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4121
Toward the Development of the Trojan Female Technique in Pest Insects: Male‐Specific Influence of Mitochondrial Haplotype on Reproductive Output in the Seed Beetle Acanthoscelides...
Published 2024-12-01“…TFT is based on the evolutionary hypothesis that, due to maternal inheritance of mitochondria, mutations which are beneficial or neutral in females but harmful in males can accumulate in the mitochondrial genome without selection acting against them. Although TFT has been theoretically substantiated, empirical work to date has focused only on Drosophila melanogaster populations, while the existence of male‐biased mutations and the TFT approach in economically important pest species remain unexplored. …”
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4122
High Prevalence of Autoimmune Diabetes and Poor Glycaemic Control among Adults in Madagascar: A Brief Report from a Humanitarian Health Campaign in Ambanja
Published 2017-01-01“…Madagascar is a geographically isolated country considered a biodiversity hotspot with unique genomics. Both the low-income and the geographical isolation represent risk factors for the development of diabetes. …”
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4123
Molecular markers in the genetic diversity studies of representatives of the genus <i>Rubus</i> L. and prospects of their application in breeding
Published 2020-03-01“…Modern breeding and genetic programs increasingly use the achievements of molecular genetics and genomics. This paper reviews the literature data on the application of molecular markers in fundamental and applied research aimed at studying the genetic diversity of cultivated and wild species of the genus Rubus. …”
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4124
Impact of frequent ARID1A mutations on protein stability provides insights into cancer pathogenesis
Published 2025-01-01“…We analyzed five frequent missense mutations R1020S, M1022K, K1047Q, G1063V, and A1089T identified in The Cancer Genome Atlas (TCGA) to assess their effects on the stability of the ARID domain using a hybrid experimental and computational approach. …”
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4125
RatDEGdb: a knowledge base of differentially expressed genes in the rat as a model object in biomedical research
Published 2023-12-01“…RatDEGdb may be interesting first of all to human geneticists, molecular biologists, clinical physicians, genetic advisors as well as experts in biopharmaceutics, bioinformatics and personalized genomics. RatDEGdb is publicly available at https://www.sysbio.ru/RatDEGdb.…”
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4126
The impact of genetic polymorphisms of IL28B gene on the efficacy of antiviral therapy of the chronic hepatitis C by using the standard Interferon-<i>α</i>
Published 2013-03-01“…The studies of genetic polymorphisms of the regions of human genome demonstrates that the positive predictive value of IL28B polymorphisms among the patients with 1-st HCV genotype is higher than among the patients with 2nd and 3d genotypes. …”
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4127
Attenuation and Immunogenicity of a Live High Pathogenic PRRSV Vaccine Candidate with a 32-Amino Acid Deletion in the nsp2 Protein
Published 2014-01-01“…Furthermore, we determined the whole genome sequences of these four intermediate viruses. …”
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4128
Cell-marking techniques for cell lineage tracing
Published 2017-02-01“…This review focuses on modern methods for cell tracing with dyes and genetic constructs encoding protein reporters that mark cell lineages. Special focus is on genome-integrated tags (genetic labeling), such as viral and cellular barcoding. …”
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4129
MeStanG—Resource for High-Throughput Sequencing Standard Data Sets Generation for Bioinformatic Methods Evaluation and Validation
Published 2025-01-01“…The simulator pipeline was evaluated by analyzing its output mock metagenomic samples containing known read abundances using read mapping, genome assembly, and taxonomic classification on three scenarios: a bacterial community composed of nine different organisms, samples resembling pathogen-infected wheat plants, and a viral pathogen serial dilution sampling. …”
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4130
New insights into the mechanism of triphenyl phosphate and its metabolite diphenyl phosphate in diabetic kidney disease
Published 2025-02-01“…Additionally, the study explored the targets of action for TPHP and DPHP using network toxicity analysis, conducted protein interaction analysis, and explored the functional aspects of action through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis. Furthermore, the study identified key proteins involved in the action and conducted experimental verification by treating cells with TPHP and DPHP. …”
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4131
Testing and identification of bovine viral diarrhea virus isolates recovered in Russia between 2019 and 2022
Published 2023-12-01“…Based on the analysis of the nucleotide sequence of genome 5’-untranslated region (5’-UTR) fragment, these isolates were classified as belonging to three genotypes of the virus. …”
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4132
Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence
Published 2019-01-01“…This review supports an association between epigenetic marks and inflammation, suggesting hypomethylation of the genome. Important gaps in the quality of studies were reported such as inadequate sample size, lack of adjustment for relevant confounders, and failure to replicate the findings. …”
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4133
Distinct MicroRNA Subcellular Size and Expression Patterns in Human Cancer Cells
Published 2012-01-01“…Here, we show distinct genome-wide sub-cellular localization distribution profiles of small noncoding RNAs in human breast cancer cells. …”
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4134
Chloroplast DNA Diversity of Tunisian Barley Landraces as Revealed by cpSSRs Molecular Markers and Implication for Conservation Strategies
Published 2022-01-01“…Information on genetic variation within the chloroplast genome is of great interest to ensure an efficient conservation strategy that takes into account the preservation of the various maternal lineages of Tunisian barley.…”
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4135
Conserved Nuclear Localization Signal in NS2 Protein of Bombyx Mori Bidensovirus: A Potential Invertebrate ssDNA Virus Trait
Published 2025-01-01“…Bombyx mori bidensovirus (BmBDV), a significant pathogen in the sericulture industry, holds a unique taxonomic position due to its distinct segmented single-stranded DNA (ssDNA) genome and the presence of a self-encoding DNA polymerase. …”
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4136
Metagenomic Insights into Pigeon Gut Microbiota Characteristics and Antibiotic-Resistant Genes
Published 2025-01-01“…Besides the shared metabolic pathways and biosynthesis of secondary metabolites, biosynthesis of amino acids was the most abundant Kyoto Encyclopedia of Genes and Genomes (KEGG) function in young pigeons, while microbial metabolism in diverse environments was abundant in older pigeons. …”
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4137
Detecting Genetic Associations between ATG5 and Lupus Nephritis by trans-eQTL
Published 2015-01-01“…As elevated ATG5 expression was observed in systemic lupus erythematosus (SLE), the study was conducted to analyze the genome-wide genetic regulatory mechanisms associated with ATG5 expression in a Chinese population with lupus nephritis (LN). …”
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4138
GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding
Published 2025-01-01“…In this study, we conduct a comprehensive genome-wide CRISPR/Cas9 knockout screen utilizing EA H1N1 SIV in porcine kidney cells. …”
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4139
A multi-trait approach identified 7 novel genes for back pain
Published 2025-02-01“…Less than half of this can be explained by known genetic variants identified in genome-wide association studies. Objectives:. We applied a powerful multi-trait and gene-based approach to association analysis of BP to identify novel genes associated with BP. …”
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4140
Comprehensive Analysis of Gene Signatures of m6ARNA Methylation Regulators in Lung Adenocarcinoma and Development of a Risk Scoring System
Published 2022-01-01“…We systematically studied correlations among important M6A methylation regulators, tumor mutational burden (TMB), and immune infiltration in clinical and sequencing data from the LUAD cohort of the cancer genome map (TCGA). The molecular subtype clusters 1 and 2 were identified by the consensus clustering of 16 M6A regulatory factors. …”
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