SMARCA4 deficiency in small cell lung cancer: A case report and narrative review of the literature by Andreas M. Matthaiou, Ioannis Tomos, Nikoleta Bizymi, Ioannis Vamvakaris, Nektarios Anagnostopoulos, Aikaterini Papadopoulou, Kalliopi Angelou, Grigoris Stratakos, Adamantia Liapikou

“… SWItch/Sucrose Non-Fermentable (SWI/SNF) is a large protein complex with a central role in chromatin remodeling and genome transcription. The catalytic subunits of the SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 (SWI/SNF SMARCA2; also called BRM) and SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 (SMARCA4; also called BRG1) are encoded by the SMARCA2 and SMARCA4 genes, respectively, and are mutually exclusive. …”
Get full text

Desmoglein-2 was a novel cancer-associated fibroblasts-related biomarker for oral squamous cell carcinoma by Jin Liu, Zhonghao Sun, Shihui Cao, Hao Dai, Ze Zhang, Jingtao Luo, Xudong Wang

“…Differentially expressed genes and Cox regression analyses were used to identify candidate genes, and their functions were evaluated using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses. The prognostic performance of the identified biomarker was evaluated using receiver operating characteristic analysis. …”
Get full text

Copper and iron as unique trace elements linked to fibromyalgia risk by Wenxing Zeng, Minhua Hu, Luyao Ma, Feng Huang, Ziwei Jiang

“…Genetic instrumental variables (single nucleotide polymorphisms, SNPs), related to these trace elements and FM were extracted from genome-wide association studies (GWAS). Analyses were performed using various methods including inverse-variance weighting (IVW), MR Egger, weighted median, weighted mode, and simple mode. …”
Get full text

Results of scientific expedition to natural biotopes of the Republic of Tyva in 2019 with the purpose of infectious disease monitoring in wild bird populations by M. S. Volkov, V. N. Irza, A. V. Varkentin, S. V. Rogolyov, A. V. Andriyasov

“…Two samples from European herring gulls were positive for avian influenza type A virus genome and subtype H13N6 was identified in one of them. …”
Get full text

Sphingosine kinase 1 promotes M2 macrophage infiltration and enhances glioma cell migration via the JAK2/STAT3 pathway by Zihan Song, Zijun Zhao, Xuehua Liu, Yiran Song, Siyu Zhu, Ziyang Jia, Yijie Li, Zairan Wang, Boyu Sun, Qianxu Jin, Shiyang Zhang, Zongmao Zhao, Liqiang Liu

“…The correlation between SPHK1 and various cancer pathways was analyzed using the Kyoto encyclopedia of genes and genomes (KEGG) analysis. The SPHK1 influence on glioma migration was examined using transwell and wound healing experiments. …”
Get full text

Structuring the genetic collection of sunflower by V. A. Gavrilova, I. N. Anisimova, N. V. Alpatieva, E. A. Porokhovinova

“…Background. The XRQ sunflower genome has been sequenced but not yet fully annotated, and not all candidate genes for most traits have been identified. …”
Get full text

Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination by Colette B. Rogers, Wendy Leung, Ryan M. Baxley, Rachel E. Kram, Liangjun Wang, Joseph P. Buytendorp, Khoi Le, David A. Largaespada, Eric A. Hendrickson, Anja-Katrin Bielinsky

“…RAD18 is a conserved eukaryotic E3 ubiquitin ligase that promotes genome stability through multiple pathways. One of these is gap-filling DNA synthesis at active replication forks and in post-replicative DNA. …”
Get full text

Antimicrobial susceptibility and epidemiological types of Legionella pneumophila human isolates from Italy (1987–2020) by Maria Scaturro, Alessio Lanni, Fabiola Mancini, Antonietta Girolamo, Silvia Fillo, Andrea Ciammaruconi, Florigio Lista, Clementina Elvezia Cocuzza, Rosario Musumeci, Christophe Ginevra, Ghislaine Descours, Sophie Jarraud, Jessica Iera, Paolo Visca, Maria Luisa Ricci

