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4301
High-throughput sequence-based microsatellite genotyping for the non-model Neotropical tree species Anadenanthera colubrina (Leguminosae)
Published 2025-01-01“…Next-generation sequencing (NGS) strategies allow simple and cost-effective development of new SSR loci from low-coverage whole genome shotgun sequencing. The main aim was to develop microsatellite markers for sequence-based high-throughput genotyping (SSRseq) in the species and to characterize their information content against traditional capillary electrophoresis-based microsatellite data by estimating the amount of molecularly accessible size homoplasy of each locus. …”
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4302
Emergence of a novel porcine pestivirus with potential for cross-species transmission in China, 2023
Published 2025-02-01“…Viremia has been detected in both piglets and mice, with high viral genome loads found in various organs. In vitro results revealed that PAAPeV replicates in ST cells and, to a lesser extent, in human (A549 and HepG2) and monkey (Vero) cells. …”
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4303
Investigating the role of iron status in the development of coeliac disease: a Mendelian randomisation study
Published 2024-05-01“…The SNPs were drawn from a meta-analysis of three genome-wide association studies (GWAS). The association between these SNPs and coeliac disease was assessed using GWAS summary statistics from the UK Biobank. …”
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4304
Estimation of translational importance of mammalian mRNA nucleotide sequence characteristics based on ribosome profiling data
Published 2017-02-01“…Thanks to ribosome profiling technology, genome-wide experimental data of translation efficiency have been obtained for many eukaryotic mRNAs. …”
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4305
Bioinformatics Method Was Used to Analyze the Highly Expressed Gene FAM83A of Breast Cancer in Young Women
Published 2022-01-01“…Digital gene representation of the Tumor Genome Project Data Library was used to select differentially expressed genes in breast cancer tissue and breast benign tumor tissue. …”
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4306
Multiomic machine learning on lactylation for molecular typing and prognosis of lung adenocarcinoma
Published 2025-01-01“…LRG mRNA and long non-coding RNA transcriptomes, epigenetic methylation data, and somatic mutation data from The Cancer Genome Atlas LUAD cohort were analyzed to identify lactylation cancer subtypes (CSs) using 10 multiomics ensemble clustering techniques. …”
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4307
Lessons from SARS-CoV, MERS-CoV, and SARS-CoV-2 Infections: What We Know So Far
Published 2022-01-01“…Therefore, this review summarizes the state-of-the-art information and compares the similarities and dissimilarities between SARS-CoV, MERS-CoV, and SARS-CoV-2, in terms of their evolution trait, genome organization, host cell entry mechanisms, tissue infectivity tropisms, transmission routes and contagiousness, and the clinical characteristics, laboratory features, and immunological abnormalities of their related illnesses. …”
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4308
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4309
Rehabilomics Strategies Enabled by Cloud-Based Rehabilitation: Scoping Review
Published 2025-01-01“… BackgroundRehabilomics, or the integration of rehabilitation with genomics, proteomics, metabolomics, and other “-omics” fields, aims to promote personalized approaches to rehabilitation care. …”
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4310
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4311
To describe the subsets of malignant epithelial cells in gastric cancer, their developmental trajectories and drug resistance characteristics
Published 2025-01-01“…This study employed single-cell RNA sequencing, using the 10 × Genomics platform, to analyze 262,532 cells from gastric cancer samples, identifying 32 distinct clusters and 10 major cell types, including immune cells (e.g., T cells, monocytes) and epithelial subpopulations. …”
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4312
Comprehensive Analysis of microRNA Methylation Profiles and Determination of Their Functional Significance in Colorectal Cancer: A Study Protocol
Published 2023-12-01“…This study aims to investigate the genome-wide methylome profiles of microRNA and clarify their roles in CRC. …”
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4313
Quaternion modeling of the helical path for analysis of the shape of the DNA molecule
Published 2018-01-01“…Taken together, these algorithms will be useful both in the in silico analysis of relatively short DNA fragments as well as in topological mapping of whole genomes.…”
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4314
Diagnostic Performance of SARS-CoV-2 Rapid Antigen Test in relation to RT-PCR Cq Value
Published 2022-01-01“…Out of 213 individuals, 75 tested positive in Ag-RDT test, while 118 tested positive for SARS-CoV-2 RNA genome via Real time PCR assay. The overall diagnostic performance of Ag-RDT showed 63.6% sensitivity and 97.9% specificity. …”
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4315
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4316
Rheumatoid Arthritis, Circulating Inflammatory Proteins, and Hypertension: A Mendelian Randomization Study
Published 2025-01-01“…The study data were obtained from publicly accessible genome‐wide association study (GWAS) databases and meta‐aggregates of large GWAS studies. …”
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4317
Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning
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4318
Interconnections between BDH1-plasma protein-type 2 diabetes Mellitus: a mediated mendelian randomization analysis using plasma proteomics
Published 2025-01-01“…This study primarily employed the Mendelian Randomization (MR) method, leveraging genetic data from numerous large-scale, publicly accessible genome-wide association studies (GWAS). Within this framework, we adopted a two-step, two-sample MR approach to evaluate the relationships between BDH1, plasma proteins, and type 2 diabetes. …”
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4319
CRISPR-Based Programmable Nucleic Acid-Binding Protein Technology Can Specifically Detect Fatal Tropical Disease-Causing Pathogens
Published 2022-01-01“…It consists of CRISPR-associated proteins (Cas) capable of targeting virtually any specific RNA or DNA genome based on the guide RNA (gRNA) sequence. Furthermore, the discovery of programmable trans-cleavage Cas proteins like Cas12a and Cas13 that can collaterally damage reporter-containing single-stranded DNA or RNA upon formation of target Cas-gRNA complex has strengthened this technology with enhanced sensitivity. …”
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4320
Gene expression signatures between Limia perugiae (Poeciliidae) populations from freshwater and hypersaline habitats, with comparisons to other teleosts.
Published 2024-01-01“…We used RNA-sequencing (RNA-seq) to investigate genome-wide variation in gene expression between a hypersaline population and a freshwater population of the livebearing fish species Limia perugiae (Poeciliidae). …”
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