Comparison of miRNA expressions among benign, premalignant and malignant lesions of the larynx: could they be transformation biomarkers? by Fatma Ruya Tuncturk, Ibrahim Akalin, Lokman Uzun, Tulay Zenginkinet

“…Finding a biomarker to overcome these concerns are ongoing challenges and recently microRNAs (miRNAs) are attributed as possible candidates since they can regulate gene expressions in the human genome. The objective of our study was to investigate their capability as a transformation biomarker for malignant laryngeal lesions. …”
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Apoptosis antagonizing transcription factor expression and its validation as a potential diagnostic and prognostic biomarker in oral squamous cell carcinoma by Ainiwaerjiang Abudourousuli, Zumulaiti Aierken, Hasiyati Mamuti, Tuxunayi Yimamu, Chengli Da

“…This study aimed to investigate the expression of apoptosis antagonizing transcription factor (AATF) in OSCC, examine its correlation with clinicopathological features, assess its prognostic implications, and explore its potential role in OSCC progression.MethodsExpression profiles and clinical data of OSCC patients were obtained from The Cancer Genome Atlas (TCGA). Immunohistochemical analysis on tissue microarrays was performed to assess AATF expression in OSCC. …”
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Altered O-Glycans in stimulated whole saliva from patients with primary Sjögren’s syndrome and non-pSS sicca by Sarah Kamounah, Kristina A. Thomsson, Christiane Elisabeth Sørensen, Eric Paul Bennett, Niclas G. Karlsson, Anne Marie Lynge Pedersen

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Genetic Markers Can Predict Chondrogenic Differentiation Potential in Bone Marrow-Derived Mesenchymal Stromal Cells by Masami Kanawa, Akira Igarashi, Katsumi Fujimoto, Yukihito Higashi, Hidemi Kurihara, Masaru Sugiyama, Tania Saskianti, Yukio Kato, Takeshi Kawamoto

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Ultrahigh piezoelectric performances of (K,Na)NbO3 based ceramics enabled by structural flexibility and grain orientation by Li-Feng Zhu, Dong Liu, Xiaoming Shi, Shiqing Deng, Jiecheng Liu, Li-Yu Wei, Zi-Qi Yang, Qi Wang, Bo-Ping Zhang, Houbing Huang, Shujun Zhang, Jing-Feng Li

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The Association between Deoxyribonucleic Acid Hypermethylation in Intron VII and Human Leukocyte Antigen-C∗07 Expression in Patients with Endometriosis by Wenrong Zhao, Lei Lei, Rui Chen, Yanmin Zhang, Linlin Chang, Jingxin Cheng

“…Six patients with surgically confirmed ovarian endometriosis and six patients who received IUD implantation for contraception without endometriosis were recruited in the East Hospital of Tongji University in 2018. The genome methylation profiling of the eutopic and ectopic endometrium of ovarian endometriosis patients and normal endometrial specimens from healthy women was determined using a methylation microarray test. …”
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Rare <i>Wolbachia</i> genotypes in laboratory <i>Drosophila melanogaster</i> strains by A. S. Ryabinin, O. D. Shishkina, Yu. Yu. Ilinsky, R. A. Bykov

“…Based on the polymorphism of the Wolbachia genome, the symbionts’ diversity in D. melanogaster is presented by two groups: MEL (wMel, wMel2, wMel3 and wMel4) and CS (wMelCS and wMelCS2). …”
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Causal association of sex hormone-related traits with Alzheimer’s disease: a multivariable and network Mendelian randomization analysis by Yan Zhang, Zhen-dong Sun, Yu-shen Yang, Wei-dong Fu

“…The study aimed to investigate the possible causal link between sex hormone-related traits and AD.MethodsThe authors collected data from extensive genome-wide association studies (GWASs) of European ancestry on sex hormone-related traits and AD. …”
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A meta-analysis of whole blood transcriptome reveals genes associated with increased neutrophil activity and T cell suppression in sepsis by T. N. Shruthi, Anbazhagan Kolandaswamy, Prabakara Somanna

“…Significant (p-value ≤ 0.05 and log fold change ≤ − 1.5 or ≥  + 1.5) common genes from six studies were subjected to network analysis and functional enrichment analysis to identify enriched Gene ontology (GO) terms, Kyoto Encyclopedia of Genes and Genomes pathways and hub genes. Results Gene expression data resulted in 233 differentially expressed genes (DEGs), 146 genes were up-regulated and 87 genes were down-regulated. …”
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Quarantine nematode species and pathotypes potentially dangerous for domestic potato production: populations diversity and the genetics of potato resistance by N. V. Mironenko, T. A. Gavrilenko, A. V. Khiutti, O. S. Afanasenko