“…The presence of the lpeAB efflux pump genes was also investigated. The genome sequences of a subpopulation of isolates showing reduced susceptibility to azithromycin were also analysed. …”
Get full text

Decreased Spp1 Expression in Acute Myocardial Infarction after Ischemia and Reperfusion Injury by Ling Li, Jungang Huang, Zongkai Zhao, Zhuzhi Wen, Kang Li, Tianjiao Ma, Lisui Zhang, Junmeng Zheng, Shi Liang

“…In addition, Gene Ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed to find the biological property of 449 RNAs from GSE83472 via the Database for Annotation, Visualization, and Integrated Discovery (DAVID). …”
Get full text

A positive experience in applying the biolistic approach to potato varieties Aksor and Nevskiy by N. P. Malakhova, Y. A. Skiba, G. A. Iskakova, D. A. Naizabayeva, B. K. Tezekbaeva, G. A. Ismagulova, E. R. Maltseva

“…The main advantages of this method include the ability to simultaneously incorporate several target genes into the plant genome, carry out transfer without unnecessary agrobacterial parts and plasmid DNA sequences, and the short time needed to produce transgenic cells. …”
Get full text

Expression Analysis and Functional Validation of DcTPSb1 in Terpene Synthesis of <i>Dendrobium chrysotoxum</i> by Yuxuan Jin, Shuting Zhou, Zhihui Du, Weize Wang, Zhilin Chen

“…Analysis of the <i>D. chrysotoxum</i> genome and transcriptional data revealed that the gene <i>DcTPSb1</i> was significantly up-regulated during flowering periods, showing a strong correlation with the accumulation of aromatic monoterpenes in the floral components of <i>Dendrobium chrysotoxum</i>. …”
Get full text

Minimization of the Bacillus subtilis divisome suggests FtsZ and SepF can form an active Z-ring, and reveals the amino acid transporter BraB as a new cell division influencing fact... by Ilkay Celik Gulsoy, Terrens N V Saaki, Michaela Wenzel, Simon Syvertsson, Taku Morimoto, Tjalling K Siersma, Leendert W Hamoen

“…Viability of the multiple deletion mutant was not greatly affected, although the frequency of cell division was considerably reduced. Whole genome sequencing suggested that the construction of this minimal divisome strain was also possible due to the accumulation of suppressor mutations. …”
Get full text

Relationship between inherited genetic variation and survival from colorectal cancer stratified by tumour location by Christopher Wills, Katie Watts, Amy Houseman, Timothy S. Maughan, David Fisher, Nada A. Al-Tassan, Richard S. Houlston, Valentina Escott-Price, Jeremy P. Cheadle

“…We studied 1899 patients with advanced CRC (514 had proximal colonic, 493 distal colonic and 892 rectal tumours) and carried out genome-wide association studies for survival. Single nucleotide polymorphisms (SNPs) suggestive of association (P < 1.0 × 10–5) were tested for replication in 5078 CRC patients from the UK Biobank. …”
Get full text

Duckweed: a starch-hyperaccumulating plant under cultivation with a combination of nutrient limitation and elevated CO2 by Ling Guo, Ling Guo, Yang Fang, Songhu Wang, Yao Xiao, Yanqiang Ding, Yanling Jin, Xueping Tian, Anping Du, Zhihua Liao, Kaize He, Shuang Chen, Yonggui Zhao, Li Tan, Zhuolin Yi, Yuqing Che, Lanchai Chen, Jinmeng Li, Leyi Zhao, Peng Zhang, Zhengbiao Gu, Fangyuan Zhang, Yan Hong, Qing Zhang, Hai Zhao

