kirill A. Elfimov, Natalia M. Gashnikova

“…Human Immunodeficiency Virus (HIV) proviral reservoirs are cells that harbor integrated HIV proviral DNA within their nuclear genomes. These cells form a heterogeneous group, represented by peripheral blood mononuclear cells (PBMCs), tissue-resident lymphoid and monocytic cells, and glial cells of the central nervous system. …”
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Marker-Assisted Selection for Recognizing Wheat Mutant Genotypes Carrying HMW Glutenin Alleles Related to Baking Quality by Mohammad Javad Zamani, Mohammad Reza Bihamta, Behnam Naserian Khiabani, Zahra Tahernezhad, Mohammad Taher Hallajian, Marzieh Varasteh Shamsi

“…Some of the primers were extracted from previous studies and the others were designed based on D genome subunits of wheat. SDS-PAGE method accomplished having confidence in these marker’s results. …”
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A review of simulation and modeling approaches in microbiology by A. I. Klimenko, Z. S. Mustafin, A. D. Chekantsev, R. K. Zudin, Yu. G. Matushkin, S. A. Lashin

“…The multiaspect nature of integration approaches used to model microbial communities is based on the need to take into account heterogeneous data obtained from various sources by applying high-throughput genome investigation methods.…”
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Studying the effect of the OsGATA rice transcription factor on salt stress tolerance in wheat by A. A. Verbitskaia, A. S. Egorova, E. A. Tsarkova, A. K. Gaponenko

“…Genetic transformation methods were used to introduce the GATA gene into the genome of the used wheat genotypes. Transgenic lines were selected on selective media under in vitro conditions.The results of the experimental work showed that the expression of the GATA gene under salt stress may be responsible for the increased compartmentalization of Na+ in the vacuole, which provides improved salt tolerance. …”
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Poly ADP-Ribosylation in a Plant Pathogenic Oomycete <i>Phytophthora infestans</i>: A Key Controller of Growth and Host Plant Colonisation by Viktoriya O. Samarskaya, Sofya Koblova, Tatiana Suprunova, Eugene A. Rogozhin, Nadezhda Spechenkova, Sofiya Yakunina, Andrew J. Love, Natalia O. Kalinina, Michael Taliansky

“…Here, we show that the <i>Phytophthora infestans</i> genome contains two PARP-like protein genes (PiPARP1 and PiPARP2), and provide evidence of PARylation activity for one of them (PiPARP2). …”
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A Network Pharmacology Study on the Cervix Prescription for Treatment of Cervical Cancer by Yingping Zhu, Liangping Wang, Leilai Xu, Pian Ying

“…Gene ontology (GO) and Kyoto Gene and Genome Encyclopedia (KEGG) pathway enrichment analysis of overlapping targets were performed using DAVID 6.8 online tool. …”
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Cas12e orthologs evolve variable structural elements to facilitate dsDNA cleavage by Danyuan Li, Shouyue Zhang, Shuo Lin, Wenjing Xing, Yun Yang, Fengxia Zhu, Dingding Su, Chunlai Chen, Jun-Jie Gogo Liu

“…Two known Cas12e nucleases, DpbCas12e and PlmCas12e, are both effective in genome editing. However, many differences exist in their in vitro dsDNA cleavage activities, reflecting the diversity in Cas12e’s enzymatic properties. …”
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Molecular genetic methods for intestinal microbiome investigation by O. L. Kardymon, A. V. Kudryavtseva

“…Modern molecular genetic methods of microbial investigation combined to the established methods of classical microbiology give the chance not only to identify microorganism species and even a strain, but also to decipher their genomes, to estimate antibiotic resistance and to establish its mechanism at genetic level, to estimate specific properties of specific microbial strain that will allow to define potential and efficacy of their clinical application etc. …”
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Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy by Sang‑Hyuk Jung, Haemin Kim, Young Mi Jung, Manu Shivakumar, Brenda Xiao, Jaeyoung Kim, Beomjin Jang, Jae-Seung Yun, Hong-Hee Won, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun, Dokyoon Kim, Seung Mi Lee

“…We evaluate the genetic risk for hypertensive disorders of pregnancy using a genome-wide polygenic risk score derived from a large-scale GWAS. …”
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Genetic Variants Related to Increased CKD Progression—A Systematic Review by Filipe S. Mira, Bárbara Oliveiros, Isabel Marques Carreira, Rui Alves, Ilda Patrícia Ribeiro

“…The selected studies included cohort studies, case-control studies, and genome-wide association studies (GWASs). The studies involved patients of different ethnicities and with comorbid diseases. …”
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Genetic association of lipid-lowering drug target genes with pancreatic cancer: a Mendelian randomization study by Bohan Su, Zhiyao Fan, Jiexi Wu, Hanxiang Zhan

“…Genetic variants associated with lipid traits and variants of genes encoding lipid-lowering drug targets were extracted from the Global Lipids Genetics Consortium genome-wide association study (GWAS). Summary statistics for PC were obtained from an independent GWAS datasets. …”
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Genes Induced by Panax Notoginseng in a Rodent Model of Ischemia-Reperfusion Injury by Lanqing Meng, Qing Huang, Xuebin Li, Ping Liang, Yueyong Li, Xiaohua Huang, Jingjie Zhao, Qiuping Chen, Rong Qiu, Lan Li, Chongdong Jian, Hongfei Yao, Jianmin Huang, Xionglin Tang, Zechen Wang, Zhongheng Wei, Jun Wu, Liuzhi Wei, Qiuju Wei, Qianli Tang, Lu Huang, Jihua Wei, Dinggui Lu, Qunqiang Luo, Kegong Xie, Yang Ouyang, Jian Chen, Genliang Li, Linxue Luo, Linbo He, Chenyi Zhuo, Anding Xu, Lingzhang Meng

“…Further analysis by Gene Oncology analysis and Kyoto Encyclopedia of Genes and Genomes revealed that most of these genes were involved in the biological function of nerves and blood vessels through the regulation of neuroactive live receptor interactions of PI3K-Akt, Rap1, cAMP, and cGMP-PKG signaling, which included in the 18 pathways identified in our research, of which, 9 were reported firstly that related to PN’s neuroprotective effect. …”
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How do monomorphic bacteria evolve? The Mycobacterium tuberculosis complex and the awkward population genetics of extreme clonality by Stritt, Christoph, Gagneux, Sebastien

“…Population genetic methods allowing to infer mutation, recombination, genetic drift, and natural selection make strong assumptions that are difficult to reconcile with clonal reproduction and fully linked genomes consisting mainly of coding regions. In this review, we highlight the challenges of extreme clonality by discussing population genetic inference with the Mycobacterium tuberculosis complex, a group of closely related obligate bacterial pathogens of mammals. …”
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Bioinformatics approaches to multi-omics analysis of the potential of CDKN2A as a biomarker and therapeutic target for uterine corpus endometrial carcinoma by Liang Ma, Yuling Li, Jingxian Wu, Yanfei Gao

“…Analysis of somatic copy number alterations in the TCGA (The Cancer Genome Atlas)-UCEC dataset revealed a connection between CDKN2A and drug metabolism in UCEC. …”
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