A Five-Year Retrospective Study of Foot-and-Mouth Disease Outbreaks in Southern Africa, 2014 to 2018 by Elliot Mpolokang Fana, Sununguko Wata Mpoloka, Melvin Leteane, LaToya Seoke, Kelebogile Masoba, Mokganedi Mokopasetso, Aobakwe Rapharing, Tshephang Kabelo, Patricia Made, Joseph Hyera

“…Foot-and-mouth disease (FMD) virus (FMDv), like other ribonucleic acid (RNA) genome viruses, has a tendency to mutate rapidly. …”
Get full text

Identification of retinol dehydrogenase 10 as a shared biomarker for metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus by Fangyu Li, Rui Li, Hongjun Deng

“…We also analyzed the enriched pathways of shared genes using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Next, hub gene validation was performed using the least absolute shrinkage and selection operator (LASSO) and receiver operating characteristic (ROC) curves. …”
Get full text

Seedling resistance of winter and spring bread wheat cultivars to <i>Pyrenophora tritici-repentis</i> by N. V. Mironenko, N. M. Kovalenko, O. A. Baranova, A. G. Khakimova, O. P. Mitrofanova

“…The disclosed diversity of bread wheat cultivars in their responses to the infection with isolates of different Ptr populations may be due to their differences in the alleles of Ptr resistance/susceptibility genes as well as the presence of still unknown effector genes in the pathogen’s genome. Cultivars resistant to two or three Ptr populations can be used by breeders as sources of seedling resistance.…”
Get full text

Associations and potential epigenetic changes between air pollution and osteoarthritis risk and survival: Insights from a prospective cohort study by Jing Qian, Jiahao Zhu, Yifan Wang, Ruoqi Dai, Jingyou Miao, Ye Yang, Wenxia Zhao, Jing Wang, Lilu Ding, Dan Zhou, Min Yu, Yingjun Li

“…Cox models assessed associations between air pollution exposure and OA incidence, joint replacement, and survival. Additionally, using genome-wide association statistics, we examined the potential causal associations between air pollution-related DNA methylation (DNAm) and OA risk. …”
Get full text

A Nodulation-Proficient Nonrhizobial Inhabitant of Pueraria phaseoloides by W. M. M. Wedage, A. H. M. N. R. Aberathne, I. N. Harischandra, D. Gunawardana

“…When a nifH fragment from the genome of this bacterium was amplified using a pair of nifH primers, it yielded an amplicon of 360 bp that, when sequenced, helped us identify the bacterium, as belonging to a species of Pseudacidovorax intermedius, at 99% sequence identity. …”
Get full text

The role of MRO as an M2 macrophage-associated gene in non-small cell lung cancer: insights into immune infiltration, prognostic significance, and therapeutic implications by Yue Gu, Miaosen Zheng, Jing Xie

“…Methods NSCLC samples from The Cancer Genome Atlas (TCGA) were analyzed using the CIBERSORT algorithm to quantify immune cell compositions. …”
Get full text

Direct and Indirect Methods for Studying Human Gut Microbiota by V. T. Ivashkin, O. S. Medvedev, E. A. Poluektova, A. V. Kudryavtseva, I. R. Bakhtogarimov, A. E. Karchevskaya

“…Integration of the data obtained by gut microbiota studies at the genome, transcriptome and metabolome levels would allow a comprehensive analysis of microbial community function and its interaction with the human organism. …”
Get full text

Association of Visceral Adipose Tissue With Hypertension: Results From the NHANES 2011–2018 and Mendelian Randomization Analyses by Jia Liao, Miaohan Qiu, Jing Li, Yi Li, Yaling Han

“…Independent genetic variants related to VAT mass were derived from genome‐wide association studies (GWAS) in 325 153 UK Biobank participants. …”
Get full text

Effects of hypoxia on the heart of the juvenile four-finger threadfin (Eleutheronema tetradactylum) based on physiological indicators and transcriptome analysis by Yi Lu, Eric Amenyogbe, Ye- Yang, Zhong-liang Wang, Zhong-liang Wang, Zhong-liang Wang, Jing-hui Jin, Rui-tao Xie, Eric Kwabena Droepenu, Jian-sheng Huang, Jian-sheng Huang, Jian-sheng Huang

“…Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis highlighted key pathways such as mitogen-activated protein kinase (MAPK), hypoxia-inducible factor-1 (HIF-1), endocytosis, and phagosome formation. …”
Get full text

DOCK4 Is a Platinum-Chemosensitive and Prognostic-Related Biomarker in Ovarian Cancer by Qianqian Zhao, Jie Zhong, Ping Lu, Xiao Feng, Ying Han, Chenqi Ling, Wenke Guo, Weijin Zhou, Fudong Yu

“…The gene expression profiles were obtained from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) database. A total of 4 genes (AP2A2, DOCK4, HSDL2, and PDK4) were the candidate differentially expressed genes (DEGs) of PPAR-TRGs with platinum chemosensitivity. …”
Get full text

Causal Effects of PM2.5, NOx, and NO2 on Cognitive Function: A Two-sample Mendelian Randomization Study by Yilin Tang, Zhenyu Li, Yicheng Fu, Mingyi Zhao