“…It was shown that due to the peculiarities of the life cycle of nematodes and lability of their genomes, the genetic variability of these organisms is very high, which creates a threat of forming new pathogenic genotypes of the parasites. …”
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The effect of cheese intake on osteoarthritis: a Mendelian randomization study by Song Wen, Zehan Huang, Bin Zhang, Yuqing Huang

“…Material and methods We performed a two-sample Mendelian randomization (MR) investigation to evaluate the causal association between cheese intake and OA based on genome-wide association studies (GWAS). The primary analysis employed the inverse variance weighted (IVW) method, while complementary analyses were conducted using the weighted median, MR-Egger, and weighted mode methods. …”
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Endometrial factors in the implantation failure spectrum: protocol of a MUltidisciplinary observational cohort study in women with Repeated Implantation failure and recurrent Misca... by Servaas Morré, Ron van Golde, Andrea Romano, Linda Stevens Brentjens, Denise Habets, Janneke Den Hartog, Salwan Al-Nasiry, Lotte Wieten, Aafke Van Montfoort

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Phylogenetic Analysis of Spike and Envelope Proteins for a Number of Bat Coronaviruses for Understanding the Hypothesis of Possible Origin for the Novel 2019- nCoV by Salar Ibrahim Ali

“…Therefore, this study aims to investigate the evolution and analysis of molecular epidemiology for both Spike and Envelope proteins of 20 available complete genome sequences of different bat coronaviruses including 2019-nCoV in order to find out which type of bat coronaviruses is more likely to be the origin of this new 2019-nCoV and also multiple amino acid sequences of Envelope protein for all bat coronaviruses were aligned for the purpose of finding the greater probability of novel 2019-nCoV original host   among bat coronaviruses. …”
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Spatial and seasonal distribution of selected nitrogen cycle genes in deep waters of the Baltic Proper by Michał Grabski, Michał Grabski, Ewa Kotlarska, Aneta Łuczkiewicz, Konrad Hryniewicz, Grzegorz Węgrzyn, Beata Szymczycha

“…Ammonia oxidation products likely fueled the production of nitrous oxide (N2O), with nitric oxide reductase (NOR)—an enzyme encoded by the Thioglobaceae genome—being responsible for further reduction. Anammox-related genes were not present within sites, thus denitrification pathway enzymes, namely, NOR and N2O reductase (NOS) were responsible for nitrogen loss. …”
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Multi-omics analysis reveals novel causal pathways in psoriasis pathogenesis by Hua Guo, Jinyang Gao, Liping Gong, Yanqing Wang

“…Methods We conducted SMR analyses integrating genome-wide association study (GWAS) summary statistics with methylation quantitative trait loci (mQTL), expression quantitative trait loci (eQTL), and protein quantitative trait loci (pQTL) data. …”
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Immune gene features and prognosis in colorectal cancer: insights from ssGSEA typing by Anwen Huang, Jinxiu Wu, Jiakuan Wang, Chengwen Jiao, Yunfei Yang, Huaiwen Xiao, Li Yao

“…Methods We obtained and merged RNA-Seq data along with clinical details for colorectal cancer (CRC) from The Cancer Genome Atlas (TCGA) repository, and then performed immunocluster typing on all CRC specimens. …”
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Association between the Number of Childbirths and the Progress of Atherosclerosis among Women with Diabetes: A Cohort Study Based on Chinese Population by Jie Wang, Yu Pei, Kang Chen, Wenhua Yan, Anping Wang, Yijun Li, Jia Li, Haibing Wang, Ping An, Linxi Zhang, Yingnan Ye, Xinye Jin, Guang Ning, Yiming Mu, Weijun Gu

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Breeding value of prolific maize varieties with nicking of parental lines by E. B. Khatefov, R. A. Kudaev, R. S. Kushkhova

“…The studied prolific maize lines developed by involving the Chalko teosinte genome appeared to be effective donors of the multiple-ear feature in crosses with single-ear maize. …”
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Genetic diversity and breeding value of synthetic hexaploid wheat introduced into the VIR collection by A. G. Khakimova, N. K. Gubareva, V. А. Koshkin, O. P. Mitrofanova

“…It is possible that the instability of accessions  is the result of genome rearrangement in SHWs. SHW accessions  and the forms isolated from them are considered as sources of new genetic variability to improve common wheat.…”
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Exploring the genetic correlation and causal relationships between breast cancer and meningioma using bidirectional Mendelian randomization by Lu Ding, Bo Chen, Zhou Zhou, Zhaojun Mei, Kan Cao, Xinyu Lu, Wei Chen

“…Genetic instrumental variables (IVs) for BC were identified from the Breast Cancer Association Consortium (BCAC), the Discovery Biology and Risk of Inherited Variants in Breast Cancer Consortium (DRIVE), the Collaborative Oncological Gene-environment Study (iCOGS), and 11 other BC genome-wide association studies (GWAS). Meningioma GWAS data were obtained from the FinnGen consortium and were further divided into intracranial and spinal meningioma groups for analysis. …”
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