“…In this study, we integrated whole-genome sequencing, epigenomics, transcriptomics, enzyme activity, and composition variation to elucidate the mechanisms of efficient starch accumulation in duckweed in terms of starch accumulation and carbon partitioning, regulation of the expression of genes in the starch metabolic pathway, and sucrose biosynthesis and transportation.Results and discussionAlthough Landoltia punctata exhibits dramatic gene family contraction, its starch content and productivity reached 72.2% (dry basis) and 10.4 g m-2 d-1, respectively, in 10 days, equivalent to a yield of 38.0 t ha-1 y-1, under nutrient limitation treatment with elevated CO2 levels. …”
Get full text

Effective resistance to powdery mildew in Aegilops L. accessions by M. A. Kolesova, N. N. Chikida, M. Kh. Belousova, L. G. Tyryshkin

“…As a result of the tests, susceptibility to powdery mildew was shown in all Aegilops accessions of the D-genome group; all the studied representatives of Ae. speltoides, Ae. caudata and Ae. biuncialis were highly resistant to powdery mildew.…”
Get full text

Comparative Metabolic Analysis of Different <i>Indica</i> Rice Varieties Associated with Seed Storability by Fangxi Wu, Yidong Wei, Yongsheng Zhu, Xi Luo, Wei He, Yingheng Wang, Qiuhua Cai, Huaan Xie, Guosheng Xie, Jianfu Zhang

“…The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis indicated that several biosynthesis pathways were involved in the observed metabolite differences, including alpha-linolenic acid metabolism, butanoate metabolism, and propanoate metabolism. …”
Get full text

Characterization of the Phosphotransferase from <i>Bacillus subtilis</i> 1101 That Is Responsible for the Biotransformation of Zearalenone by Yuzhuo Wu, Qiuyu Zhou, Junqiang Hu, Yunfan Shan, Jinyue Liu, Gang Wang, Yin-Won Lee, Jianrong Shi, Jianhong Xu

“…In this study, a ZEA phosphotransferase, ZPH1101, was identified from <i>Bacillus subtilis</i> 1101 using genome sequencing. The product transformed by ZPH1101 was identified as phosphorylated ZEA (ZEA-P) through LC-TOF-MS/MS analysis. …”
Get full text

Bidirectional Mendelian Randomization Analysis of the Association Between Mitochondrial Proteins and Neurodegenerative Diseases by Fangyuan Wang, Zhou Jing, Qingyi Wang, Minghe Li, Bingqi Lu, Ao Huo, Chenglin Zhao, Huanyu Zhou, Wulong Liang, Weihua Hu, Xudong Fu

“…Methods Herein, we utilized data from genome‐wide association studies (GWAS) on mitochondrial proteins and neurodegenerative diseases. …”
Get full text

SARS-CoV-2 excretion and genetic evolution in nasopharyngeal and stool samples from primary immunodeficiency and immunocompetent pediatric patients by Haifa Khemiri, Ilhem Ben Fraj, Alessio Lorusso, Najla Mekki, Iolanda Mangone, Mariem Gdoura, Adriano Di Pasqual, Cesare Cammà, Valeria Di Lollo, Asma Cherni, Henda Touzi, Amel Sadraoui, Zina Meddeb, Nahed Hogga, Imen Ben Mustapha, Mohamed-Ridha Barbouche, Monia Ouederni, Henda Triki, Sondes Haddad-Boubaker

“…RNA detection was performed using RT-qPCR, and whole-genome sequencing was conducted with the NexSeq 1000 platform. …”
Get full text

Newly isolated halotolerant Gordonia terrae S-LD serves as a microbial cell factory for the bioconversion of used soybean oil into polyhydroxybutyrate by Song Xu, Ruiqin Han, Lidan Tao, Zhipeng Zhang, Junfei Gao, Xinyuan Wang, Wei Zhao, Xiaoxia Zhang, Zhiyong Huang

“…In addition, the whole genome was sequenced, and the PHB biosynthetic pathway and quantitative expression of key genes were delineated in the novel isolated strain. …”
Get full text