“…We conducted a two-sample Mendelian randomization (MR) study using pooled statistics from publicly available genome-wide association study (GWAS) data to show the association between air pollutants and cognitive decline in the European population. …”
Get full text

A two-sample bidirectional Mendelian randomization analysis between telomere length and hyperthyroidism by Shiben Zhu, Ziyu Hao, Qihang Chen, Xiaoliu Liu, Wenyan Wu, Fang Zhang

“…However, the casual association between telomere length (TL) and hyperthyroidism remains unclear.ObjectiveWe aim to explore the casual relationship between TL and hyperthyroidism.MethodsA two-sample bidirectional Mendelian randomization (MR) analysis employed the inverse variance weighted (IVW) method, supplemented by additional approaches such as Weighted Median (WM), and MR Egger.ResultsThe summary statistics for TL were derived from the UK Biobank, comprising 472,174 individuals, while the data for hyperthyroidism were sourced from the GWAS Catalog and the FinnGen database, encompassing cohorts of 460,499 and 173,938 individuals, respectively. Utilizing 139 genome-wide significant single nucleotide polymorphisms (SNPs) as instrumental variables (IVs) for TL, forward MR analyses indicated a negative causal effect of TL on hyperthyroidism. …”
Get full text

Description of a new Ornithodoros (Pavlovskyella) (Ixodida: Argasidae) tick species from Pakistan by Abid Ali, Mehran Khan, Muhammad Numan, Abdulaziz Alouffi, Mashal M. Almutairi, Ronel Pienaar, Minique H. de Castro, Lidia Chitimia-Dobler, Sebastián Muñoz-Leal, Ben J. Mans, Ala Tabor

“…Phylogenetic analyses of the full-length mitochondrial genome and the 18S and 28S ribosomal RNA genes, combined with pairwise nucleotide comparisons of cox1, cox2, atp8, atp6, cox3, nad3, nad5, nad4, nad4L, nad6, cytb, nad1, nad2, 12S rDNA, 16S rDNA, 18S rDNA and 28S rDNA further support that the new species belongs to the Pavlovskyella subgenus, clustering with O. tholozani, Ornithodoros verrucosus and Ornithodoros tartakovskyi.…”
Get full text

Molecular Typing of Klebsiella pneumoniae Clinical Isolates by Enterobacterial Repetitive Intergenic Consensus Polymerase Chain Reaction by Parinaz Sedighi, Omid Zarei, Kiana Karimi, Mohammad Taheri, Pezhman Karami, Leili Shokoohizadeh

“…Also, the samples were evaluated by PCR method for the detection of aerobactin gene within their genome. Finding. The genetic relatedness among K. pneumoniae isolates was studied, and results established the genetic diversity of the clinical isolates by detecting 25 different ERIC types, including 14 common types and 11 unique types. …”
Get full text

An initial exploration of core collection construction and DNA fingerprinting in Elymus sibiricus L. using SNP markers by Xinrui Li, Xinrui Li, Xinrui Li, Daping Song, Mingfeng Li, Daxu Li, Minghong You, Yan Peng, Jiajun Yan, Shiqie Bai

“…Additionally, we identified 290 SNP loci from among the high-quality SNP loci generated by whole-genome sequencing of the 90 E. sibiricus samples as candidate markers. …”
Get full text

In vitro multiplication and phytochemical evaluation of Apios americana Medik for enhanced production of the staple food and tissues with versatile bioactivities. by Okello, Denis, Gang, Roggers, Rahmat, Endang, Yang, Sungyu, Ban, Yeongjun, Chung, Yuseong, Lee, Jun, Kang, Youngmin

“…Americana plant stocks with stable genome size/ploidy level, meeting the exponentially growing demand for plant tissues. …”
Get full text

Deciphering the dose-dependent effects of thymoquinone on cellular proliferation and transcriptomic changes in A172 glioblastoma cells. by Rachana Pandey, Purushothaman Natarajan, Umesh K Reddy, Wei Du, Cristian Sirbu, Moussa Sissoko, Gerald R Hankins

“…We confirmed their expression levels through quantitative RT-PCR and performed Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses for these DEGs. …”
Get full text

Determination of Total Phenolics, Flavonoids, and Antioxidant Activity and GC-MS Analysis of Malaysian Stingless Bee Propolis Water Extracts by Sharifah Nur Amalina Syed Salleh, Nur Ayuni Mohd Hanapiah, Hafandi Ahmad, Wan Lutfi Wan Johari, Nurul Huda Osman, Mohd Razif Mamat

Get full text

Genotyping and Molecular Characterization of VP6 and NSP4 Genes of Unusual Rotavirus Group A Isolated from Children with Acute Gastroenteritis by Charilaos Dellis, Elizabeth-Barbara Tatsi, Dimitra-Maria Koukou, Filippos Filippatos, Evangelia-Eirini Vetouli, Emmanouil Zoumakis, Athanasios Michos, Vasiliki Syriopoulou

“…Continuous surveillance of the RVA based on the whole genome will provide better knowledge of its evolution.…”
Get full text

Efficient k-mer based curation of raw sequence data: application in Drosophila suzukii by Gautier, Mathieu

“…We applied it to high-throughput whole-genome raw sequence data for 236 Ind-Seq and 22 Pool-Seq samples of the invasive species Drosophila suzukii. …”
Get full text